3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone and Precursor-T-Cell-Lymphoblastic-Leukemia-Lymphoma

Our previous studies have demonstrated that a previously unrecognized role of CFTR in hematopoiesis and acute leukemia. Here, we show that CFTR inhibitor CFTR-inh172 possesses ability to inhibit human T-cell acute lymphoblastic leukemia cells. In detail, CFTR-inh172 inhibited cell proliferation, promoted apoptosis and arrested the cell cycle in human T-cell acute lymphoblastic leukemia cell CCRF-CEM, JURKAT and MOLT-4. Furthermore, transcriptome analysis reveals that CFTR-inh172 induces significant alteration of gene expression related to apoptosis and proliferation. These findings demonstrate the potential of CFTR inhibitor CFTR-inh172 in human T-cell acute lymphoblastic leukemia treatment.

Topics: Apoptosis; Benzoates; Cell Cycle; Cell Proliferation; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression Regulation; Humans; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Signal Transduction; Thiazolidines; Transcriptome; Tumor Cells, Cultured