3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Carcinoma, Non-Small Cell Lung in 2 studies
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gefitinib treatment induced EGFR arrest in the early endosome, and YC-1 treatment promoted delayed EGFR transport into the late endosome as well as receptor degradation." | 1.56 | YC-1 potentiates the antitumor activity of gefitinib by inhibiting HIF-1α and promoting the endocytic trafficking and degradation of EGFR in gefitinib-resistant non-small-cell lung cancer cells. ( Hu, H; Hu, MN; Li, JY; Miao, XK; Mou, LY; Xu, JJ; Yang, WL; Zhang, JY; Zhang, XW; Zhou, TX, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, H | 1 |
| Miao, XK | 1 |
| Li, JY | 1 |
| Zhang, XW | 1 |
| Xu, JJ | 1 |
| Zhang, JY | 1 |
| Zhou, TX | 1 |
| Hu, MN | 1 |
| Yang, WL | 1 |
| Mou, LY | 1 |
| Ikezawa, Y | 1 |
| Sakakibara-Konishi, J | 1 |
| Mizugaki, H | 1 |
| Oizumi, S | 1 |
| Nishimura, M | 1 |
2 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
YC-1 potentiates the antitumor activity of gefitinib by inhibiting HIF-1α and promoting the endocytic trafficking and degradation of EGFR in gefitinib-resistant non-small-cell lung cancer cells.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resista | 2020 |
Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Female; Humans; Hypoxia-Ind | 2017 |