20-hydroxy-5,8,11,14-eicosatetraenoic acid and Hypertension

20-hydroxy-5,8,11,14-eicosatetraenoic acid has been researched along with Hypertension in 120 studies

Research

Studies (120)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (10.00)	18.2507
2000's	56 (46.67)	29.6817
2010's	44 (36.67)	24.3611
2020's	8 (6.67)	2.80

Authors

Authors	Studies
Adebesin, AM; Agostinucci, K; Falck, JR; Garcia, V; Gupte, S; Hossain, S; Hutcheson, R; Pascale, JV; Schwartzman, ML; Villegas, E; Zhang, F	1
Froogh, G; Garcia, V; Laniado Schwartzman, M	1
Adebesin, AM; Ali, S; Baruch, DE; Diegisser, D; Dirice, E; Falck, JR; Garcia, V; Kadish, Y; Kim, N; Kulaprathazhe, MM; Pascale, JV; Schwartzman, ML; Wolf, A; Yahaya, MAF; Yemane, D	1
Barma, D; Barma, DK; Dakarapu, R; Errabelli, R; Falck, JR; Garcia, V; Laniado Schwartzman, M; Manthati, VL; Michael Adebesin, A; Zhang, F	1
Barden, AE; Beilin, LJ; Mori, TA; Puddey, IB	1
Booz, GW; Fan, F; Fan, L; Li, M; Roman, RJ; Shekhar, S; Varghese, K	1
Ito, D; Ito, O; Kohzuki, M; Miura, T; Muroya, Y; Ogawa, Y; Sakuyama, A; Takahashi, J; Xu, L	1
Baranowska, I; Červenka, L; Falck, JR; Gawrys, O; Honetschlägerová, Z; Husková, Z; Imig, JD; Kikerlová, S; Kompanowska-Jezierska, E; Sadowski, J; Škaroupková, P; Vaňourková, Z; Walkowska, A	1
Angioni, C; Ferreirós, N; Geisslinger, G; Hahnefeld, L; Möser, CV; Niederberger, E; Schmetzer, J; Thomas, D; Wolters, MC	1
Chen, F; Lai, G; Wu, J; Zhang, B; Zhao, Y	1
Bar, A; Chlopicki, S; Enggaard, C; Hansen, PBL; Jasztal, A; Jensen, B; Kieronska-Rudek, A; Kij, A; Marczyk, B; Mateuszuk, L; Matyjaszczyk-Gwarda, K; Proniewski, B; Przyborowski, K; Tworzydlo, A; Walczak, M	1
Capdevila, JH; Dakarapu, R; Falck, JR; Gandham, SK; Garcia, V; Gilani, A; Graves, JP; Gruzdev, A; Pandey, V; Reddy, NR; Schwartzman, ML; Shkolnik, B; Zeldin, DC; Zhang, FF	1
Fan, F; Roman, RJ	2
Aslan, M; Basralı, F; Nasırcılar Ülker, S; Özcan, F; Özen, N; Şentürk, ÜK; Ülker, P	1
Bradford, C; Falck, JR; Gotlinger, KH; Gupte, SA; Hunter, I; Hutcheson, B; Hutcheson, R; Joseph, G; Joshi, SR; Maniyar, R; Proctor, S; Rocic, P; Schwartzman, ML; Soler, A; Yang, J; Zhang, FF	1
Booz, GW; Fan, F; He, X; Wang, S; Yu, Q; Zhang, C	1
Hu, G; Ito, O; Kohzuki, M; Miura, T; Muroya, Y; Ogawa, Y; Rong, R; Wang, W	1
Lombard, JH; Lukaszewicz, KM	1
Capdevila, JH; Cheng, J; Ding, Y; Falck, JR; Garcia, V; Gotlinger, K; Manthati, VL; Mei, S; Schwartzman, ML; Weidenhammer, A; Wu, CC; Zhang, F	1
Capdevila, JH; Dimitrova, I; Ding, Y; Falck, JR; Garcia, V; Joseph, G; Manthati, VL; Schwartzman, ML; Weidenhammer, A; Wu, CC; Zhang, F	1
Csiszar, A; Deak, F; Gautam, T; Koller, A; Mitschelen, M; Sonntag, WE; Sosnowska, D; Tarantini, S; Toth, P; Tucsek, Z; Ungvari, Z	1
Csiszar, A; Gautam, T; Koller, A; Schwartzman, ML; Sonntag, WE; Sosnowska, D; Toth, P; Tucsek, Z; Ungvari, Z	1
Carretero, OA; D'Ambrosio, MA; Garvin, JL; Peterson, EL; Ren, Y	1
Falck, JR; Fan, F; Ge, Y; Liu, R; Murphy, SR; Roman, RJ; Williams, JM	1
Capdevila, JH; Falck, JR; Gangadhariah, MH; Garcia, V; Hayward, SW; Imig, JD; Love, HD; Luther, JM; Manthati, VL; Paueksakon, P; Pozzi, A; Schwartzman, ML; Zent, R; Zhang, MZ	1
Carroll, MA; Chander, PN; Kang, Y; Stier, CT	1
Fan, F; Muroya, Y; Roman, RJ	1
Fan, F; Geurts, AM; Jacob, HJ; Murphy, SR; Pabbidi, MR; Roman, RJ	1
Bernstein, KE; Capdevila, JH; Dakarapu, R; Ding, Y; Falck, JR; Garcia, V; Gotlinger, K; Joseph, G; Schwartzman, ML; Shkolnik, B; Zhang, FF	1
Grassi, G; Mallamaci, F; Zoccali, C	1
Dalmasso, C; Maranon, R; Moulana, M; Patil, C; Reckelhoff, JF; Romero, DG	1
Allen, K; Bloch, DB; Bloch, KD; Brouckaert, P; Buys, ES; Daly, MJ; Dordea, AC; Falck, JR; Garcia, V; Hindle, AG; Kirby, A; Lieb, WS; Malhotra, R; Mikelman, S; Nathan, DI; Raher, MJ; Schwartzman, ML; Sips, PY; Stevens, C; Tainsh, LT; Tainsh, RE; Thoonen, R; Vandenwijngaert, S; Zhang, F	1
Garcia, V; Schwartzman, ML	1
Amrein, K; Buki, A; Czeiter, E; Horvath, P; Ivic, I; Koller, A; Szarka, N; Toth, P	1
Almgren, P; Berglund, G; Engström, G; Fava, C; Hedblad, B; Lippi, G; Melander, O; Minuz, P; Montagnana, M; Rosberg, L	1
Chang, HH; Dong, Z; Huang, H; Luo, P; Wang, CY; Wang, MH; Yang, T; Zhou, Y	1
Fenoy, FJ; Fredrich, K; Garrett, MR; Hoagland, KM; Jacob, HJ; Lazar, J; Lopez, B; Moreno, C; Roman, RJ; Ryan, RP; Sarkis, A; Sharma, M; Williams, JM	1
Dunn, KM; Falck, J; Flasch, AK; Harder, DR; Renic, M; Roman, RJ	1
Chen, JR; Yang, HY	1
Barden, AE; Beilin, LJ; Croft, KD; Falck, JR; Mori, TA; Puddey, IB; Tsai, IJ	1
Chen, F; Liu, H; Liu, X; Wang, L; Yang, X; Zhang, Y; Zhao, Y; Zheng, Z	1
Croft, KD; Mori, TA; Ong, SL; Temple, SE; Vickers, JJ; Whitworth, JA; Wu, JH; Zhang, Y	1
Cai, Y	1
Abraham, NG; Cao, J; Falck, JR; Gotlinger, KH; Inoue, K; Laniado-Schwartzman, M; Puri, N; Rezzani, R; Sodhi, K	1
Barden, AE; Clarke, MW; Croft, KD; Hodgson, JM; Indrawan, AP; Puddey, IB; Wu, JH	1
Fava, C; Melander, O; Montagnana, M	1
Certíková Chábová, V; Cervenka, L; Falck, JR; Hammock, BD; Imig, JD; Kompanowska-Jezierska, E; Kopkan, L; Kramer, HJ; Kujal, P; Sadowski, J; Vanecková, I; Vanourková, Z; Vernerová, Z; Walkowska, A	1
Benter, IF; Yousif, MH	1
Imig, JD	1
Abraham, NG; Cheng, J; Falck, JR; Goli, M; Gotlinger, K; Inoue, K; Schwartzman, ML; Sodhi, K; Wu, CC	1
Estes, AM; Fang, XR; Farjana, N; Jennings, BL; Khan, AI; Malik, KU; Sahan-Firat, S; Song, CY; Yaghini, FA	1
Burke, M; Murphy, S; Roman, RJ; Williams, JM	1
Fidelis, P; Oyekan, AO; Thomas, K; Villalobos, M; Wilson, L	1
Cheng, J; Falck, JR; Gotlinger, KH; Jat, JL; Kelkar, M; Schwartzman, ML; Wu, CC; Zhang, FF; Zhang, Y	1
Baker, R; Davis, DD; Fan, F; Lima, R; Moulana, M; Reckelhoff, JF; Roman, RJ; Romero, DG; Ryan, MJ; Yanes, LL; Yuan, K; Zhang, H	1
Schwartzman, ML; Wu, CC	1
Boonprasert, K; Na-Bangchang, K; Ruengweerayut, R; Satarug, S	1
Drenjancević, I; Pat Kunert, M	1
Arany, M; Cockrell, K; George, EM; Granger, JP; Speed, JS	1
Lai, G; Liu, H; Liu, X; Wu, J; Zhao, Y	1
Fan, F; Jacob, HJ; Lazar, J; Murphy, S; Roman, RJ; Schreck, C; Williams, JM	1
Lai, G; Liu, X; Wu, J; Zhao, Y	1
Davis, DD; Lima, R; Reckelhoff, JF; Yanes, LL	1
Capdevila, JH; Marji, JS; Nakagawa, K; Schwartzman, ML; Waterman, MR	1
Elijovich, F; Laffer, CL; Laniado-Schwartzman, M; Nasjletti, A; Wang, MH	2
Hoagland, KM; Maier, KG; Roman, RJ	1
Abraham, NG; Goodman, AI; Quan, S; Synghal, A; Yang, L	1
Flasch, AK; Hoagland, KM; Roman, RJ	1
Elijovich, F; Laffer, CL; Laniado-Schwartzman, M; Nasjletti, A	1
Dahly-Vernon, AJ; dos Santos, EA; Flasch, AK; Hoagland, KM; Knepper, MA; Roman, RJ	1
Lopez, B; Roman, RJ; Sarkis, A	1
Beilin, LJ; Croft, KD; Falck, JR; Hodgson, J; Puddey, IB; Rivera, J; Ward, NC	1
Deng, H; Falck, JR; Gopal, VR; Kemp, R; Laniado-Schwartzman, M; Nasjletti, A; Singh, H; Zhang, F	1
Ishizuka, T; Ito, O; Ito, S; Omata, K	1
Bellamine, A; Brown, NJ; Capdevila, JH; Cupples, LA; Dawson, EP; Demissie, S; Gainer, JV; Grant, SW; Guo, CY; O'Donnell, CJ; Wang, Y; Waterman, MR; Womble, KE	1
Fleming, I	1
Brandes, RP; Busse, R; Fleming, I; Hammock, BD; Jung, O; Kim, IH; Schmidt, R; Schweda, F	1
Bohman, Q; Flasch, A; Roman, RJ; Stec, DE; Taylor, M; Vera, T	1
Dahly-Vernon, AJ; Ledbetter, SR; McCarthy, ET; Roman, RJ; Savin, VJ; Sharma, M	1
Beilin, LJ; Croft, KD; Hodgson, JM; Puddey, IB; Ward, NC	1
Bolad, I; Delafontaine, P	1
Doggrell, SA	1
Chen, CL; Cianflone, K; Qian, JQ; Wang, DW; Xiao, X; Yan, JT; Zhang, F	1
Chang, HH; Du, J; Huang, H; Wang, CY; Wang, MH; Wu, JF; Zhou, Y	1
Garrett, MR; Hoagland, KM; Jacob, HJ; Kwitek, AE; Lazar, J; Lopez, B; Rapp, JP; Roman, RJ; Sarkis, A	1
Abraham, NG; Deng, H; Hintze, TH; Ishizuka, T; Kemp, R; Laniado-Schwartzman, M; Nasjletti, A; Singh, H; Wang, JS; Wolin, MS; Zhang, F	1
Harder, DR; Roman, RJ	1
Elijovich, F	1
Barden, A; Beilin, LJ; Burke, V; Croft, K; Mori, T; Puddey, IB; Zilkens, RR	1
Lombard, JH; Roman, RJ	1
Cheng, J; Deng, H; Ishizuka, T; Kemp, R; Nasjletti, A; Schwartzman, ML; Singh, H	1
Huo, HL; Zeng, QH; Zhang, D; Zhang, YN	1
Capdevila, JH	1
Certíková Chábová, V; Cervenka, L; Falck, JR; Imig, JD; Kramer, HJ; Skaroupková, P; Tesar, V; Thumová, M; Vanecková, I	1
Brown, NJ; Capdevila, JH; Elijovich, F; Gainer, JV; Laffer, CL; Laniado-Schwartzman, M; Nasjletti, A; Waterman, MR	1
Fu, L; Li, Y; Liu, H; Lu, J; Nie, D; Shi, J; Yu, D; Zhao, Y	1
Fava, C; Jiang, H; Lechi, A; McGiff, JC; Minuz, P; Morganti, A; Patrignani, P; Ricci, M; Tacconelli, S; Turolo, L	1
Barden, A; Croft, KD; Hodgson, JM; Puddey, IB; Tsai, IJ; van Bockxmeer, FM; Ward, NC	1
Ma, YH; Roman, RJ; Schwartzman, ML	1
Abraham, NG; Da Silva, JL; Escalante, B; Levere, RD; Park, E; Schwartzman, ML; Tiefenthaler, M	1
Frohlich, B; Ma, YH; Markham, B; Roman, RJ	1
Drummond, HA; Roman, RJ; Zou, AP	1
Abe, K; Arima, S; Ito, S; Omata, K; Tsunoda, K	1
Jacob, HJ; Krieger, JE; Roman, RJ; Stec, DE; Trolliet, MR	1
Abraham, NG; da Silva, JL; Lin, F; Nishimura, M; Schwartzman, ML	1
Mattson, DL; Roman, RJ; Stec, DE	1
Alonso-Galicia, M; Roman, RJ; Wilson, TW	1
Kaushal, KM; Kroetz, DL; Su, P	1
Conetta, J; McAward, K; McGiff, JC; Oyekan, AO; Rosenfeld, L	1
Benzoni, D; Bernard, N; Messer-Létienne, I; Roman, RJ; Sassard, J	1
Falck, JR; Frisbee, JC; Linderman, JR; Lombard, JH; Roman, RJ	1
Erdmann, B; Gross, V; Honeck, H; Kärgel, E; Luft, FC; Milia, AF; Neunaber, R; Schneider, W; Schunck, WH	1
McGiff, JC; Quilley, J	1
Adas, F; Breyer, MD; Capdevila, JH; Falck, JR; Holla, VR; Imig, JD; Keeney, DS; Kovacs, WJ; Magnuson, MA; Olsen, N; Price, E; Waterman, MR; Zhao, X	1
Falck, JR; Frisbee, JC; Lombard, JH; Murali Krishna, U; Roman, RJ	1
Falck, JR; Krishna, UM; Laniado-Schwartzman, M; Nasjletti, A; Wang, MH; Zhang, F	1
Qian, JQ; Wang, DW; Zhang, F	1
Alonso-Galicia, M; Cowley, AW; Greene, AS; Maier, KG; Roman, RJ	1

Reviews

19 review(s) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and Hypertension

Article	Year
The CYP/20-HETE/GPR75 axis in hypertension. Advances in pharmacology (San Diego, Calif.), 2022, Volume: 94 Topics: Blood Pressure; Cardiovascular Diseases; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Receptors, G-Protein-Coupled	2022
Alcohol and Hypertension-New Insights and Lingering Controversies. Current hypertension reports, 2019, 09-07, Volume: 21, Issue:10 Topics: Alcohol Drinking; Alcohol-Related Disorders; Blood Pressure; Cardiovascular Diseases; Cardiovascular System; Diabetes Mellitus, Type 2; Ethanol; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Mendelian Randomization Analysis; Metabolic Syndrome; Oxidative Stress; Risk Factors; Sex Factors	2019
Conflicting Roles of 20-HETE in Hypertension and Stroke. International journal of molecular sciences, 2019, Sep-11, Volume: 20, Issue:18 Topics: Animals; Disease Progression; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Models, Biological; Polymorphism, Genetic; Stroke	2019
20-HETE: Hypertension and Beyond. Hypertension (Dallas, Tex. : 1979), 2018, Volume: 72, Issue:1 Topics: Animals; Blood Pressure; Cytochrome P-450 CYP3A Inhibitors; Endothelium, Vascular; Glomerular Filtration Rate; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Vasodilation	2018
Conflicting roles of 20-HETE in hypertension and renal end organ damage. European journal of pharmacology, 2018, Aug-15, Volume: 833 Topics: Animals; Antihypertensive Agents; Arachidonic Acid; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Fibrosis; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Muscle, Smooth, Vascular; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptors, G-Protein-Coupled; Renal Elimination; Renal Insufficiency; Renin-Angiotensin System; Sodium; Vascular Remodeling	2018
Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat. Clinical science (London, England : 1979), 2013, Volume: 124, Issue:12 Topics: Animals; Blood Pressure; Cerebral Arteries; Cytochrome P-450 CYP4A; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Muscle, Smooth, Vascular; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Reactive Oxygen Species; Signal Transduction; Sodium Chloride, Dietary; Up-Regulation; Vasoconstriction	2013
Cytochrome P450 eicosanoids in hypertension and renal disease. Current opinion in nephrology and hypertension, 2015, Volume: 24, Issue:1 Topics: Arachidonic Acids; Blood Vessels; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Diseases; Kidney Tubules; Sodium	2015
Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid. Current opinion in nephrology and hypertension, 2017, Volume: 26, Issue:2 Topics: Animals; Endothelial Cells; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle	2017
20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension. Journal of cardiovascular pharmacology, 2010, Volume: 56, Issue:4 Topics: Animals; Antihypertensive Agents; Arachidonic Acid; Biological Transport; Blood Vessels; Disease Models, Animal; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Molecular Targeted Therapy; Sodium	2010
The role of 20-HETE in androgen-mediated hypertension. Prostaglandins & other lipid mediators, 2011, Volume: 96, Issue:1-4 Topics: Acetylcholinesterase; Androgens; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP4A; Endothelial Cells; Enzyme Induction; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Natriuresis; Postmenopause; Premenopause; Rats; Renin-Angiotensin System; Rodentia; Signal Transduction	2011
20-hydroxyeicosatetraenoic acid, endothelial dysfunction and hypertension. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2011, Volume: 8, Issue:2 Topics: Cytochrome P-450 Enzyme System; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Nitric Oxide; Oxidative Stress; Renin-Angiotensin System	2011
Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension. Current opinion in nephrology and hypertension, 2004, Volume: 13, Issue:2 Topics: Animals; Arachidonic Acids; Epoxy Compounds; Hemodynamics; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Models, Animal; Muscle, Smooth, Vascular	2004
Endothelial dysfunction: its role in hypertensive coronary disease. Current opinion in cardiology, 2005, Volume: 20, Issue:4 Topics: Angiotensin II; Antihypertensive Agents; Arginine; Coronary Disease; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Nitric Oxide; Oxidants	2005
Taking the 20-HETE out of the cardiovascular system: the potential of 20-HETE synthesis inhibitors. Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:9 Topics: Amidines; Angiogenesis Inhibitors; Animals; Cerebrovascular Circulation; Enzyme Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Myocardial Reperfusion Injury; Oligonucleotides, Antisense	2005
Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress? Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:1 Topics: Animals; Cardiovascular Diseases; Dihydrotestosterone; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Oxidative Stress; Risk Factors; Sex Characteristics	2007
[Roles of 20-HETE on physiologic and pathologic regulation in organism]. Sheng li ke xue jin zhan [Progress in physiology], 2007, Volume: 38, Issue:2 Topics: Animals; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Muscle, Smooth, Vascular; Pre-Eclampsia; Pregnancy; Vasomotor System	2007
Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Current opinion in nephrology and hypertension, 2007, Volume: 16, Issue:5 Topics: Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Eicosapentaenoic Acid; Electrophysiology; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Ion Transport; Ions; Kidney; Models, Biological; Sodium Channels	2007
Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats. American journal of hypertension, 1997, Volume: 10, Issue:5 Pt 2 Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Drug Resistance; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Rats; Rats, Inbred Strains; Sodium Chloride	1997
20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure. Current opinion in nephrology and hypertension, 2001, Volume: 10, Issue:2 Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Tubules, Proximal; Muscle, Skeletal; Oxygen; Rats; Renal Circulation	2001

Trials

4 trial(s) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and Hypertension

Article	Year
20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction. Free radical biology & medicine, 2009, Jan-15, Volume: 46, Issue:2 Topics: Adult; Aged; Biomarkers; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; F2-Isoprostanes; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Metabolic Syndrome; Middle Aged; Obesity; Oxidative Stress; Risk Factors; Weight Loss	2009
Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:5 Topics: Antihypertensive Agents; Dietary Supplements; Dioxoles; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; In Vitro Techniques; Lignans; Male; Microsomes, Liver; Middle Aged; Plant Extracts; Probability; Reference Values; Treatment Outcome	2009
Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension. Circulation, 2003, Feb-04, Volume: 107, Issue:4 Topics: Adult; Blood Pressure; Creatinine; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Middle Aged; Natriuresis; Obesity; Sodium; Sodium Chloride, Dietary	2003
A reduction in alcohol consumption is associated with reduced plasma F2-isoprostanes and urinary 20-HETE excretion in men. Free radical biology & medicine, 2007, Jun-01, Volume: 42, Issue:11 Topics: Adult; Aged; Alcohol Drinking; Blood Pressure; Ethanol; F2-Isoprostanes; gamma-Glutamyltransferase; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Middle Aged	2007

Other Studies

97 other study(ies) available for 20-hydroxy-5,8,11,14-eicosatetraenoic acid and Hypertension

Article	Year
Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase. Journal of hypertension, 2022, 03-01, Volume: 40, Issue:3 Topics: Animals; Blood Pressure; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Mice; Muscle, Smooth; Receptors, G-Protein-Coupled	2022
20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond. Advances in pharmacology (San Diego, Calif.), 2023, Volume: 97 Topics: Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Vascular Remodeling	2023
19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension. Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19 Topics: Animals; Antihypertensive Agents; Cytochrome P450 Family 4; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Glomerulus; Male; Mice; Mice, Knockout; Microvessels; Phenylephrine; Vasoconstrictor Agents	2019
Exercise training delays renal disorders with decreasing oxidative stress and increasing production of 20-hydroxyeicosatetraenoic acid in Dahl salt-sensitive rats. Journal of hypertension, 2020, Volume: 38, Issue:7 Topics: Animals; Antihypertensive Agents; Arachidonic Acid; Blood Pressure; Fibrosis; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Kidney Diseases; Male; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Inbred Dahl; Sodium Chloride; Sodium Chloride, Dietary; Thiobarbituric Acid Reactive Substances	2020
Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. Journal of hypertension, 2020, Volume: 38, Issue:9 Topics: Animals; Antihypertensive Agents; Blood Pressure; Eicosanoids; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Rats; Rats, Inbred SHR	2020
Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers. Cells, 2020, 09-16, Volume: 9, Issue:9 Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Arachidonic Acid; Biological Variation, Population; Blood Pressure; Cross-Over Studies; Dinoprostone; Exercise; Female; Healthy Volunteers; Heart Rate; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Lipid Metabolism; Male; Pilot Projects; Post-Exercise Hypotension; Thromboxanes	2020
Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice. Kidney & blood pressure research, 2021, Volume: 46, Issue:5 Topics: Animals; Blood Pressure; Cytochrome P450 Family 4; Diet, High-Fat; Gene Expression Regulation; HEK293 Cells; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Mice, Transgenic; Obesity; Solute Carrier Family 12, Member 1; Up-Regulation	2021
Thrombin Inhibition Prevents Endothelial Dysfunction and Reverses 20-HETE Overproduction without Affecting Blood Pressure in Angiotensin II-Induced Hypertension in Mice. International journal of molecular sciences, 2021, Aug-12, Volume: 22, Issue:16 Topics: Angiotensin II; Animals; Antithrombins; Chromatography, Liquid; Dabigatran; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Intercellular Adhesion Molecule-1; Male; Mice; Nitric Oxide; Tandem Mass Spectrometry; Vascular Remodeling; von Willebrand Factor	2021
20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G Circulation research, 2017, May-26, Volume: 120, Issue:11 Topics: Animals; Cells, Cultured; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Mice; Mice, Transgenic; Protein Binding; Rats; Receptors, G-Protein-Coupled; Signal Transduction; Vascular Remodeling	2017
GPR75 Identified as the First 20-HETE Receptor: A Chemokine Receptor Adopted by a New Family. Circulation research, 2017, 05-26, Volume: 120, Issue:11 Topics: Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Receptors, Chemokine; Receptors, G-Protein-Coupled	2017
Effect of 20-HETE inhibition on L-NAME-induced hypertension in rats. Clinical and experimental hypertension (New York, N.Y. : 1993), 2018, Volume: 40, Issue:3 Topics: Amidines; Animals; Blood Pressure; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Tissue Culture Techniques; Vascular Resistance; Vasoconstriction; Vasodilation	2018
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation. Journal of molecular and cellular cardiology, 2018, Volume: 117 Topics: Animals; Blood Pressure; Collagen Type I; Collagen Type III; Compliance; Cytochrome P-450 CYP4A; Cytochrome P450 Family 4; Diastole; Elastin; Enzyme Activation; Hydroxyeicosatetraenoic Acids; Hypertension; Losartan; Male; Matrix Metalloproteinase 12; Metabolic Syndrome; Proteolysis; Rats, Sprague-Dawley; RNA, Small Interfering; Vascular Stiffness	2018
Angiotensin II upregulates CYP4A isoform expression in the rat kidney through angiotensin II type 1 receptor. Prostaglandins & other lipid mediators, 2018, Volume: 139 Topics: Angiotensin II; Animals; Arachidonic Acid; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cytochrome P-450 CYP4A; Disease Models, Animal; Gene Expression Regulation; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Protein Isoforms; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Tetrazoles	2018
Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. Journal of the American Society of Nephrology : JASN, 2013, Volume: 24, Issue:8 Topics: Androgens; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dihydrotestosterone; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Up-Regulation	2013
20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. American journal of physiology. Renal physiology, 2013, Sep-01, Volume: 305, Issue:5 Topics: Animals; Blood Pressure; Dihydrotestosterone; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Mice; Rats; Rats, Sprague-Dawley; Renal Artery; Reserpine	2013
Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013, Volume: 33, Issue:11 Topics: Actins; Adaptation, Physiological; Aging; Angiotensin II; Animals; Behavior, Animal; Blood-Brain Barrier; Cerebrovascular Circulation; Cytokines; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microvessels; Middle Cerebral Artery; TRPC Cation Channels; TRPC6 Cation Channel; Up-Regulation	2013
Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. American journal of physiology. Heart and circulatory physiology, 2013, Volume: 305, Issue:12 Topics: Aging; Angiotensin II; Animals; Calcium; Calcium Signaling; Hydroxyeicosatetraenoic Acids; Hypertension; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Male; Mice; Mice, Inbred C57BL; Middle Cerebral Artery; Muscle Contraction; Muscle, Smooth, Vascular; TRPC Cation Channels; Vasoconstriction	2013
Mechanism of impaired afferent arteriole myogenic response in Dahl salt-sensitive rats: role of 20-HETE. American journal of physiology. Renal physiology, 2014, Sep-01, Volume: 307, Issue:5 Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Arterioles; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Microvessels; Muscle Development; Norepinephrine; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Vasoconstriction	2014
Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats. American journal of physiology. Renal physiology, 2014, Sep-01, Volume: 307, Issue:5 Topics: Adenosine; Afferent Pathways; Animals; Arachidonic Acid; Arterioles; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Microvessels; Muscle Development; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Rats, Sprague-Dawley; Regional Blood Flow; Transforming Growth Factors; Vasoconstriction	2014
Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. Journal of the American Society of Nephrology : JASN, 2015, Volume: 26, Issue:3 Topics: Animals; Collagen; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Diabetic Nephropathies; Glomerular Basement Membrane; Hydralazine; Hydrochlorothiazide; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Mice, Knockout; Orchiectomy; Renin-Angiotensin System; Reserpine; Sodium	2015
Azilsartan is associated with increased circulating angiotensin-(1-7) levels and reduced renovascular 20-HETE levels. American journal of hypertension, 2015, Volume: 28, Issue:5 Topics: Angiotensin I; Animals; Benzimidazoles; Blood Pressure; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Hypertension, Renovascular; Male; Oxadiazoles; Peptide Fragments; Rats; Rats, Sprague-Dawley; Vasoconstriction	2015
Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Mar-01, Volume: 308, Issue:5 Topics: Animals; Arterial Pressure; Blood-Brain Barrier; Capillary Permeability; Cerebrovascular Circulation; Cytochrome P-450 CYP4A; Disease Models, Animal; Genotype; Homeostasis; Hydroxyeicosatetraenoic Acids; Hypertension; Middle Cerebral Artery; Phenotype; Rats, Inbred Dahl; Rats, Inbred Lew; Rats, Transgenic; Sodium Chloride, Dietary; Transposases; Vascular Remodeling; Vasoconstriction	2015
Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Jul-01, Volume: 309, Issue:1 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Mice, Transgenic; Microvessels; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Time Factors; Vascular Remodeling	2015
20-Hydroxyeicosatetraenoic acid, a far-reaching autacoid in chronic kidney disease: hypertension and beyond. Journal of hypertension, 2015, Volume: 33, Issue:9 Topics: Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Renal Insufficiency, Chronic	2015
20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats. American journal of physiology. Renal physiology, 2016, 07-01, Volume: 311, Issue:1 Topics: Androgens; Animals; Body Weight; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Female; Gene Deletion; Gene Knockout Techniques; Hydroxyeicosatetraenoic Acids; Hyperandrogenism; Hypertension; Microcirculation; Rats; Rats, Inbred Dahl; Renal Circulation; Steroids	2016
Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE. American journal of physiology. Heart and circulatory physiology, 2016, 06-01, Volume: 310, Issue:11 Topics: Androgens; Animals; Blood Pressure; Cytochrome P450 Family 4; Female; Genetic Linkage; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Mice, Knockout; Quantitative Trait Loci; Sex Factors; Soluble Guanylyl Cyclase; Testosterone	2016
Hypertension-Induced Enhanced Myogenic Constriction of Cerebral Arteries Is Preserved after Traumatic Brain Injury. Journal of neurotrauma, 2017, 07-15, Volume: 34, Issue:14 Topics: Animals; Brain Injuries, Diffuse; Brain Injuries, Traumatic; Cerebrovascular Circulation; Disease Models, Animal; Hydroxyeicosatetraenoic Acids; Hypertension; Middle Cerebral Artery; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY	2017
The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:2 Topics: Analysis of Variance; Anthropometry; Brain Ischemia; Cohort Studies; Cytochrome P-450 CYP4A; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Heterozygote; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kaplan-Meier Estimate; Male; Middle Aged; Polymorphism, Genetic; Probability; Proportional Hazards Models; Sex Factors; Stroke	2008
Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension. Kidney international, 2008, Volume: 74, Issue:8 Topics: Animals; Blood Pressure; Clofibrate; Cytochrome P-450 CYP4A; Desoxycorticosterone; Hydroxyeicosatetraenoic Acids; Hypernatremia; Hypertension; Kidney Tubules; Mice; Mice, Knockout; PPAR alpha; Sodium Chloride	2008
Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. American journal of physiology. Renal physiology, 2008, Volume: 295, Issue:6 Topics: Animals; Chromosome Mapping; Cytochrome P-450 CYP4A; DNA Primers; Gene Expression Regulation, Enzymologic; Gene Transfer Techniques; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Cortex; Kidney Medulla; Microsomes; Rats; Rats, Inbred Dahl; Rats, Inbred Lew; Serum Albumin; Species Specificity	2008
Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:6 Topics: Amidines; Animals; Blood Pressure; Cerebral Arteries; Cerebrovascular Circulation; Cytochrome P-450 CYP4A; Disease Models, Animal; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Infarction, Middle Cerebral Artery; Isoenzymes; Male; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Severity of Illness Index; Stroke; Time Factors; Up-Regulation	2008
Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:7 Topics: Animals; Cytochrome P-450 CYP4A; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Soybean Proteins	2008
Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. Kidney international, 2009, Volume: 75, Issue:12 Topics: Animals; Base Sequence; Blood Pressure; Cell Line; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Disease Models, Animal; DNA, Complementary; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Tubules, Proximal; Mice; Mice, Transgenic; Promoter Regions, Genetic; Recombinant Proteins; Transfection	2009
The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension. Journal of hypertension, 2009, Volume: 27, Issue:8 Topics: Adrenocorticotropic Hormone; Amidines; Animals; Body Weight; Dexamethasone; F2-Isoprostanes; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Organ Size; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Systole	2009
Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model?? Kidney international, 2009, Volume: 75, Issue:12 Topics: Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Disease Models, Animal; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Mice; Mice, Transgenic; Models, Cardiovascular; Recombinant Proteins	2009
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:4 Topics: Acetylcholine; AMP-Activated Protein Kinases; Animals; Antigens, CD; Blood Pressure; Cadherins; Cell Line; Cytochrome P-450 Enzyme System; DNA, Complementary; Endothelium, Vascular; Gene Targeting; Gene Transfer Techniques; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Lentivirus; Nitric Oxide Synthase Type III; Oxidation-Reduction; Phosphorylation; Promoter Regions, Genetic; Proteinuria; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Superoxides; Vasodilation	2009
Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. Kidney international, 2009, Volume: 76, Issue:8 Topics: Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Disease Models, Animal; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Mice; Mice, Transgenic; Species Specificity; Up-Regulation	2009
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clinical science (London, England : 1979), 2010, Feb-23, Volume: 118, Issue:10 Topics: 8,11,14-Eicosatrienoic Acid; Amides; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Drug Evaluation, Preclinical; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Multiple Organ Failure; Norepinephrine; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renal Circulation; Sulfones; Vasoconstrictor Agents	2010
Role of 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of vascular function in a model of hypertension and endothelial dysfunction. Pharmacology, 2010, Volume: 86, Issue:3 Topics: Amidines; Animals; Arachidonic Acids; Blood Pressure; Carbachol; Cardiovascular Physiological Phenomena; Carotid Arteries; Endothelial Cells; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Urea; Vascular Diseases; Vasoconstriction; Vasoconstrictor Agents; Vasodilation	2010
20-hydroxyeicosatetraenoic acid and angiotensin: a positive feedback system to cause hypertension. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:5 Topics: Angiotensins; Animals; Hydroxyeicosatetraenoic Acids; Hypertension; Rats; Renin-Angiotensin System	2010
CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:5 Topics: Amidines; Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blotting, Western; Cells, Cultured; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Lentivirus; Lisinopril; Losartan; Mass Spectrometry; Oligonucleotide Array Sequence Analysis; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Time Factors	2010
2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:6 Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Antihypertensive Agents; Aorta; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Cardiomegaly; Cytochrome P-450 CYP1B1; Desoxycorticosterone; Disease Models, Animal; Diuresis; Endothelium, Vascular; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocardium; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; p38 Mitogen-Activated Protein Kinases; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Stilbenes; Superoxides; Time Factors; Vasoconstriction; Vasodilation	2010
Renal function and vasomotor activity in mice lacking the Cyp4a14 gene. Experimental biology and medicine (Maywood, N.J.), 2010, Volume: 235, Issue:11 Topics: Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Female; Gene Deletion; Hydroxyeicosatetraenoic Acids; Hypertension; In Vitro Techniques; Kidney; Lipid Peroxides; Male; Mice; Mice, Knockout; Microsomes; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Renal Circulation; Sodium Chloride; Vasoconstriction	2010
Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase. Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:4 Topics: Androgens; Animals; Blood Pressure; Dihydrotestosterone; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; I-kappa B Kinase; Rats; Rats, Sprague-Dawley; Renal Artery; Sesquiterpenes; Vasoconstriction	2011
Postmenopausal hypertension: role of 20-HETE. American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 300, Issue:6 Topics: Aging; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Disease Models, Animal; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Postmenopause; Rats; Rats, Inbred SHR; Triazoles	2011
Study on the association between environmental cadmium exposure, cytochrome P450-mediated 20-HETE, heme-oxygenase-1 polymorphism and hypertension in Thai population residing in a malaria endemic areas with cadmium pollution. Environmental toxicology and pharmacology, 2011, Volume: 31, Issue:3 Topics: Adult; Arachidonic Acid; Cadmium; Cytochrome P-450 Enzyme System; Endemic Diseases; Environmental Exposure; Environmental Monitoring; Environmental Pollution; Epidemiological Monitoring; Female; Heme Oxygenase-1; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Diseases; Kidney Function Tests; Malaria; Male; Middle Aged; Polymorphism, Genetic; Smoking; Thailand	2011
Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade. PloS one, 2011, Volume: 6, Issue:10 Topics: Animals; Blood Pressure; Endothelin B Receptor Antagonists; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Medulla; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Time Factors	2011
Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice. Gene, 2012, Sep-01, Volume: 505, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Androgens; Animals; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Mice, Transgenic	2012
Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2012, May-15, Volume: 302, Issue:10 Topics: Animals; Blood Pressure; Cytochrome P-450 CYP4A; Disease Models, Animal; Genetic Therapy; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rats; Rats, Inbred BN; Rats, Inbred Dahl; RNA, Messenger; Time Factors	2012
20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway. Molecular endocrinology (Baltimore, Md.), 2012, Volume: 26, Issue:11 Topics: Amidines; Animals; Blood Glucose; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Glucose Transporter Type 1; Glycogen Phosphorylase; Hydroxyeicosatetraenoic Acids; Hyperglycemia; Hypertension; Insulin Receptor Substrate Proteins; Isoquinolines; Liver; Male; Mice; Mice, Transgenic; Phosphorylase Kinase; Phosphorylation; Signal Transduction; Sulfonamides	2012
Roles played by 20-HETE, angiotensin II and endothelin in mediating the hypertension in aging female spontaneously hypertensive rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Volume: 304, Issue:3 Topics: Aging; Angiotensin II; Animals; Blood Pressure; Endothelins; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Rats; Rats, Inbred SHR	2013
Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:4 Topics: Animals; Blood Pressure; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Induction; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sex Characteristics; Testosterone	2003
Contributions of 20-HETE to the antihypertensive effects of Tempol in Dahl salt-sensitive rats. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:3 Pt 2 Topics: Animals; Antihypertensive Agents; Antioxidants; Cyclic N-Oxides; Dinoprost; F2-Isoprostanes; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Nitric Oxide; Rats; Rats, Inbred Dahl; Spin Labels; Superoxides	2003
20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:3 Pt 2 Topics: Adult; Aldosterone; Blood Pressure; Female; Furosemide; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Natriuresis; Renin; Sodium; Sodium Chloride	2003
Functional expression of human heme oxygenase-1 gene in renal structure of spontaneously hypertensive rats. Experimental biology and medicine (Maywood, N.J.), 2003, Volume: 228, Issue:5 Topics: Animals; Animals, Newborn; Blood Pressure; Female; Gene Expression Regulation, Enzymologic; Gene Transfer Techniques; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Membrane Proteins; Pregnancy; Rats; Rats, Inbred SHR; Retroviridae; Transduction, Genetic	2003
Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:4 Topics: Amidines; Animals; Arachidonic Acid; Blood Pressure; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride; Triazoles	2003
20-HETE and circulating insulin in essential hypertension with obesity. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:2 Topics: Blood Pressure; Body Mass Index; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Sodium	2004
Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:4 Topics: Animals; Animals, Genetically Modified; Arachidonic Acid; Blood Pressure; Chromosomes; Cytochrome P-450 CYP4A; Diet, Sodium-Restricted; Genetic Predisposition to Disease; Hydroxyeicosatetraenoic Acids; Hypertension; Ion Transport; Kidney Cortex; Kidney Medulla; Loop of Henle; Male; Natriuresis; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Sodium; Sodium Chloride, Dietary; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Solute Carrier Family 12, Member 1	2004
Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans. Circulation, 2004, Jul-27, Volume: 110, Issue:4 Topics: Body Mass Index; Brachial Artery; Endothelium, Vascular; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Models, Cardiovascular; Ultrasonography; Vasodilation	2004
Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:1 Topics: Amides; Animals; Arachidonic Acid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Hydroxyeicosatetraenoic Acids; Hypertension; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Sulfones; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasopressins	2005
[Role of androgens in the renal production of 20-hydroxyeicosatetraenoic acid in spontaneously hypertensive rats]. Nihon Jinzo Gakkai shi, 2004, Volume: 46, Issue:7 Topics: Androgens; Animals; Cytochrome P-450 CYP4A; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sex Factors; Testosterone	2004
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation, 2005, Jan-04, Volume: 111, Issue:1 Topics: Adult; Aged; Alleles; Amino Acid Substitution; Arachidonic Acid; Black People; Blood Pressure; Codon; Cohort Studies; Comorbidity; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Introns; Kidney; Lauric Acids; Male; Middle Aged; Multifactorial Inheritance; Mutagenesis, Insertional; Mutation, Missense; Point Mutation; Sequence Deletion; Tennessee; United States; White People	2005
Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension. Circulation, 2005, Jan-04, Volume: 111, Issue:1 Topics: Amino Acid Substitution; Animals; Arachidonic Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Female; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Lauric Acids; Male; Mice; Mixed Function Oxygenases; Mutation, Missense; Point Mutation; Polymorphism, Genetic; Rats; Sequence Homology, Nucleic Acid; Sex Factors; Signal Transduction; Vasoconstriction	2005
Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:4 Topics: Adamantane; Amides; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Diuresis; Epoxide Hydrolases; Hydroxyeicosatetraenoic Acids; Hypertension; In Vitro Techniques; Lauric Acids; Male; Mice; Mice, Inbred Strains; Natriuresis; Renal Circulation; Solubility; Sulfones; Vasoconstrictor Agents; Vasodilation	2005
Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:4 Topics: Angiotensin II; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Fenofibrate; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Mice, Inbred C57BL; Vasoconstrictor Agents	2005
Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:4 Topics: Animals; Hydroxyeicosatetraenoic Acids; Hypertension; In Vitro Techniques; Kidney; Kidney Glomerulus; Microscopy, Electron; Permeability; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sodium Chloride, Dietary; Transforming Growth Factor beta; Transforming Growth Factor beta1	2005
Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjects. Free radical biology & medicine, 2005, Apr-15, Volume: 38, Issue:8 Topics: Aged; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Middle Aged; Oxidative Stress	2005
Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase. Cell research, 2005, Volume: 15, Issue:9 Topics: Animals; Blood Pressure; Blotting, Northern; Blotting, Western; Cloning, Molecular; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dependovirus; DNA, Complementary; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Liver; Male; Protein Isoforms; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; RNA; RNA, Messenger; Systole; Time Factors	2005
Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:1 Topics: Animals; Blood Pressure; Clofibrate; Cytochrome P-450 CYP4A; Dietary Fats; Enzyme Induction; Hydroxyeicosatetraenoic Acids; Hypertension; Hypolipidemic Agents; Kidney; Kidney Function Tests; Male; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium	2006
Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. American journal of physiology. Renal physiology, 2006, Volume: 290, Issue:6 Topics: Animals; Blood Pressure; Cytochrome P-450 CYP4A; Hemodynamics; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Kidney Medulla; Male; Rats; Rats, Inbred Dahl; Rats, Inbred Lew; Sodium Chloride, Dietary; Time Factors	2006
Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circulation research, 2006, Apr-14, Volume: 98, Issue:7 Topics: Adenoviridae; Animals; Blood Pressure; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Genetic Vectors; Hydroxyeicosatetraenoic Acids; Hypertension; Myocardium; Oxidative Stress; Rats; Rats, Inbred Lew; Rats, Wistar	2006
Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circulation research, 2006, Apr-14, Volume: 98, Issue:7 Topics: Adenoviridae; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Models, Biological; Rats; Transduction, Genetic	2006
20-HETE and salt-sensitivity of blood pressure a novel emerging concept. American journal of hypertension, 2006, Volume: 19, Issue:11 Topics: Animals; Clofibric Acid; Cytochrome P-450 CYP4A; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Hypolipidemic Agents; Natriuresis; Rats; Risk Factors; Sodium Chloride	2006
Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:1 Topics: Acetylcholine; Amidines; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Dihydrotestosterone; Drug Synergism; Endothelium, Vascular; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Artery; Superoxides; Vasodilation; Vasodilator Agents	2007
The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats. Kidney & blood pressure research, 2007, Volume: 30, Issue:5 Topics: Animals; Animals, Genetically Modified; Arachidonic Acids; Blood Pressure; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rats; Rats, Sprague-Dawley	2007
The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adult; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Female; Gene Frequency; Genotype; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Insulin; Insulin Resistance; Male; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide	2008
Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:4 Topics: Adult; Case-Control Studies; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Female; Haplotypes; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Middle Aged	2008
Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Arachidonic Acids; Case-Control Studies; Creatinine; Cross-Sectional Studies; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Hypertension, Renovascular; Male; Middle Aged; Renal Artery Obstruction	2008
A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:5 Topics: Aged; Alleles; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Female; Genotype; Humans; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Middle Aged; Mutation; Polymorphism, Single Nucleotide; Regression Analysis	2008
Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Prostaglandins; Rats; Rats, Inbred Strains; Sodium Chloride	1994
Tin-mediated heme oxygenase gene activation and cytochrome P450 arachidonate hydroxylase inhibition in spontaneously hypertensive rats. The American journal of the medical sciences, 1994, Volume: 307, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tin; Transcriptional Activation	1994
Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats. Hypertension (Dallas, Tex. : 1979), 1993, Volume: 21, Issue:6 Pt 2 Topics: Animals; Arachidonic Acid; Blood Pressure; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Lipids; Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Sodium Chloride	1993
Role of 20-HETE in elevating loop chloride reabsorption in Dahl SS/Jr rats. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:3 Pt 2 Topics: Animals; Biological Transport; Chlorides; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Hypertension; Loop of Henle; Rats	1996
20-HETE requires increased vascular tone to constrict rabbit afferent arterioles. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:3 Pt 2 Topics: Animals; Arachidonic Acid; Arterioles; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Rabbits; Vascular Resistance	1996
Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:6 Topics: Animals; Arachidonic Acid; Base Sequence; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Lod Score; Male; Mixed Function Oxygenases; Molecular Sequence Data; Phenotype; Rats; Rats, Inbred BN; Rats, Inbred SHR; Rats, Inbred WKY; Sodium, Dietary; Species Specificity	1996
Cytochrome P450 4A expression and arachidonic acid omega-hydroxylation in the kidney of the spontaneously hypertensive rat. Nephron, 1996, Volume: 73, Issue:4 Topics: Aging; Animals; Arachidonic Acid; Blotting, Northern; Blotting, Southern; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Hydroxylation; Hypertension; Immunoblotting; Kidney; Male; Mixed Function Oxygenases; Nephrons; Oligonucleotide Probes; Polymerase Chain Reaction; Rats; Rats, Inbred SHR	1996
Inhibition of renal outer medullary 20-HETE production produces hypertension in Lewis rats. Hypertension (Dallas, Tex. : 1979), 1997, Volume: 29, Issue:1 Pt 2 Topics: Animals; Blood Pressure; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney Medulla; Microsomes; Oleic Acids; Rats; Rats, Inbred Lew; Steroid Hydroxylases	1997
Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. The American journal of physiology, 1998, Volume: 275, Issue:2 Topics: Animals; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Reference Values; Triazoles	1998
Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension. The American journal of physiology, 1999, Volume: 276, Issue:3 Topics: Animals; Arachidonic Acid; Blood Pressure; Body Weight; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Endothelin-1; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Myocardium; Organ Size; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium Chloride	1999
20-Hydroxyeicosatetraenoic acid and renal function in Lyon hypertensive rats. European journal of pharmacology, 1999, Aug-13, Volume: 378, Issue:3 Topics: Animals; Biphenyl Compounds; Blood Pressure; Body Weight; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Heptanoic Acids; Hydroxyeicosatetraenoic Acids; Hypertension; In Vitro Techniques; Kidney; Male; Miconazole; Organ Size; Oxygenases; Rats; Receptors, Thromboxane; Renal Circulation; Systole; Vascular Resistance; Vasodilation	1999
Impairment of flow-induced dilation of skeletal muscle arterioles with elevated oxygen in normotensive and hypertensive rats. Microvascular research, 2000, Volume: 60, Issue:1 Topics: Amides; Animals; Arterioles; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hemorheology; Hydroxyeicosatetraenoic Acids; Hypertension; Male; Microcirculation; Microscopy, Video; Mixed Function Oxygenases; Muscle, Skeletal; Oxygen; Partial Pressure; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sulfones; Vasodilation	2000
Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 36, Issue:4 Topics: Animals; Arachidonic Acid; Bezafibrate; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Hydroxyeicosatetraenoic Acids; Hydroxylation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypolipidemic Agents; In Situ Hybridization; Kidney; Lovastatin; Male; Mice; Mice, Inbred Strains; Microsomes; Mixed Function Oxygenases; NADP; Nephrectomy; RNA, Messenger; Sodium Chloride	2000
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9 Topics: Androgens; Animals; Arachidonic Acid; Blood Pressure; Castration; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Enzyme Induction; Female; Gene Deletion; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mice; Mice, Knockout; Microsomes; Mixed Function Oxygenases; Renal Circulation; RNA, Messenger; Sex Characteristics; Testosterone; Vascular Resistance	2001
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats. Microcirculation (New York, N.Y. : 1994), 2001, Volume: 8, Issue:2 Topics: Animals; Arachidonic Acid; Arteries; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Hypertension; Hypoxia; In Vitro Techniques; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred Dahl; Vascular Resistance; Vasodilation	2001
Modulation by 20-HETE of phenylephrine-induced mesenteric artery contraction in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension (Dallas, Tex. : 1979), 2001, Dec-01, Volume: 38, Issue:6 Topics: Amides; Animals; Disintegrins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; In Vitro Techniques; Isometric Contraction; Mesenteric Arteries; Muscle, Smooth, Vascular; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity; Sulfones; Vasopressins; Viper Venoms	2001
Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure. Acta pharmacologica Sinica, 2002, Volume: 23, Issue:6 Topics: Animals; Arachidonic Acid; Blood Pressure; Cloning, Molecular; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; DNA, Antisense; Eukaryotic Cells; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mixed Function Oxygenases; Monophenol Monooxygenase; Rats; RNA, Messenger; Transfection	2002
Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:1 Topics: Amides; Angiotensin II; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfones; Triazoles; Vasoconstriction; Vasoconstrictor Agents	2002