25-hydroxyvitamin-d-2 and Vitamin-A-Deficiency

To investigate the correlation of serum vitamin A, D, and E levels with a recurrent respiratory infection (RRI) in children.. The medical records of 422 children with RRI (a study group) in Cangzhou Central Hospital from January 2015 to December 2018 were retrospectively analyzed (the study group was divided into an active group and a stable group). Further 100 healthy children who underwent physical examination at the same time were enrolled as a control group. High-performance liquid chromatography (HPLC) was used to determine vitamin A, D, and E levels, so as to analyze their differences between the groups.. Vitamin A, D, and E in the active and stable groups were significantly lower than those in the control group (p < 0.001); in the active group they were significantly lower than those in the stable group (p < 0.001). According to partial correlation analysis, in children with active RRI, vitamin A was respectively positively correlated with vitamin D (r=0.945, p < 0.001), and vitamin E (r=0.988, p < 0.001). Moreover, vitamin E was positively correlated with vitamin D (r=0.959, p < 0.001).. The deficiency of vitamin A, D, and E is positively correlated with the disease activity of children with RRI. Therefore, the supplement of vitamin A, D, and E through dietary adjustment is beneficial to the rehabilitation of the children.

Topics: 25-Hydroxyvitamin D 2; Case-Control Studies; Child, Preschool; China; Chromatography, High Pressure Liquid; Female; Humans; Infant; Male; Recurrence; Respiratory Tract Infections; Retrospective Studies; Vitamin A; Vitamin A Deficiency; Vitamin D Deficiency; Vitamin E; Vitamin E Deficiency

Celiac disease (CD) is an autoimmune disorder characterized by damage to the intestinal mucosa and nutrient malabsorption in severe cases. However, it remains unclear whether nutrient deficiencies and other adverse health effects are prevalent in individuals with positive CD serology identified through screening studies.. The objective was to determine whether biomarkers of cardiometabolic health and nutritional status differ between those with positive and negative CD serology identified in a screening study of Canadian adults.. Participants ( n=2832) were from the Toronto Nutrigenomics and Health Study and the Toronto Healthy Diet Study. Individuals were screened for CD-specific anti-tissue transglutaminase autoantibodies. Lipid profiles as well as concentrations of six carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein, lycopene, and zeaxanthin), three tocopherols (α-tocopherol, δ-tocopherol, and γ-tocopherol), retinol, ascorbic acid, and 25-hydroxyvitamin D were cross-sectionally compared between those with positive and negative CD serology using general linear mixed models.. Individuals with positive CD serology ( n=23) had significantly lower levels of HDL-cholesterol ( p=0.008) and apolipoprotein-AI ( p=0.02), a higher ratio of total cholesterol to HDL-cholesterol ( p=0.006), and a higher apolipoprotein-B/AI ratio ( p=0.03) than those with negative CD serology. Positive CD serology was also associated with significantly lower concentrations of retinol ( p=0.006) in fully adjusted models. Those with positive CD serology had lower serum 25-hydroxyvitamin D in unadjusted models ( p=0.01), but not in fully adjusted models ( p=0.08).. Individuals with undiagnosed CD may have unfavorable lipid profiles and be at elevated risk for inadequacy of certain fat-soluble vitamins, but not widespread nutrient deficiencies.

Topics: 25-Hydroxyvitamin D 2; Adult; Asymptomatic Diseases; Autoantibodies; Biomarkers; Calcifediol; Cardiovascular Diseases; Celiac Disease; Cross-Sectional Studies; Female; Humans; Male; Malnutrition; Mass Screening; Nutritional Status; Ontario; Risk; Severity of Illness Index; Transglutaminases; Vitamin A; Vitamin A Deficiency; Vitamin D Deficiency

Topics: 25-Hydroxyvitamin D 2; Alkaline Phosphatase; Animals; Carotenoids; Child; Child, Preschool; Ergocalciferols; Humans; Infections; Intestinal Absorption; Phytic Acid; Protein-Energy Malnutrition; Retinol-Binding Proteins; Stress, Physiological; Sunlight; Vitamin A; Vitamin A Deficiency; Vitamin D Deficiency