Page last updated: 2024-09-03

3-(2,4-dimethoxybenzylidene)anabaseine and Schizophrenia

3-(2,4-dimethoxybenzylidene)anabaseine has been researched along with Schizophrenia in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (37.50)29.6817
2010's10 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Buchanan, RW; Christians, U; Freedman, R; Harris, J; Johnson, L; Kem, WR; Olincy, A; Wagner, BD1
Buchanan, RW; Freedman, R; Kem, WR; Lewis, AS; Olincy, A; Picciotto, MR1
Bourin, C; Bristow, LJ; Easton, A; Jones, KM; McDonald, IM; Olson, RE1
Freedman, R1
Hashimoto, K1
Legget, KT; Smucny, J; Tregellas, JR; Wylie, KP1
Arias, HR; Hołuj, M; Kos, T; Nikiforuk, A; Popik, P; Potasiewicz, A1
Buccafusco, JJ; Terry, AV1
Du, YP; Freedman, R; Johnson, L; Kem, WR; Martin, LF; Olincy, A; Shatti, S; Singel, D; Soti, F; Tanabe, J; Tregellas, JR1
Freedman, R; Johnson, L; Kem, WR; Leonard, S; Martin, LF; Olincy, A; Rojas, DC; Shatti, S; Soti, F; Tanabe, J; Tregellas, JR1
Cannon, CE; Eddins, D; Egbertson, MS; Puri, V; Uslaner, JM; Vivian, JA1
Kem, WR; O'Neill, HC; Rieger, K; Stevens, KE1
Freedman, R; Kem, WR; Martin, LF1
Adler, LE; Allensworth, D; Ellis, J; Freedman, R; Harris, JG; Johnson, LL; Kem, WR; Kongs, S; Leonard, S; Martin, L; Olincy, A; Pender, V; Soti, F; Stevens, JO; Stevens, KE; Zerbe, GO1
Olincy, A; Stevens, KE1
Allensworth, D; Ball, MP; Buchanan, RW; Clement, B; Freedman, R; Gold, JM; Guzman-Bonilla, A; Harris, JG; Johnson, L; Kem, WR; Kutnick, J; Martin, LF; Olincy, A; Pender, V; Soti, F; Stevens, KE; Wagner, BD; Zerbe, GO1

Reviews

5 review(s) available for 3-(2,4-dimethoxybenzylidene)anabaseine and Schizophrenia

ArticleYear
α7-nicotinic acetylcholine receptor agonists for cognitive enhancement in schizophrenia.
    Annual review of medicine, 2014, Volume: 65

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Benzylidene Compounds; Cognition; Eye Movements; Fetal Development; Humans; Memory; Nicotine; Nicotinic Agonists; Pyridines; Schizophrenia; Sensory Gating; Smoking

2014
Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker.
    Current pharmaceutical design, 2015, Volume: 21, Issue:26

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Benzylidene Compounds; Biomarkers; Evoked Potentials, Auditory; Humans; Pyridines; Quinuclidines; Schizophrenia; Sensory Gating; Thiadiazoles

2015
Targeting Functional Biomarkers in Schizophrenia with Neuroimaging.
    Current pharmaceutical design, 2016, Volume: 22, Issue:14

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Biomarkers; Cholinergic Agents; Humans; Magnetic Resonance Imaging; Neuroimaging; Pyridines; Schizophrenia

2016
Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia.
    Psychopharmacology, 2004, Volume: 174, Issue:1

    Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzylidene Compounds; Chromosomes, Human, Pair 15; Clozapine; Evoked Potentials, Auditory; Humans; Neural Inhibition; Nicotinic Agonists; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Schizophrenia; Sensation Disorders

2004
Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men.
    Biochemical pharmacology, 2007, Oct-15, Volume: 74, Issue:8

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Evoked Potentials, Auditory; Humans; Learning; Male; Memory; Mice; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Schizophrenia

2007

Trials

5 trial(s) available for 3-(2,4-dimethoxybenzylidene)anabaseine and Schizophrenia

ArticleYear
Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:3

    Topics: Adolescent; Adult; alpha7 Nicotinic Acetylcholine Receptor; Antipsychotic Agents; Archaeal Proteins; Benzylidene Compounds; Cognition; Cognition Disorders; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotinic Agonists; Pyridines; Schizophrenia; Schizophrenic Psychology; Young Adult

2018
Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:4

    Topics: Adult; Benzylidene Compounds; Brain; Brain Mapping; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Nicotinic Agonists; Oxygen; Pyridines; Schizophrenia

2010
Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia.
    Biological psychiatry, 2011, Jan-01, Volume: 69, Issue:1

    Topics: Adult; alpha7 Nicotinic Acetylcholine Receptor; Benzylidene Compounds; Brain; Brain Mapping; Cognition Disorders; Dose-Response Relationship, Drug; Eye Movements; Female; Genotype; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Nicotinic Agonists; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Schizophrenia

2011
Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia.
    Archives of general psychiatry, 2006, Volume: 63, Issue:6

    Topics: Adult; Benzylidene Compounds; Cognition Disorders; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Evoked Potentials, Auditory; Female; Humans; Male; Neuropsychological Tests; Nicotinic Agonists; Placebos; Psychiatric Status Rating Scales; Pyridines; Receptors, Nicotinic; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index

2006
Initial phase 2 trial of a nicotinic agonist in schizophrenia.
    The American journal of psychiatry, 2008, Volume: 165, Issue:8

    Topics: Adult; Attention; Benzylidene Compounds; Brief Psychiatric Rating Scale; Cognition Disorders; Drug Administration Schedule; Female; Humans; Male; Memory, Short-Term; Middle Aged; Neuropsychological Tests; Nicotinic Agonists; Pyridines; Receptors, Cholinergic; Receptors, Nicotinic; Schizophrenia; Severity of Illness Index

2008

Other Studies

6 other study(ies) available for 3-(2,4-dimethoxybenzylidene)anabaseine and Schizophrenia

ArticleYear
Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia.
    Schizophrenia research, 2018, Volume: 195

    Topics: Benzylidene Compounds; Humans; Nicotinic Agonists; Psychiatric Status Rating Scales; Pyridines; Schizophrenia; Schizophrenic Psychology

2018
Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats.
    Psychopharmacology, 2014, Volume: 231, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Attention; Benzamides; Benzylidene Compounds; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Clozapine; Cognition Disorders; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Discovery; Male; Maze Learning; Neuropsychological Tests; Pyridines; Rats; Rats, Sprague-Dawley; Schizophrenia; Set, Psychology

2014
3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats.
    Neuropharmacology, 2017, Volume: 113, Issue:Pt A

    Topics: Acrylamides; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Attention; Benzylidene Compounds; Cognition; Disease Models, Animal; Furans; Ketamine; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Social Behavior

2017
A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists.
    Biochemical pharmacology, 2009, Oct-01, Volume: 78, Issue:7

    Topics: Animals; Antipsychotic Agents; Benzylidene Compounds; Cognition Disorders; Conditioning, Operant; Cotinine; Female; Hallucinogens; Ketamine; Macaca nemestrina; Male; Memory; Nicotinic Agonists; Pyridines; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology

2009
The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys.
    Neuropharmacology, 2013, Volume: 64

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzylidene Compounds; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Indans; Ketamine; Macaca mulatta; Male; Molecular Targeted Therapy; Nicotinic Agonists; Nootropic Agents; Piperidines; Psychomotor Performance; Pyridines; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Schizophrenia

2013
DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats.
    Psychopharmacology, 2003, Volume: 169, Issue:3-4

    Topics: Animals; Auditory Diseases, Central; Benzylidene Compounds; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials, Auditory; Male; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Schizophrenia; Social Isolation; Time Factors

2003