3-(2-4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone and Lung-Neoplasms

Previous studies suggested that mdivi-1 (mitochondrial division inhibitor), a putative inhibitor of dynamin-related protein (DRP1), decreased cancer cell proliferation through inducing mitochondrial fusion and altering oxygen consumption. However, the metabolic reprogramming underlying the DRP1 inhibition is still unclear in cancer cells.. To better understand the metabolic effect of DRP1 inhibition, [U-. Mitochondrial staining confirmed that mdivi-1 treatment and DRP1 deficiency induced mitochondrial fusion. Surprisingly, metabolic isotope tracing found that mdivi-1 decreased mitochondrial oxidative metabolism in the lung cancer cell lines H460, A549 and the colon cancer cell line HCT116. [U-. Our data suggest that, in cancer cells, mdivi-1, a putative inhibitor of DRP1, decreases oxidative metabolism to impair cell proliferation.

Topics: A549 Cells; Animals; Carbon Isotopes; Cell Proliferation; Colonic Neoplasms; Dynamins; Gene Knockout Techniques; Glucose; HCT116 Cells; Humans; Lung Neoplasms; Mice; Mitochondria; Mitochondrial Dynamics; Oxidative Stress; Oxygen Consumption; Quinazolinones