Page last updated: 2024-10-29

2-propanol and Melanosis

2-propanol has been researched along with Melanosis in 33 studies

2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.

Melanosis: Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.

Research Excerpts

ExcerptRelevanceReference
"To investigate the incidence of iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients by a prospective and observer-masked study."9.09Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients. ( Abe, K; Chiba, T; Furuichi, M; Iijima, H; Kashiwagi, K; Kogure, S; Shibuya, T; Tsukahara, S, 2001)
"To investigate the incidence of iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients by a prospective and observer-masked study."5.09Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients. ( Abe, K; Chiba, T; Furuichi, M; Iijima, H; Kashiwagi, K; Kogure, S; Shibuya, T; Tsukahara, S, 2001)
"To examine the histopathologic features of iridectomy specimens from patients undergoing glaucoma surgery and to compare histologic abnormalities in a group of patients with a history of latanoprost therapy with those in a group of patients who had no history of prostaglandin therapy (controls)."3.72A study of iridectomy histopathologic features of latanoprost- and non-latanoprost-treated patients. ( Albert, DM; Damico, CM; Fisher, MR; Gangnon, RE; Gleiser, J; Green, WR; Grossniklaus, HE; Zimbric, ML, 2004)
"Naevi or freckles on iris, conjunctiva, or eye lids were not affected."2.68The incidence and time-course of latanoprost-induced iridial pigmentation as a function of eye color. ( Olsson, K; Stjernschantz, J; Wistrand, PJ, 1997)
"Most freckles were observed in the inferior temporal quadrant."1.46Iris Freckles a Potential Biomarker for Chronic Sun Damage. ( Hofmann-Wellenhof, R; Langmann, G; Mayer, C; Richtig, E; Richtig, G; Richtig, M; Riedl, R; Schwab, C; Tarmann, L; Wackernagel, W; Wedrich, A; Zalaudek, I, 2017)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199016 (48.48)18.7374
1990's3 (9.09)18.2507
2000's8 (24.24)29.6817
2010's2 (6.06)24.3611
2020's4 (12.12)2.80

Authors

AuthorsStudies
Ozturk Durmaz, E1
Ridge, A1
Lim, BCW1
Avalos, G1
Laing, M1
Featherstone, HJ1
Scurrell, EJ1
Rhodes, M1
Pinheiro de Lacerda, R1
Mozo Cuadrado, M1
Tabuenca Del Barrio, L1
Schwab, C1
Mayer, C1
Zalaudek, I1
Riedl, R1
Richtig, M1
Wackernagel, W1
Hofmann-Wellenhof, R1
Richtig, G1
Langmann, G1
Tarmann, L1
Wedrich, A1
Richtig, E1
Elyadari, M1
Zarrouki, M1
Elorch, H1
Elharchali, S1
Elmerrouni, S1
Azennoud, S1
Hajji, Z1
Abdallah, E1
Boulanoir, A1
Berraho, A1
Shields, JA1
Shields, CL1
Davidson, R1
Eagle, RC1
Bivolaru, I1
Selaru, D1
Serghiescu, I1
VRABEC, J1
STAFFORD, WR1
ROE, FJ2
MILLICAN, D1
MALLETT, JM1
JUNCEDA, J1
Arranz-Marquez, E1
Teus, MA1
Saornil, MA1
Mendez, MC1
Gil, R1
Albert, DM2
Gangnon, RE2
Zimbric, ML1
Damico, CM1
Fisher, MR1
Gleiser, J1
Grossniklaus, HE2
Green, WR2
Darjatmoko, S1
Kulkarni, AD1
Rennie, IG1
Bleehen, SS1
Ragge, NK1
Acheson, J1
Murphree, AL1
Selén, G1
Stjernschantz, J2
Resul, B1
Wistrand, PJ1
Olsson, K1
Taylor, GN1
Lloyd, RD1
Miller, SC1
Muggenburg, BA1
Chiba, T1
Kashiwagi, K1
Kogure, S1
Abe, K1
Shibuya, T1
Furuichi, M1
Iijima, H1
Tsukahara, S1
Tsai, JC1
Sivak-Callcott, JA1
Haik, BG1
Zhang, J1
McLean, IW1
Tinning, S1
Mevorah, B1
Frenk, E1
Delacrétaz, J1
Weingeist, TA1
Kupfer, C1
Kuwabara, T1
Kaiser-Kupfer, M1
Babel, J1
Schmack, W1
Vogel, MH1
Dähler, H1
Scherz, W1
Henkind, P1
Friedman, AH1
Kendrey, G1
Stucchi, CA1
Kessous-Odermatt, FL1
Paul, EV1
Zimmerman, LE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Latanoprost, Bimatoprost and Travoprost on Periocular Skin Pigmentation[NCT00705757]Phase 489 participants (Actual)Interventional2008-03-31Completed
Pigment Dispersion Syndrome With and Without Glaucoma[NCT00001152]175 participants Observational1976-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

The Extent of Latanoprost, Bimatoprost and Travoprost Induced Periocular Skin Hyperpigmentation Over a One Year Time Course in Newly Diagnosed Primary Open Angle and Ocular Hypertension Patients.

"Periocular skin color was measured with the Minolta Chroma Meter CR-400 and the L*a*b* system, also known as Commission Internationale de l'Eclairage. This is a well-accepted unit of measurement in which L* corresponds to brightness and a* and b* correspond to chromaticity.~Measurements were taken at baseline and 1 year. Data from each time point and each location (upper and lower eyelids or cheeks/face) were averaged, and subtracted from the baseline value for that location. Six predetermined areas on and around the upper and lower eyelid and 2 areas of the face/cheek were measured.Upper and lower eyelid values were averaged and reported as single value for each location ie;-upper eyelids, lower eyelid and cheek/face. A decrease in luminance indicates increased pigmentation at the site of measurement." (NCT00705757)
Timeframe: one year

,,
InterventionL*a*b* (Mean)
Upper LidLower LidCheek/Face
Lumigan-0.90-0.370.30
Travatan-0.900.170.51
Xalatan-1.420.480.55

Trials

2 trials available for 2-propanol and Melanosis

ArticleYear
The incidence and time-course of latanoprost-induced iridial pigmentation as a function of eye color.
    Survey of ophthalmology, 1997, Volume: 41 Suppl 2

    Topics: Adrenergic beta-Antagonists; Double-Blind Method; Europe; Eye Color; Glaucoma; Humans; Incidence; In

1997
Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients.
    Journal of glaucoma, 2001, Volume: 10, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Eye Color; Female; Glaucoma; Humans; Incide

2001

Other Studies

31 other studies available for 2-propanol and Melanosis

ArticleYear
Chalk-white fluorescence under Wood light in a case of terra firma-forme dermatosis.
    Clinical and experimental dermatology, 2021, Volume: 46, Issue:1

    Topics: 2-Propanol; Calcium Carbonate; Dermoscopy; Diagnosis, Differential; Fluorescence; Humans; Hyperpigme

2021
The iris clue: blue-grey periphery, blue collarette and absence of freckles predict risk of skin cancer in a Northern European population.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2022, Volume: 36, Issue:7

    Topics: Humans; Iris; Melanosis; Skin Neoplasms; White People

2022
Iris biopsy to investigate feline iris hyperpigmentation.
    Veterinary ophthalmology, 2020, Volume: 23, Issue:2

    Topics: Animals; Biopsy; Cat Diseases; Cats; Female; Hyperpigmentation; Iris; Iris Neoplasms; Male; Melanoma

2020
Iris mammillations: Images and OCT findings.
    Journal francais d'ophtalmologie, 2020, Volume: 43, Issue:10

    Topics: Amblyopia; Female; Humans; Iris; Iris Diseases; Melanosis; Pigmentation Disorders; Scleral Diseases;

2020
Iris Freckles a Potential Biomarker for Chronic Sun Damage.
    Investigative ophthalmology & visual science, 2017, 05-01, Volume: 58, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Child; Child, Preschool; Chronic Dise

2017
[Ocular melanocytosis].
    Journal francais d'ophtalmologie, 2018, Volume: 41, Issue:1

    Topics: Eye Diseases; Humans; Iris; Male; Melanosis; Morocco; Sclera; Young Adult

2018
Iris melanoma arising from sector congenital ocular melanocytosis in a child.
    Cornea, 2009, Volume: 28, Issue:10

    Topics: Adolescent; Eye Diseases; Humans; Iris; Iris Neoplasms; Male; Melanocytes; Melanoma; Melanosis; Micr

2009
[Congenital ocular melanocytosis and delayed psycho-intellectual development--a new association?].
    Oftalmologia (Bucharest, Romania : 1990), 2009, Volume: 53, Issue:4

    Topics: Child; Developmental Disabilities; Diagnosis, Differential; Eye Diseases; Humans; Iris; Male; Melano

2009
[Bilateral isolated melanosis of the iris].
    Ceskoslovenska oftalmologie, 1959, Volume: 15, Issue:1

    Topics: Humans; Iris; Iris Diseases; Melanosis

1959
Congenital melanosis oculi. Report of a case.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1962, Volume: 68

    Topics: Eye Abnormalities; Humans; Iris; Melanosis; Sclera

1962
INDUCTION OF MELANOTIC LESIONS OF THE IRIS IN RATS BY URETHANE GIVEN DURING THE NEONATAL PERIOD.
    Nature, 1963, Sep-21, Volume: 199

    Topics: Animals; Animals, Newborn; Eye Neoplasms; Iris; Melanoma; Melanosis; Rats; Research; Toxicology; Ure

1963
NEVUS OF OTA.
    American journal of ophthalmology, 1965, Volume: 59

    Topics: Child; Congenital Abnormalities; Conjunctiva; Eye Diseases; Humans; Iris; Melanosis; Nevus; Nevus of

1965
Analysis of irises with a latanoprost-induced change in iris color.
    American journal of ophthalmology, 2004, Volume: 138, Issue:4

    Topics: Aged; Antihypertensive Agents; Biopsy; Exfoliation Syndrome; Eye Color; Female; Glaucoma, Open-Angle

2004
A study of iridectomy histopathologic features of latanoprost- and non-latanoprost-treated patients.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2004, Volume: 122, Issue:11

    Topics: Antihypertensive Agents; Eye Color; Female; Glaucoma; Humans; Intraocular Pressure; Iridectomy; Iris

2004
A study of histopathological features of latanoprost-treated irides with or without darkening compared with non-latanoprost-treated irides.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2008, Volume: 126, Issue:5

    Topics: Antihypertensive Agents; Endothelium, Vascular; Fibroblasts; Glaucoma; Humans; Iridectomy; Iris; Iri

2008
Melanosis oculi. An ultrastructural study of an affected iris.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1983, Volume: 101, Issue:12

    Topics: Aged; Eye Diseases; Female; Humans; Iris; Iris Diseases; Melanocytes; Melanosis

1983
Iris mammillations: significance and associations.
    Eye (London, England), 1996, Volume: 10 ( Pt 1)

    Topics: Adult; Child; Child, Preschool; Female; Humans; Iris; Iris Diseases; Iris Neoplasms; Male; Melanosis

1996
Prostaglandin-induced iridial pigmentation in primates.
    Survey of ophthalmology, 1997, Volume: 41 Suppl 2

    Topics: Administration, Topical; Animals; Dinoprost; Dinoprostone; Eye Color; Iris; Iris Diseases; Latanopro

1997
Radium-induced eye melanomas in dogs.
    Health physics, 2000, Volume: 79, Issue:2

    Topics: Animals; Ciliary Body; Dogs; Dose-Response Relationship, Drug; Eye Neoplasms; Hyperplasia; Injection

2000
Latanoprost-induced iris heterochromia and open-angle glaucoma: a clinicopathologic report.
    Journal of glaucoma, 2001, Volume: 10, Issue:5

    Topics: Antihypertensive Agents; Diagnosis, Differential; Female; Glaucoma, Open-Angle; Humans; Intraocular

2001
Malignant melanoma of the conjunctiva and the iris in a case of primary acquired melanosis of the conjunctiva.
    Acta ophthalmologica, 1978, Volume: 56, Issue:5

    Topics: Aged; Conjunctiva; Eye Diseases; Eye Neoplasms; Eyelid Neoplasms; Female; Humans; Iris; Melanoma; Me

1978
Dermal melanocytosis. Report of an unusual case.
    Dermatologica, 1977, Volume: 154, Issue:2

    Topics: Adult; Diagnosis, Differential; Female; Humans; Iris; Melanocytes; Melanosis; Nevus; Skin Diseases;

1977
The pigmentary dispersion syndrome and glaucoma.
    Ophthalmic seminars, 1976, Volume: 1, Issue:4

    Topics: Adult; Age Factors; Aged; Atrophy; Corneal Diseases; Epithelium; Eye Diseases; Female; Glaucoma; Hum

1976
The histopathology of pigmentary dispersion syndrome with glaucoma.
    American journal of ophthalmology, 1975, Volume: 80, Issue:5

    Topics: Atrophy; Cornea; Epithelial Cells; Epithelium; Female; Glaucoma; Humans; Iris; Melanosis; Middle Age

1975
[Tumors of the iris].
    Archives d'ophtalmologie et revue generale d'ophtalmologie, 1968, Volume: 28, Issue:8

    Topics: Adult; Choroid Neoplasms; Ciliary Body; Eye Neoplasms; Glaucoma; Hemangioma; Humans; Intraocular Pre

1968
[Unilateral melanosis of the iris and ciliary body with glaucoma].
    Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1972, Volume: 71

    Topics: Adult; Ciliary Body; Diagnosis, Differential; Eye Neoplasms; Female; Glaucoma; Humans; Iris; Melanos

1972
[Clinical aspects of malignant melanoma of the iris (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1974, Volume: 164, Issue:2

    Topics: Adult; Cysts; Diagnosis, Differential; Eye Diseases; Eye Neoplasms; Female; Fibroma; Granuloma; Hema

1974
External ocular pigmentation.
    International ophthalmology clinics, 1971,Fall, Volume: 11, Issue:3

    Topics: Adult; Aged; Conjunctiva; Epinephrine; Eye Diseases; Eye Neoplasms; Eyelid Neoplasms; Facial Neoplas

1971
Melanotic lesions of the eye in August hooded rats induced by urethan or N-hydroxyurethan given during the neonatal period: a histopathological study.
    Journal of the National Cancer Institute, 1969, Volume: 43, Issue:4

    Topics: Animals; Carcinogens; Choroid Neoplasms; Ciliary Body; Eye Diseases; Eye Neoplasms; Female; Injectio

1969
[Benign congenital ocular melanosis].
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1970, Volume: 161, Issue:2

    Topics: Adolescent; Adult; Child; Conjunctiva; Eye Diseases; Female; Humans; Iris; Male; Melanosis; Middle A

1970
Some observations on the ocular pathology of onchocerciasis.
    Human pathology, 1970, Volume: 1, Issue:4

    Topics: Adult; Africa; Anterior Chamber; Blindness; Central America; Choroiditis; Congo; Conjunctivitis; Cor

1970