24-24-difluoro-1-25-dihydroxyvitamin-d3 has been researched along with Vitamin-D-Deficiency* in 4 studies
4 other study(ies) available for 24-24-difluoro-1-25-dihydroxyvitamin-d3 and Vitamin-D-Deficiency
| Article | Year |
|---|---|
Biological activity of fluorine-substituted 1,25-dihydroxyvitamin D3 in rats, in chicken and in Japanese quails.
The biological activity of two fluorinated analogs of 1,25(OH)2D3 was compared with 1,25(OH)2D3 in various vitamin D assays. The effect of 24,24-F2-1,25(OH)2D3 on plasma calcium, bone weight and duodenal calcium binding protein in chicken, on calcium excretion via egg shell in Japanese quails and on mobilization of calcium from the bone in rats was twice as high as the effect of the most potent naturally occurring vitamin D3 metabolite 1,25(OH)2D3. In contrast, 24R-F-1,25(OH)2D3 has less than 50% of the potency of 1,25(OH)2D3. Due to the wider therapeutic dosage range, this compound might be of clinical value. Topics: Animals; Body Weight; Bone and Bones; Calcitriol; Calcium; Chickens; Coturnix; Dose-Response Relationship, Drug; Duodenum; Egg Shell; Male; Rats; Rats, Inbred Strains; S100 Calcium Binding Protein G; Vitamin D Deficiency | 1986 |
Biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3.
The biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3 was compared with 1,25-dihydroxyvitamin D3 in the rat. The 24,24-difluoro-1,25-dihydroxyvitamin D3 has a potency of approximately 5-10 times that of 1,25-dihydroxyvitamin D3 in the known in vivo vitamin D responsive systems. These systems include intestinal calcium transport, bone calcium mobilization, calcification of epiphyseal plate cartilage, and elevation of plasma calcium and phosphorus concentrations. Thus, 24,24-difluoro-1,25-dihydroxyvitamin D3 is the first known analogue with higher potency than 1,25-dihydroxyvitamin D3 in vivo. Topics: Animals; Calcitriol; Calcium; Duodenum; Intestinal Absorption; Intestinal Mucosa; Kinetics; Male; Phosphates; Rats; Structure-Activity Relationship; Vitamin D Deficiency | 1983 |
Determination of biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3 in the chick using a new method for assessing intestinal calcium uptake.
Topics: Animals; Calcitriol; Calcium; Chickens; Dose-Response Relationship, Drug; Duodenum; Intestinal Absorption; Oxygen; Sodium Chloride; Time Factors; Vitamin D Deficiency | 1982 |
24,24-difluoro-1,25-dihydroxyvitamin D3: in vitro production, isolation, and biological activity.
Topics: Animals; Bone and Bones; Calcitriol; Calcium; Chickens; Dihydroxycholecalciferols; Fluorine; Hydroxycholecalciferols; Intestinal Mucosa; Kidney; Male; Rats; Structure-Activity Relationship; Vitamin D Deficiency | 1980 |