3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with Epilepsy in 25 studies
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 7.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
| "Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 3.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.00) | 18.7374 |
| 1990's | 16 (64.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herrington, R | 2 |
| Lévesque, M | 2 |
| Avoli, M | 13 |
| Gonzalez-Sulser, A | 1 |
| Wang, J | 1 |
| Motamedi, GK | 1 |
| Vicini, S | 1 |
| Dzakpasu, R | 1 |
| Marcuccilli, CJ | 1 |
| Tryba, AK | 1 |
| van Drongelen, W | 1 |
| Koch, H | 1 |
| Viemari, JC | 1 |
| Peña-Ortega, F | 1 |
| Doren, EL | 1 |
| Pytel, P | 1 |
| Chevalier, M | 1 |
| Mrejeru, A | 1 |
| Kohrman, MH | 1 |
| Lasky, RE | 1 |
| Lew, SM | 1 |
| Frim, DM | 1 |
| Ramirez, JM | 1 |
| Ayala, GX | 1 |
| Tapia, R | 1 |
| Papatheodoropoulos, C | 1 |
| Moschovos, C | 1 |
| Kostopoulos, G | 1 |
| Fueta, Y | 1 |
| Mattia, D | 1 |
| Hwa, GG | 5 |
| Mitsuyoshi, I | 1 |
| Ito, M | 1 |
| Shirasaka, Y | 1 |
| Mikawa, H | 1 |
| Serikawa, T | 1 |
| Yamada, J | 1 |
| Nagao, T | 1 |
| Alonso, A | 1 |
| Lopantsev, V | 1 |
| Chakravarty, DN | 1 |
| Faingold, CL | 1 |
| Vezzani, A | 1 |
| Conti, M | 1 |
| De Luigi, A | 1 |
| Ravizza, T | 1 |
| Moneta, D | 1 |
| Marchesi, F | 1 |
| De Simoni, MG | 1 |
| Psarropoulou, C | 2 |
| Descombes, S | 1 |
| Oliver, A | 1 |
| Villemure, JG | 1 |
| Marciani, MG | 1 |
| Santone, G | 1 |
| Sancesario, G | 1 |
| Massa, R | 1 |
| Stanzione, P | 1 |
| Bernardi, G | 1 |
| Urban, L | 1 |
| Aitken, PG | 1 |
| Friedman, A | 1 |
| Somjen, GG | 1 |
| Drapeau, C | 1 |
| Perreault, P | 1 |
| Louvel, J | 1 |
| Pumain, R | 1 |
| Mitrovic, N | 1 |
| Besson, MJ | 1 |
| Maurin, Y | 1 |
| Watson, GB | 1 |
| Rader, RK | 1 |
| Lanthorn, TH | 1 |
| Löscher, W | 1 |
| Nolting, B | 1 |
| Hönack, D | 1 |
25 other studies available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Epilepsy
| Article | Year |
|---|---|
Neurosteroids modulate epileptiform activity and associated high-frequency oscillations in the piriform cortex.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Biophysics; Cerebral Cortex; Desoxycorticosterone; D | 2014 |
Subiculum-entorhinal cortex interactions during in vitro ictogenesis.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Entorhinal Cortex; Epilepsy; Hippocampus; Male; Piperazin | 2015 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Ani | 2011 |
Neuronal bursting properties in focal and parafocal regions in pediatric neocortical epilepsy stratified by histology.
Topics: Action Potentials; Adolescent; Bicuculline; Child; Child, Preschool; Electric Stimulation; Epilepsy; | 2010 |
Expression of heat shock protein 70 induced by 4-aminopyridine through glutamate-mediated excitotoxic stress in rat hippocampus in vivo.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Cell Count; Chromatography, High Pressure Liquid; Dizocil | 2003 |
Greater contribution of N-methyl-D-aspartic acid receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsy | 2005 |
Tetraethylammonium-induced epileptiform activity in young and adult rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Bicuculline; Dose-Response Relationship, Drug; | 1993 |
Epileptiform activity induced by 4-aminopyridine in guinea-pig and rat neocortices.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Cerebral Cortex; El | 1993 |
Changes of NMDA receptor binding in spontaneously epileptic rat and parent strains.
Topics: Animals; Binding, Competitive; Brain; Cerebral Cortex; Epilepsy; Female; Hippocampus; Male; Mesencep | 1993 |
Epileptiform activity induced by pilocarpine in the rat hippocampal-entorhinal slice preparation.
Topics: Animals; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Hippocam | 1996 |
Laminar organization of epileptiform discharges in the rat entorhinal cortex in vitro.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Calcium; Electrop | 1998 |
Differential roles in the neuronal network for audiogenic seizures are observed among the inferior colliculus subnuclei and the amygdala.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy | 1999 |
Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures.
Topics: Animals; Antibodies; Anticonvulsants; Antirheumatic Agents; Bicuculline; Cell Count; Electroencephal | 1999 |
Differential bicuculline-induced epileptogenesis in rat neonatal, juvenile and adult CA3 pyramidal neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Animals; Animals, Newborn; Bicuculli | 1999 |
CPP, an NMDA-receptor antagonist, blocks 4-aminopyridine-induced spreading depression episodes but not epileptiform activity in immature rat hippocampal slices.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Anticonvuls | 1992 |
Excitatory synaptic transmission mediated by NMDA and non-NMDA receptors in the superficial/middle layers of the epileptogenic human neocortex maintained in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Cerebral Cortex; Epilepsy; Evoked Po | 1992 |
Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro.
Topics: 2-Amino-5-phosphonovalerate; Bicuculline; Cerebral Cortex; Electric Stimulation; Epilepsy; Evoked Po | 1991 |
The involvement of excitatory amino acids in neocortical epileptogenesis: NMDA and non-NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Dizocilpin | 1991 |
Epileptic activity following cerebral ischemia in Mongolian gerbils is depressed by CPP, a competitive antagonist of the N-methyl-D-aspartate receptor.
Topics: Animals; Brain Ischemia; Carotid Arteries; Electroencephalography; Epilepsy; Gerbillinae; Hippocampu | 1991 |
An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Electric Stimulation; Epilepsy; Hippocampus; Humans; | 1990 |
Epileptiform activity induced by low chloride medium in the CA1 subfield of the hippocampal slice.
Topics: Animals; Anticonvulsants; Chlorides; Electric Stimulation; Electrodes; Epilepsy; Evoked Potentials; | 1990 |
Anticonvulsant effects of antagonists of the N-methyl-D-aspartate receptor complex in a genetic model of epilepsy: the quaking mouse.
Topics: Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Injections, Intraveno | 1990 |
NMDA receptor antagonists CPP and MK-801 partially suppress the epileptiform discharges induced by the convulsant drug bicuculline in the rat neocortex.
Topics: Animals; Bicuculline; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Male; Pi | 1989 |
Epileptiform activity in vitro can produce long-term synaptic failure and persistent neuronal depolarization.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Epilepsy; Hippocampus; In Vitr | 1989 |
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Electroshock; Epilepsy; Female; Gerbill | 1988 |