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3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Hepatic Encephalopathy

3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Hepatic Encephalopathy in 2 studies

3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miñana, MD1
Corbalán, R2
Montoliu, C1
Teng, CM1
Felipo, V2
Monfort, P1
Martinez, L1
López-Talavera, J1
Córdoba, J1

Other Studies

2 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Hepatic Encephalopathy

ArticleYear
Chronic hyperammonemia in rats impairs activation of soluble guanylate cyclase in neurons and in lymphocytes: a putative peripheral marker for neurological alterations.
    Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2

    Topics: Ammonia; Animals; Biomarkers; Cells, Cultured; Chronic Disease; Cyclic GMP; Enzyme Activation; Excit

1999
Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis.
    Neuroscience, 2001, Volume: 104, Issue:4

    Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Excitatory Amino Acid Ag

2001