24-25-dihydroxyvitamin-d-3 and Fractures--Ununited

24-25-dihydroxyvitamin-d-3 has been researched along with Fractures--Ununited* in 2 studies

Other Studies

2 other study(ies) available for 24-25-dihydroxyvitamin-d-3 and Fractures--Ununited

Article	Year
Blood levels of active metabolites of vitamin D3 in fracture repair in humans. A preliminary report. Archives of orthopaedic and trauma surgery, 1990, Volume: 109, Issue:5 Blood levels of the active metabolites of vitamin D3, 25-hydroxycholecalciferol [25(OH)D3], 1,25-dihydroxycholecalciferol [1,25(OH)2D3] and 24,25-dihydroxycholecalciferol [24,25(OH)2D3] were determined in seven patients. Two subjects suffered from delayed union of tibial fractures; one showed a delayed union after a proximal tibial osteotomy; one patient suffered from bilateral femoral neck fractures, of which one failed to unite and the other united late; two patients had multiple fractures that united normally; and one patient exhibited staged bilateral femoral neck fractures whose occurrence was separated by a short interval and which united without undue delay. The blood levels of 25(OH)D3 were within the normal range. A relative decrease in 24,25(OH)2D3 values was noted in all patients, whereas in three subjects the decrease was absolute, to non-detectable levels. A decrease in 1,25(OH)2D3 levels was noted in only two patients. We postulate that these changes reflect the consumption of these metabolites during healing at the fracture site. Topics: 24,25-Dihydroxyvitamin D 3; Adult; Calcifediol; Calcitriol; Dihydroxycholecalciferols; Female; Fractures, Bone; Fractures, Ununited; Humans; Male; Middle Aged; Wound Healing	1990
Vitamin D metabolites in patients with established non-union of fracture. Bone and mineral, 1986, Volume: 1, Issue:3 The serum concentrations of vitamin D metabolites and biochemical markers of bone metabolism were measured in 15 patients with established non-union of fracture and in 15 age- and sex-matched controls. No significant differences between the two groups were observed in the concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3; or in the biochemical indices of skeletal metabolism. These results suggest that patients with established non-union have normal bone turnover with no evidence of disturbed production or utilization of 24,25-dihydroxyvitamin D3 or other major vitamin D metabolites. Disturbances in vitamin D metabolism are unlikely therefore to make a major contribution to the maintenance of non-union of fracture. Topics: 24,25-Dihydroxyvitamin D 3; Adolescent; Adult; Aged; Aged, 80 and over; Bone and Bones; Dihydroxycholecalciferols; Female; Fractures, Ununited; Humans; Male; Middle Aged; Vitamin D	1986

Article

Year

Blood levels of active metabolites of vitamin D3 in fracture repair in humans. A preliminary report.

Archives of orthopaedic and trauma surgery, 1990, Volume: 109, Issue:5

Blood levels of the active metabolites of vitamin D3, 25-hydroxycholecalciferol [25(OH)D3], 1,25-dihydroxycholecalciferol [1,25(OH)2D3] and 24,25-dihydroxycholecalciferol [24,25(OH)2D3] were determined in seven patients. Two subjects suffered from delayed union of tibial fractures; one showed a delayed union after a proximal tibial osteotomy; one patient suffered from bilateral femoral neck fractures, of which one failed to unite and the other united late; two patients had multiple fractures that united normally; and one patient exhibited staged bilateral femoral neck fractures whose occurrence was separated by a short interval and which united without undue delay. The blood levels of 25(OH)D3 were within the normal range. A relative decrease in 24,25(OH)2D3 values was noted in all patients, whereas in three subjects the decrease was absolute, to non-detectable levels. A decrease in 1,25(OH)2D3 levels was noted in only two patients. We postulate that these changes reflect the consumption of these metabolites during healing at the fracture site.

Topics: 24,25-Dihydroxyvitamin D 3; Adult; Calcifediol; Calcitriol; Dihydroxycholecalciferols; Female; Fractures, Bone; Fractures, Ununited; Humans; Male; Middle Aged; Wound Healing

1990

Vitamin D metabolites in patients with established non-union of fracture.

Bone and mineral, 1986, Volume: 1, Issue:3

The serum concentrations of vitamin D metabolites and biochemical markers of bone metabolism were measured in 15 patients with established non-union of fracture and in 15 age- and sex-matched controls. No significant differences between the two groups were observed in the concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3; or in the biochemical indices of skeletal metabolism. These results suggest that patients with established non-union have normal bone turnover with no evidence of disturbed production or utilization of 24,25-dihydroxyvitamin D3 or other major vitamin D metabolites. Disturbances in vitamin D metabolism are unlikely therefore to make a major contribution to the maintenance of non-union of fracture.

Topics: 24,25-Dihydroxyvitamin D 3; Adolescent; Adult; Aged; Aged, 80 and over; Bone and Bones; Dihydroxycholecalciferols; Female; Fractures, Ununited; Humans; Male; Middle Aged; Vitamin D

1986