3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Disease Models, Animal in 20 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conclude that in preeclampsia, the decrease of relaxation responses and the decrease of cGMP content could be due to the reduction in stimulation of sGC and the decrease in cGMP levels." | 1.39 | Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model. ( Bagcivan, I; Karadas, B; Parlak, M; Temiz, TK; Turgut, B; Turgut, NH, 2013) |
| "YC-1 (20mg/kg) pretreatment with heat stroke (YC-1+HS) group, the MAP and heart rate were return to normal, and the biochemical markers were all significantly recovered to normal." | 1.39 | The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats. ( Cheng, PY; Ding, C; Lam, KK; Lee, YM; Liu, WH; Liu, YP; Yen, MH, 2013) |
| "Acute lung injury was associated with a higher degree of pulmonary HIF-1α and iNOS expression as well as apoptosis in the lungs." | 1.38 | Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats. ( Hu, R; Huang, Y; Jiang, H; Li, QF; Xu, H, 2012) |
| "In a model of fatal pulmonary thromboembolism induced by intravenous injection of ADP (300 micrograms/g), YC-1 was effective in reducing mortality when administered intraperitoneally at doses of 10-30 micrograms/g." | 1.30 | YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice. ( Ko, FN; Kuo, SC; Lee, FY; Teng, CM; Wu, CC, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Dong, W | 1 |
| Yu, P | 1 |
| Zhang, T | 1 |
| Zhu, C | 1 |
| Qi, J | 1 |
| Liang, J | 1 |
| Yan, Z | 1 |
| An, J | 1 |
| Shang, Q | 1 |
| Zhou, N | 1 |
| Ma, J | 1 |
| Dong, Y | 1 |
| Li, Y | 1 |
| Feng, D | 1 |
| Wang, J | 1 |
| Wen, H | 1 |
| Liu, D | 1 |
| Zhao, D | 1 |
| Liu, H | 1 |
| Gao, G | 1 |
| Yin, Z | 1 |
| Qin, H | 1 |
| Turgut, NH | 1 |
| Temiz, TK | 1 |
| Turgut, B | 1 |
| Karadas, B | 1 |
| Parlak, M | 1 |
| Bagcivan, I | 1 |
| Wu, J | 1 |
| Ke, X | 1 |
| Fu, W | 1 |
| Gao, X | 1 |
| Zhang, H | 1 |
| Wang, W | 1 |
| Ma, N | 1 |
| Zhao, M | 1 |
| Hao, X | 1 |
| Zhang, Z | 1 |
| Kimura, K | 1 |
| Iwano, M | 1 |
| Higgins, DF | 1 |
| Yamaguchi, Y | 1 |
| Nakatani, K | 1 |
| Harada, K | 1 |
| Kubo, A | 1 |
| Akai, Y | 1 |
| Rankin, EB | 1 |
| Neilson, EG | 1 |
| Haase, VH | 1 |
| Saito, Y | 1 |
| Xu, Y | 1 |
| Gu, Y | 1 |
| Keep, RF | 1 |
| Heth, J | 1 |
| Muraszko, KM | 1 |
| Xi, G | 1 |
| Hua, Y | 1 |
| Keswani, AN | 1 |
| Peyton, KJ | 1 |
| Durante, W | 1 |
| Schafer, AI | 1 |
| Tulis, DA | 1 |
| DeNiro, M | 1 |
| Al-Halafi, A | 1 |
| Al-Mohanna, FH | 1 |
| Alsmadi, O | 1 |
| Al-Mohanna, FA | 1 |
| Chen, C | 1 |
| Ostrowski, RP | 1 |
| Zhou, C | 1 |
| Tang, J | 1 |
| Zhang, JH | 1 |
| Yan, J | 1 |
| Zhou, B | 1 |
| Taheri, S | 1 |
| Shi, H | 1 |
| Jiang, H | 1 |
| Huang, Y | 1 |
| Xu, H | 1 |
| Hu, R | 1 |
| Li, QF | 1 |
| Lam, KK | 1 |
| Cheng, PY | 1 |
| Lee, YM | 1 |
| Liu, YP | 1 |
| Ding, C | 1 |
| Liu, WH | 1 |
| Yen, MH | 1 |
| Pili, R | 1 |
| Donehower, RC | 1 |
| Pan, SL | 1 |
| Guh, JH | 1 |
| Peng, CY | 1 |
| Chang, YL | 1 |
| Cheng, FC | 1 |
| Chang, JH | 1 |
| Kuo, SC | 2 |
| Lee, FY | 2 |
| Teng, CM | 2 |
| Wu, CC | 1 |
| Ko, FN | 1 |
| Stasch, JP | 1 |
| Becker, EM | 1 |
| Alonso-Alija, C | 1 |
| Apeler, H | 1 |
| Dembowsky, K | 1 |
| Feurer, A | 1 |
| Gerzer, R | 1 |
| Minuth, T | 1 |
| Perzborn, E | 1 |
| Pleiss, U | 1 |
| Schröder, H | 1 |
| Schroeder, W | 1 |
| Stahl, E | 1 |
| Steinke, W | 1 |
| Straub, A | 1 |
| Schramm, M | 1 |
| Monfort, P | 1 |
| Corbalán, R | 1 |
| Martinez, L | 1 |
| López-Talavera, J | 1 |
| Córdoba, J | 1 |
| Felipo, V | 1 |
20 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Adrenomedullin serves a role in the humoral pathway of delayed remote ischemic preconditioning via a hypoxia-inducible factor-1α-associated mechanism.
Topics: Adrenomedullin; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Hypoxia-Inducible | 2018 |
YC-1 Inhibits VEGF and Inflammatory Mediators Expression on Experimental Central Retinal Vein Occlusion in Rhesus Monkey.
Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Follow-Up Studies; Guanylate Cyc | 2018 |
Protective effect of HIF-1α against hippocampal apoptosis and cognitive dysfunction in an experimental rat model of subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Blood Pressure; Caspase 3; Cognition Disorders; Disease Models, Animal; DNA Frag | 2013 |
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relation | 2013 |
Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.
Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line; Cobalt; Diabetic Retinopathy; Disease Mod | 2016 |
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
Topics: Aging; Animals; Disease Models, Animal; Enzyme Activators; Epithelial Cells; Female; Fibrosis; Gene | 2008 |
Thrombin up-regulates vascular endothelial growth factor in experimental gliomas.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Glioma; Hemos | 2009 |
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects.
Topics: Animals; Apoptosis; Carotid Artery Injuries; Cell Proliferation; Cyclic GMP; Disease Models, Animal; | 2009 |
Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Indazoles; Mice; Mice, Inbred C57BL; Neovasculari | 2010 |
Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia.
Topics: 2-Methoxyestradiol; Acute Disease; Animals; Brain; Brain Ischemia; Central Nervous System Agents; Di | 2010 |
Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Endothelial Cells; Gene Expres | 2011 |
Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats.
Topics: Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Caspase 3; Cytoprotection; Disease Models, Animal; | 2012 |
The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats.
Topics: Animals; Arterial Pressure; Disease Models, Animal; DNA-Binding Proteins; Enzyme Activators; Gene Ex | 2013 |
Is HIF-1 alpha a valid therapeutic target?
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Basic Helix- | 2003 |
A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models.
Topics: Animals; Blotting, Western; Cyclic GMP; Cytokines; Disease Models, Animal; DNA; Endotoxemia; Humans; | 2005 |
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice.
Topics: Adenosine Diphosphate; Animals; Bleeding Time; Blood Coagulation; Blood Platelets; Disease Models, A | 1997 |
NO-independent regulatory site on soluble guanylate cyclase.
Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cyclic N-Oxide | 2001 |
Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis.
Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Excitatory Amino Acid Ag | 2001 |