2-pyridinecarboxaldehyde-1-oxide-3-4-dimethoxybenzene-sulfonylhydrazone has been researched along with Leukemia-P388* in 1 studies
1 other study(ies) available for 2-pyridinecarboxaldehyde-1-oxide-3-4-dimethoxybenzene-sulfonylhydrazone and Leukemia-P388
| Article | Year |
|---|---|
Synthesis and antineoplastic activity of phenyl-substituted benzenesulfonylhydrazones of 2-pyridinecarboxyaldehyde 1-oxide.
A variety of derivatives of 2-pyridinecarboxaldehyde 1-oxide benzenesulfonylhydrazone, containing substituents on the benzene or pyridine rings as well as on the nitrogen atom which is bonded directly to the sulfonyl group, have been synthesized. The antineoplastic activity of these compounds has been assessed in mice bearing either leukemia L1210 or P388. The most potent agents in this series were 2,4-dimethoxy,3,4-dimethoxy-, and 2,4,6-trimethylbenzenesulfonylhydrazone of 2-pyridinecarboxyaldehyde 1-oxide, all causing disappearance of tumors in 20-80% of leukemia-bearing mice. Topics: Animals; Antineoplastic Agents; Cyclic N-Oxides; Female; Hydrazones; Leukemia L1210; Leukemia P388; Mice; Pyridines; Structure-Activity Relationship | 1980 |