3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid has been researched along with Acute Brain Injuries in 7 studies
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid: structure given in first source; NMDA receptor antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that traumatic injury in the infant rat brain is mediated by endogenous excitotoxins (Glu and aspartate) acting at NMDA receptors and can be substantially mitigated by timely treatment with NMDA receptor antagonists." | 1.29 | Prevention of trauma-induced neurodegeneration in infant rat brain. ( Ikonomidou, C; Kirby, C; Labruyere, J; Olney, JW; Qin, Y, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oertel, M | 1 |
| Kelly, DF | 1 |
| Lee, JH | 1 |
| Glenn, TC | 1 |
| Vespa, PM | 1 |
| Martin, NA | 1 |
| Bernert, H | 1 |
| Turski, L | 3 |
| Ikonomidou, C | 3 |
| Qin, Y | 1 |
| Labruyere, J | 1 |
| Kirby, C | 1 |
| Olney, JW | 2 |
| Pohl, D | 1 |
| Bittigau, P | 1 |
| Ishimaru, MJ | 1 |
| Stadthaus, D | 1 |
| Hübner, C | 1 |
| Myers, WA | 1 |
| Churchill, JD | 1 |
| Muja, N | 1 |
| Garraghty, PE | 1 |
| Stefovska, V | 1 |
| Faden, AI | 1 |
| Demediuk, P | 1 |
| Panter, SS | 1 |
| Vink, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Changes of the Short Portable Mental Status Questionnaire (SPMSQ-E) After Ketamine Administration on Ophthalmic Surgery in Geriatric Population.[NCT02049411] | Phase 2 | 80 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid and Acute Brain Injuries
| Article | Year |
|---|---|
Is CPP therapy beneficial for all patients with high ICP?
Topics: Anticonvulsants; Blood Pressure; Brain Injuries; Humans; Intracranial Hypertension; Intracranial Pre | 2002 |
Traumatic brain damage prevented by the non-N-methyl-D-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f] quinoxaline.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acid Antagonists; | 1996 |
Prevention of trauma-induced neurodegeneration in infant rat brain.
Topics: Animals; Brain Injuries; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Piperazi | 1996 |
N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Caudate Nucleus; Disease Models, Animal; Dizocilpine Male | 1999 |
Role of NMDA receptors in adult primate cortical somatosensory plasticity.
Topics: Animals; Brain Injuries; Brain Mapping; Denervation; Excitatory Amino Acid Antagonists; Median Nerve | 2000 |
Neuronal death enhanced by N-methyl-D-aspartate antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Injuries; Cell Death; Dizoc | 2000 |
The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Injuries; Dextrorphan; Glutamates; Glutam | 1989 |