3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with Seizures in 37 studies
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pilocarpine injection into rodents leads to the development of chronic limbic seizures that follow an initial status epilepticus and a seizure-free interval." | 7.69 | Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Köhling, R; Lücke, A; Nagao, T; Speckmann, EJ, 1995) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 7.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| "4-aminopyridine, particularly the tonic convulsions, but were less effective against those produced by i." | 5.29 | Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. ( Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME, 1996) |
| "To characterize the potential interaction between the excitatory and inhibitory neurotransmitter systems, the effects of dizocilpine, CPP, and lorazepam on open-field behavior and pentylenetetrazol-induced seizures were evaluated in mice." | 3.70 | Lorazepam attenuates the behavioral effects of dizocilpine. ( Fahey, JM; Greenblatt, DJ; Pratt, JS; Pritchard, GA; Shader, RI, 1999) |
| "Aminophylline reversed the protective action of both, D-3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid (D-CPP-ene-a competitive NMDA antagonist) and valproate (used as a conventional antiepileptic drug for comparative purposes) against maximal electroshock-induced seizures." | 3.69 | Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, WA; Tutka, P, 1996) |
| "Pilocarpine injection into rodents leads to the development of chronic limbic seizures that follow an initial status epilepticus and a seizure-free interval." | 3.69 | Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures. ( Avoli, M; Köhling, R; Lücke, A; Nagao, T; Speckmann, EJ, 1995) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 3.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| " Mice withdrawn from chronic treatment with diazepam showed a time-related evolution of anxiety, muscle rigidity, and seizures between days 4 and 21 after treatment discontinuation." | 3.68 | Diazepam dependence prevented by glutamate antagonists. ( Steppuhn, KG; Turski, L, 1993) |
| "To investigate the possible role of N-methyl-D-aspartate (NMDA) receptors in the development and expression of amygdaloid-kindled seizures, rats were either chronically infused with 2-amino-5-phosphonovalerate (APV, 20-40 mM) or pre-injected with carboxypiperazine-phosphonate (CPP, 1-10 mg/kg), both selective NMDA-receptor antagonists, and then kindled from the amygdala." | 3.68 | The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures. ( Bilkey, DK; Goddard, GV; Holmes, KH; Laverty, R, 1990) |
| "The anticonvulsant activity of two competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor, 2-amino-7-phosphonoheptanoic acid (APH) and 3-[2-carboxypiperazin-4-yl]-propyl-1-phosphonate (CPP), and two non-competitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), were compared in 4 models of induced seizures in mice." | 3.67 | A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor. ( Arnolde, SM; Nevins, ME, 1989) |
| "Both CVP and MET induced dose-dependent seizure activity and death in mice." | 1.31 | On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. ( Blaszczak, P; Dekundy, A; Kaminski, R; Turski, WA, 2001) |
| "In rats, generalized tonic-clonic seizures are precipitated by auditory stimulation during the ethanol withdrawal syndrome." | 1.29 | Seizures during ethanol withdrawal are blocked by focal microinjection of excitant amino acid antagonists into the inferior colliculus and pontine reticular formation. ( Faingold, CL; Riaz, A, 1994) |
| "When studied 28 d after the last evoked seizure, we found that kindling induced a 2." | 1.29 | Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3. ( Bonhaus, DW; Kraus, JE; McNamara, JO; Nadler, JV; Yeh, GC, 1994) |
| "Budipine is a novel antiparkinsonian drug which is particularly beneficial in the treatment of parkinsonian tremor." | 1.29 | Effects of the antiparkinsonian drug budipine on central neurotransmitter systems. ( Klockgether, T; Löschmann, PA; Petersen, V; Steinbach, JP; Turski, L; Wüllner, U, 1996) |
| "4-aminopyridine, particularly the tonic convulsions, but were less effective against those produced by i." | 1.29 | Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. ( Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME, 1996) |
| "Cocaine HCl (90 mg/kg, IP) induced seizures in 95% and death within 24 h in 68% (n = 135) of the animals." | 1.28 | Glutamate receptor antagonists block cocaine-induced convulsions and death. ( Andrew, M; Farley, JM; Ho, IK; Oden, G; Rockhold, RW, 1991) |
| "Experimental febrile seizures can be evoked in epileptic chicks by elevation of their body temperature." | 1.28 | Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists. ( Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, RI, 1990) |
| "Audiogenic convulsions in DBA/2 mice were blocked by CPP (ED50 = 1." | 1.27 | CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo. ( Bennett, DA; Bernard, P; Boehm, C; Lehmann, J; McPherson, S; Murphy, DE; Pastor, G; Schneider, J; Steel, DJ; Tsai, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.11) | 18.7374 |
| 1990's | 27 (72.97) | 18.2507 |
| 2000's | 5 (13.51) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaoni, Y | 1 |
| Chapman, AG | 2 |
| Parvez, N | 1 |
| Pook, PC | 1 |
| Jane, DE | 1 |
| Watkins, JC | 2 |
| Köhling, R | 2 |
| D'Antuono, M | 2 |
| Benini, R | 1 |
| de Guzman, P | 2 |
| Avoli, M | 4 |
| Lévesque, M | 1 |
| Herrington, R | 1 |
| Hamidi, S | 1 |
| Génin, A | 1 |
| French, P | 1 |
| Doyère, V | 1 |
| Davis, S | 1 |
| Errington, ML | 1 |
| Maroun, M | 1 |
| Stean, T | 1 |
| Truchet, B | 1 |
| Webber, M | 1 |
| Wills, T | 1 |
| Richter-Levin, G | 1 |
| Sanger, G | 1 |
| Hunt, SP | 1 |
| Mallet, J | 1 |
| Laroche, S | 1 |
| Bliss, TV | 1 |
| O'Connor, V | 1 |
| Celik, T | 1 |
| Kayir, H | 1 |
| Ceyhan, M | 1 |
| Demirtaş, S | 1 |
| Coşar, A | 1 |
| Uzbay, IT | 1 |
| Dekundy, A | 2 |
| Kaminski, RM | 1 |
| Zielinska, E | 1 |
| Turski, WA | 4 |
| Riaz, A | 1 |
| Faingold, CL | 3 |
| De Sarro, G | 1 |
| Ammendola, D | 1 |
| Nava, F | 1 |
| De Sarro, A | 1 |
| Starr, MS | 1 |
| Starr, BS | 1 |
| Kaura, S | 1 |
| Croucher, MJ | 1 |
| Bradford, HF | 1 |
| Sunter, DC | 1 |
| Kraus, JE | 1 |
| Yeh, GC | 2 |
| Bonhaus, DW | 2 |
| Nadler, JV | 2 |
| McNamara, JO | 2 |
| Hirayama, K | 1 |
| Murata, R | 1 |
| Matsuura, S | 1 |
| Steppuhn, KG | 1 |
| Turski, L | 2 |
| Randall, ME | 1 |
| Naritoku, DK | 1 |
| Boersma Anderson, CA | 1 |
| Doyle, KM | 1 |
| Shaw, GG | 1 |
| Tutka, P | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Klockgether, T | 1 |
| Wüllner, U | 1 |
| Steinbach, JP | 1 |
| Petersen, V | 1 |
| Löschmann, PA | 1 |
| Morales-Villagrán, A | 1 |
| Ureña-Guerrero, ME | 1 |
| Tapia, R | 1 |
| Lücke, A | 1 |
| Nagao, T | 1 |
| Speckmann, EJ | 1 |
| Fahey, JM | 1 |
| Pritchard, GA | 1 |
| Pratt, JS | 1 |
| Shader, RI | 1 |
| Greenblatt, DJ | 1 |
| Chakravarty, DN | 1 |
| Blaszczak, P | 1 |
| Kaminski, R | 1 |
| Rockhold, RW | 2 |
| Surrett, RS | 1 |
| Oden, G | 2 |
| Acuff, CG | 1 |
| Zhang, T | 1 |
| Farley, JM | 2 |
| Hoskins, B | 1 |
| Ho, IK | 2 |
| Holmes, KH | 2 |
| Bilkey, DK | 2 |
| Laverty, R | 2 |
| Zeng, YC | 1 |
| Pezzola, A | 1 |
| Scotti De Carolis, A | 1 |
| Sagratella, S | 1 |
| Andrew, M | 1 |
| Singh, L | 1 |
| Vass, CA | 1 |
| Hunter, JC | 1 |
| Woodruff, GN | 1 |
| Hughes, J | 1 |
| Goddard, GV | 1 |
| Dunn, RW | 1 |
| Corbett, R | 1 |
| Martin, LL | 1 |
| Payack, JF | 1 |
| Laws-Ricker, L | 1 |
| Wilmot, CA | 1 |
| Rush, DK | 1 |
| Cornfeldt, ML | 1 |
| Fielding, S | 1 |
| Chiamulera, C | 1 |
| Costa, S | 1 |
| Reggiani, A | 1 |
| Pedder, SC | 1 |
| Wilcox, RI | 1 |
| Tuchek, JM | 1 |
| Johnson, DD | 1 |
| Crawford, RD | 1 |
| Urbanska, E | 1 |
| Dziki, M | 1 |
| Parada-Turska, J | 1 |
| Ikonomidou, C | 1 |
| Graham, J | 1 |
| Meldrum, BS | 1 |
| Nevins, ME | 1 |
| Arnolde, SM | 1 |
| Lehmann, J | 1 |
| Schneider, J | 1 |
| McPherson, S | 1 |
| Murphy, DE | 1 |
| Bernard, P | 1 |
| Tsai, C | 1 |
| Bennett, DA | 1 |
| Pastor, G | 1 |
| Steel, DJ | 1 |
| Boehm, C | 1 |
37 other studies available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Seizures
| Article | Year |
|---|---|
Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives.
Topics: Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Animals; Animals, Newborn; Anticonvulsants; | 1994 |
Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cations, Monovale | 2016 |
Interneurons spark seizure-like activity in the entorhinal cortex.
Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Entorhinal Cortex; Excitatory A | 2016 |
LTP but not seizure is associated with up-regulation of AKAP-150.
Topics: A Kinase Anchor Proteins; Adaptor Proteins, Signal Transducing; Animals; Anticonvulsants; Carrier Pr | 2003 |
Initiation of electrographic seizures by neuronal networks in entorhinal and perirhinal cortices in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Entorhinal Cortex; Excitatory Amino Acid Antagonists; H | 2004 |
CPP and amlodipine alter the decrease in basal acetylcholine and choline release by audiogenic stimulus in hippocampus of ethanol-withdrawn rats in vivo.
Topics: Acetylcholine; Acoustic Stimulation; Alcohol-Induced Disorders, Nervous System; Amlodipine; Animals; | 2004 |
NMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in mice.
Topics: Animals; Atropine; Carbamates; Cholinesterase Inhibitors; Dichlorvos; Dizocilpine Maleate; Dose-Resp | 2007 |
Seizures during ethanol withdrawal are blocked by focal microinjection of excitant amino acid antagonists into the inferior colliculus and pontine reticular formation.
Topics: Acoustic Stimulation; Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Brain Mapping; Dizocilp | 1994 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvuls | 1995 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Di | 1993 |
Relative anticonvulsant potencies of CPP and some novel analogues in the kindled rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Kindling, Neurologic; Male; Piperazines; Rats | 1993 |
Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3.
Topics: Animals; Base Sequence; Glycine; Hippocampus; Kindling, Neurologic; Male; Molecular Probes; Molecula | 1994 |
Effects of an N-methyl-D-aspartate antagonist and a GABAergic antagonist on entorhinal tetanic responses during the early stages of amygdala kindling in rats.
Topics: Amygdala; Animals; Electrophysiology; GABA Antagonists; Kindling, Neurologic; Limbic System; Male; N | 1994 |
Diazepam dependence prevented by glutamate antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Tolerance; Electroencephalography; Ele | 1993 |
Noncompetitive and competitive NMDA antagonists exert anticonvulsant effects by actions on different sites within the neuronal network for audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Brain; Dizocilpine Maleate; Female; Male; N-Methylas | 1993 |
Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo.
Topics: Animals; Brain; Cerebral Ventricles; Dizocilpine Maleate; Female; Kynurenic Acid; Mice; Neuroprotect | 1996 |
Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice.
Topics: Aminophylline; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Convulsants; Electros | 1996 |
Effects of the antiparkinsonian drug budipine on central neurotransmitter systems.
Topics: Animals; Antiparkinson Agents; Biperiden; Central Nervous System; Dopamine; Excitatory Amino Acid An | 1996 |
Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anticonvulsants; Convulsants; Dizocilpine Mal | 1996 |
Extracellular potassium elevations in the hippocampus of rats with long-term pilocarpine seizures.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Excitatory Amino | 1995 |
Lorazepam attenuates the behavioral effects of dizocilpine.
Topics: Animals; Dizocilpine Maleate; Drug Antagonism; Excitatory Amino Acid Antagonists; GABA Modulators; L | 1999 |
Differential roles in the neuronal network for audiogenic seizures are observed among the inferior colliculus subnuclei and the amygdala.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy | 1999 |
On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chlorfenvinphos; Cholinesterase Inhibitors; Dizocilp | 2001 |
Inhibition of cocaine intoxication by excitatory amino acid receptor antagonists.
Topics: Animals; Anticonvulsants; Cocaine; Death; Dextrorphan; Dizocilpine Maleate; Glutamates; Kynurenic Ac | 1992 |
The infusion of an NMDA antagonist into perirhinal cortex suppresses amygdala-kindled seizures.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cerebral Cortex; Injections; Kindling, Neurologic; M | 1992 |
Inhibitory influence of morphinans on ictal and interictal EEG changes induced by cortical application of penicillin in rabbits: a comparative study with NMDA antagonists and pentobarbitone.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Dizocilpine Maleate; Electroencephalography; Injections; | 1992 |
Glutamate receptor antagonists block cocaine-induced convulsions and death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Cocaine; Death; Dextrorphan; Dizocil | 1991 |
The anticonvulsant action of CI-977, a selective kappa-opioid receptor agonist: a possible involvement of the glycine/NMDA receptor complex.
Topics: Animals; Anticonvulsants; Benzofurans; Dizocilpine Maleate; In Vitro Techniques; Mice; Mice, Inbred | 1990 |
The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; | 1990 |
Preclinical anxiolytic profiles of 7189 and 8319, novel non-competitive NMDA antagonists.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Binding, Competi | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic A | 1990 |
Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Chickens; Diaminopimelic Acid | 1990 |
Excitatory amino acid antagonists protect mice against seizures induced by bicuculline.
Topics: Animals; Bicuculline; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; M | 1990 |
Potent oral anticonvulsant action of CPP and CPPene in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Mice; Mice, Inbred DBA; Organophosphorus Compounds; | 1990 |
N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.
Topics: Animals; Convulsants; Electric Stimulation; Glycine; Hippocampus; Illicit Drugs; Ion Channels; Kindl | 1989 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpin | 1989 |
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebellum; Corpus Striatum; Cyclic GMP; Glutamates; Glutamic | 1987 |