2-propanol and Nausea studies

2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

Excerpt	Relevance	Reference
"We compared the efficacy of inhaled isopropyl alcohol (IPA) with ondansetron for the control of postoperative nausea and vomiting (PONV) during a 24-hour period in 100 ASA class I-III women undergoing laparoscopic surgery."	9.12	A comparative analysis of isopropyl alcohol and ondansetron in the treatment of postoperative nausea and vomiting from the hospital setting to the home. ( Cotton, JW; Hood, RR; Pellegrini, JE; Rowell, LR, 2007)
"We compare aromatherapy with inhaled isopropyl alcohol versus oral ondansetron for treating nausea among emergency department (ED) patients not requiring immediate intravenous access."	5.27	Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. ( April, MD; Davis, WT; Hunter, CJ; Ng, PC; Oliver, JJ; Ong, D; Simon, EM, 2018)
"We compared the efficacy of inhaled isopropyl alcohol (IPA) with ondansetron for the control of postoperative nausea and vomiting (PONV) during a 24-hour period in 100 ASA class I-III women undergoing laparoscopic surgery."	5.12	A comparative analysis of isopropyl alcohol and ondansetron in the treatment of postoperative nausea and vomiting from the hospital setting to the home. ( Cotton, JW; Hood, RR; Pellegrini, JE; Rowell, LR, 2007)
" If postoperative nausea or vomiting persisted after three sequences, intravenous ondansetron was administered as rescue therapy."	5.09	An alternative method to alleviate postoperative nausea and vomiting in children. ( Hofstadter, MB; Kain, ZN; Wang, SM, 1999)
"Nausea and vomiting is a common ED chief complaint."	3.01	Isopropyl alcohol inhalation for the treatment of nausea in adult emergency department patients: a systematic review and meta-analysis. ( Lee, SY; Tamale, JR, 2023)

Research

Studies (14)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Nausea 100 mm Visual Analogue Scale (VAS)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (14.29)	18.7374
1990's	1 (7.14)	18.2507
2000's	1 (7.14)	29.6817
2010's	5 (35.71)	24.3611
2020's	5 (35.71)	2.80

Authors	Studies
Erdogan-Ongel, E	1
Heung, Y	1
Rozman de Moraes, A	1
Geng, Y	1
Bruera, E	1
Lee, SY	1
Tamale, JR	1
Kimber, JS	1
Kovoor, JG	1
Glynatsis, JM	1
West, SJ	1
Mai, TTN	1
Jacobsen, JHW	1
Ovenden, CD	1
Bacchi, S	1
Hewitt, JN	1
Gupta, AK	1
Edwards, S	1
Taverner, FJ	1
Watson, DI	1
Candemir, H	1
Akoglu, H	1
Sanri, E	1
Onur, O	1
Denizbasi, A	1
April, MD	2
Oliver, JJ	1
Davis, WT	1
Ong, D	1
Simon, EM	1
Ng, PC	1
Hunter, CJ	2
Steurer, J	1
Lindblad, AJ	1
Ting, R	1
Harris, K	1
Dalrymple, RA	1
Beadle, KL	1
Helbling, AR	1
Love, SL	1
Hunt, R	1
Dienemann, J	1
Norton, HJ	1
Hartley, W	1
Hudgens, A	1
Stern, T	1
Divine, G	1
Cotton, JW	1
Rowell, LR	1
Hood, RR	1
Pellegrini, JE	1
Wang, SM	1
Hofstadter, MB	1
Kain, ZN	1
Truhlsen, SM	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
Isopropyl Alcohol Inhalation as Anti-emetic Therapy in the Emergency Department[NCT04464915]		0 participants (Actual)	Interventional	2020-07-31	Withdrawn (stopped due to Given the COVID-19 pandemic, there has been a temporary suspension of study activities, therefore the study has not yet been initiated.)
Inhaled Isopropyl Alcohol Versus Placebo to Manage Nausea at Electronic Dance Music Festivals[NCT04307550]		70 participants (Anticipated)	Interventional	2021-07-12	Recruiting
Nasally Inhaled Isopropyl Alcohol Versus Oral Ondansetron for the Treatment of Nausea in the Emergency Department: A Double-Blind Randomized Controlled Trial[NCT02760069]	Phase 4	122 participants (Actual)	Interventional	2016-01-31	Completed
Inhalation Intervention for Nausea in the Emergency Department[NCT02092441]		80 participants (Actual)	Interventional	2014-04-30	Completed
Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)[NCT03125811]	Early Phase 1	121 participants (Actual)	Interventional	2017-07-17	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Full Scale Name: Nausea 100-mm visual analogue scale. Scale Construct: Measures nausea as reported by the patient Scale Range: Minimum is 0 (no nausea) to 100 (worst nausea imaginable). These values quantify, on an interval scale anchored at 0, the patient's subjective sensation of nausea. Higher values represent worse outcomes (e.g., more nausea). Patient makes a single vertical mark on a 100 mm horizontal line with 0 at the left and 100 on the right to depict their nausea. (NCT02760069)
Timeframe: 30 minutes post intervention

Number of Participants Who Required Rescue Anti-emetics

Intervention	units on a scale (Mean)
Inhaled ISO + Oral Ondansetron	23
Inhaled ISO + Oral Placebo	19
Inhaled Placebo + Oral Ondansetron	42

Whether patient required rescue anti-emetics (binary variable). Measured using nurse drug administration record. (NCT02760069)
Timeframe: Study duration (up to 5 hours post intervention)

Nausea Verbal Numerical Rating Scale (0-10) at 10 Minutes Post Intervention

Intervention	Participants (Count of Participants)
Inhaled ISO + Oral Ondansetron	11
Inhaled ISO + Oral Placebo	10
Inhaled Placebo + Oral Ondansetron	18

"Primary outcome is nausea and vomiting measured on a scale from 0 (no nausea) to 10 (worst nausea imaginable) Verbal Numerical Response Scale (VNRS) at 10 minutes post intervention." (NCT02092441)
Timeframe: 10 minutes post intervention

Satisfaction Measured on a 5-point Likert Scale

Intervention	VNRS (Median)
Alcohol Prep Pad Group	3
Normal Saline Prep Pad	6

"Patient satisfaction of smelling prep pad to alleviate nausea on a scale from 1 (completely unsatisfied) to 5 (completely satisfied)" (NCT02092441)
Timeframe: 10 minutes post intervention

Verbal Numerical Rating Scale Pain Score (0-10) at 10 Minutes Post Intervention

Intervention	5 point Likert Scale (Median)
Alcohol Prep Pad Group	4
Normal Saline Prep Pad	2

"Scale ranges from 0 (no pain) to 10 (worst pain imaginable)" (NCT02092441)
Timeframe: 10 minutes post intervention

Article	Year
Inhalation of Isopropyl Alcohol for the Management of Nausea and Vomiting: A Systematic Review. Journal of palliative medicine, 2023, Volume: 26, Issue:1 Topics: 2-Propanol; Antiemetics; Female; Humans; Nausea; Pregnancy; Single-Blind Method; Vomiting	2023
Isopropyl alcohol inhalation for the treatment of nausea in adult emergency department patients: a systematic review and meta-analysis. Emergency medicine journal : EMJ, 2023, Volume: 40, Issue:9 Topics: 2-Propanol; Adult; Emergency Service, Hospital; Humans; Nausea; Ondansetron; Vomiting	2023
Isopropyl alcohol inhalation versus 5-HT European journal of clinical pharmacology, 2023, Volume: 79, Issue:11 Topics: 2-Propanol; Antiemetics; Humans; Nausea; Serotonin; Serotonin 5-HT3 Receptor Antagonists	2023

Article	Year
Isopropyl alcohol nasal inhalation for nausea in the triage of an adult emergency department. The American journal of emergency medicine, 2021, Volume: 41 Topics: 2-Propanol; Administration, Inhalation; Adolescent; Adult; Aged; Double-Blind Method; Emergency Serv	2021
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial. Annals of emergency medicine, 2018, Volume: 72, Issue:2 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Antiemetics; Aromatherapy; Doub	2018
Praxis, 2018, Volume: 107, Issue:14 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Emergency Service, Hospital; Fe	2018
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Isopropyl Alcohol Nasal Inhalation for Nausea in the Emergency Department: A Randomized Controlled Trial. Annals of emergency medicine, 2016, Volume: 68, Issue:1 Topics: 2-Propanol; Administration, Intranasal; Adult; Antiemetics; Double-Blind Method; Emergency Service,	2016
Aromatherapy as treatment for postoperative nausea: a randomized trial. Anesthesia and analgesia, 2013, Volume: 117, Issue:3 Topics: 2-Propanol; Adult; Ambulatory Surgical Procedures; Antiemetics; Aromatherapy; Data Interpretation, S	2013
A comparative analysis of isopropyl alcohol and ondansetron in the treatment of postoperative nausea and vomiting from the hospital setting to the home. AANA journal, 2007, Volume: 75, Issue:1 Topics: 2-Propanol; Adult; Antiemetics; Female; Humans; Laparoscopy; Nausea; Ondansetron; Postoperative Comp	2007
An alternative method to alleviate postoperative nausea and vomiting in children. Journal of clinical anesthesia, 1999, Volume: 11, Issue:3 Topics: 2-Propanol; Administration, Inhalation; Adolescent; Antiemetics; Child; Double-Blind Method; Female;	1999

Article	Year
Inhaled isopropyl alcohol for nausea and vomiting in the emergency department. Canadian family physician Medecin de famille canadien, 2018, Volume: 64, Issue:8 Topics: 2-Propanol; Administration, Inhalation; Emergency Service, Hospital; Humans; Nausea; Ondansetron; Pa	2018
Inhaling isopropyl alcohol from alcohol wipes was amore effective antiemetic than oral ondansetron in nauseated adults. Archives of disease in childhood. Education and practice edition, 2020, Volume: 105, Issue:3 Topics: 2-Propanol; Administration, Inhalation; Administration, Oral; Adult; Aged; Aged, 80 and over; Antiem	2020
Three versus five corneoscleral sutures. A comparison of complications and results in 400 cataract operations. American journal of ophthalmology, 1968, Volume: 66, Issue:5 Topics: Adult; Aged; Anterior Chamber; Astigmatism; Cataract Extraction; Corneal Injuries; Eye Diseases; Fem	1968
Three versus five corneoscleral sutures: a comparison of complications and results in 400 cataract operations. Transactions of the American Ophthalmological Society, 1968, Volume: 66 Topics: Adult; Aged; Anterior Chamber; Astigmatism; Cataract Extraction; Cornea; Eye Diseases; Eye Injuries;	1968

2-propanol and Nausea