25-hydroxyvitamin-d-2 and Chronic-Disease

25-hydroxyvitamin-d-2 has been researched along with Chronic-Disease* in 8 studies

Other Studies

8 other study(ies) available for 25-hydroxyvitamin-d-2 and Chronic-Disease

ArticleYear
Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study.
    BMC gastroenterology, 2018, Nov-08, Volume: 18, Issue:1

    Chronic autoimmune atrophic gastritis (CAAG) is an autoimmune disease characterized by hypo/achlorhydria. A role of CAAG in the pathogenesis of nutritional deficiencies has been reported, therefore we hypothesized a possible association between CAAG and 25-OH-Vitamin D [25(OH)D] deficiency. Aim of the present study is to evaluate the prevalence of 25(OH)D deficiency in CAAG patients.. 87 CAAG patients (71 females; mean age 63.5 ± 12.8 years) followed at our Centre from January 2012 to July 2015 were consecutively evaluated. 25(OH)D, vitamin B. Data from the present study showed a significant reduction of 25(OH)D levels in CAAG patients and a possible impairment of vitamin D absorption in CAAG may be postulated. Any implication to the genesis of gastric carcinoids remains to be elucidated.

    Topics: 25-Hydroxyvitamin D 2; Aged; Autoimmune Diseases; Calcium; Chronic Disease; Female; Gastritis, Atrophic; Humans; Intestinal Absorption; Male; Middle Aged; Parathyroid Hormone; Prospective Studies; Vitamin B 12; Vitamin D Deficiency

2018
[Vitamin D deficiency in children with chronic diseases evaluated because of osteopenia].
    Revista medica de Chile, 2002, Volume: 130, Issue:6

    Chronic diseases in children may determine limited sun exposure, use of drugs, and other risk factors of osteopenia.. To evaluate vitamin D deficiency and their risk factor, in children with chronic diseases with suspected osteopenia.. We measured bone mineral density, bone remodeling markers, calcium, phosphate, parathormone, and 25 hydroxyvitamin D levels, and wrist X-ray.. We found 8 children of 25 with suspected osteopenia, with biochemical abnormalities suggestive of vitamin D deficiency. All children had low levels of 25 hydroxyvitamin D, 5 had reduced bone mineral density, 4 had hyperparathyroidism, 2 had hyperphosphatasemia, and 1 hypocalcemia and hypophosphatemia. None had rickets.. Osteopenia in chronic sick children is due to multiple factors; however, vitamin D deficiency is a preventable disorder. We recommend that all children with a chronic disease with risk factors for vitamin D deficiency should be monitored with 25 hydroxyvitamin D serum levels.

    Topics: 25-Hydroxyvitamin D 2; Adolescent; Bone Diseases, Metabolic; Child; Child, Preschool; Chile; Chronic Disease; Female; Humans; Male; Risk Factors; Vitamin D Deficiency

2002
Bone hyperresorption is prevalent in chronically critically ill patients.
    Chest, 1998, Volume: 114, Issue:4

    Chronically critically ill (CCI) patients are primarily elderly people who have survived a life-threatening episode of sepsis but remain profoundly debilitated and ventilator dependent. The objective of this study was to determine the prevalence of bone hyperresorption and parathyroid hormone (PTH)-vitamin D axis abnormalities in these patients.. Prevalence survey.. Respiratory care step-down unit (RCU) at a tertiary care teaching hospital.. Forty-nine ventilator-dependent CCI patients transferred from ICUs within the same institution.. None.. N-telopeptide (NTx) levels in 24-h urine collections and serum intact PTH, 25-vitamin D, and 1,25-vitamin D levels were measured within 48 h of RCU admission. Patients were hospitalized a median of 30 days before RCU admission. Four patients (9%) had normal NTx and PTH levels. Forty-five patients (92%) had elevated urine NTx levels consistent with bone hyperresorption. Nineteen patients (42% of total patients) had elevated PTH levels consistent with predominant vitamin D deficiency, 4 patients (9%) had suppressed PTH levels consistent with predominant hyperresorption from immobilization, and 22 patients (49%) had normal PTH levels consistent with an overlap of both vitamin D deficiency and immobilization. There were no differences in vitamin D metabolites among these groups.. CCI patients have a high prevalence of bone hyperresorption in which PTH levels may clarify the cause. Further studies will determine the efficacy and cost-effectiveness of routine NTx and PTH screening in these patients and the role of vitamin D and antiresorptive therapies.

    Topics: 25-Hydroxyvitamin D 2; Adult; Aged; Aged, 80 and over; Bed Rest; Biomarkers; Bone Resorption; Calcitriol; Chronic Disease; Collagen; Collagen Type I; Critical Illness; Female; Follow-Up Studies; Humans; Length of Stay; Male; Middle Aged; Parathyroid Hormone; Peptides; Prevalence; Prospective Studies; Respiratory Care Units; Vitamin D Deficiency

1998
Bone disease in chronic childhood cholestasis. I. Vitamin D absorption and metabolism.
    Hepatology (Baltimore, Md.), 1989, Volume: 9, Issue:2

    Metabolic bone disease is common in children and adults with chronic cholestasis. We evaluated baseline vitamin D (vitamin D2 and D3), 25-OH vitamin D2 and D3, 1,25(OH)2 vitamin D, vitamin D-binding protein, bone mineral content and dietary mineral content in six children (mean age: 12.1 years) with cholestasis since infancy. Absorption of 25-OH vitamin D3 and vitamin D2 was evaluated by measuring serial serum concentrations after a test dose. Bone mineral content was reduced by greater than 2 S.D. in five of six subjects compared to age-specific controls; none had radiographic evidence of rickets but all had osteopenia. Dietary Ca and P content in the subjects was comparable to the recommended daily allowance for age-specific children. Baseline serum vitamin D2 concentrations were undetectable in all but one cholestatic subject despite oral supplementation with 2,500 to 50,000 IU per day vitamin D2. Baseline serum 25-OH vitamin D was 33.2 +/- 6.0 ng per ml (mean +/- S.E.) and comparable to our laboratory norms (15 to 50 ng per ml). Serum 1,25(OH)2 vitamin D and "free" 1,25(OH)2 vitamin D were both significantly (p less than 0.05) reduced compared to controls. A significantly blunted rise and reduced area under the absorption curve (both p less than 0.001) after 1,000 IU per kg vitamin D2 was found in cholestatic children (0.8 ng +/- 0.5 ng per ml and 18.0 +/- 14.3 ng hr per ml, respectively) compared to controls (59.5 +/- 10.0 ng per ml and 1,780 +/- 253 ng hr per ml, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

    Topics: 25-Hydroxyvitamin D 2; Absorption; Adolescent; Bone and Bones; Bone Diseases; Calcifediol; Calcitriol; Calcium; Child; Child, Preschool; Cholestasis, Intrahepatic; Chronic Disease; Ergocalciferols; Female; Humans; Infant; Male; Minerals; Phosphorus; Vitamin D; Vitamin D-Binding Protein; Vitamin E

1989
Bone rarefaction and crush fractures in juvenile chronic arthritis.
    Archives of disease in childhood, 1982, Volume: 57, Issue:5

    Seventy children with juvenile chronic arthritis have had measurements of cortical and trabecular bone density in one or both radii. In 7 children with unilateral disease of one wrist, there was a substantial reduction in growth on the affected side. Trabecular bone density in the distal radius was reduced in the main group of 63 patients compared with controls, and this deficit was appreciably worse if the wrist was clinically affected by disease or if the child was being treated with steroids. Cortical bone density in the midshaft was less affected. Crush fractures of the spine were associated with more prolonged periods of bed rest, steroid therapy, radial trabecular bone density more than 2 standard deviations below normal, and subnormal 25-hydroxycholecalciferol concentrations in the serum. Since steroid therapy is often mandatory the main therapeutic implications are that the more severely affected child often needs vitamin D supplementation in "physiological" dosage, and that early mobilisation and reduction of steroid dosage should be constant aims.

    Topics: 25-Hydroxyvitamin D 2; Absorptiometry, Photon; Adolescent; Arthritis, Juvenile; Bone and Bones; Bone Diseases; Child; Chronic Disease; Ergocalciferols; Fractures, Closed; Fractures, Spontaneous; Humans; Organ Size; Spinal Injuries; Steroids

1982
Osteomalacia, vitamin D deficiency and cholestasis in chronic liver disease.
    The Quarterly journal of medicine, 1982, Volume: 51, Issue:201

    Twenty-nine patients with chronic liver disease, nine of whom had symptoms suggesting bone disease, were studied by bone histology. Nine had osteomalacia; six associated with cholestatic liver disease and three with primarily hepatocellular disease. Two of these had clinical and biochemical features of cholestasis for at least a year and the other had alcoholic cirrhosis associated with severe malnutrition. Excluding the latter patient, histological osteomalacia was significantly associated with presence and duration of cholestasis. Plasma 25-hydroxyvitamin D was low and fasting urine hydroxyproline/creatinine ratio was high in all patients with osteomalacia but were abnormal also in some patients who did not have histological osteomalacia. Serum calcium, phosphate, alkaline phosphatase, vitamin D-binding protein and radiology were unhelpful in many patients with osteomalacia. Vitamin D-deficiency correlated significantly with deficiency of other fat-soluble vitamins and those patients with rachitic levels of plasma 25-hydroxyvitamin D showed no seasonal variation, suggesting a combination of malabsorption of vitamin D and reduced sunlight exposure. We suggest that patients with chronic liver disease with cholestasis for at least a year are at risk from osteomalacia and that those likely to have this complication may be identified by plasma 25-hydroxyvitamin D and/or fasting urine hydroxyproline/creatinine ratio measurements. The diagnosis can only be made with certainty by bone biopsy.

    Topics: 25-Hydroxyvitamin D 2; Adolescent; Adult; Aged; Cholestasis; Chronic Disease; Ergocalciferols; Humans; Liver Diseases; Middle Aged; Osteomalacia; Risk; Seasons; Vitamin D Deficiency

1982
Evidence for secondary hyperparathyroidism in the osteomalacia associated with chronic liver disease.
    Clinical endocrinology, 1981, Volume: 15, Issue:4

    Previous reports have suggested that secondary hyperparathyroidism is extremely uncommon in hepatic osteomalacia. This, together with other findings, has led to suggestions that in chronic liver disease there may be selective resistance of bone to vitamin D or a specific bone mineralization defect unrelated to Vitamin D. To examine these possibilities, twenty-five patients with chronic liver disease have been studied by bone biopsy, serum calcium and inorganic phosphate, plasma 25-hydroxyvitamin D, plasma immunoreactive parathormone (iPTH), fasting urine cAMP, fasting renal tubular maximal reabsorptive capacity for phosphate (TmP/GFR) and fine grain hand x-rays. Nine of the patients had osteomalacia on bone biopsy, eight of these had subnormal levels of plasma 25-hydroxyvitamin D and the other had a borderline result. Based on the consensus of all the tests, five of these had evidence of secondary hyperparathyroidism. Plasma iPTH was higher in patients with osteomalacia than in patients without osteomalacia (P less than 0.01) or controls (P less than 0.01). Urine cAMP was higher in patients with osteomalacia than in patients without osteomalacia (P less than 0.001) or controls (P less than 0.01). TmP/GFR was significantly lower in patients with osteomalacia than in controls (P less than 0.05) but not significantly different from patients without osteomalacia. The findings of this study indicate that hyperparathyroidism occurs in a substantial proportion of patients with the osteomalacia of chronic liver disease. Moreover, osteomalacia in chronic liver disease is clearly related to reduced levels of plasma 25-hydroxyvitamin D. We conclude that hepatic osteomalacia is a vitamin D deficiency state and there is no need to suggest an unusual aetiology.

    Topics: 25-Hydroxyvitamin D 2; Chronic Disease; Cyclic AMP; Ergocalciferols; Humans; Hyperparathyroidism, Secondary; Liver Diseases; Osteomalacia; Parathyroid Hormone

1981
[Vitamin D metabolism in chronic glomerulonephritis (author's transl)].
    Nihon Jinzo Gakkai shi, 1981, Volume: 23, Issue:9

    Topics: 25-Hydroxyvitamin D 2; Adult; Aged; Calcium; Chronic Disease; Ergocalciferols; Female; Glomerulonephritis; Humans; Male; Middle Aged; Phosphates; Vitamin D

1981
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