3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone has been researched along with Precursor-T-Cell-Lymphoblastic-Leukemia-Lymphoma* in 1 studies
1 other study(ies) available for 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone and Precursor-T-Cell-Lymphoblastic-Leukemia-Lymphoma
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Treatment of human T-cell acute lymphoblastic leukemia cells with CFTR inhibitor CFTRinh-172.
Our previous studies have demonstrated that a previously unrecognized role of CFTR in hematopoiesis and acute leukemia. Here, we show that CFTR inhibitor CFTR-inh172 possesses ability to inhibit human T-cell acute lymphoblastic leukemia cells. In detail, CFTR-inh172 inhibited cell proliferation, promoted apoptosis and arrested the cell cycle in human T-cell acute lymphoblastic leukemia cell CCRF-CEM, JURKAT and MOLT-4. Furthermore, transcriptome analysis reveals that CFTR-inh172 induces significant alteration of gene expression related to apoptosis and proliferation. These findings demonstrate the potential of CFTR inhibitor CFTR-inh172 in human T-cell acute lymphoblastic leukemia treatment. Topics: Apoptosis; Benzoates; Cell Cycle; Cell Proliferation; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression Regulation; Humans; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Signal Transduction; Thiazolidines; Transcriptome; Tumor Cells, Cultured | 2019 |