25-hydroxyvitamin-d-2 and Hashimoto-Disease

Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases.. To measure vitamin D levels in children with Hashimoto’s thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls.. We included 68 children with HT aged 12 ± 4 years (39 females) from a pediatric outpatient clinic and 68 healthy children aged 10 ± 4 years (37 females). Calcium metabolism parameters, thyroid function tests and anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and 25 hydroxy vitamin D (25OHD) levels were measured.. Patients were older than controls but well matched by gender distribution. Mean 25OHD levels were significantly lower in HT patients than controls (16.8 ± 9.3 and 24.1 ± 9.4 ng/mL respectively, P < 0.01). Frequency of vitamin D deficiency was 76 and 35% in HT patients and controls, respectively (P < 0.001).. Vitamin D deficiency is more common in children with HT than healthy controls.

Topics: 25-Hydroxyvitamin D 2; Autoantibodies; Case-Control Studies; Child; Female; Hashimoto Disease; Humans; Iodide Peroxidase; Male; Vitamin D Deficiency

Vitamin D is shown to be a potent immunomodulator. Considering the potential role of low serum vitamin D levels in autoimmune disorder, we evaluated the association between Hashimoto's thyroiditis (HT) (with subclinical or overt hypothyroidism) and serum 25-hydroxyvitamin D (25OHD) levels in an Iranian population.. A total number of 86 individuals were enrolled. The case group included 41 patients with hypothyroid HT (overt or subclinical). The control group comprised 45 healthy euthyroid persons. Serum 25OHD levels were measured in all subjects.. control ratio of geometric means of 25OHD levels was 0.66 (95 % CI: 0.49-0.90; P = 0.008). There was a significant inverse association between serum 25OHD levels and HT (OR: 0.81 for 5 ng/ml increase in 25OHD level, 95 % CI: 0.68-0.96; P = 0.018). This association remained significant after adjustment for potential confounding factors including age, sex and BMI.. Our study suggested that higher serum 25OHD levels was associated with decreased risk of HT so that each 5 ng/ml increase in the serum 25OHD levels results in 19 % decrease in odds of HT.

Topics: 25-Hydroxyvitamin D 2; Adult; Calcifediol; Case-Control Studies; Cross-Sectional Studies; Female; Hashimoto Disease; Hospitals, Teaching; Humans; Iran; Male; Middle Aged; Outpatient Clinics, Hospital; Risk; Severity of Illness Index; Statistics as Topic; Thyroid Gland; Thyroid Hormones; Vitamin D Deficiency