Compounds > 3-(2,4-dimethoxybenzylidene)anabaseine
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3-(2,4-dimethoxybenzylidene)anabaseine and Sepsis

3-(2,4-dimethoxybenzylidene)anabaseine has been researched along with Sepsis in 9 studies

*Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK. [MeSH]

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's5 (55.56)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Chokchaisiri, R; Chuprajob, T; Lin, Y; Lu, X; Shen, X; Sornkaew, N; Suksamrarn, A; Wang, F; Wang, P; Wongkrajang, K; Yang, L; Yang, N; Zhang, G; Zhou, Z1
Chen, K; Fang, Q; Li, H; Li, XY; Luo, H; Song, XM; Wang, HY; Wang, YL; Wu, XJ; Yan, XT; Yang, XM; Zhang, Y; Zhang, ZZ1
Gromov, MS; Maslyakov, VV; Zabrodskii, PF1
Hu, B; Li, J; Li, R; Peng, Z; Rao, X; Wang, J; Yang, X; Zhou, W1
Cao, Y; Gao, Y; Kang, K; Kong, W; Liu, H; Liu, W; Meng, X; Yang, S; Yu, K; Zhang, J; Zhao, M1
Boeckxstaens, GE; De Man, JG; De Winter, BY; Francque, S; Malhotra-Kumar, S; Matteoli, G; Nullens, S; Peleman, C; Schrijvers, DM; Staessens, M1
Li, J; Li, Z; Sang, M; Wang, J; Zhou, W1
Al-Abed, Y; Czura, CJ; Gallowitsch-Puerta, M; Larosa, GJ; Levi, J; Lin, X; Miller, EJ; Ochani, K; Ochani, M; Parrish, WR; Pavlov, VA; Rosas-Ballina, M; Tracey, KJ; Yang, LH1
Bojalil, R1

Other Studies

9 other study(ies) available for 3-(2,4-dimethoxybenzylidene)anabaseine and Sepsis

ArticleYear
Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo.
    Bioorganic & medicinal chemistry, 2022, 07-15, Volume: 66

    Topics: Animals; Anti-Inflammatory Agents; Diarylheptanoids; Janus Kinase 2; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Sepsis; STAT3 Transcription Factor

2022
GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice.
    Cytokine, 2020, Volume: 128

    Topics: Alanine Transaminase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartate Aminotransferases; Autophagy; Benzylidene Compounds; Cytokines; Disease Models, Animal; Inflammation; Interleukin-6; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Pyridines; Sepsis; Tumor Necrosis Factor-alpha

2020
Combined Effects of M1 Muscarinic Acetylcholine Receptor Agonist TBPB and α7n-Acetylcholine Receptor Activator GTS-21 on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis.
    Bulletin of experimental biology and medicine, 2017, Volume: 162, Issue:6

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzimidazoles; Benzylidene Compounds; Drug Therapy, Combination; Escherichia coli; Escherichia coli Infections; Female; Gene Expression Regulation; Interleukin-1beta; Interleukin-6; Male; Mice; Muscarinic Agonists; Nicotinic Agonists; Piperidines; Pyridines; Receptor, Muscarinic M1; Sepsis; Survival Analysis; Treatment Outcome; Tumor Necrosis Factor-alpha

2017
GTS-21 Reduces Inflammation in Acute Lung Injury by Regulating M1 Polarization and Function of Alveolar Macrophages.
    Shock (Augusta, Ga.), 2019, Volume: 51, Issue:3

    Topics: Acute Lung Injury; Adoptive Transfer; Animals; Benzylidene Compounds; Inflammation; Lipopolysaccharides; Macrophages, Alveolar; Mice; Nitric Oxide Synthase Type II; Pyridines; Sepsis

2019
GTS-21 Protected Against LPS-Induced Sepsis Myocardial Injury in Mice Through α7nAChR.
    Inflammation, 2018, Volume: 41, Issue:3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Apoptosis; Benzylidene Compounds; Bungarotoxins; Heart Injuries; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pyridines; Sepsis

2018
EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE.
    Shock (Augusta, Ga.), 2016, Volume: 45, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Colon; Gastrointestinal Motility; Inflammation; Male; Mice; Mice, Knockout; Permeability; Pyridines; Sepsis

2016
MicroRNA-205‑5b inhibits HMGB1 expression in LPS-induced sepsis.
    International journal of molecular medicine, 2016, Volume: 38, Issue:1

    Topics: Animals; Benzylidene Compounds; Gene Expression Profiling; Gene Expression Regulation; HMGB1 Protein; Lipopolysaccharides; Mice; Mice, Inbred BALB C; MicroRNAs; Oligonucleotide Array Sequence Analysis; Pyridines; RAW 264.7 Cells; Sepsis; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation

2016
Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis.
    Critical care medicine, 2007, Volume: 35, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Cell Line; Dose-Response Relationship, Drug; Endotoxemia; HMGB1 Protein; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Sepsis; Severity of Illness Index; Survival Rate; Tumor Necrosis Factor-alpha

2007
Are we finally taming inflammation?
    Critical care medicine, 2007, Volume: 35, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Endotoxemia; HMGB1 Protein; Inflammation; Mice; NF-kappa B; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Sepsis; Severity of Illness Index; Tumor Necrosis Factor-alpha

2007