Compounds > 3-((2-methyl-1-3-thiazol-4-yl)ethynyl)piperidine

3-((2-methyl-1-3-thiazol-4-yl)ethynyl)piperidine and Opioid-Related-Disorders

3-((2-methyl-1-3-thiazol-4-yl)ethynyl)piperidine has been researched along with Opioid-Related-Disorders* in 1 studies

Other Studies

1 other study(ies) available for 3-((2-methyl-1-3-thiazol-4-yl)ethynyl)piperidine and Opioid-Related-Disorders

Article	Year
The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice. Drug and alcohol dependence, 2012, Jun-01, Volume: 123, Issue:1-3 The mGlu5 receptor (mGluR5) has been implicated in the rewarding effect of various drugs of abuse and drug-seeking behaviour. In the present study we investigated the impact of antagonism of mGluR5 with the selective negative allosteric, modulator 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on operant self-administration of morphine as well as cue-induced drug-seeking in adult CD1 mice. Administration of MTEP (20 mg/kg, i.p.) attenuated operant responding for morphine (0.1 mg/kg/infusion) and cue-induced morphine-seeking after a period of forced abstinence. Collectively, these data implicate mGluR5 in the reinforcing effects of opiates and support the proposition that mGluR5 is a potential therapeutic target for treatment of drug addiction. Topics: Analgesics, Opioid; Analysis of Variance; Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Mice; Morphine; Motor Activity; Narcotics; Opioid-Related Disorders; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement, Psychology; Self Administration; Substance Abuse, Intravenous; Thiazoles	2012

Article

Year

The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice.

Drug and alcohol dependence, 2012, Jun-01, Volume: 123, Issue:1-3

The mGlu5 receptor (mGluR5) has been implicated in the rewarding effect of various drugs of abuse and drug-seeking behaviour. In the present study we investigated the impact of antagonism of mGluR5 with the selective negative allosteric, modulator 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on operant self-administration of morphine as well as cue-induced drug-seeking in adult CD1 mice. Administration of MTEP (20 mg/kg, i.p.) attenuated operant responding for morphine (0.1 mg/kg/infusion) and cue-induced morphine-seeking after a period of forced abstinence. Collectively, these data implicate mGluR5 in the reinforcing effects of opiates and support the proposition that mGluR5 is a potential therapeutic target for treatment of drug addiction.

Topics: Analgesics, Opioid; Analysis of Variance; Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Mice; Morphine; Motor Activity; Narcotics; Opioid-Related Disorders; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement, Psychology; Self Administration; Substance Abuse, Intravenous; Thiazoles

2012