3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with Brain Ischemia in 8 studies
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroprotection against cerebral ischemia can be realized if the brain is preconditioned by previous exposure to a brief period of sublethal ischemia." | 1.30 | Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning. ( Gidday, JM; Holtzman, DM; Maceren, RG; Park, TS; Pelligrino, DA; Shah, AR; Wang, Q, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, LL | 1 |
| Lee, GE | 1 |
| Lee, TB | 1 |
| Rush, DK | 1 |
| Wilmot, CA | 1 |
| Paulus, E | 1 |
| Elben, U | 1 |
| Grome, JJ | 1 |
| Porsche-Wiebking, E | 1 |
| Rudolphi, KA | 1 |
| Vornov, JJ | 1 |
| Gidday, JM | 1 |
| Shah, AR | 1 |
| Maceren, RG | 1 |
| Wang, Q | 1 |
| Pelligrino, DA | 1 |
| Holtzman, DM | 1 |
| Park, TS | 1 |
| Marciani, MG | 1 |
| Santone, G | 1 |
| Sancesario, G | 1 |
| Massa, R | 1 |
| Stanzione, P | 1 |
| Bernardi, G | 1 |
| Urban, L | 1 |
| Neill, KH | 1 |
| Crain, BJ | 1 |
| Nadler, JV | 1 |
| Somjen, GG | 1 |
| Marcoux, FW | 1 |
| Probert, AW | 1 |
| Weber, ML | 1 |
| Swan, JH | 1 |
| Meldrum, BS | 1 |
| Carter, C | 1 |
| Benavides, J | 1 |
| Legendre, P | 1 |
| Vincent, JD | 1 |
| Noel, F | 1 |
| Thuret, F | 1 |
| Lloyd, KG | 1 |
| Arbilla, S | 1 |
| Zivkovic, B | 1 |
| MacKenzie, ET | 1 |
8 other studies available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Brain Ischemia
| Article | Year |
|---|---|
Synthesis, resolution, and SAR of (+/-)-2-amino-N-methyl-alpha-(3-methyl-2-thienyl)benzeneethanamine++ + and related analogs as noncompetitive NMDA antagonists with neuroprotective properties.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain Ischem | 1994 |
Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Culture Techniques; Deoxyglucose; Dose-Re | 1995 |
Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning.
Topics: Animals; Animals, Newborn; Brain Ischemia; Calcium; Dizocilpine Maleate; Enzyme Inhibitors; Guanidin | 1999 |
Epileptic activity following cerebral ischemia in Mongolian gerbils is depressed by CPP, a competitive antagonist of the N-methyl-D-aspartate receptor.
Topics: Animals; Brain Ischemia; Carotid Arteries; Electroencephalography; Epilepsy; Gerbillinae; Hippocampu | 1991 |
Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.
Topics: Animals; Brain Ischemia; Gerbillinae; Male; Membrane Potentials; N-Methylaspartate; Piperazines; Rec | 1990 |
Hypoxic neuronal injury in tissue culture is associated with delayed calcium accumulation.
Topics: Animals; Brain Ischemia; Calcium; Cerebral Cortex; Culture Techniques; Hypoxia, Brain; Neurons; Pipe | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Isch | 1990 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Do | 1988 |