27-hydroxycholesterol has been researched along with Breast Cancer in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.38) | 29.6817 |
| 2010's | 28 (66.67) | 24.3611 |
| 2020's | 13 (30.95) | 2.80 |
| Authors | Studies |
|---|---|
| Holly, JMP; Mashat, RM; Perks, CM; Zielinska, HA | 1 |
| Rajavelu, A; Sreeharshan, S; Vini, R | 1 |
| Bao, L; Chen, Y; Corley, CD; Fang, Y; Kumar, A; Luo, M; Luo, W; McDonald, JG; Nelson, ER; Wang, C; Wang, JE; Wang, Y; Xing, C; Xue, Y; Zhang, B | 1 |
| Abdalkareem Jasim, S; Abed Jawad, M; Ahmad, I; Al-Gazally, ME; Haider Hamad, M; Karampoor, S; Kzar, HH; Mirzaei, R; Oudaha, KH; Sivaraman, R; Thaeer Hammid, A; Ziyadullaev, S | 1 |
| Cheng, I; DeRouen, MC; Franke, AA; Hernandez, BY; Le Marchand, L; Li, Y; Loo, LWM; Setiawan, V; Shvetsov, Y; Tome, AN; White, KK; Wilkens, LR; Wu, AH; Yang, J | 1 |
| Lekshmi, A; Rajavelu, A; Ravindran, S; Sreeja, S; Sujathan, K; Thulaseedharan, JV; Vini, R | 1 |
| Jiao, K; Li, Z; Shen, Z; Teng, M | 1 |
| Fortner, RT; Herpel, E; Johnson, TS; Kaaks, R; Kühn, T; Le Cornet, C; Sookthai, D; Walter, B | 1 |
| Hu, C; Jiao, K; Li, Y; Li, Z; Teng, M; Wu, M; Yang, K; Zhen, J; Zhou, M; Zhou, Q | 1 |
| Baek, AE; Chen, JJ; Han, C; He, S; Henn, MA; Ma, L; Menon, K; Nanjappa, SG; Nelson, AT; Nelson, ER; Park, S; Shahoei, SH; Shapiro, DJ; Vardanyan, A; Wang, L | 1 |
| Hu, C; Jiao, K; Li, Z; Wu, M; Xiao, W; Yang, B; Yang, K; Zhen, J; Zhou, M; Zhou, Q | 1 |
| Borgquist, S; Elebro, K; Inasu, M; Isaksson, K; Jernström, H; Jirström, K; Kimbung, S; Nodin, B; Stålhammar, T; Tryggvadottir, H; Ygland Rödström, M | 1 |
| Chakraborty, B; Chang, CY; Kazmin, D; Liu, W; McDonnell, DP; Safi, R | 1 |
| Bendahl, PO; Borgquist, S; Chang, CY; Dubois, L; Kimbung, S; McDonnell, DP; Thompson, JW | 1 |
| Ghribi, O; Hammer, K; Marwarha, G; Raza, S | 1 |
| Nelson, ER | 2 |
| He, S; Nelson, ER | 1 |
| Baek, AE; Chang, CY; Dubois, LG; Gunn, MD; He, S; Kemper, JK; Kwon, S; McDonnell, DP; McDowell, HB; Nelson, ER; Pillai, RV; Sullivan, PM; Thompson, JW; Wardell, SE; Yu, YA | 1 |
| Alexandrova, L; Feldman, D; Going, CC; Lau, K; Pitteri, SJ; Yeh, CY | 1 |
| Fortner, RT; Johnson, TS; Kaaks, R; Le Cornet, C; Lu, DL; Sookthai, D | 1 |
| Brekken, RA; Euhus, DM; Girard, L; Ishikawa, T; McDonald, JG; Mineo, C; Shaul, PW; Sirianni, R; Tang, H; Thompson, B; Umetani, M; Wu, Q; Xie, Y; Yuhanna, IS | 1 |
| Kaiser, J | 1 |
| Carver, NJ; Geradts, J; Howe, MK; Jasper, JS; McDonnell, DP; Nelson, ER; Park, S; Pillai, RV; Sondhi, V; Suchindran, S; Sullivan, PM; Umetani, M; Wardell, SE | 1 |
| Gustafsson, JA; Warner, M | 1 |
| Chang, CY; Goulet, MT; Guyton, JR; Jasper, J; McDonnell, DP; Nelson, ER; Norris, JD; Park, S; Wardell, SE | 1 |
| Chang, CY; McDonnell, DP; Nelson, ER | 2 |
| Javitt, NB | 1 |
| Dhasarathy, A; Ghribi, O; Hammer, KD; Ohm, JE; Raza, S; Roche, C; Schommer, J | 1 |
| Umetani, M | 1 |
| Ali, S; Barozzi, I; Castellano, L; Coombes, RC; Darbre, P; Faronato, M; Frige, G; Győrffy, B; Lombardo, Y; Magnani, L; Meira, A; Minucci, S; Nguyen, VT; Patel, N; Patten, DK; Periyasamy, M; Steel, JH; Vircillo, V; Woodley, L | 1 |
| Juberiya, AM; Sreeja, S; Vini, R | 1 |
| Cao, HX; Chen, D; Feng, JF; Hu, Y; Liu, Y; Wu, Y; Yan, DL; Yu, DD; Yu, SR; Zhang, HD | 1 |
| Krauss, S; Lund, K; Lundanes, E; Roberg-Larsen, H; Seterdal, KE; Solberg, N; Solheim, S; Vehus, T; Wilson, SR | 1 |
| Magnani, L; Perone, Y | 1 |
| Chen, J; Hu, C; Li, Y; Li, Z; Liu, J; Liu, Y; Shen, Z; Zhu, D | 2 |
| DuSell, CD; McDonnell, DP | 1 |
| Shaul, PW; Umetani, M | 1 |
| Cruz, P; Epuñan, MJ; Ramírez, ME; Sierralta, WD; Torres, CG; Valladares, LE | 1 |
10 review(s) available for 27-hydroxycholesterol and Breast Cancer
| Article | Year |
|---|---|
The emerging role of 27-hydroxycholesterol in cancer development and progression: An update.
Topics: Breast Neoplasms; Cholesterol; Humans; Hydroxycholesterols; Male; Oxysterols | 2022 |
27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer.
Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Death; Cell Proliferation; Endoplasmic Reticulum Stress; Female; Humans; Hydroxycholesterols; Male; Prostatic Neoplasms | 2017 |
The significance of cholesterol and its metabolite, 27-hydroxycholesterol in breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cholesterol; Disease Models, Animal; Female; Humans; Hydroxycholesterols; Mice; Neoplasm Recurrence, Local; Prognosis; Receptors, Estrogen | 2018 |
27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator.
Topics: Animals; Atherosclerosis; Breast Neoplasms; Cognitive Dysfunction; Female; Humans; Hydroxycholesterols; Male; Osteoporosis; Prostatic Neoplasms; Receptors, Estrogen; Selective Estrogen Receptor Modulators | 2017 |
Cholesterol and breast cancer pathophysiology.
Topics: Breast Neoplasms; Cholesterol; Female; Humans; Hydroxycholesterols; Liver X Receptors; Orphan Nuclear Receptors; Receptors, Estrogen | 2014 |
Breast cancer and (25R)-26-hydroxycholesterol.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Humans; Hydroxycholesterols; Macrophages; Receptors, Estrogen; Tamoxifen | 2015 |
Re-adopting classical nuclear receptors by cholesterol metabolites.
Topics: Animals; Bone Density; Breast Neoplasms; Cardiovascular Diseases; Cholesterol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Humans; Hydroxycholesterols; Liver X Receptors; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Sterols | 2016 |
Liver X receptor as a drug target for the treatment of breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle Checkpoints; Drug Resistance, Neoplasm; Female; Humans; Hydroxycholesterols; Ligands; Liver X Receptors; Male; Molecular Targeted Therapy; Orphan Nuclear Receptors; Receptors, Estrogen; Tumor Microenvironment | 2016 |
Going off the grid: ERα breast cancer beyond estradiol.
Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Epigenesis, Genetic; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxycholesterols; Lipid Metabolism | 2016 |
27-Hydroxycholesterol: the first identified endogenous SERM.
Topics: Animals; Breast Neoplasms; Calcification, Physiologic; Cardiovascular System; Female; Humans; Hydroxycholesterols; Mice; Models, Biological; Selective Estrogen Receptor Modulators | 2011 |
1 trial(s) available for 27-hydroxycholesterol and Breast Cancer
| Article | Year |
|---|---|
Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Biopsy; Breast Neoplasms; Cell Line, Tumor; Cholestanetriol 26-Monooxygenase; Dietary Supplements; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxycholesterols; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Vitamin D | 2018 |
31 other study(ies) available for 27-hydroxycholesterol and Breast Cancer
| Article | Year |
|---|---|
A Role for ER-Beta in the Effects of Low-Density Lipoprotein Cholesterol and 27-Hydroxycholesterol on Breast Cancer Progression: Involvement of the IGF Signalling Pathway?
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholesterol, LDL; Disease Progression; Epithelial-Mesenchymal Transition; ErbB Receptors; Estrogen Receptor beta; Female; Humans; Hydroxycholesterols; Insulin-Like Growth Factor I; Metabolome; Neoplasm Invasiveness; Receptor, IGF Type 1; Signal Transduction; Triple Negative Breast Neoplasms | 2021 |
27-Hydroxycholesterol, The Estrogen Receptor Modulator, Alters DNA Methylation in Breast Cancer.
Topics: Breast Neoplasms; DNA Methylation; Estrogen Receptor Modulators; Female; Humans; Hydroxycholesterols; Tumor Microenvironment | 2022 |
ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells.
Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Cholesterol; Epigenesis, Genetic; Female; Humans; Hydroxycholesterols; Mice; Neoplastic Stem Cells | 2022 |
Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case-control study of the Multiethnic Cohort Study.
Topics: Breast Neoplasms; Case-Control Studies; Cohort Studies; Female; Humans; Hydroxycholesterols; Risk Factors; Testosterone | 2023 |
27-Hydroxycholesterol represses G9a expression via oestrogen receptor alpha in breast cancer.
Topics: Breast Neoplasms; Estrogen Receptor alpha; Female; Humans; Hydroxycholesterols; Receptors, Estrogen | 2023 |
Activation of STAT-3 signalling by RECK downregulation
Topics: Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Female; GPI-Linked Proteins; Humans; Hydroxycholesterols; Neoplasm Invasiveness; Reactive Oxygen Species; STAT3 Transcription Factor; Transfection | 2020 |
Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort.
Topics: Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Cholestanetriol 26-Monooxygenase; Cytochrome P450 Family 7; Estrogen Receptor beta; Female; Germany; Humans; Hydroxycholesterols; Liver X Receptors; Middle Aged; Molecular Typing; Neoplasm Grading; Nutrition Assessment; Prospective Studies; Risk Factors; Steroid Hydroxylases | 2020 |
27-Hydroxycholesterol-induced EndMT acts
Topics: Acetylation; Benzoates; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Endothelium, Vascular; Epithelial-Mesenchymal Transition; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydroxycholesterols; Nitrobenzenes; Pyrazolones; Resveratrol; Signal Transduction; STAT3 Transcription Factor; Tumor Microenvironment | 2020 |
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression.
Topics: Animals; ATP Binding Cassette Transporter 1; Breast Neoplasms; Cell Line, Tumor; Cholestanetriol 26-Monooxygenase; Female; Gene Knockout Techniques; Humans; Hydroxycholesterols; Liver X Receptors; Mice; Myeloid Cells; Neoplasm Transplantation; T-Lymphocytes | 2020 |
The 14-3-3η/GSK-3β/β-catenin complex regulates EndMT induced by 27-hydroxycholesterol in HUVECs and promotes the migration of breast cancer cells.
Topics: beta Catenin; Breast Neoplasms; Epithelial-Mesenchymal Transition; Female; Glycogen Synthase Kinase 3 beta; Humans; Hydroxycholesterols | 2021 |
CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients.
Topics: Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast; Breast Neoplasms; Chemotherapy, Adjuvant; Cholestanetriol 26-Monooxygenase; Disease-Free Survival; Female; Follow-Up Studies; Humans; Hydroxycholesterols; Immunohistochemistry; Kaplan-Meier Estimate; Mastectomy; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Postmenopause; Prognosis; Receptors, Estrogen; Time Factors | 2020 |
Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer.
Topics: Animals; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cholesterol; Female; Ferroptosis; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Homeostasis; Humans; Hydroxycholesterols; Lipid Metabolism; Lung Neoplasms; MCF-7 Cells; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasms; Xenograft Model Antitumor Assays | 2021 |
Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cholestanetriol 26-Monooxygenase; Cohort Studies; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Middle Aged | 2017 |
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.
Topics: Animals; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cholesterol, Dietary; Female; Humans; Hydroxycholesterols; Mice; Mice, Inbred C57BL; Myeloid Cells; Neoplasm Metastasis; Obesity | 2017 |
Circulating 27-Hydroxycholesterol and Breast Cancer Risk: Results From the EPIC-Heidelberg Cohort.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Female; Follow-Up Studies; Humans; Hydroxycholesterols; Menopause; Middle Aged; Prognosis; Prospective Studies; Receptors, Estrogen; Receptors, Progesterone; Risk Factors | 2019 |
27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.
Topics: Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cytochrome P450 Family 7; Disease Models, Animal; Female; Gene Expression; Heterografts; Humans; Hydroxycholesterols; MCF-7 Cells; Mice; Mice, SCID; Receptors, Estrogen; Signal Transduction; Steroid Hydroxylases | 2013 |
Cancer. Cholesterol forges link between obesity and breast cancer.
Topics: Animals; Breast Neoplasms; Female; Humans; Hydroxycholesterols; Hypercholesterolemia | 2013 |
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cholestanetriol 26-Monooxygenase; Disease Models, Animal; Female; Humans; Hydroxycholesterols; Hypercholesterolemia; Lung Neoplasms; Mice; Tumor Cells, Cultured | 2013 |
On estrogen, cholesterol metabolism, and breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cholestanetriol 26-Monooxygenase; Cholesterol; Disease Models, Animal; Estradiol; Estrogens; Female; Humans; Hydroxycholesterols; Lung Neoplasms; Mice | 2014 |
Cholesterol metabolite linked to breast cancer.
Topics: Animals; Breast Neoplasms; Diet, High-Fat; Female; Humans; Hydroxycholesterols; Mice; Postmenopause | 2014 |
Obesity, cholesterol metabolism, and breast cancer pathogenesis.
Topics: Breast Neoplasms; Cholesterol; Female; Humans; Hydroxycholesterols; Lipid Metabolism; Obesity; Risk Factors | 2014 |
The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.
Topics: Animals; Autocrine Communication; Breast Neoplasms; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Estrogen Receptor alpha; Female; Humans; Hydroxycholesterols; Hyperlipidemias; Incidence; Neoplasm Recurrence, Local; Obesity; Paracrine Communication; Receptors, Estrogen; Risk Factors; Selective Estrogen Receptor Modulators | 2014 |
The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells.
Topics: Acetanilides; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxycholesterols; Imidazoles; MCF-7 Cells; Piperazines; Protein Binding; Proto-Oncogene Proteins c-mdm2; Receptors, Estrogen; RNA Interference; Selective Estrogen Receptor Modulators; Signal Transduction; Thiourea; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53 | 2015 |
Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol.
Topics: Biological Assay; Breast Neoplasms; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxycholesterols; Ligands; MCF-7 Cells; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Selective Estrogen Receptor Modulators; Transfection; Workflow | 2016 |
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biosynthetic Pathways; Blotting, Western; Breast Neoplasms; Cholesterol; Chromatin Immunoprecipitation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Estrogen Receptor alpha; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; In Vitro Techniques; MCF-7 Cells; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Transplantation; Real-Time Polymerase Chain Reaction; Up-Regulation | 2015 |
Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol.
Topics: Animals; Breast Neoplasms; Endometrial Neoplasms; Estrogen Receptor alpha; Female; Humans; Hydroxycholesterols; Lythraceae; MCF-7 Cells; Mice; Obesity; Ovarian Neoplasms; Plant Extracts; Uterine Cervical Neoplasms | 2016 |
Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes.
Topics: Breast Neoplasms; Cell Line, Tumor; Chromatography, Liquid; Cytoplasm; Estrogen Receptor alpha; Exosomes; Female; HEK293 Cells; Humans; Hydroxycholesterols; Mass Spectrometry; MCF-7 Cells; Reproducibility of Results | 2017 |
The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells.
Topics: Angiogenesis Inducing Agents; Autocrine Communication; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Female; Gene Knockdown Techniques; Humans; Hydroxycholesterols; Neovascularization, Pathologic; Reactive Oxygen Species; Selective Estrogen Receptor Modulators; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2016 |
27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3.
Topics: Breast Neoplasms; Cell Culture Techniques; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Hydroxycholesterols; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; STAT3 Transcription Factor; Transfection | 2017 |
27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling.
Topics: Animals; Breast Neoplasms; Cardiovascular Diseases; Cholesterol; Disease Models, Animal; Humans; Hydroxycholesterols; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Signal Transduction; Transcription, Genetic | 2008 |
27-hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype.
Topics: Adherens Junctions; Animals; beta Catenin; Breast Neoplasms; Cadherins; Cell Growth Processes; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Estradiol; Female; Humans; Hydroxycholesterols; Phenotype | 2011 |