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3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Aging

3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with Aging in 14 studies

3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"We investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats."3.69Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats. ( Riekkinen, M; Riekkinen, P, 1997)
"[3H]-glycine binding sites were severely decreased in the telencephalic regions, including the hippocampus and cerebral cortex, in aged brain."1.28Influence of age on NMDA receptor complex in rat brain studied by in vitro autoradiography. ( Kito, S; Miyoshi, R; Nomoto, T, 1990)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (71.43)18.2507
2000's3 (21.43)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kouvaros, S1
Kotzadimitriou, D1
Papatheodoropoulos, C1
Ma, CL1
Kelly, JB1
Wu, SH1
Dieguez, D1
Barea-Rodriguez, EJ1
Fueta, Y1
Avoli, M3
Louvel, J1
Kurcewicz, I1
Pumain, R1
Barbarosie, M1
Riekkinen, M2
Riekkinen, P2
Psarropoulou, C2
Descombes, S1
Magnusson, KR1
Aamodt, SM1
Kozlowski, MR1
Nordeen, EJ1
Nordeen, KW1
Miyoshi, R2
Kito, S2
Doudou, N1
Nomoto, T2
Erdö, SL1
Wolff, JR1

Other Studies

14 other studies available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Aging

ArticleYear
Hippocampal sharp waves and ripples: Effects of aging and modulation by NMDA receptors and L-type Ca2+ channels.
    Neuroscience, 2015, Jul-09, Volume: 298

    Topics: Action Potentials; Aging; Animals; Biophysics; Calcium Channel Blockers; Calcium Channels, L-Type; D

2015
AMPA and NMDA receptors mediate synaptic excitation in the rat's inferior colliculus.
    Hearing research, 2002, Volume: 168, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Excitatory Amino

2002
Aging impairs the late phase of long-term potentiation at the medial perforant path-CA3 synapse in awake rats.
    Synapse (New York, N.Y.), 2004, Volume: 52, Issue:1

    Topics: Aging; Animals; Arousal; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsyn

2004
Tetraethylammonium-induced epileptiform activity in young and adult rat hippocampus.
    Brain research. Developmental brain research, 1993, Mar-19, Volume: 72, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Bicuculline; Dose-Response Relationship, Drug;

1993
Extracellular free potassium and calcium during synchronous activity induced by 4-aminopyridine in the juvenile rat hippocampus.
    The Journal of physiology, 1996, Jun-15, Volume: 493 ( Pt 3)

    Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Analgesics; Animals; Calcium; Electrop

1996
Dorsal hippocampal muscarinic acetylcholine and NMDA receptors disrupt water maze navigation.
    Neuroreport, 1997, Feb-10, Volume: 8, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Excitatory Amino Acid Antagonists; Hippocampus; Infusions, Par

1997
Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats.
    Neuroreport, 1997, Feb-10, Volume: 8, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Cycloserine; Excitatory Amino Acid Antagonists; Male; Maze Lea

1997
Differential bicuculline-induced epileptogenesis in rat neonatal, juvenile and adult CA3 pyramidal neurons in vitro.
    Brain research. Developmental brain research, 1999, Oct-20, Volume: 117, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Aging; Animals; Animals, Newborn; Bicuculli

1999
Declines in mRNA expression of different subunits may account for differential effects of aging on agonist and antagonist binding to the NMDA receptor.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Mar-01, Volume: 20, Issue:5

    Topics: Aging; Animals; Binding, Competitive; Brain Chemistry; Excitatory Amino Acid Agonists; Excitatory Am

2000
CPP, an NMDA-receptor antagonist, blocks 4-aminopyridine-induced spreading depression episodes but not epileptiform activity in immature rat hippocampal slices.
    Neuroscience letters, 1992, Jan-20, Volume: 135, Issue:1

    Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Anticonvuls

1992
Distribution and developmental change in [3H]MK-801 binding within zebra finch song nuclei.
    Journal of neurobiology, 1992, Volume: 23, Issue:8

    Topics: Aging; Animals; Auditory Pathways; Autoradiography; Binding, Competitive; Birds; Dizocilpine Maleate

1992
Influence of age on N-methyl-D-aspartate antagonist binding sites in the rat brain studied by in vitro autoradiography.
    Synapse (New York, N.Y.), 1991, Volume: 8, Issue:3

    Topics: Aging; Animals; Autoradiography; Brain; Brain Chemistry; In Vitro Techniques; Kinetics; Male; N-Meth

1991
Influence of age on NMDA receptor complex in rat brain studied by in vitro autoradiography.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1990, Volume: 38, Issue:12

    Topics: Aging; Animals; Autoradiography; Brain; Cerebral Cortex; Glycine; Hippocampus; Male; Piperazines; Ra

1990
Postnatal development of the excitatory amino acid system in visual cortex of the rat. Changes in ligand binding to NMDA, quisqualate and kainate receptors.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1990, Volume: 8, Issue:2

    Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Male; Piper

1990