Compounds > 24-24-difluoro-1-25-dihydroxyvitamin-d3

24-24-difluoro-1-25-dihydroxyvitamin-d3 and Body-Weight

24-24-difluoro-1-25-dihydroxyvitamin-d3 has been researched along with Body-Weight* in 2 studies

Other Studies

2 other study(ies) available for 24-24-difluoro-1-25-dihydroxyvitamin-d3 and Body-Weight

Article	Year
Biological activity of fluorine-substituted 1,25-dihydroxyvitamin D3 in rats, in chicken and in Japanese quails. Annals of nutrition & metabolism, 1986, Volume: 30, Issue:1 The biological activity of two fluorinated analogs of 1,25(OH)2D3 was compared with 1,25(OH)2D3 in various vitamin D assays. The effect of 24,24-F2-1,25(OH)2D3 on plasma calcium, bone weight and duodenal calcium binding protein in chicken, on calcium excretion via egg shell in Japanese quails and on mobilization of calcium from the bone in rats was twice as high as the effect of the most potent naturally occurring vitamin D3 metabolite 1,25(OH)2D3. In contrast, 24R-F-1,25(OH)2D3 has less than 50% of the potency of 1,25(OH)2D3. Due to the wider therapeutic dosage range, this compound might be of clinical value. Topics: Animals; Body Weight; Bone and Bones; Calcitriol; Calcium; Chickens; Coturnix; Dose-Response Relationship, Drug; Duodenum; Egg Shell; Male; Rats; Rats, Inbred Strains; S100 Calcium Binding Protein G; Vitamin D Deficiency	1986
Stimulatory effect of 1 alpha, 25-dihydroxyvitamin D3 on the formation of skin tumors in mice treated chronically with 7,12-dimethylbenz[a]anthracene. Biochemical and biophysical research communications, 1985, Jul-31, Volume: 130, Issue:2 The effect of 1 alpha, 25-dihydroxyvitamin D3 (1 alpha, 25-(OH)2D3) and its 24,24-difluoro analog on the formation of skin tumors in mice was evaluated in a complete carcinogenesis model using 7,12-dimethylbenz[a]anthracene (DMBA) as the carcinogen. Twice weekly topical application of 0.25-0.50 nmol of 1 alpha, 25-(OH)2D3 or 0.05-0.10 nmol of the difluoro analog of 1 alpha, 25-(OH)2D3 1 hour prior to treatment with 50 nmol DMBA stimulated tumor formation several fold compared to animals receiving DMBA alone. Topical application of 0.50 nmol of 1 alpha, 25-(OH)2D3 24 hours after treatment with DMBA, or half of this dose of the vitamin D3 metabolite, applied 1 hour before and 24 hours after treatment with DMBA, also stimulated tumor formation several fold. These results are in marked contrast to the potent inhibitory effect of 1 alpha, 25-(OH)2D3 and its difluoro analog on the formation of skin tumors in mice promoted by 12-O-tetradecanoylphorbol-13-acetate. Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Body Weight; Calcitriol; Cocarcinogenesis; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin	1985

Article

Year

Biological activity of fluorine-substituted 1,25-dihydroxyvitamin D3 in rats, in chicken and in Japanese quails.

Annals of nutrition & metabolism, 1986, Volume: 30, Issue:1

The biological activity of two fluorinated analogs of 1,25(OH)2D3 was compared with 1,25(OH)2D3 in various vitamin D assays. The effect of 24,24-F2-1,25(OH)2D3 on plasma calcium, bone weight and duodenal calcium binding protein in chicken, on calcium excretion via egg shell in Japanese quails and on mobilization of calcium from the bone in rats was twice as high as the effect of the most potent naturally occurring vitamin D3 metabolite 1,25(OH)2D3. In contrast, 24R-F-1,25(OH)2D3 has less than 50% of the potency of 1,25(OH)2D3. Due to the wider therapeutic dosage range, this compound might be of clinical value.

Topics: Animals; Body Weight; Bone and Bones; Calcitriol; Calcium; Chickens; Coturnix; Dose-Response Relationship, Drug; Duodenum; Egg Shell; Male; Rats; Rats, Inbred Strains; S100 Calcium Binding Protein G; Vitamin D Deficiency

1986

Stimulatory effect of 1 alpha, 25-dihydroxyvitamin D3 on the formation of skin tumors in mice treated chronically with 7,12-dimethylbenz[a]anthracene.

Biochemical and biophysical research communications, 1985, Jul-31, Volume: 130, Issue:2

The effect of 1 alpha, 25-dihydroxyvitamin D3 (1 alpha, 25-(OH)2D3) and its 24,24-difluoro analog on the formation of skin tumors in mice was evaluated in a complete carcinogenesis model using 7,12-dimethylbenz[a]anthracene (DMBA) as the carcinogen. Twice weekly topical application of 0.25-0.50 nmol of 1 alpha, 25-(OH)2D3 or 0.05-0.10 nmol of the difluoro analog of 1 alpha, 25-(OH)2D3 1 hour prior to treatment with 50 nmol DMBA stimulated tumor formation several fold compared to animals receiving DMBA alone. Topical application of 0.50 nmol of 1 alpha, 25-(OH)2D3 24 hours after treatment with DMBA, or half of this dose of the vitamin D3 metabolite, applied 1 hour before and 24 hours after treatment with DMBA, also stimulated tumor formation several fold. These results are in marked contrast to the potent inhibitory effect of 1 alpha, 25-(OH)2D3 and its difluoro analog on the formation of skin tumors in mice promoted by 12-O-tetradecanoylphorbol-13-acetate.

Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Body Weight; Calcitriol; Cocarcinogenesis; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin

1985