25-hydroxyvitamin-d-2 and Skin-Neoplasms

25-hydroxyvitamin-d-2 has been researched along with Skin-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for 25-hydroxyvitamin-d-2 and Skin-Neoplasms

Article	Year
High prevalence of vitamin D deficiency in patients with xeroderma pigmetosum-A under strict sun protection. European journal of clinical nutrition, 2015, Volume: 69, Issue:6 Xeroderma pigmentosum (XP) is a rare autosomal recessive disease characterized by defective repair of ultraviolet (UV) irradiation-induced DNA damage and high risk of skin cancer. Thus, these patients require strict photoprotection. Considering the importance of UV-mediated cutaneous vitamin D production, such rigorous photoprotection would cause vitamin D deficiency. Then, we have studied the vitamin D status in patients with XP-A, a group requiring the most strict photoprotection.. Twenty-one patients with XP-A (aged 6-25) were evaluated for their vitamin D intake, serum levels of 25-hydroxy-vitamin D (25OHD) and parathyroid hormone (PTH). Vitamin D intake was assessed by a 2-day food weighing method.. Median dietary intake of vitamin D was 4.1 μg/day, and the median concentrations of serum 25OHD and PTH were 7.7 and 49.9 pg/ml, respectively. In 76% of the patients, serum 25OHD level was lower than 10 ng/ml, indicating vitamin D deficiency. Vitamin D intake and serum 25OHD level were significantly lower in patients under enteral nutrition (EN) than those with oral intake (OI). Multivariate analyses revealed that EN was a significant predictor of decreased serum 25OHD level (β coefficient=-0.59, P=0.03).. Vitamin D deficiency is highly prevalent in XP-A patients, and supplementation should be considered to avoid unfavorable skeletal consequences in these patients. In addition, determination of dietary vitamin D requirement has been a difficult work issue in the decision of dietary reference intakes (DRIs) because of its cutaneous production. Data from XP patients would yield useful information for the determination of DRIs for vitamin D. Topics: 25-Hydroxyvitamin D 2; Adolescent; Adult; Calcifediol; Child; Combined Modality Therapy; Cross-Sectional Studies; Female; Hospitals, University; Humans; Japan; Life Style; Male; Nutritional Status; Outpatient Clinics, Hospital; Parathyroid Hormone; Patient Compliance; Prevalence; Risk; Skin Neoplasms; Sunscreening Agents; Vitamin D Deficiency; Xeroderma Pigmentosum; Young Adult	2015
[Basal cell and squamous carcinomas: vitamin D value increases the risk of skin cancer in light skinned patients]. MMW Fortschritte der Medizin, 2011, Sep-01, Volume: 153, Issue:35 Topics: 25-Hydroxyvitamin D 2; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cohort Studies; Humans; Longitudinal Studies; Neoplasms, Radiation-Induced; Risk Factors; Skin Neoplasms; Statistics as Topic; Sunlight	2011

Article

Year

High prevalence of vitamin D deficiency in patients with xeroderma pigmetosum-A under strict sun protection.

European journal of clinical nutrition, 2015, Volume: 69, Issue:6

Xeroderma pigmentosum (XP) is a rare autosomal recessive disease characterized by defective repair of ultraviolet (UV) irradiation-induced DNA damage and high risk of skin cancer. Thus, these patients require strict photoprotection. Considering the importance of UV-mediated cutaneous vitamin D production, such rigorous photoprotection would cause vitamin D deficiency. Then, we have studied the vitamin D status in patients with XP-A, a group requiring the most strict photoprotection.. Twenty-one patients with XP-A (aged 6-25) were evaluated for their vitamin D intake, serum levels of 25-hydroxy-vitamin D (25OHD) and parathyroid hormone (PTH). Vitamin D intake was assessed by a 2-day food weighing method.. Median dietary intake of vitamin D was 4.1 μg/day, and the median concentrations of serum 25OHD and PTH were 7.7 and 49.9 pg/ml, respectively. In 76% of the patients, serum 25OHD level was lower than 10 ng/ml, indicating vitamin D deficiency. Vitamin D intake and serum 25OHD level were significantly lower in patients under enteral nutrition (EN) than those with oral intake (OI). Multivariate analyses revealed that EN was a significant predictor of decreased serum 25OHD level (β coefficient=-0.59, P=0.03).. Vitamin D deficiency is highly prevalent in XP-A patients, and supplementation should be considered to avoid unfavorable skeletal consequences in these patients. In addition, determination of dietary vitamin D requirement has been a difficult work issue in the decision of dietary reference intakes (DRIs) because of its cutaneous production. Data from XP patients would yield useful information for the determination of DRIs for vitamin D.

Topics: 25-Hydroxyvitamin D 2; Adolescent; Adult; Calcifediol; Child; Combined Modality Therapy; Cross-Sectional Studies; Female; Hospitals, University; Humans; Japan; Life Style; Male; Nutritional Status; Outpatient Clinics, Hospital; Parathyroid Hormone; Patient Compliance; Prevalence; Risk; Skin Neoplasms; Sunscreening Agents; Vitamin D Deficiency; Xeroderma Pigmentosum; Young Adult

2015

[Basal cell and squamous carcinomas: vitamin D value increases the risk of skin cancer in light skinned patients].

MMW Fortschritte der Medizin, 2011, Sep-01, Volume: 153, Issue:35

Topics: 25-Hydroxyvitamin D 2; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cohort Studies; Humans; Longitudinal Studies; Neoplasms, Radiation-Induced; Risk Factors; Skin Neoplasms; Statistics as Topic; Sunlight

2011