24-25-dihydrolanosterol and Cataract

24-25-dihydrolanosterol has been researched along with Cataract* in 2 studies

Other Studies

2 other study(ies) available for 24-25-dihydrolanosterol and Cataract

Article	Year
Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation. Journal of medicinal chemistry, 2018, 10-11, Volume: 61, Issue:19 We describe here the development of potent synthetic analogues of the naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other scaffolds in terms of efficacy and generality in previous studies. Various modified lanosterol derivatives were synthesized via modification of the side chain, ring A, ring B, and ring C. Evaluation of these synthetic analogues draws a clear picture for SAR. In particular, hydroxylation of the 25-position in the side chain profoundly improved the potency, and 2-fluorination further enhanced the biological activity. This work also revealed that synthetic lanosterol analogues could reverse multiple types of mutant-crystallin aggregates in cell models with excellent potency and efficacy. Notably, lanosterol analogues have no cytotoxicity but can improve the viability of the HLE-B3 cell line. Furthermore, representative compound 6 successfully redissolved the aggregated crystallin proteins from the amyloid-like fibrils in a concentration-dependent manner. Topics: Cataract; Cell Survival; Cells, Cultured; Crystallins; HeLa Cells; Humans; Lanosterol; Lens, Crystalline; Mutant Proteins; Mutation; Protein Aggregation, Pathological; Structure-Activity Relationship	2018
The state of neutral lipids in normal and cataractous human lenses. Experimental eye research, 1983, Volume: 37, Issue:1 A simple and rapid high pressure liquid chromatographic method (HPLC) was developed to analyse the neutral lipid fraction from normal and cataractous human lenses. No differences were found between old normal and cataractous lenses suggesting that membrane deterioration in cataracts is not due to oxidation of these components. Several new lens components were isolated and identified including cholesterol metabolites, and vitamin E (alpha-tocopherol). Topics: Adult; Aged; Aging; Cataract; Ceramides; Cholesterol; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Lanosterol; Lens, Crystalline; Lipid Metabolism; Middle Aged; Vitamin E	1983

Article

Year

Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.

Journal of medicinal chemistry, 2018, 10-11, Volume: 61, Issue:19

We describe here the development of potent synthetic analogues of the naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other scaffolds in terms of efficacy and generality in previous studies. Various modified lanosterol derivatives were synthesized via modification of the side chain, ring A, ring B, and ring C. Evaluation of these synthetic analogues draws a clear picture for SAR. In particular, hydroxylation of the 25-position in the side chain profoundly improved the potency, and 2-fluorination further enhanced the biological activity. This work also revealed that synthetic lanosterol analogues could reverse multiple types of mutant-crystallin aggregates in cell models with excellent potency and efficacy. Notably, lanosterol analogues have no cytotoxicity but can improve the viability of the HLE-B3 cell line. Furthermore, representative compound 6 successfully redissolved the aggregated crystallin proteins from the amyloid-like fibrils in a concentration-dependent manner.

Topics: Cataract; Cell Survival; Cells, Cultured; Crystallins; HeLa Cells; Humans; Lanosterol; Lens, Crystalline; Mutant Proteins; Mutation; Protein Aggregation, Pathological; Structure-Activity Relationship

2018

The state of neutral lipids in normal and cataractous human lenses.

Experimental eye research, 1983, Volume: 37, Issue:1

A simple and rapid high pressure liquid chromatographic method (HPLC) was developed to analyse the neutral lipid fraction from normal and cataractous human lenses. No differences were found between old normal and cataractous lenses suggesting that membrane deterioration in cataracts is not due to oxidation of these components. Several new lens components were isolated and identified including cholesterol metabolites, and vitamin E (alpha-tocopherol).

Topics: Adult; Aged; Aging; Cataract; Ceramides; Cholesterol; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Lanosterol; Lens, Crystalline; Lipid Metabolism; Middle Aged; Vitamin E

1983