25-hydroxyvitamin-d-2 and Kidney-Diseases

Topics: 24,25-Dihydroxyvitamin D 3; 25-Hydroxyvitamin D 2; Animals; Calcitriol; Calcium; Chick Embryo; Dihydroxycholecalciferols; Dogs; Ergocalciferols; Female; Humans; Kidney Diseases; Liver Diseases; Pregnancy; Vitamin D; Vitamin D Deficiency

To investigate associations between baseline serum 25-hydroxyvitamin D [25(OH)D] levels and myocardial structure and function after 8 years of follow-up in older Dutch subjects.. We included 256 subjects of the Hoorn Study, a population-based cohort. They underwent a standardized 2-dimensional echocardiogram at baseline between 2000 and 2001, and again between 2007 and 2009. We studied the association of 25(OH)D quartiles with echocardiographic measures of the left ventricular mass index (LVMI), left ventricular systolic function and markers of diastolic function using linear regression analyses.. At baseline, subjects had a mean age of 67.4 ± 5.2 years and 41.4% had prior cardiovascular disease (CVD). Low serum 25(OH)D levels were only associated with higher LVMI at 8-year follow-up in subjects without prior CVD and in subjects with low kidney function (median estimated glomerular filtration rate ≤77.5 ml/min/1.73m(2)). The associations attenuated after adjustments for parathyroid hormone (PTH), which was associated with higher LVMI (g/m(2.7)) in subjects with low kidney function (regression coefficient highest quartile 6.3, 95% CI: 0.2, 12.5).. This study showed no strong associations of 25(OH)D with myocardial structure and function. However, PTH - a possible modifiable mediator in the relation between 25(OH)D and myocardial structure - was positively associated with LVMI in subjects with low kidney function.

Topics: 25-Hydroxyvitamin D 2; Aged; Anthropometry; Blood Glucose; Blood Pressure; Calcifediol; Comorbidity; Diastole; Female; Follow-Up Studies; Glomerular Filtration Rate; Heart; Heart Ventricles; Humans; Hypertrophy, Left Ventricular; Kidney Diseases; Lipids; Male; Middle Aged; Myocardium; Netherlands; Parathyroid Hormone; Risk Factors; Socioeconomic Factors; Systole; Ultrasonography; Vitamin D Deficiency

Serum 1,25-dihydroxyvitamin D [1,25(OH)2D] and 25-hydroxyvitamin D [25(OH)D] were measured in 7 women living in a cadmium-polluted area in Toyama, Japan. Despite the fact that these subjects had severe proximal renal tubular dysfunction showing increased fractional excretion of beta 2-microglobulin (FE beta 2-m) ranging from 9.7-49.1% with a mean of 30.7%, the levels of serum 1,25(OH)2D, which is produced in the proximal tubules, were within the normal range in 6 subjects. Significant correlations were found between 1,25(OH)2D and creatinine clearance (r = 0.802, P less than 0.05), and FE beta 2-m (r = -0.829, P less than 0.05), respectively. These results suggest that renal production of 1,25(OH)2D decreases with progression of cadmium-induced renal tubular dysfunction.

Topics: 25-Hydroxyvitamin D 2; Aged; beta 2-Microglobulin; Cadmium; Calcitriol; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Kidney Tubules, Proximal; Parathyroid Hormone

Serum 25-hydroxyvitamin D and immunoreactive parathyroid hormone concentrations were measured in normal elderly subjects living at home and in sick elderly patients in hospital. Normal old people tended to have high 25-hydroxyvitamin D and low parathyroid hormone concentrations; in the sick elderly this pattern was reversed. The raised serum parathyroid hormone concentrations in the sick elderly were not due to poor renal function and may have been a response to vitamin D deficiency. A high serum parathyroid hormone concentration in an elderly patient must be interpreted in the light of the patient's general health and nutritional state. Caution is needed in diagnosing primary hyperparathyroidism in this age group.

Topics: 25-Hydroxyvitamin D 2; Aged; Alkaline Phosphatase; Ergocalciferols; Female; Humans; Hyperparathyroidism; Kidney Diseases; Male; Middle Aged; Parathyroid Hormone