27-hydroxycholesterol has been researched along with Alzheimer Disease in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 22 (64.71) | 24.3611 |
| 2020's | 6 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Hao, L; Ju, M; Liu, W; Wang, L; Wang, T; Wang, Y; Xiao, R; Zhang, X | 1 |
| Feng, W; Hao, L; Ju, M; Liu, W; Wang, L; Wang, T; Wang, Y; Xiao, R | 1 |
| Feng, W; Hao, L; Ju, M; Wang, L; Xiao, R; Yu, H | 1 |
| Feng, W; Guo, Z; Hao, L; Ju, M; Sun, X; Wang, L; Xiao, R | 1 |
| Cedazo-Minguez, A; DeFelipe, J; Gerenu, G; Gómez-Galán, M; Lindskog, M; Loera-Valencia, R; Merino-Serrais, P; Muñoz, A; Vazquez-Juarez, E | 1 |
| Edgington-Mitchell, L; Lei, K; Liu, P; Liu, X; Wang, XC; Wang, ZH; Xia, Y; Ye, K; Yu, SP | 1 |
| Ghribi, O; Gongol, B; Jeppson, JD; Kirsch, WM; Marin, TL; Mayagoitia, K; Sanchez, N; Shin, S; Soriano, S; Vinters, HV; Wilson, CG | 1 |
| An, Y; Liu, W; Tao, L; Wang, T; Wang, Y; Xi, Y; Xiao, R; Yu, H; Zhang, X | 1 |
| Goikolea, J; Loera-Valencia, R; Maioli, S; Merino-Serrais, P; Parrado-Fernandez, C | 1 |
| Caccia, C; Leoni, V | 1 |
| Ghribi, O; Marwarha, G; Prasanthi, JR; Raza, S | 1 |
| Fenart, L; Gosselet, F; Saint-Pol, J | 1 |
| Biasi, F; Gamba, P; Gargiulo, S; Giaccone, G; Guglielmotto, M; Iuliano, L; Leonarduzzi, G; Mauro, A; Monteleone, D; Poli, G; Tamagno, E; Testa, G; Zerbinati, C | 1 |
| Dias, IH; Fell, S; Griffiths, HR; Lip, GY; Mistry, J; Polidori, MC; Reis, A; Spickett, CM | 1 |
| Ghribi, O; Marwarha, G | 1 |
| Kuo, SH; Liu, N; Liu, XG; Song, QY; Wang, HL; Wang, MW; Wang, YY | 1 |
| An, Y; Feng, L; Liu, Q; Lu, Y; Wang, C; Xiao, R; Yu, H | 1 |
| Ghribi, O | 1 |
| Andreasen, N; Besga, A; Björkhem, I; Julin, P; Kivipelto, M; Leoni, V; Oksengård, AR; Soininen, H; Solomon, A; Svensson, L; Wahlund, LO; Winblad, B | 1 |
| Dasari, B; Ghribi, O; Marwarha, G; Prasanthi, JR; Schommer, J | 1 |
| Dasari, B; Ghribi, O; Marwarha, G; Prasanthi, JR; Singh, BB | 1 |
| Biasi, F; Gamba, P; Gargiulo, S; Guglielmotto, M; Leonarduzzi, G; Mauro, A; Poli, G; Sottero, B; Tamagno, E; Testa, G; Viña, J | 1 |
| Björkhem, I; Cedazo-Mínguez, A; Gil-Bea, FJ; Ismail, MA; Leoni, V; Mateos, L; Winblad, B | 1 |
| Björkhem, I; Lövgren-Sandblom, A; Marutle, A; Nordberg, A; Olin, M; Pettersson, H; Pikuleva, I; Shafaati, M; Winblad, B | 1 |
| Jeitner, TM; Reiss, AB; Voloshyna, I | 1 |
| Bossù, P; Caltagirone, C; Gianni, W; Iuliano, L; Monticolo, R; Spalletta, G; Spoletini, I; Straface, G | 1 |
| Dasari, B; Ghribi, O; Marwarha, G | 1 |
| Ghribi, O; Larson, T; Prasanthi, JR; Schommer, J | 1 |
| Becker, JT; Evans, RW; Hughes, TM; Kuller, LH; Lopez, OL; Rosano, C; Sutton-Tyrrell, K | 1 |
| Jessen, F; Kölsch, H; Kornhuber, J; Lewczuk, P; Lütjohann, D; Maier, W; Meichsner, S; Popp, J | 1 |
| Bayer, T; Björkhem, I; Bogdanovic, N; Bretillon, L; Diczfalusy, U; Heverin, M; Lütjohann, D; Pikuleva, I; Winblad, B | 1 |
| Brown, J; Crowley, J; Eckman, CB; Gottardi-Littell, N; Lee, JM; Magnuson, D; Rahman, MM; Reiss, AB; Sambamurti, K; Silberman, S; Theisler, C; Wolozin, B; Yager, D | 1 |
| Björkhem, I; Diczfalusy, U; Heverin, M; Leoni, V; Meaney, S | 1 |
| Björkhem, I | 1 |
9 review(s) available for 27-hydroxycholesterol and Alzheimer Disease
| Article | Year |
|---|---|
Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment.
Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Brain; Cholestanetriol 26-Monooxygenase; Cholesterol; Cholesterol 24-Hydroxylase; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Risk Factors | 2019 |
Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid.
Topics: Alzheimer Disease; Animals; Biomarkers; Brain; Cholesterol; Humans; Hydroxycholesterols; Neurodegenerative Diseases; Oxidation-Reduction | 2013 |
Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Biological Transport; Blood-Brain Barrier; Brain; Cholesterol; Homeostasis; Humans; Hydroxycholesterols | 2014 |
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?
Topics: alpha-Synuclein; Alzheimer Disease; Animals; Brain; Cholesterol, Dietary; Disease Models, Animal; Endoplasmic Reticulum Stress; Homeostasis; Humans; Hydroxycholesterols; Lipid Metabolism; Liver X Receptors; Orphan Nuclear Receptors; Parkinson Disease; Plaque, Amyloid; Rabbits | 2015 |
Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis.
Topics: Alzheimer Disease; Cholesterol; Cognitive Dysfunction; Databases, Bibliographic; Humans; Hydroxycholesterols | 2016 |
Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Brain Chemistry; Cholesterol; Hippocampus; Humans; Hydroxycholesterols; Muscle, Skeletal; Myositis, Inclusion Body; Organ Culture Techniques; Rabbits; tau Proteins | 2008 |
Oxysterol derivatives of cholesterol in neurodegenerative disorders.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholesterol; Humans; Hydroxycholesterols; Multiple Sclerosis; Neurodegenerative Diseases; Paraplegia; Structure-Activity Relationship | 2011 |
Oxysterols and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Brain; Humans; Hydroxycholesterols; Hypercholesterolemia | 2006 |
Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Diseases; Cholesterol; Cholesterol 24-Hydroxylase; Homeostasis; Humans; Hydroxycholesterols; Infant; Rats; Steroid Hydroxylases | 2006 |
25 other study(ies) available for 27-hydroxycholesterol and Alzheimer Disease
| Article | Year |
|---|---|
High cholesterol and 27-hydroxycholesterol contribute to phosphorylation of tau protein by impairing autophagy causing learning and memory impairment in C57BL/6J mice.
Topics: Alzheimer Disease; Animals; Autophagy; Cholesterol; Cholesterol, Dietary; Glycogen Synthase Kinase 3 beta; Hydroxycholesterols; Hypercholesterolemia; Male; Mammals; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Phosphorylation; RNA, Small Interfering; tau Proteins; TOR Serine-Threonine Kinases | 2022 |
27-Hydroxycholesterol-Induced Dysregulation of Cholesterol Metabolism Impairs Learning and Memory Ability in ApoE ε4 Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anastrozole; Animals; Apolipoprotein A-I; Apolipoprotein E4; Apolipoproteins E; Cholesterol; Hydroxycholesterols; Ligases; Lipoproteins, LDL; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2022 |
The Interaction Effect of 27-Hydroxycholesterol Metabolism Disorder and CYP27A1 Single Nucleotide Polymorphisms in Mild Cognitive Impairment: Evidence from a Case-Control Study.
Topics: Alzheimer Disease; Case-Control Studies; Cholestanetriol 26-Monooxygenase; Cognitive Dysfunction; Cytochrome P-450 Enzyme System; Humans; Hydroxycholesterols; Polymorphism, Single Nucleotide | 2023 |
27-Hydroxycholesterol impairs learning and memory ability via decreasing brain glucose uptake mediated by the gut microbiota.
Topics: Alzheimer Disease; Animals; Anti-Bacterial Agents; Brain; Gastrointestinal Microbiome; Glucose; Male; Memory Disorders; Mice; Mice, Inbred C57BL | 2023 |
High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus.
Topics: Alzheimer Disease; Animals; CA1 Region, Hippocampal; Cognitive Dysfunction; Dendritic Spines; Disease Models, Animal; Hippocampus; Humans; Hydroxycholesterols; Long-Term Potentiation; Male; Mice; Mice, Transgenic; Microfilament Proteins; Neuronal Plasticity; Pyramidal Cells; Synapses; Synaptic Transmission | 2021 |
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Apolipoprotein E4; CCAAT-Enhancer-Binding Protein-beta; Cytokines; Hydroxycholesterols; Mice | 2021 |
Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Forkhead Box Protein O1; Gene Expression Regulation; Hormesis; Humans; Hydroxycholesterols; Intracellular Signaling Peptides and Proteins; Intracellular Space; Male; Mice; Microtubule-Associated Proteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Transcription, Genetic | 2017 |
27-hydroxycholesterol promotes Aβ accumulation via altering Aβ metabolism in mild cognitive impairment patients and APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Brain; Case-Control Studies; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Humans; Hydroxycholesterols; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments; Plaque, Amyloid; Presenilin-1 | 2019 |
Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line, Tumor; Disease Models, Animal; Gene Expression Regulation; Humans; Hydroxycholesterols; Male; Mice; Mice, Transgenic; Neurons; NF-kappa B; Promoter Regions, Genetic; Protein Binding; RNA, Small Interfering; Signal Transduction; Transcription Factor CHOP; Transcription, Genetic | 2013 |
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Disease Progression; Humans; Hydroxycholesterols; Neurons; Oxidative Stress; Up-Regulation | 2014 |
Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line, Tumor; Cell Survival; Cholesterol, LDL; Desipramine; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Humans; Hydroxycholesterols; Lipid Metabolism; Lipoproteins, LDL; Membrane Microdomains; Oxidation-Reduction; Sphingomyelin Phosphodiesterase | 2014 |
Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.
Topics: Aged; Alzheimer Disease; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Female; Humans; Hydroxycholesterols; Male; Mass Spectrometry; Middle Aged | 2016 |
Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease.
Topics: Age Factors; Aged; Alzheimer Disease; Apolipoproteins E; Brain; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cognition Disorders; Female; Genotype; Humans; Hydroxycholesterols; Lanosterol; Male; Middle Aged; Organ Size; Sex Factors | 2009 |
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Hydroxycholesterols; Leptin; Male; Organ Culture Techniques; Phosphorylation; Rabbits; tau Proteins | 2010 |
The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Blotting, Western; Calcium; Cells, Cultured; Cholesterol; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxycholesterols; Immunohistochemistry; Macular Degeneration; Microscopy, Confocal; Oxidative Stress; Reactive Oxygen Species; Retinal Pigment Epithelium | 2010 |
Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Apoptosis; Brain; CD36 Antigens; Cell Line, Tumor; Genistein; Glutathione; Glutathione Disulfide; Humans; Hydroxycholesterols; Integrin beta Chains; NADPH Oxidases; Necrosis; Neurons; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Plaque, Amyloid; Quercetin; Reactive Oxygen Species; Up-Regulation | 2011 |
Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Angiotensinogen; Animals; Biomarkers; Brain Chemistry; Cells, Cultured; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; Hydroxycholesterols; Male; Middle Aged; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Up-Regulation | 2011 |
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Blotting, Western; Brain; Cholesterol; Female; Humans; Hydroxycholesterols; Male; Middle Aged; Mutation; Phytosterols; Sitosterols | 2011 |
Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Biomarkers; Cognition Disorders; Female; Humans; Hydroxycholesterols; Male; Middle Aged; Oxidative Stress; Vitamin E | 2010 |
Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Expression Regulation; Humans; Hydroxycholesterols; Leptin; Neuroblastoma; Phosphorylation; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; tau Proteins; Transcription Factor CHOP | 2012 |
Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Gene Silencing; Hippocampus; Hydroxycholesterols; Rabbits; RNA, Small Interfering; Transcription Factor CHOP | 2011 |
Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Brain; Cerebrovascular Disorders; Cognition Disorders; Cohort Studies; Female; Humans; Hydroxycholesterols; Magnetic Resonance Imaging; Male; Retrospective Studies | 2012 |
Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Biomarkers; Cholesterol; Female; Humans; Hydroxycholesterols; Male; Middle Aged; Up-Regulation | 2012 |
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Brain; Female; Humans; Hydroxycholesterols; Male; Mice; Mice, Transgenic; Middle Aged; Mixed Function Oxygenases; Water | 2004 |
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Topics: Adenoviridae; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Benzothiazoles; Brain; Cells, Cultured; Cerebral Cortex; Cholestanetriol 26-Monooxygenase; Cholesterol 24-Hydroxylase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxycholesterols; Immunoblotting; Immunohistochemistry; Inhibitory Concentration 50; Liver X Receptors; Neurons; Oligodendroglia; Orphan Nuclear Receptors; Polymorphism, Genetic; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Steroid Hydroxylases; Thiazoles; Time Factors | 2004 |