3-(2-4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone and Parkinson-Disease--Secondary

3-(2-4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone has been researched along with Parkinson-Disease--Secondary* in 1 studies

Other Studies

1 other study(ies) available for 3-(2-4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone and Parkinson-Disease--Secondary

ArticleYear
Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.
    Scientific reports, 2017, 08-08, Volume: 7, Issue:1

    Alpha-synuclein (α-syn) is involved in both familial and sporadic Parkinson's disease (PD). One of the proposed pathogenic mechanisms of α-syn mutations is mitochondrial dysfunction. However, it is not entirely clear the impact of impaired mitochondrial dynamics induced by α-syn on neurodegeneration and whether targeting this pathway has therapeutic potential. In this study we evaluated whether inhibition of mitochondrial fission is neuroprotective against α-syn overexpression in vivo. To accomplish this goal, we overexpressed human A53T-α- synuclein (hA53T-α-syn) in the rat nigrostriatal pathway, with or without treatment using the small molecule Mitochondrial Division Inhibitor-1 (mdivi-1), a putative inhibitor of the mitochondrial fission Dynamin-Related Protein-1 (Drp1). We show here that mdivi-1 reduced neurodegeneration, α-syn aggregates and normalized motor function. Mechanistically, mdivi-1 reduced mitochondrial fragmentation, mitochondrial dysfunction and oxidative stress. These in vivo results support the negative role of mutant α-syn in mitochondrial function and indicate that mdivi-1 has a high therapeutic potential for PD.

    Topics: alpha-Synuclein; Animals; Corpus Striatum; Dynamins; Gene Expression; Injections, Intraperitoneal; Mitochondria; Mitochondrial Dynamics; Motor Activity; Mutation; Neuroprotective Agents; Oxidative Stress; Parkinson Disease, Secondary; Pars Compacta; Protein Aggregates; Quinazolinones; Rats; Rats, Sprague-Dawley; Striatonigral Degeneration

2017