25-hydroxyvitamin-d-2 and Hyperinsulinism

To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults.. Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC-tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors.. Individuals born in Jerusalem during 1974-1976.. Participants of the Jerusalem Perinatal Study (n 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity.. Mean total 25(OH)D concentration among participants was 21·7 (sd 8·9) ng/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, β=-0·011, P=0·004) after adjustment for BMI. However, these associations were not present among females (P for sex interaction=0·005).. We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.

Topics: 25-Hydroxyvitamin D 2; Adult; Biomarkers; Body Mass Index; Calcifediol; Cardiovascular Diseases; Cohort Studies; Cross-Sectional Studies; Female; Humans; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Insulin Resistance; Israel; Longitudinal Studies; Male; Metabolic Syndrome; Overweight; Risk Factors; Sex Factors; Vitamin D Deficiency