24-25-dihydroxyvitamin-d-3 and Genital-Neoplasms--Female

24-25-dihydroxyvitamin-d-3 has been researched along with Genital-Neoplasms--Female* in 1 studies

Other Studies

1 other study(ies) available for 24-25-dihydroxyvitamin-d-3 and Genital-Neoplasms--Female

Article	Year
The effects of chemotherapy including cisplatin on vitamin D metabolism. Endocrine journal, 1993, Volume: 40, Issue:6 Plasma concentrations of three major vitamin D3 metabolites, 25-hydroxyvitamin D3 (25-OHD3), 24R, 25-dihydroxyvitamin D3 (24,25-(OH)2D3), and 1 alpha, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), were determined serially in patients with gynecological malignancies treated by chemotherapy which included cisplatin. While 25-OHD3 and 24,25-(OH)2D3 levels did not change regularly, 1,25-(OH)2D3 decreased significantly (50%) after only one or two courses of the treatment in all cases. In concert with declining 1,25-(OH)2D3, the PTH levels increased two or three times. The results were explained by the impairment by cisplatin of mitochondrial function in proximal tubules in the kidney. Topics: 24,25-Dihydroxyvitamin D 3; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adult; Antineoplastic Combined Chemotherapy Protocols; Calcifediol; Calcitriol; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Epirubicin; Female; Genital Neoplasms, Female; Humans; Kidney Diseases; Kidney Tubules, Proximal; Middle Aged; Mitochondria; Mitomycin; Parathyroid Hormone; Vitamin D	1993

Article

Year

The effects of chemotherapy including cisplatin on vitamin D metabolism.

Endocrine journal, 1993, Volume: 40, Issue:6

Plasma concentrations of three major vitamin D3 metabolites, 25-hydroxyvitamin D3 (25-OHD3), 24R, 25-dihydroxyvitamin D3 (24,25-(OH)2D3), and 1 alpha, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), were determined serially in patients with gynecological malignancies treated by chemotherapy which included cisplatin. While 25-OHD3 and 24,25-(OH)2D3 levels did not change regularly, 1,25-(OH)2D3 decreased significantly (50%) after only one or two courses of the treatment in all cases. In concert with declining 1,25-(OH)2D3, the PTH levels increased two or three times. The results were explained by the impairment by cisplatin of mitochondrial function in proximal tubules in the kidney.

Topics: 24,25-Dihydroxyvitamin D 3; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Adult; Antineoplastic Combined Chemotherapy Protocols; Calcifediol; Calcitriol; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Epirubicin; Female; Genital Neoplasms, Female; Humans; Kidney Diseases; Kidney Tubules, Proximal; Middle Aged; Mitochondria; Mitomycin; Parathyroid Hormone; Vitamin D

1993