2-thioxo-4-thiazolidinecarboxylic-acid and Skin-Diseases

Few studies have been conducted to explore how personal factors-personal hygiene, personal protective equipment, and skin exposure affect the exposure-dose relationship in workers exposed to carbon disulfide (CS(2)).. Personal environmental monitoring of airborne CS(2) and 2-thiothiazolidine-4-carboxylic acid (TTCA) levels in post-shift urine were determined for sixty-five rayon workers. The personal factors affecting the CS(2)-TTCA relationship were measured by questionnaire and dermatological diagnosis.. In simple linear regression analyses, we found shower right after work, respirator, gloves, apron, and skin disease were significantly associated with U-TTCA levels among all personal factors. Skin disease was, however, the only personal factor that remained significant throughout multivariate linear regression analyses.. In this study, the personal factor like host's skin disease was found to possibly affect the relations of U-TTCA to the occupational exposure to CS(2). The skin exposure to CS(2) for those who have skin problems on the sites possibly or potentially exposed to CS(2) in the occupational environment such as in the rayon manufacturing process is noteworthy. Workers with susceptible skins should either be assigned to work in areas without contacting hazardous materials directly or required to wear appropriately protective clothing.

Topics: Administration, Cutaneous; Adult; Biomarkers; Carbon Disulfide; Cellulose; Chemical Industry; Female; Humans; Hygiene; Male; Middle Aged; Occupational Exposure; Protective Clothing; Skin Diseases; Thiazoles; Thiazolidines

The reported investigations on the uptake of carbon disulphide (CS2) and the excretion of its metabolite 2-thiothiazolidine-4-carboxylic acid (TTCA) were based on results from 403 personal air samples (352 passive and 51 active samples) and 362 TTCA determinations in biological material measured during a field study on the adverse effects due to CS2 exposure. The external exposure ranged from below the detection limit (0.2 ppm) to 66 ppm and the urinary TTCA excretion from below the detection limit (0.16 mg./l) to 33.4 mg/l. The excretion of TTCA in postshift urine related to creatinine and volume showed a linear correlation to the CS2 air concentration. On the basis of these results the influence on the internal exposure of physical work load, dermal exposure and individual parameters (age, Brocaindex, disturbed skin barrier) was evaluated. Correlations between the TTCA values in the postshift urine and the individually measured CS2 concentrations were carried out separately for individual departments and persons with and without indications of a disturbed skin barrier. In order to be able to judge the individual internal exposure related to external exposure, a personal quotient was formed from the TTCA level in the urine and the CS2 air concentration measured on the same day (relative internal exposure RIE index = TTCA mg/g creatinine/CS2 in ppm). On investigating interindividual differences, higher relative internal exposures were found in persons with a heavy physical work load and more intensive skin contact. It could be shown for a large group of persons exposed to CS2 that a pathological skin condition leads to an increase in the dermal penetration rate of hazardous substances.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Adult; Carbon Disulfide; Chemical Industry; Environmental Monitoring; Humans; Linear Models; Male; Middle Aged; Occupational Exposure; Skin Absorption; Skin Diseases; Thiazoles; Thiazolidines