3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with Injuries in 3 studies
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist
Injuries: Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that traumatic injury in the infant rat brain is mediated by endogenous excitotoxins (Glu and aspartate) acting at NMDA receptors and can be substantially mitigated by timely treatment with NMDA receptor antagonists." | 1.29 | Prevention of trauma-induced neurodegeneration in infant rat brain. ( Ikonomidou, C; Kirby, C; Labruyere, J; Olney, JW; Qin, Y, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikonomidou, C | 2 |
| Qin, Y | 1 |
| Labruyere, J | 1 |
| Kirby, C | 1 |
| Olney, JW | 1 |
| Stefovska, V | 1 |
| Turski, L | 1 |
| Woolf, CJ | 1 |
| Thompson, SWN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intra-operative Magnesium Sulphate for Post-operative Pain in Patients Undergoing Total Abdominal Hysterectomy Under General Anesthesia[NCT06026527] | Phase 3 | 42 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| A Prospective, Randomized, Single Blinded Comparison of Intraoperative Ketamine Infusion Versus Placebo in Patients Having Spinal Fusion[NCT02424591] | Phase 4 | 46 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Beck's Depression Inventory (BDI) is a 21-item, self-report rating inventory that measures attitudes and symptoms of depression. Each sentence has a rating from 0 to 3 and the sentences go from mild to fairly severe descriptions of moods. The numbers are tabulated, the lowest possible score is 0 and the highest is 63.~A score of 1-10 indicates normal ups and downs. 11-16 indicates a mild mood disturbance; 17-20, borderline clinical depression; 21-30, moderate depression; 31-40, severe depression; over 40, extreme depression" (NCT02424591)
Timeframe: Post-op Day 3
| Intervention | points (Median) |
|---|---|
| Ketamine | 8 |
| Placebo | 9 |
"McGill Short Form measures pain in different ways. The first part of the form lists 15 adjectives for pain, for which the answers can be none (0), Mild (1), Moderate (2) and Severe (3). Descriptors 1-11 represent the sensory dimension of pain experience and 12-15 represent the affective dimension. A score of 0 is good, and a score of 45 indicates extreme pain. The lower the score the less pain a subject feels (better), as the scores go up, so do the pain levels (worse).~PPI (Present Pain Intensity) asks patients to measure pain from 0 (no pain) to 5 (excruciating). Again, a lower score is ideal." (NCT02424591)
Timeframe: Post-op Day 3
| Intervention | points (Median) |
|---|---|
| Ketamine | 11 |
| Placebo | 10.5 |
Quality of Recovery 15 questions questionnaires that ask, on a scale of 0-10, with 0 always being bad and 10 always being best, how the patient is recovering. The total number is reviewed, so the highest total score possible is 150 and the lowest is 0. (NCT02424591)
Timeframe: Post-op Day 3
| Intervention | points (Median) |
|---|---|
| Ketamine | 95 |
| Placebo | 101 |
3 other studies available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Injuries
| Article | Year |
|---|---|
Prevention of trauma-induced neurodegeneration in infant rat brain.
Topics: Animals; Brain Injuries; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Piperazi | 1996 |
Neuronal death enhanced by N-methyl-D-aspartate antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Injuries; Cell Death; Dizoc | 2000 |
The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Motor Neurons; Mustard Plant; Pain; Physical Stimul | 1991 |
The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Motor Neurons; Mustard Plant; Pain; Physical Stimul | 1991 |
The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Motor Neurons; Mustard Plant; Pain; Physical Stimul | 1991 |
The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Motor Neurons; Mustard Plant; Pain; Physical Stimul | 1991 |