2-tert-butylprimaquine has been researched along with Malaria* in 1 studies
1 other study(ies) available for 2-tert-butylprimaquine and Malaria
| Article | Year |
|---|---|
Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity.
To eliminate an unwarranted metabolic pathway of the quinoline ring, a set of two compounds, where C-2 position of the antimalarial drug primaquine is blocked by metabolically stable bulky alkyl group are synthesized. Compound 2 [R = C(CH(3))(3)] of the series has produced excellent antimalarial efficacy against P. berghei and highly virulent multidrug-resistant P. yoelii nigeriensis strain in vivo. Compound 2 was also evaluated for methemoglobin (MetHb) toxicity. This study describes the discovery of a highly potent blood-schizontocidal antimalarial analogue 2, completely devoid of MetHb toxicity. Topics: Animals; Antimalarials; Malaria; Methemoglobin; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Primaquine; Structure-Activity Relationship | 2004 |