3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with Anterior Circulation Transient Ischemic Attack in 7 studies
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| " The noncompetitive antagonist MK-801 and a glycine-site blocker were equally neuroprotective in both normal and reduced conditions, but there was a significant rightward shift in the dose-response curves of the competitive antagonists APV and CPP and the uncompetitive antagonist memantine." | 1.31 | Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro. ( Eshak, M; Iannotti, F; Pringle, AK; Self, J, 2000) |
| " Two potent, selective and competitive NMDA antagonists, cis-4-(phosphonomethyl)-2-piperidine-carboxylic acid (CGS 19755) and 4-(3-phosphonopropyl)-2-piperazine-carboxylic acid (CPP), were characterized in the gerbil ischemia model with respect to dose-response and time course effects." | 1.27 | The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils. ( Boast, CA; Etienne, PE; Gerhardt, SC; Lehmann, J; Liebman, JM; Pastor, G, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sugimoto, A | 1 |
| Takeda, A | 1 |
| Kogure, K | 1 |
| Onodera, H | 1 |
| Kinney, WA | 1 |
| Abou-Gharbia, M | 1 |
| Garrison, DT | 1 |
| Schmid, J | 1 |
| Kowal, DM | 1 |
| Bramlett, DR | 1 |
| Miller, TL | 1 |
| Tasse, RP | 1 |
| Zaleska, MM | 1 |
| Moyer, JA | 1 |
| Pringle, AK | 1 |
| Self, J | 1 |
| Eshak, M | 1 |
| Iannotti, F | 1 |
| Haba, K | 1 |
| Ogawa, N | 1 |
| Mizukawa, K | 1 |
| Mori, A | 1 |
| Rader, RK | 1 |
| Lanthorn, TH | 1 |
| Jarvis, MF | 1 |
| Murphy, DE | 1 |
| Williams, M | 1 |
| Gerhardt, SC | 2 |
| Boast, CA | 2 |
| Pastor, G | 1 |
| Lehmann, J | 1 |
| Etienne, PE | 1 |
| Liebman, JM | 1 |
7 other studies available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Anterior Circulation Transient Ischemic Attack
| Article | Year |
|---|---|
NMDA receptor (NMDAR1) expression in the rat hippocampus after forebrain ischemia.
Topics: Animals; Astrocytes; Autoradiography; Hippocampus; In Situ Hybridization; Ischemic Attack, Transient | 1994 |
Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere.
Topics: Animals; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclobutanes; Disease Models | 1998 |
Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; | 2000 |
Time course of changes in lipid peroxidation, pre- and postsynaptic cholinergic indices, NMDA receptor binding and neuronal death in the gerbil hippocampus following transient ischemia.
Topics: Acetylcholinesterase; Animals; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Kinetics; Lipid | 1991 |
Experimental ischemia induces a persistent depolarization blocked by decreased calcium and NMDA antagonists.
Topics: Animals; Calcium; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Male; Membrane Poten | 1989 |
The novel N-methyl-D-aspartate (NMDA) antagonist CGS 19755 prevents ischemia-induced reductions of adenosine A1, NMDA, and PCP receptors in gerbil brain.
Topics: Adenosine; Animals; Autoradiography; Female; Flunitrazepam; Gerbillinae; Image Processing, Computer- | 1988 |
The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils.
Topics: Animals; Aspartic Acid; Brain; Female; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Motor A | 1988 |