25-hydroxyvitamin-d-2 and Respiratory-Tract-Infections

Topics: 25-Hydroxyvitamin D 2; Biomarkers; Calcifediol; Child; Child Nutritional Physiological Phenomena; Child, Preschool; Cross-Sectional Studies; Female; Follow-Up Studies; Food, Fortified; Humans; Immune System; Infant; Inflammation Mediators; Influenza, Human; Male; Nutrition Assessment; Nutritional Status; Quebec; Respiratory Tract Infections; Seasons; Urban Health; Vitamin D; Vitamin D Deficiency

To investigate the correlation of serum vitamin A, D, and E levels with a recurrent respiratory infection (RRI) in children.. The medical records of 422 children with RRI (a study group) in Cangzhou Central Hospital from January 2015 to December 2018 were retrospectively analyzed (the study group was divided into an active group and a stable group). Further 100 healthy children who underwent physical examination at the same time were enrolled as a control group. High-performance liquid chromatography (HPLC) was used to determine vitamin A, D, and E levels, so as to analyze their differences between the groups.. Vitamin A, D, and E in the active and stable groups were significantly lower than those in the control group (p < 0.001); in the active group they were significantly lower than those in the stable group (p < 0.001). According to partial correlation analysis, in children with active RRI, vitamin A was respectively positively correlated with vitamin D (r=0.945, p < 0.001), and vitamin E (r=0.988, p < 0.001). Moreover, vitamin E was positively correlated with vitamin D (r=0.959, p < 0.001).. The deficiency of vitamin A, D, and E is positively correlated with the disease activity of children with RRI. Therefore, the supplement of vitamin A, D, and E through dietary adjustment is beneficial to the rehabilitation of the children.

Topics: 25-Hydroxyvitamin D 2; Case-Control Studies; Child, Preschool; China; Chromatography, High Pressure Liquid; Female; Humans; Infant; Male; Recurrence; Respiratory Tract Infections; Retrospective Studies; Vitamin A; Vitamin A Deficiency; Vitamin D Deficiency; Vitamin E; Vitamin E Deficiency

Vitamin D affects multiple body functions through the regulation of gene expression. In sports medicine, its influence on musculoskeletal health and performance is of particular interest. Vitamin D insufficiency might decrease athletic performance and increase the risk of musculoskeletal injuries. Several studies have demonstrated vitamin D deficiency in professional athletes; however, the prevalence of vitamin D insufficiency in professional handball players is yet unknown.. The study was planned as a prospective, non-interventional study. We examined 70 male elite handball athletes (first league) in a pre-competition medical assessment in July. Age, height, weight, body mass index, 25-OH vitamin D, calcium, and parathyroid hormone were evaluated, and a sun exposure score was calculated. Players were then divided into two groups of vitamin D levels: insufficient (<30 ng/mL) and sufficient (≥30 ng/mL).. The mean 25-OH vitamin D level of the 70 players was 33.5 ± 10.9 ng/mL (median 32.2, IQR 26.5-38.9 ng/mL). Thirty-nine (55.7%) had sufficient and 31 (44.3%) insufficient levels. Athletes with sufficient vitamin D levels had significantly lower parathyroid hormone levels than athletes with insufficiency (24.9 ± 12.1 vs. 33.5 ± 15.1 ng/mL, p = 0.02). All other parameters evaluated demonstrated no significant difference between the two groups.. Vitamin D insufficiency is a common finding in professional handball athletes even in summer, which might negatively affect physical performance. Furthermore, it might lead to an increased risk of musculoskeletal injuries and infections. This should be evaluated in further studies.

Topics: 25-Hydroxyvitamin D 2; Adult; Athletic Performance; Body Mass Index; Calcium; Germany; Humans; Male; Musculoskeletal System; Parathyroid Hormone; Prevalence; Prospective Studies; Respiratory Tract Infections; Risk Factors; Seasons; Sports; Vitamin D Deficiency; Young Adult