3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Cerebral Ischemia in 5 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kong, L | 1 |
| Ma, Y | 1 |
| Wang, Z | 1 |
| Liu, N | 1 |
| Ma, G | 1 |
| Liu, C | 1 |
| Shi, R | 1 |
| Du, G | 1 |
| Tai, SH | 2 |
| Lee, WT | 2 |
| Lee, AC | 1 |
| Lin, YW | 2 |
| Hung, HY | 1 |
| Huang, SY | 1 |
| Wu, TS | 2 |
| Lee, EJ | 2 |
| Chen, C | 1 |
| Ostrowski, RP | 1 |
| Zhou, C | 1 |
| Tang, J | 1 |
| Zhang, JH | 1 |
| Yan, J | 1 |
| Zhou, B | 1 |
| Taheri, S | 1 |
| Shi, H | 1 |
5 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Cerebral Ischemia
| Article | Year |
|---|---|
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Topics: Animals; Brain Ischemia; Cerebral Hemorrhage; Endothelial Cells; HMGB1 Protein; Hypoxia-Inducible Fa | 2021 |
Therapeutic window for YC‑1 following glutamate‑induced neuronal damage and transient focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium; Calcium Signaling; Cytoprotection; Glutamic Acid; Indazoles; Mice; | 2018 |
YC‑1 reduces inflammatory responses by inhibiting nuclear factor‑κB translocation in mice subjected to transient focal cerebral ischemia.
Topics: Animals; Brain Edema; Brain Ischemia; Indazoles; Interleukin-1beta; Interleukin-6; Matrix Metallopro | 2018 |
Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia.
Topics: 2-Methoxyestradiol; Acute Disease; Animals; Brain; Brain Ischemia; Central Nervous System Agents; Di | 2010 |
Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Endothelial Cells; Gene Expres | 2011 |