Page last updated: 2024-09-03

3-(2,4-dimethoxybenzylidene)anabaseine and Inflammation

3-(2,4-dimethoxybenzylidene)anabaseine has been researched along with Inflammation in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (16.67)29.6817
2010's9 (50.00)24.3611
2020's6 (33.33)2.80

Authors

AuthorsStudies
Huang, L; Li, J; Wang, L; Xu, F; Zhang, J; Zhang, X1
Bai, X; Li, T; Wu, S; Zhang, X; Zhou, B; Zuo, X1
Chen, K; Fang, Q; Li, H; Li, XY; Luo, H; Song, XM; Wang, HY; Wang, YL; Wu, XJ; Yan, XT; Yang, XM; Zhang, Y; Zhang, ZZ1
Cai, D; Chen, Z; Wang, H; Wang, Y1
Akimitsu, N; Fujii, R; Fukaya, D; Hasegawa, S; Inagi, R; Inoue, T; Nakamura, Y; Nangaku, M; Ozeki, A; Peerapanyasut, W; Surattichaiyakul, B; Uni, R; Wada, Y; Wu, CH1
Ashby, CR; Daley, LA; Gauthier, AG; Kennedy, TP; Lin, M; Mantell, LL; Wu, J1
Le, LL; Li, JG; Liang, H; Song, XM; Wang, YL; Wu, XJ; Xu, Y; Yang, XM; Zhang, Y; Zhang, ZZ1
Al-Abed, Y; Chatterjee, PK; Kumar, G; Metz, CN; Pavlov, VA; Solanki, MH; Xue, X; Yeboah, MM1
Hu, B; Li, J; Li, R; Peng, Z; Rao, X; Wang, J; Yang, X; Zhou, W1
Chen, J; Li, X; Mei, Z; Tian, X; Wang, Y; Xie, C; Yang, C; Yao, Y; Zhang, S1
Koo, G; Qing, X; Redecha, P; Salmon, JE; Vukelic, M1
Cheng, W; Hu, Y; Li, J; Liu, R; Pan, X; Peng, J; Yue, Y; Zhang, P1
Boeckxstaens, GE; De Man, JG; De Winter, BY; Francque, S; Malhotra-Kumar, S; Matteoli, G; Nullens, S; Peleman, C; Schrijvers, DM; Staessens, M1
Goto, T; Kaneki, M; Kashiwagi, S; Kem, WR; Khan, MA; Martyn, JA; Tompkins, RG; Yasuhara, S1
Hoedemaekers, CW; Kox, M; Pickkers, P; Pompe, JC; van der Hoeven, JG; van Velzen, JF1
Cai, B; Chen, F; Conejero-Goldberg, C; de Jonge, WJ; Deitch, EA; Ji, Y; Kiss, L; Szabo, C; Ulloa, L1
Al-Abed, Y; Chatterjee, PK; Dowling, O; Metz, CN; Powell, SR; Xue, X; Yeboah, MM1
Bojalil, R1

Reviews

1 review(s) available for 3-(2,4-dimethoxybenzylidene)anabaseine and Inflammation

ArticleYear
From nicotine to the cholinergic anti-inflammatory reflex - Can nicotine alleviate the dysregulated inflammation in COVID-19?
    Journal of immunotoxicology, 2021, Volume: 18, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Antibodies, Monoclonal, Humanized; Benzylidene Compounds; Cholinergic Agents; Cigarette Smoking; COVID-19 Drug Treatment; Dexamethasone; HMGB1 Protein; Humans; Inflammation; Nicotine; Pandemics; Pyridines; SARS-CoV-2; Tobacco Use Disorder

2021

Other Studies

17 other study(ies) available for 3-(2,4-dimethoxybenzylidene)anabaseine and Inflammation

ArticleYear
The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain.
    Inflammopharmacology, 2021, Volume: 29, Issue:5

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Cell Line, Tumor; Chronic Pain; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Gene Knockdown Techniques; Humans; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; NF-kappa B; Pyridines; TNF Receptor-Associated Factor 6

2021
GTS-21 alleviates murine collagen-induced arthritis through inhibition of peripheral monocyte trafficking into the synovium.
    International immunopharmacology, 2023, Volume: 122

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Inflammation; Mice; Monocytes; Synovial Membrane

2023
GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice.
    Cytokine, 2020, Volume: 128

    Topics: Alanine Transaminase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartate Aminotransferases; Autophagy; Benzylidene Compounds; Cytokines; Disease Models, Animal; Inflammation; Interleukin-6; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Pyridines; Sepsis; Tumor Necrosis Factor-alpha

2020
GTS-21 Promotes α7 nAChR to Alleviate Intestinal Ischemia-Reperfusion-Induced Apoptosis and Inflammation of Enterocytes.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, May-17, Volume: 26

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Apoptosis; Benzylidene Compounds; Cell Line; Cytokines; Enterocytes; Glucose; Humans; Inflammation; Intestinal Mucosa; Intestines; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Pyridines; Reperfusion; Reperfusion Injury; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2020
Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration.
    Scientific reports, 2020, 06-11, Volume: 10, Issue:1

    Topics: Acute Kidney Injury; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Cisplatin; Cytokines; Inflammation; Kidney; Macrophages; Male; Mice; Mice, Inbred C57BL; Pyridines; Reperfusion Injury; Spleen; Vagus Nerve; Vagus Nerve Stimulation

2020
The Role of Erbin in GTS-21 Regulating Inflammtory Responses in MDP-Stimulated Macrophages.
    Shock (Augusta, Ga.), 2017, Volume: 47, Issue:5

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Benzylidene Compounds; Carrier Proteins; Enzyme-Linked Immunosorbent Assay; Inflammation; Intracellular Signaling Peptides and Proteins; Macrophages; Mice; Pyridines; RAW 264.7 Cells; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

2017
Activation of the cholinergic anti-inflammatory pathway by GTS-21 attenuates cisplatin-induced acute kidney injury in mice.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Acute Kidney Injury; Animals; Benzylidene Compounds; Cisplatin; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyridines

2017
GTS-21 Reduces Inflammation in Acute Lung Injury by Regulating M1 Polarization and Function of Alveolar Macrophages.
    Shock (Augusta, Ga.), 2019, Volume: 51, Issue:3

    Topics: Acute Lung Injury; Adoptive Transfer; Animals; Benzylidene Compounds; Inflammation; Lipopolysaccharides; Macrophages, Alveolar; Mice; Nitric Oxide Synthase Type II; Pyridines; Sepsis

2019
α7‑nAchR agonist GTS‑21 reduces radiation‑induced lung injury.
    Oncology reports, 2018, Volume: 40, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Apoptosis; Benzylidene Compounds; Cell Proliferation; Cells, Cultured; Female; Fibrosis; Inflammation; Lung Injury; Macrophages; Mice; Mice, Inbred C57BL; Nicotinic Agonists; Pyridines; Radiation Injuries, Experimental

2018
Cholinergic receptors modulate immune complex-induced inflammation in vitro and in vivo.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Aug-15, Volume: 191, Issue:4

    Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Ascitic Fluid; Benzylidene Compounds; Cell Adhesion; Cells, Cultured; Chemokine CXCL1; Chemotaxis, Leukocyte; Complement C5a; Cytokines; Female; Humans; I-kappa B Kinase; Immune Complex Diseases; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Nicotine; Nicotinic Agonists; Phagocytes; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Reactive Oxygen Species; Receptor, Anaphylatoxin C5a; Receptors, IgG; Recombinant Proteins; Respiratory Burst; Specific Pathogen-Free Organisms

2013
GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor.
    International immunopharmacology, 2015, Volume: 29, Issue:2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Bungarotoxins; Coumarins; Cytokines; Inflammation; Lipopolysaccharides; Mice; NF-kappa B; Nicotinic Antagonists; Oncogene Protein v-akt; Pyridines; RAW 264.7 Cells; Signal Transduction

2015
EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE.
    Shock (Augusta, Ga.), 2016, Volume: 45, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Colon; Gastrointestinal Motility; Inflammation; Male; Mice; Mice, Knockout; Permeability; Pyridines; Sepsis

2016
Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting by GTS-21, a Specific Agonist for α7 Nicotinic Acetylcholine Receptors.
    Shock (Augusta, Ga.), 2017, Volume: 47, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Burns; Immunoblotting; Inflammation; Male; Mice; Mice, Inbred C57BL; Muscular Atrophy; Pyridines

2017
GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation.
    Biochemical pharmacology, 2009, Oct-01, Volume: 78, Issue:7

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Anti-Inflammatory Agents, Non-Steroidal; Benzylidene Compounds; Cells, Cultured; Cytokines; Down-Regulation; Drug Partial Agonism; Enzyme Activation; Humans; Inflammation; Janus Kinase 2; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphorylation; Pyridines; Receptors, Nicotinic; Signal Transduction; STAT3 Transcription Factor; Toll-Like Receptors; Transcription, Genetic

2009
Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation.
    Journal of cellular and molecular medicine, 2009, Volume: 13, Issue:9B

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Cholinergic Agonists; HMGB1 Protein; Inflammation; Male; NF-kappa B; Poly(ADP-ribose) Polymerases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Resuscitation; Spleen; Treatment Outcome; Tumor Necrosis Factor-alpha

2009
Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Acute Kidney Injury; Animals; Benzylidene Compounds; Inflammation; Lipopolysaccharides; Mice; Nicotinic Antagonists; Proteasome Endopeptidase Complex; Protective Agents; Pyridines; Receptors, Nicotinic

2012
Are we finally taming inflammation?
    Critical care medicine, 2007, Volume: 35, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Endotoxemia; HMGB1 Protein; Inflammation; Mice; NF-kappa B; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Sepsis; Severity of Illness Index; Tumor Necrosis Factor-alpha

2007