Compounds > 3-(1-adamantyl)-6-7-8-9-tetrahydro-5h-(1-2-4)triazolo(4-3-a)azepine

3-(1-adamantyl)-6-7-8-9-tetrahydro-5h-(1-2-4)triazolo(4-3-a)azepine and Disease-Models--Animal

3-(1-adamantyl)-6-7-8-9-tetrahydro-5h-(1-2-4)triazolo(4-3-a)azepine has been researched along with Disease-Models--Animal* in 2 studies

Other Studies

2 other study(ies) available for 3-(1-adamantyl)-6-7-8-9-tetrahydro-5h-(1-2-4)triazolo(4-3-a)azepine and Disease-Models--Animal

Article	Year
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11 4-Methyl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). They were active in vitro and in an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented. Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Combinatorial Chemistry Techniques; Disease Models, Animal; Enzyme Inhibitors; Humans; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles	2008
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11 3-(Phenylcyclobutyl)-1,2,4-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). These were active both in vitro and in an in vivo mouse pharmacodynamic (PD) model. Fluorine substitution of the cyclobutane ring improved the pharmacokinetic profile significantly. The synthesis and structure-activity relationships are presented. Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Administration, Oral; Animals; Combinatorial Chemistry Techniques; Cortisone; Disease Models, Animal; Enzyme Inhibitors; Humans; Hydrocortisone; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles	2008

Article

Year

4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11

4-Methyl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). They were active in vitro and in an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented.

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Combinatorial Chemistry Techniques; Disease Models, Animal; Enzyme Inhibitors; Humans; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles

2008

Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11

3-(Phenylcyclobutyl)-1,2,4-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). These were active both in vitro and in an in vivo mouse pharmacodynamic (PD) model. Fluorine substitution of the cyclobutane ring improved the pharmacokinetic profile significantly. The synthesis and structure-activity relationships are presented.

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Administration, Oral; Animals; Combinatorial Chemistry Techniques; Cortisone; Disease Models, Animal; Enzyme Inhibitors; Humans; Hydrocortisone; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles

2008