3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with Disease Models, Animal in 22 studies
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 7.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
| "Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 3.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
| "The novel tricyclic antidepressant drug tianeptine had an antidepressant-like effect on a rat model of depression based on the deficit in open field activity observed on the day after 2 h restraint." | 3.68 | Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour. ( Curzon, G; Datla, KP; Sarna, GS; Whitton, PS, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, LL | 1 |
| Lee, GE | 1 |
| Lee, TB | 1 |
| Rush, DK | 1 |
| Wilmot, CA | 1 |
| Paulus, E | 1 |
| Elben, U | 1 |
| Grome, JJ | 1 |
| Porsche-Wiebking, E | 1 |
| Rudolphi, KA | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Lévesque, M | 1 |
| Herrington, R | 1 |
| Hamidi, S | 1 |
| Avoli, M | 2 |
| Niimi, K | 1 |
| Takahashi, E | 1 |
| Itakura, C | 1 |
| Ayala, GX | 1 |
| Tapia, R | 1 |
| Yang, GY | 1 |
| Woo, YW | 1 |
| Park, MK | 1 |
| Bae, YC | 1 |
| Ahn, DK | 1 |
| Bonfa, E | 1 |
| Gonzalez-Sulser, A | 1 |
| Wang, J | 1 |
| Motamedi, GK | 1 |
| Vicini, S | 1 |
| Dzakpasu, R | 1 |
| Carli, M | 1 |
| Calcagno, E | 1 |
| Mainolfi, P | 1 |
| Mainini, E | 1 |
| Invernizzi, RW | 1 |
| Autry, AE | 1 |
| Adachi, M | 1 |
| Nosyreva, E | 1 |
| Na, ES | 1 |
| Los, MF | 1 |
| Cheng, PF | 1 |
| Kavalali, ET | 1 |
| Monteggia, LM | 1 |
| Celik, T | 1 |
| Kayir, H | 1 |
| Ceyhan, M | 1 |
| Demirtaş, S | 1 |
| Coşar, A | 1 |
| Uzbay, IT | 1 |
| Lagali, PS | 1 |
| Balya, D | 1 |
| Awatramani, GB | 1 |
| Münch, TA | 1 |
| Kim, DS | 1 |
| Busskamp, V | 1 |
| Cepko, CL | 1 |
| Roska, B | 1 |
| Bernert, H | 1 |
| Turski, L | 3 |
| Kinney, WA | 1 |
| Abou-Gharbia, M | 1 |
| Garrison, DT | 1 |
| Schmid, J | 1 |
| Kowal, DM | 1 |
| Bramlett, DR | 1 |
| Miller, TL | 1 |
| Tasse, RP | 1 |
| Zaleska, MM | 1 |
| Moyer, JA | 1 |
| Pohl, D | 1 |
| Bittigau, P | 1 |
| Ishimaru, MJ | 1 |
| Stadthaus, D | 1 |
| Hübner, C | 1 |
| Olney, JW | 1 |
| Ikonomidou, C | 1 |
| Görgülü, A | 2 |
| Kiriş, T | 2 |
| Unal, F | 2 |
| Türkoğlu, U | 2 |
| Küçük, M | 1 |
| Cobanoğlu, S | 2 |
| Follis, FM | 1 |
| Blisard, KS | 1 |
| Varvitsiotis, PS | 1 |
| Pett, SB | 1 |
| Temes, RT | 1 |
| Wernly, JA | 1 |
| Ekuklu, G | 1 |
| Fritz, KI | 1 |
| Zanelli, S | 1 |
| Mishra, OP | 1 |
| Delivoria-Papadopoulos, M | 1 |
| Whitton, PS | 1 |
| Sarna, GS | 1 |
| Datla, KP | 1 |
| Curzon, G | 1 |
| Murphy, DL | 1 |
| Löschmann, PA | 1 |
| Lange, KW | 1 |
| Kunow, M | 1 |
| Rettig, KJ | 1 |
| Jähnig, P | 1 |
| Honoré, T | 1 |
| Wachtel, H | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040] | Phase 2 | 172 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | ||
| Evaluation of the Initial Prescription of Ketamine and Milnacipran Forin Depression in Patients With a Progressive Disease[NCT02783430] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2016-09-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
22 other studies available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis, resolution, and SAR of (+/-)-2-amino-N-methyl-alpha-(3-methyl-2-thienyl)benzeneethanamine++ + and related analogs as noncompetitive NMDA antagonists with neuroprotective properties.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain Ischem | 1994 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Interneurons spark seizure-like activity in the entorhinal cortex.
Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Entorhinal Cortex; Excitatory A | 2016 |
Improved short-term memory and increased expression of NR2B observed in senescence-accelerated mouse (SAM) P6.
Topics: Aging, Premature; Animals; Blotting, Western; Disease Models, Animal; Excitatory Amino Acid Antagoni | 2008 |
HSP70 expression protects against hippocampal neurodegeneration induced by endogenous glutamate in vivo.
Topics: 4-Aminopyridine; Animals; Cell Count; Disease Models, Animal; Dizocilpine Maleate; Electroencephalog | 2008 |
Intracisternal administration of NR2 antagonists attenuates facial formalin-induced nociceptive behavior in rats.
Topics: Animals; Behavior, Animal; Cisterna Magna; Disease Models, Animal; Excitatory Amino Acid Antagonists | 2010 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Ani | 2011 |
Effects of aripiprazole, olanzapine, and haloperidol in a model of cognitive deficit of schizophrenia in rats: relationship with glutamate release in the medial prefrontal cortex.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Benzodiazepines | 2011 |
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dis | 2011 |
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dis | 2011 |
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dis | 2011 |
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dis | 2011 |
CPP and amlodipine alter the decrease in basal acetylcholine and choline release by audiogenic stimulus in hippocampus of ethanol-withdrawn rats in vivo.
Topics: Acetylcholine; Acoustic Stimulation; Alcohol-Induced Disorders, Nervous System; Amlodipine; Animals; | 2004 |
Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroporation; Evoked Potentials, Visual; Excit | 2008 |
Traumatic brain damage prevented by the non-N-methyl-D-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f] quinoxaline.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Antagonists; | 1996 |
Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere.
Topics: Animals; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclobutanes; Disease Models | 1998 |
N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Caudate Nucleus; Disease Models, Animal; Dizocilpine Male | 1999 |
Protective effect of the N-methyl-D-aspartate receptor antagonists, MK-801 and CPP on cold-induced brain oedema.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Body Water; Brain Edema; Cold Temperature; Disea | 1999 |
Selective protection of gray and white matter during spinal cord ischemic injury.
Topics: Animals; Brain; Disease Models, Animal; Evaluation Studies as Topic; Excitatory Amino Acid Antagonis | 1999 |
Superoxide dismutase activity and the effect of N-methyl-D-aspartate antagonists on lipid peroxidation in the early phase of cold injury.
Topics: Animals; Brain Concussion; Cold Temperature; Disease Models, Animal; Dizocilpine Maleate; Excitatory | 1999 |
Effect of graded hypoxia on the high-affinity CPP binding site of the NMDA receptor in the cerebral cortex of newborn piglets.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Binding Sites; Cell Membrane; Cerebral Cortex; Disea | 2001 |
Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Disease Models, Animal; Mal | 1991 |
The serotonin connection in OCD. Comments on "Recent advances in obsessive-compulsive disorder".
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dogs; Obsessive-Compulsive Disorder; Piperazines; | 1991 |
Synergism of the AMPA-antagonist NBQX and the NMDA-antagonist CPP with L-dopa in models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Ac | 1991 |