3-(2,4-dimethoxybenzylidene)anabaseine has been researched along with Alzheimer Disease in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Chopra, K; Dhaliwal, J; Kondepudi, KK; Ray, RS; Yadav, M; Yadav, S; Yamini, P | 1 |
| Amamiya, T; Ashihara, E; Ito, A; Kawanishi, S; Kem, WR; Kitade, T; Kitamura, R; Kitamura, Y; Kuroda, E; Mizoguchi, H; Nagasawa, T; Okamoto, H; Saito, Y; Shimohama, S; Sugino, Y; Takata, K; Takegami, S; Tawa, M; Toda, Y | 1 |
| Arias, HR; Chou, KC; Gu, H; Gu, RX; Wang, JF; Wei, DQ; Xie, ZY | 1 |
| Kornprobst, JM; Métais, P; Zawieja, P | 1 |
| Arias, HR; Chou, KC; Du, QS; Sirois, S; Wei, DQ | 1 |
| Chou, KC; Wang, C; Wei, DQ; Wei, H; Zhang, R; Zheng, H | 1 |
| Andre, JC; Azuma, R; Black, SR; Komuro, M; Korsch, BH; Mathews, JM; Onnagawa, O | 1 |
| Azuma, R; Black, SR; Komuro, M; Mathews, JM | 1 |
| Kem, WR | 1 |
2 review(s) available for 3-(2,4-dimethoxybenzylidene)anabaseine and Alzheimer Disease
| Article | Year |
|---|---|
3-(2,4-dimethoxybenzylidene)-anabaseine: a promising candidate drug for Alzheimer's disease?
Topics: Alzheimer Disease; Benzylidene Compounds; Humans; Nicotinic Agonists; Pyridines | 2012 |
The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21).
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Benzylidene Compounds; Cerebral Cortex; Clinical Trials, Phase I as Topic; Female; Hippocampus; Humans; Male; Mice; Neuropsychological Tests; Nicotinic Agonists; Pyridines; Rabbits; Rats; Receptors, Nicotinic | 2000 |
7 other study(ies) available for 3-(2,4-dimethoxybenzylidene)anabaseine and Alzheimer Disease
| Article | Year |
|---|---|
α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzylidene Compounds; Cholinergic Agents; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Insulin Resistance; Maze Learning; Mice; Mice, Inbred C57BL; Oxidative Stress; Proto-Oncogene Proteins c-akt; Pyridines | 2022 |
Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse mode
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Benzylidene Compounds; Brain; Cells, Cultured; Cognitive Dysfunction; Disease Models, Animal; Humans; Mice, Transgenic; Microglia; Neuroblastoma; Phagocytosis; Pyridines; Rats; Tumor Cells, Cultured | 2018 |
Possible drug candidates for Alzheimer's disease deduced from studying their binding interactions with alpha7 nicotinic acetylcholine receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Benzylidene Compounds; Binding Sites; Drug Design; Drug Evaluation, Preclinical; Hydrogen Bonding; Models, Molecular; Protein Binding; Pyridines; Receptors, Nicotinic; Thermodynamics | 2009 |
Theoretical studies of Alzheimer's disease drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine (GTS-21) and its derivatives.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Benzylidene Compounds; Binding Sites; Brain Chemistry; Computer Simulation; Dimerization; Drug Delivery Systems; Drug Design; Humans; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Pyridines; Receptors, Nicotinic; Sequence Analysis, Protein | 2005 |
Screening for new agonists against Alzheimer's disease.
Topics: Alzheimer Disease; Benzylidene Compounds; Humans; Models, Molecular; Pyridines | 2007 |
Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Area Under Curve; Benzylidene Compounds; Bile; Biological Availability; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dogs; Feces; Humans; Male; Microsomes, Liver; Molecular Structure; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Urine | 1999 |
The effect of repeat administration of GTS-21 on mixed-function oxidase activities in rat.
Topics: Alzheimer Disease; Animals; Benzylidene Compounds; Cytochrome P-450 Enzyme System; Cytochromes b5; Isoenzymes; Male; Mixed Function Oxygenases; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Species Specificity | 1999 |