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3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Breast Neoplasms

3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole has been researched along with Breast Neoplasms in 7 studies

3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source
lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.

Breast Neoplasms: Tumors or cancer of the human BREAST.

Research Excerpts

ExcerptRelevanceReference
" In the clinical scenario, germline variation in VAV3 was associated with the response to tamoxifen in Japanese breast cancer patients (rs10494071 combined P value = 8."3.80VAV3 mediates resistance to breast cancer endocrine therapy. ( Aguilar, H; Balart, J; Barril, X; Beijersbergen, RL; Bonifaci, N; Bostner, J; Brunet, J; Burnstein, KL; Bustelo, XR; Caizzi, L; Carlson, KE; Clarke, R; Climent, F; Di Croce, L; Esteller, M; Extremera, AI; Figueras, A; Fornander, T; García, N; Garcia-Mata, R; Gil, M; Gómez-Baldó, L; Halonen, P; Islam, A; Jansen, MP; Karlsson, E; Katzenellenbogen, JA; Kiyotani, K; Martrat, G; Mushiroda, T; Nakamura, Y; Nevedomskaya, E; Pérez Tenorio, G; Pujana, MA; Rodríguez-Peña, AB; Rodríguez-Vida, A; Serra-Musach, J; Sgroi, DC; Soler, MT; Stål, O; Urruticoechea, A; Villanueva, A; Vizoso, M; Zembutsu, H; Zwart, W, 2014)
"Parkin downregulation in breast cancer cells promotes metastasis, which can be inhibited by targeting HIF-1α with RNA interference or the small-molecule inhibitor YC-1."1.46Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. ( Chen, J; Feng, Z; Gao, J; Gatza, ML; Haffty, BG; Hu, W; Huang, S; Khella, CA; Liu, J; Tomsky, K; White, E; Wu, H; Xia, D; Xie, H; Yue, X; Zhang, C; Zhao, Y, 2017)
"In YC-1-treated breast cancer cells and tumour specimens from YC-1-treated MDA-MB-468 xenografts, EZH2 expression was analysed by Western blotting."1.40YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. ( Chang, LC; Chou, RH; Hsieh, MT; Huang, LJ; Hung, HY; Kuo, SC; Lee, FY; Lin, HY; Teng, CM; Tsai, MT; Yu, YL, 2014)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, J1
Zhang, C1
Zhao, Y1
Yue, X1
Wu, H1
Huang, S1
Chen, J1
Tomsky, K1
Xie, H1
Khella, CA1
Gatza, ML1
Xia, D1
Gao, J1
White, E1
Haffty, BG1
Hu, W1
Feng, Z1
Lee, JC1
Chou, LC1
Lien, JC1
Wu, JC1
Huang, CH1
Chung, CH1
Lee, FY2
Huang, LJ2
Kuo, SC2
Way, TD1
Chang, LC1
Lin, HY1
Tsai, MT1
Chou, RH1
Teng, CM1
Hsieh, MT1
Hung, HY1
Yu, YL1
Aguilar, H1
Urruticoechea, A1
Halonen, P1
Kiyotani, K1
Mushiroda, T1
Barril, X1
Serra-Musach, J1
Islam, A1
Caizzi, L1
Di Croce, L1
Nevedomskaya, E1
Zwart, W1
Bostner, J1
Karlsson, E1
Pérez Tenorio, G1
Fornander, T1
Sgroi, DC1
Garcia-Mata, R1
Jansen, MP1
García, N1
Bonifaci, N1
Climent, F1
Soler, MT1
Rodríguez-Vida, A1
Gil, M1
Brunet, J1
Martrat, G1
Gómez-Baldó, L1
Extremera, AI1
Figueras, A1
Balart, J1
Clarke, R1
Burnstein, KL1
Carlson, KE1
Katzenellenbogen, JA1
Vizoso, M1
Esteller, M1
Villanueva, A1
Rodríguez-Peña, AB1
Bustelo, XR1
Nakamura, Y1
Zembutsu, H1
Stål, O1
Beijersbergen, RL1
Pujana, MA1
Cheng, Y1
Li, W1
Liu, Y1
Cheng, HC1
Ma, J1
Qiu, L1
Harrison, H1
Rogerson, L1
Gregson, HJ1
Brennan, KR1
Clarke, RB1
Landberg, G1
Hiraga, T1
Kizaka-Kondoh, S1
Hirota, K1
Hiraoka, M1
Yoneda, T1

Other Studies

7 other studies available for 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole and Breast Neoplasms

ArticleYear
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.
    Nature communications, 2017, 11-28, Volume: 8, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Heterografts; H

2017
CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo.
    Oncology reports, 2013, Volume: 30, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Apoptosis; Breast Neoplasms

2013
YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK.
    British journal of pharmacology, 2014, Volume: 171, Issue:17

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response R

2014
VAV3 mediates resistance to breast cancer endocrine therapy.
    Breast cancer research : BCR, 2014, May-28, Volume: 16, Issue:3

    Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast; Br

2014
YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition.
    Chinese journal of cancer, 2012, Volume: 31, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Prol

2012
Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status.
    Cancer research, 2013, Feb-15, Volume: 73, Issue:4

    Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Estrogen Antagonists;

2013
Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.
    Cancer research, 2007, May-01, Volume: 67, Issue:9

    Topics: Animals; Bone Neoplasms; Breast Neoplasms; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Female; Humans

2007