25-hydroxyvitamin-d-2 and Cognitive-Dysfunction

Despite abundant cross-sectional evidence that low vitamin D status is associated with risk of cognitive decline in ageing, interventional evidence for benefits of vitamin D supplementation is lacking. This study was a 6 month randomised, double-blinded placebo-controlled clinical trial of the effects of vitamin D3 (D3), enhanced vitamin D2 in a mushroom matrix (D2M), standard mushroom (SM) and placebo (PL) on cognition and mood in

Topics: 25-Hydroxyvitamin D 2; Affect; Agaricales; Calcifediol; Cholecalciferol; Cognition; Cognitive Dysfunction; Dietary Supplements; Double-Blind Method; Ergocalciferols; Female; Humans; Male; Middle Aged; Seasons; Treatment Outcome; Vitamin D; Vitamin D Deficiency

As life expectancy increases, cognitive performance decline in the elderly has become one of the major global challenges. We aimed to evaluate the association of dietary vitamin D (VD), serum 25-hydroxyvitamin D3 (25(OH)D. The data from the National Health and Nutrition Examination Survey (NHANES), 2011-2014 was used. The cognitive performance was assessed by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning sub-test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). A binary logistic regression model was applied to evaluate the association between VD and cognitive performance, and restricted cubic spline model was adopted to evaluate the dose-response relationship.. While comparing to the lowest dietary VD intake group, the multivariate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of the highest dietary VD intake group were 0.51 (0.36-0.72) for the Animal Fluency test score and 0.45 (0.31-0.66) for DSST score, respectively; and those of serum total 25(OH)D and 25(OH)D. The study indicates that dietary VD intake, serum total 25(OH)D and 25(OH)D

Topics: 25-Hydroxyvitamin D 2; Aged; Animals; Calcifediol; Cognition; Cognitive Dysfunction; Cross-Sectional Studies; Diet; Dietary Supplements; Female; Humans; Logistic Models; Male; Middle Aged; Nutrition Surveys; Nutritional Status; United States; Vitamin D; Vitamins