2-propanol and Glaucoma studies

2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.

Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Research Excerpts

Excerpt	Relevance	Reference
"The efficacy and safety of bimatoprost, a member of a new class of pharmacological agents called prostamides, were compared with the efficacy and safety of timolol in patients with glaucoma or ocular hypertension."	9.09	Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. ( Brandt, J; Sherwood, M, 2001)
"To investigate the incidence of iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients by a prospective and observer-masked study."	9.09	Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients. ( Abe, K; Chiba, T; Furuichi, M; Iijima, H; Kashiwagi, K; Kogure, S; Shibuya, T; Tsukahara, S, 2001)
"0% apraclonidine in preventing laser-induced intraocular pressure (IOP) elevation after trabeculoplasty, neodymium: YAG (Nd: YAG) iridotomy, and capsulotomy."	9.08	Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. ( Gieser, DK; Grewal, RK; Karalekas, DP; Krupin, T; McDaniel, DL; Rosenberg, LF; Ruderman, J; Siegfried, C; Williams, R, 1995)
"To measure the concentration of betaxolol in tissues of humans with glaucoma and normal monkeys after topical administration."	7.73	Concentrations of betaxolol in ocular tissues of patients with glaucoma and normal monkeys after 1 month of topical ocular administration. ( Chastain, J; Curtis, M; Dahlin, DC; DeSantis, L; Faulkner, R; Holló, G; McCue, B; Przydryga, J; Sanders, M; Whitson, JT; Wieland, H, 2006)
" The lesion had been known since childhood and increasing intraocular pressure (IOP) was treated with timolole, dipivefrin and finally with latanoprost."	7.72	[Relative contraindication of latanoprost in iris tumors with secondary glaucoma]. ( Fröhlich, SJ; Kampik, A; Mueller, AJ, 2003)
"To determine the incidence of intraocular pressure (IOP) rise of varying degrees after laser peripheral iridotomy (LPI) in patients with and without glaucoma treated perioperatively with pilocarpine and apraclonidine."	7.70	The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. ( Gangnon, R; Heatley, GA; Kaufman, PL; Lewis, R; Perkins, TW, 1998)
"We evaluated the effectiveness of topical apraclonidine (ALO 2145, p-amino clonidine hydrochloride) in suppressing an acute postoperative intraocular pressure (IOP) rise following Nd:YAG laser iridotomy."	7.67	Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy."	7.67	The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"Posterior pupillary synechiae affect a proportion of eyes subjected to iridectomy with or without drainage operation because (1) aqueous humour bypasses the pupil; (2) traumatic iridocyclitis occurs; (3) there is immobility of the iris in the iridectomy sector; (4) in eyes with angle closure glaucoma closer apposition of the iris to the anterior lens capsule increases the tendency; (5) pilocarpine aggravates (4) both in angle closure glaucoma and open angle glaucoma and produces a small immobile pupil facilitating pupillary membrane formation (occlusio pupillae)."	7.67	Posterior synechiae after glaucoma operations: aggravation by shallow anterior chamber and pilocarpine. ( Clark, CV; Levy, AM; Phillips, CI, 1987)
"Tonometry in 9 eyes (7 patients) provides some evidence that timolol eye drops are useful in improving control of pressure in eyes operated for closed-angle glaucoma."	7.66	Timolol in operated closed-angle glaucoma. ( Phillips, CI, 1980)
"By using a continuous wave argon laser in a multiburn fashion, successful iridectomies were achieved in 42 out of 45 phakic eyes with either acute or chronic angle-closure glaucoma."	7.66	Continuous wave argon laser iridectomy in angle-closure glaucoma. ( Anders, MD; Kels, BD; Moss, AP; Podos, SM; Ritch, R, 1979)
"In the last four years we have treated with the mobile argon-laser beam 25 cases of aphakic pupillary block glaucoma (p."	7.66	[Clinical and pathologic-anatomical results following the application of a mobile argon-laser beam in aphakic pupillary block glaucoma (author's transl)]. ( Kouris-Bairaktari, E; Theodossiadis, G; Velissaropoulos, P, 1979)
"Forty-nine patients with bilateral pigmentary dispersion syndrome (abnormal accumulation of pigment in the anterior chamber, principally from the posterior layers of the iris), including 31 patients with pigmentary glaucoma, underwent 10% phenylephrine testing in one eye for evaluation of liberation of pigment floaters into the anterior chamber and the influence of phenylephrine on the intraocular pressure."	7.66	Phenylephrine provocative testing in the pigmentary dispersion syndrome. ( Boger, WP; Epstein, DL; Grant, WM, 1978)
"Gas argon laser peripheral iridectomy was attempted as an alternative to surgical peripheral iridectomy in the treatment of acute angle-closure glaucoma and the prophylactic treatment of fellow eyes."	7.65	Peripheral argon laser iridectomy in narrow-angle glaucoma. ( Dodd, CL; Gupta, R; Lakenpal, GK; Rosen, ES; Sutton, JE, 1976)
"Presbyopia is an early manifestation of physiological ageing resulting in the impossibility to read without additional spectacle correction."	5.32	[Geriatric eye diseases]. ( De Laey, JJ; Tassignon, MJ, 2004)
"The efficacy and safety of bimatoprost, a member of a new class of pharmacological agents called prostamides, were compared with the efficacy and safety of timolol in patients with glaucoma or ocular hypertension."	5.09	Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. ( Brandt, J; Sherwood, M, 2001)
"To investigate the incidence of iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients by a prospective and observer-masked study."	5.09	Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients. ( Abe, K; Chiba, T; Furuichi, M; Iijima, H; Kashiwagi, K; Kogure, S; Shibuya, T; Tsukahara, S, 2001)
"0% apraclonidine in preventing laser-induced intraocular pressure (IOP) elevation after trabeculoplasty, neodymium: YAG (Nd: YAG) iridotomy, and capsulotomy."	5.08	Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. ( Gieser, DK; Grewal, RK; Karalekas, DP; Krupin, T; McDaniel, DL; Rosenberg, LF; Ruderman, J; Siegfried, C; Williams, R, 1995)
"Neodymium:YAG (Nd:YAG) and argon laser iridotomies were compared in a prospective, randomized clinical trial of 43 patients with bilateral chronic pupillary-block glaucoma."	5.06	Neodymium: YAG and argon laser iridotomy. Long-term follow-up in a prospective, randomized clinical trial. ( Del Priore, LV; Pollack, IP; Robin, AL, 1988)
"We conducted a short-term prospective clinical study to evaluate Q-switched neodymium-YAG laser iridotomy in 33 eyes with pupillary block glaucoma in which the argon laser was unable to create an iridotomy."	5.06	Q-switched neodymium-YAG laser iridotomy in patients in whom the argon laser fails. ( Pollack, IP; Robin, AL, 1986)
"One hundred and nineteen eyes from 68 patients with open-angle glaucoma were provoked by means of a pilocarpine phenylephrine provocative test."	5.04	Mechanisms in open-angle glaucoma. ( Mapstone, R, 1978)
"A 54-year-old man with normotensive glaucoma presented with recovery of left lower lid orbital fat pad prolapsus, deepening of the lid sulcus, and iris color and eyelash changes 8 months after initiation of bimatoprost therapy in his left eye (OS)."	4.86	Recovery of orbital fat pad prolapsus and deepening of the lid sulcus from topical bimatoprost therapy: 2 case reports and review of the literature. ( Aydin, S; Işikligil, I; Kir, E; Tekşen, YA, 2010)
"With laser iridotomy, argon laser trabeculoplasties, cyclophotocoagulations with diode laser and Nd: YAG goniopunctures after deep sclerectomy, among other procedures, the laser has offered a very wide range of treatments for managing glaucomatous patients for roughly twenty years."	4.81	[Current place of laser in the management of glaucomas]. ( Detry-Morel, M, 2002)
"Yag laser iridotomy was performed immediately after argon laser application in 59 eyes with chronic angle closure glaucoma, occludable angle and secondary glaucoma."	4.77	[Contribution of the argon laser in iridotomy using the Yag laser]. ( Awaya, S; Harada, T; Mizuno, K, 1989)
"To describe 7 cases of unilateral, chronic and/or recurrent anterior uveitis caused by cytomegalovirus (CMV) in immunocompetent patients; to identify specific ophthalmologic characteristics; and to evaluate the clinical effect of valganciclovir treatment."	3.74	Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients. ( Los, LI; van Boxtel, LA; van der Lelij, A; van der Meer, J, 2007)
" Six others had the abrupt onset of a dense cataract, including 5 with iris atrophy, that occurred during the initial 6 months of therapy with chlorhexidine, a diamidine, and adjunctive corticosteroid."	3.74	Rapidly progressive cataract and iris atrophy during treatment of Acanthamoeba keratitis. ( Herz, NL; Matoba, AY; Wilhelmus, KR, 2008)
"To measure the concentration of betaxolol in tissues of humans with glaucoma and normal monkeys after topical administration."	3.73	Concentrations of betaxolol in ocular tissues of patients with glaucoma and normal monkeys after 1 month of topical ocular administration. ( Chastain, J; Curtis, M; Dahlin, DC; DeSantis, L; Faulkner, R; Holló, G; McCue, B; Przydryga, J; Sanders, M; Whitson, JT; Wieland, H, 2006)
" The lesion had been known since childhood and increasing intraocular pressure (IOP) was treated with timolole, dipivefrin and finally with latanoprost."	3.72	[Relative contraindication of latanoprost in iris tumors with secondary glaucoma]. ( Fröhlich, SJ; Kampik, A; Mueller, AJ, 2003)
"To examine the histopathologic features of iridectomy specimens from patients undergoing glaucoma surgery and to compare histologic abnormalities in a group of patients with a history of latanoprost therapy with those in a group of patients who had no history of prostaglandin therapy (controls)."	3.72	A study of iridectomy histopathologic features of latanoprost- and non-latanoprost-treated patients. ( Albert, DM; Damico, CM; Fisher, MR; Gangnon, RE; Gleiser, J; Green, WR; Grossniklaus, HE; Zimbric, ML, 2004)
"The anterior segments of both eyes of 43 patients with glaucoma were photographed after unilateral latanoprost therapy."	3.71	Incidence of iris colour change in latanoprost treated eyes. ( Arranz-Márquez, E; Lucea-Suescun, P; Teus, MA, 2002)
"To determine the incidence of intraocular pressure (IOP) rise of varying degrees after laser peripheral iridotomy (LPI) in patients with and without glaucoma treated perioperatively with pilocarpine and apraclonidine."	3.70	The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. ( Gangnon, R; Heatley, GA; Kaufman, PL; Lewis, R; Perkins, TW, 1998)
" Visually significant cataract developed in 5/15 re-examined eyes that underwent trabeculectomy alone (33%), possibly associated with pre-existing cataract and diagnosis of angle closure glaucoma, but not with mitomycin C use."	3.70	Long term results of glaucoma surgery among participants in an east African population survey. ( Buhrmann, RR; Isseme, I; Oliva, MS; Quigley, HA; Scudder, M; West, SK, 2000)
"Experimental glaucoma was induced in 1 eye of 6 cynomolgus monkeys by laser treatment of the trabecular meshwork."	3.69	Ocular blood flow in experimental glaucoma: a study in cynomolgus monkeys. ( Alm, A; Lambrou, GN; Mäepea, O; Nilsson, SF; Percicot, C, 1997)
" Out of that 1100 were retinal Argon laser coagulations because of diabetic retinopathy, 200 YAG laser capsulotomies because of secondary cataract, and 30 laser iridotomies because of glaucoma."	3.69	In ophthalmology new possibilities for the use Nd:YAG laser. ( Békési, L; Berta, A; Sohajda, Z, 1997)
"We studied three sector iridectomy specimens from three patients who had undergone neodymium:YAG (Nd:YAG) laser iridotomies 3 to 5 years earlier for treatment of imminent angle closure glaucoma."	3.68	Late histopathological findings of neodymium:YAG laser iridotomies in humans. ( Küchle, M; Naumann, GO; Tetsumoto, K, 1992)
"This paper presents for the first time documented evidence, clinical details, and photographic illustrations of metipranolol-associated granulomatous anterior uveitis in 26 eyes of 15 patients being treated for glaucoma."	3.68	Metipranolol-associated granulomatous anterior uveitis. ( Akingbehin, T; Villada, JR, 1991)
"Various studies were conducted to evaluate the effects of timolol, an S-enantiomer, relative to its R-enantiomer upon intraocular pressure and related ocular systems in the rabbit."	3.67	R-enantiomer of timolol: a potential selective ocular antihypertensive agent. ( Gautheron, P; Gross, DM; Hall, RA; Lotti, VJ; Schmitt, C; Share, NN; Stone, CA, 1984)
"We used a continuous-wave argon laser to produce iridotomies in 28 eyes of 17 patients (12 women and five men ranging in age from 44 to 84 years) with angle-closure glaucoma."	3.67	Corneal endothelial changes after argon laser iridotomy. ( Smith, J; Whitted, P, 1984)
"The antimetabolite 5-fluorouracil (5-FU) was used as adjunctive treatment in glaucomatous eyes with poor prognoses undergoing filtering surgery."	3.67	Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects. ( Weinreb, RN, 1987)
"We evaluated the effectiveness of topical apraclonidine (ALO 2145, p-amino clonidine hydrochloride) in suppressing an acute postoperative intraocular pressure (IOP) rise following Nd:YAG laser iridotomy."	3.67	Use of apraclonidine to reduce acute intraocular pressure rise following Q-switched Nd:YAG laser iridotomy. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"cAMP and cGMP contents were studied in various eye tissues of rabbits with experimental glaucoma induced by chronic intravenous adrenaline administration."	3.67	[Cyclic nucleotides in experimental glaucoma]. ( Kashintseva, LT; Kopp, OP; Kryshanowskiĭ, GN; Lipovetskaia, EM; Mikheĭtseva, IN, 1988)
"We evaluated the ability of topical clonidine to suppress an acute rise in postoperative intraocular pressure (IOP) following Nd:YAG laser iridotomy."	3.67	The prevention of an acute rise in intraocular pressure following Q-switched Nd:YAG laser iridotomy with clonidine. ( Kitazawa, Y; Sugiyama, K; Taniguchi, T, 1989)
"Cystinosis is a rare autosomal recessive metabolic disorder that results in the widespread accumulation of cystine crystals in ocular tissues as well as in bone marrow, liver, spleen, lymph nodes, and kidneys."	3.67	Pupillary-block glaucoma associated with childhood cystinosis. ( Minckler, DS; Rao, NA; Wan, WL, 1986)
"Posterior pupillary synechiae affect a proportion of eyes subjected to iridectomy with or without drainage operation because (1) aqueous humour bypasses the pupil; (2) traumatic iridocyclitis occurs; (3) there is immobility of the iris in the iridectomy sector; (4) in eyes with angle closure glaucoma closer apposition of the iris to the anterior lens capsule increases the tendency; (5) pilocarpine aggravates (4) both in angle closure glaucoma and open angle glaucoma and produces a small immobile pupil facilitating pupillary membrane formation (occlusio pupillae)."	3.67	Posterior synechiae after glaucoma operations: aggravation by shallow anterior chamber and pilocarpine. ( Clark, CV; Levy, AM; Phillips, CI, 1987)
"Iridotomy with red krypton laser instead of blue-green argon laser was performed on 68 eyes with various types of angle-closure glaucoma."	3.67	Iridotomy with red krypton laser. ( David, R; Marmour, U; Rosenblatt, I; Yassur, Y, 1986)
"In aging eyes phenylephrine drops have no significant effect on the depth of the anterior chamber, whereas pilocarpine drops produce a significant shallowing."	3.66	Acute shallowing of the anterior chamber. ( Mapstone, R, 1981)
"Currently employed techniques utilizing a continuous wave argon laser for the production of peripheral iridotomies in the treatment of angle-closure glaucoma are successful in producing patient iridotomies; however, complications such as corneal, lenticular, and retinal burns have been experienced."	3.66	Short exposure times in argon laser iridotomy. ( Mandelkorn, RM; Mendelsohn, AD; Olander, KW; Zimmerman, TJ, 1981)
"The tertiary nitrogen derivative of carbachol, N-demethylated carbachol, was synthesized to produce a drug that could be used as an alternative to pilocarpine in the treatment of open-angle glaucoma."	3.66	Effects of N-demethylated carbachol on iris and ciliary muscles. ( Chiou, GC; Trzeciakowski, J, 1980)
"Tonometry in 9 eyes (7 patients) provides some evidence that timolol eye drops are useful in improving control of pressure in eyes operated for closed-angle glaucoma."	3.66	Timolol in operated closed-angle glaucoma. ( Phillips, CI, 1980)
"By using a continuous wave argon laser in a multiburn fashion, successful iridectomies were achieved in 42 out of 45 phakic eyes with either acute or chronic angle-closure glaucoma."	3.66	Continuous wave argon laser iridectomy in angle-closure glaucoma. ( Anders, MD; Kels, BD; Moss, AP; Podos, SM; Ritch, R, 1979)
"In the last four years we have treated with the mobile argon-laser beam 25 cases of aphakic pupillary block glaucoma (p."	3.66	[Clinical and pathologic-anatomical results following the application of a mobile argon-laser beam in aphakic pupillary block glaucoma (author's transl)]. ( Kouris-Bairaktari, E; Theodossiadis, G; Velissaropoulos, P, 1979)
"Forty-nine patients with bilateral pigmentary dispersion syndrome (abnormal accumulation of pigment in the anterior chamber, principally from the posterior layers of the iris), including 31 patients with pigmentary glaucoma, underwent 10% phenylephrine testing in one eye for evaluation of liberation of pigment floaters into the anterior chamber and the influence of phenylephrine on the intraocular pressure."	3.66	Phenylephrine provocative testing in the pigmentary dispersion syndrome. ( Boger, WP; Epstein, DL; Grant, WM, 1978)
"During the course of negative provocative test for closed-angle glaucoma using pilocarpine and phenylephrine 60% of eyes develop significant reductions in outflow facility at some stage during the test."	3.65	Partial angle closure. ( Mapstone, R, 1977)
"An evaluation of 70 trabecular meshwork biopsies obtained at the time of therapeutic surgery in glaucomatous and cataractous eyes revealed that the mesothelial cells in the iridocorneal angle had a marked abundance of cilia and centrioles."	3.65	Centrioles and cilia in the mesothelial cells of the pericanalicular region. ( Wickham, MG; Worthen, DM, 1976)
"Argon laser photomydriasis was used to enlarge 20 miotic pupils in 18 open-angle glaucoma patients, with beneficial visual results in patients properly selected before treatment."	3.65	Argon laser photomydriasis. ( de Roetth, A; Forbes, M; James, WA; L'Esperance, FA, 1976)
"Gas argon laser peripheral iridectomy was attempted as an alternative to surgical peripheral iridectomy in the treatment of acute angle-closure glaucoma and the prophylactic treatment of fellow eyes."	3.65	Peripheral argon laser iridectomy in narrow-angle glaucoma. ( Dodd, CL; Gupta, R; Lakenpal, GK; Rosen, ES; Sutton, JE, 1976)
" All of the eyes had no light perception and had angle-closure glaucoma."	3.65	Optic nerve extension of intraocular neoplasms. ( Spencer, WH, 1975)
"Patients with primary angle closure glaucoma/PAC are 10 times more likely to maintain drop-free good IOP control with initial CLE surgery than LPI."	3.30	Predictors of long-term intraocular pressure control after lens extraction in primary angle closure glaucoma: results from the EAGLE trial. ( Azuara-Blanco, A; Burr, J; Chang, D; Cochran, C; Cooper, D; Foster, PJ; Friedman, D; Halawa, O; Mitchell, WG; Norrie, J; Ramsay, CR, 2023)
"Primary angle closure glaucoma is the main type of glaucoma in Asia."	2.82	[Progress in the research of plateau iris]. ( Wu, LL; Yan, YJ, 2022)
"Glaucoma is a serious complication associated with this disorder."	2.82	A systematic approach to the management of microspherophakia. ( Haripriya, A; Mohan, N; Rajendran, A; Venkataraman, P, 2022)
"Aniridia is a pan-ocular genetic developmental eye disorder characterized by complete or partial iris and foveal hypoplasia, for which there is no treatment currently."	2.82	( Abdolkarimi, D; Cunha, DL; Lahne, M; Moosajee, M, 2022)
"Naevi or freckles on iris, conjunctiva, or eye lids were not affected."	2.68	The incidence and time-course of latanoprost-induced iridial pigmentation as a function of eye color. ( Olsson, K; Stjernschantz, J; Wistrand, PJ, 1997)
"In eyes treated with PI/LI and ALT, the IOP control was improved in 12 per cent, unchanged in 30 per cent and remained uncontrolled in 58 per cent."	2.66	Argon laser trabeculoplasty in narrow angle glaucoma. ( Hitchings, RA; Nagasubramanian, S; Wishart, PK, 1987)
"Weill-Marchesani syndrome was then diagnosed by ocular examinations, and was accompanied by systemic abnormalities, including brachymorphia and brachydactyly."	2.52	Weill-Marchesani syndrome with advanced glaucoma and corneal endothelial dysfunction: a case report and literature review. ( Cai, K; Guo, H; Qiao, Z; Wu, X, 2015)
"Congenital glaucoma is generally related to an iridocorneal angle malformation, with an obstacle to aqueous humor outflow."	2.43	[Congenital glaucoma and trabeculodysgenesis. Clinical and genetic aspects]. ( Dureau, P, 2006)
"The echocardiogram revealed an atrial septal defect with interatrial aneurysm."	2.41	Atrial septal defect with interatrial aneurysm and Axenfeld-Rieger syndrome. ( Bekir, NA; Güngör, K, 2000)
"Axenfeld-Rieger syndrome is a term that can be used to describe a variety of overlapping phenotypes."	2.41	Axenfeld-Rieger syndrome in the age of molecular genetics. ( Alward, WL, 2000)
"Bimatoprost (Lumigan) is a pharmacologically unique and highly efficacious ocular hypotensive agent."	2.41	The pharmacology of bimatoprost (Lumigan). ( Andrews, SW; Archeampong, A; Brar, B; Burk, RM; Chen, J; Chen, R; Garst, ME; Gil, DW; Kaplan, LJ; Kedzie, KM; Kharlamb, A; Krauss, AH; Lai, RK; Liang, Y; Ling, J; Madhu, C; Ni, J; Rix, P; Shi, L; Spada, CS; Tang-Liu, DD; Usansky, H; Usansky, J; Weber, A; Welty, D; Wheeler, LA; Woodward, DF; Yang, W, 2001)
"Acute angle-closure glaucoma is best treated by iridectomy."	2.38	[Surgical therapy of glaucoma]. ( Grehn, F, 1990)
"Cataract and glaucoma are the most important complications."	2.37	Doyne lecture. Heterochromic iridocyclitis. ( O'Connor, GR, 1985)
"This complex case of chronic angle closure glaucoma with an atypical pupillary membrane highlights the importance of maintaining a broad differential and ruling out secondary pathologies such as iris melanoma."	1.91	Chronic angle closure glaucoma with an atypical iris-pupillary membrane. ( Amarasekera, DC; Lam, SS; Razeghinejad, R, 2023)
"Glaucoma is often associated with elevated intraocular pressure (IOP), generally due to obstruction of aqueous humor outflow within the trabecular meshwork (TM)."	1.91	A method describing the microdissection of trabecular meshwork tissue from Brown Norway rat eyes. ( Cepurna, WO; Chan, F; Ing, E; Keller, KE; Lozano, DC; Morrison, JC; Yang, YF, 2023)
"In January 2021, we found one case of Axenfeld-Rieger syndrome combined with pigment dispersion syndrome (PDS), and this patient additionally manifested a symptom of ectropion uveae."	1.91	Axenfeld-Rieger syndrome combined with ectropion uveae and pigment dispersion syndrome: A case report. ( Bi, H; Li, Y; Liu, J; Ma, X; Tian, Q; Zhao, Y, 2023)
"Two cases with a recent history of coronavirus disease 2019 (COVID-19) presented with a complaint of decreased vision."	1.91	Bilateral Acute Iris Transillumination and Elevated Intraocular Pressure After COVID-19 Infection. ( Evereklioglu, C; Gulmez Sevim, D; Sener, H, 2023)
" The main side effect was dry eye syndrome in both groups, but severe side effects such as limbal stem cell failure were found only in the wPBR group (4/51; 7."	1.91	Side Effects of Proton Beam Radiotherapy Treatment on Iris Melanoma. ( Eibenberger, K; Gatchalian, L; Heimann, H; Hussain, R; Kacperek, A, 2023)
"Iridocorneal endothelial syndrome is a rare ophthalmic disease, most of which are unilateral and common in women."	1.72	[A case of atypical iris corneal endothelial syndrome]. ( Chen, H; Cheng, SM; Cheng, YY; Xu, HJ; Yin, J, 2022)
"Myopia is a known risk factor of pigmentary glaucoma (PG), and the increased prevalence of myopia in Asian countries indicates that more cases of PG will likely develop soon."	1.72	Characteristics of pigmentary glaucoma in Japanese individuals. ( Fujiwara, K; Sakamoto, T; Shiihara, H; Tanaka, M; Terasaki, H; Yamashita, T, 2022)
"Iris inclusion cysts are not uncommon; however, ocular outcomes are generally benign and limited to obstruction of the pupillary axis."	1.72	Spontaneous rupture of secondary iris inclusion cyst causing acute glaucoma and other ocular sequelae. ( Allen, JC; Craven, C; Jones, JK; Price, KW; Shabto, JM; Wells, J, 2022)
"We herein describe the kissing MVR technique in cases of microspherophakia for safe and effective endocapsular lens aspiration."	1.72	Kissing microvitreoretinal blade technique: A novel approach for safe and effective endocapsular lens aspiration in microspherophakia. ( Sharma, N; Singh, R; Titiyal, JS; Urkude, J, 2022)
"Glaucoma combined with diabetes complications may increase the biomechanical damage of IOP to the whole eye."	1.72	Correlation study of biomechanical changes between diabetic eye disease and glaucoma using finite element model of human eye with different iris-lens channel distances. ( Cao, Y; Shi, H; Xie, Z; Yan, Y; Zhao, Y, 2022)
"Uveal melanoma is the most common primary malignancy of the eye in adults."	1.62	Iris melanoma with ciliary body infiltration presenting as a presumed chronic unilateral inflammatory glaucoma. The challenges of iris tumor biopsy assessment. ( Adamski, W; Brązert, A; Marszałek, A; Rospond-Kubiak, I; Stodolska-Nowak, A; Sygut, J, 2021)
"Reduction of the intraocular pressure is often a symptomatic therapy with surgical, pressure lowering procedures showing a limited success rate in many forms of secondary angle closure glaucoma."	1.62	[Secondary Angle Closure Glaucoma]. ( Lübke, J; Nüßle, S, 2021)
"Ocular siderosis is induced by a retained intraocular foreign body (IOFB) containing iron and can present as siderotic glaucoma."	1.56	Siderotic glaucoma without detectable intraocular foreign body in a pseudophakic eye: a case report. ( Huang, Y; Li, Z; Ye, Z, 2020)
"The intraocular pressure was refractory to maximal medical treatment, but was eventually controlled with trans-scleral diode laser cyclo-photocoagulation."	1.48	Secondary Glaucoma due to Iridescent Crystalline Particles Masquerading as Refractory Hypertensive Uveitis in an Eye With Irradiated Iris Melanoma. ( Bansal, A; Chahal, R; Heimann, H; Mohite, AA, 2018)
"Glaucoma is a common cause of visual impairment in the Veterans Affairs (VA) health care system, but to our knowledge, no data exist concerning tertiary glaucoma care (ie, laser and filtering surgery)."	1.48	Differences in Tertiary Glaucoma Care in the Veterans Affairs Health Care System. ( Cockerham, G; Lee, AY; Lee, CS; Lynch, MG; Maa, AY; Pieters, M, 2018)
"Intraocular pressure was measured weekly, electrophysiology and optical coherence tomography every 6 weeks."	1.46	DBA/2J mouse model for experimental glaucoma: pitfalls and problems. ( Graham, SL; Gupta, V; Klistorner, A; Turner, AJ; Vander Wall, R, 2017)
"Glaucoma was equally common in both groups."	1.46	Biometric and structural ocular manifestations of Marfan syndrome. ( Gehle, P; Goergen, B; Pilger, D; Robinson, PN; Ruokonen, P; Salchow, DJ, 2017)
"Glaucoma was found in 156 eyes (70%) at presentation and the median (Q1, Q3) intraocular pressure in eyes with glaucoma was 24 (16, 38) mm Hg."	1.46	Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects. ( Chandran, P; Choudhari, NS; Garudadri, CS; Mandal, AK; Rao, HL; Senthil, S, 2017)
"Urrets-Zavalia syndrome is an uncommon complication of the deep anterior lamellar keratoplasty in keratoconus."	1.43	Urrets-Zavalia syndrome after deep anterior lamellar keratoplasty ( Jovanović, V; Nikolić, L, 2016)
"Glaucomas treatment."	1.43	[Glaucoma treatment]. ( Bluwol, E, 2016)
"Glaucoma is the primary cause of irreversible blindness worldwide associated with high intraocular pressure (IOP)."	1.43	Fluid and structure coupling analysis of the interaction between aqueous humor and iris. ( Liu, Z; Qian, X; Song, H; Wang, W; Zhang, M, 2016)
"Management of glaucoma is difficult with the IOP remaining high in spite of combined medical and surgical management."	1.42	Visual outcome and incidence of glaucoma in patients with microspherophakia. ( Ankush, K; George, VP; Muralidhar, R; Vijayalakshmi, P, 2015)
"Aniridia is a rare panocular disorder characterized by iris hypoplasia and other associated eye anomalies."	1.42	Mutational analysis and genotype-phenotype correlations in southern Indian patients with sporadic and familial aniridia. ( Dubey, SK; Mahalaxmi, N; Sundaresan, P; Vijayalakshmi, P, 2015)
"Malignant glaucoma was diagnosed a mean of 5."	1.40	Malignant glaucoma after cataract surgery. ( Ahmed, II; Belovay, GW; Tam, DY; Varma, DK, 2014)
"Congenital iris ectropion is an uncommon malformation of the anterior segment of the eye."	1.37	Congenital iris ectropion associated with juvenile glaucoma. ( Başer, E; Seymenoğlu, G, 2011)
"The commonest cause of aphakia was following complicated phacoemulsification in 17 of the 32 eyes (53."	1.37	Visual outcomes following Artisan aphakia iris claw lens implantation. ( Chaudhuri, PR; Lett, KS, 2011)
"8 nM) whose corneal permeability and ocular bioavailability were significantly increased when the compound was dosed as the isopropyl ester prodrug, PF-04217329."	1.37	Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma. ( Almaden, C; Anderson, S; Carreiro, S; Dinh, D; Fortner, J; Gale, D; Gukasyan, H; Krauss, A; Lafontaine, J; Niesman, M; Prasanna, G; Sartnurak, S; Toris, C; Wells, P; Xiang, C; Younis, H, 2011)
"Glaucoma is an optic nerve disease resulting in loss of vision."	1.37	Focal biologically inspired feature for glaucoma type classification. ( Aung, T; Baskaran, M; Cheng, J; Lee, BH; Liu, J; Tao, D; Wong, DW; Wong, TY, 2011)
"Glaucoma is a long-term ocular neuropathy defined by optic disc or retinal nerve fiber structural abnormalities and visual-field defects."	1.35	Laser therapies for glaucoma: new frontiers. ( Pasquale, N; Scuderi, GL, 2008)
"Glaucoma is the main complication and occurred immediately after surgery, suggesting a possible direct mechanical effect of the large BDI lens."	1.35	Implantation of the black diaphragm intraocular lens in congenital and traumatic aniridia. ( Aslam, SA; Ficker, LA; MacLaren, RE; Wong, SC, 2008)
"ARM-associated glaucoma is a bilateral anterior segment dysgenesis disease that affects males and females equally."	1.34	Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations. ( Dinu, I; Strungaru, MH; Walter, MA, 2007)
"ICE syndrome is commonly progressive and frequently complicated by secondary glaucoma and corneal decompensation."	1.34	[Iridocorneal endothelial syndrome and glaucoma]. ( Denis, P, 2007)
"Axenfeld-Rieger syndrome is an ocular anterior segment dysgenesis, autosomal dominantly inherited, commonly associated with glaucoma and systemic anomalies."	1.34	[Variability of clinical manifestations in the family with Axenfeld-Rieger syndrome]. ( Kamińska, A; Pawluczyk-Dyjecińska, M; Sokołowska-Oracz, A; Szaflik, JP, 2007)
"Ocular contusions are common and cause significant morbidity."	1.33	[Ocular injuries in mild facial trauma]. ( Montard, R, 2006)
"Glaucoma is not a rare condition in patients with FAP, especially because liver transplantation now enables patients with FAP to live longer."	1.32	Secondary glaucoma in patients with familial amyloidotic polyneuropathy. ( Ando, E; Ando, Y; Arimura, K; Fukushima, M; Hirata, A; Kimura, A; Koga, T; Negi, A; Tanihara, H, 2003)
" The altered corneal thickness attributable to increased forkhead gene dosage is particularly important, because it may affect the clinical management of certain glaucoma subtypes and lead to excessive treatment."	1.32	Novel anterior segment phenotypes resulting from forkhead gene alterations: evidence for cross-species conservation of function. ( Bell, R; Bhattacharya, SS; Blixt, A; Brice, G; Carlsson, P; Hitchings, RA; Johansson, B; John, SW; Jordan, T; Khaw, PT; Lehmann, OJ; Smith, R; Tuft, S, 2003)
"Rieger syndrome is a rare, autosomal dominant disorder due to developmental arrest of tissues derived from neural crest ectoderm in the third trimester."	1.32	The Rieger syndrome: orofacial manifestations. Case report of a rare condition. ( Lehl, G; Pannu, K; Singh, J, 2003)
" In the current study, the possible role of altered PITX2 gene dosage in the etiology of AR was investigated."	1.32	Characterization and prevalence of PITX2 microdeletions and mutations in Axenfeld-Rieger malformations. ( Allingham, RR; Damji, KF; Héon, E; Kozlowski, K; Kulak, SC; Levin, AV; Lines, MA; Newlin, A; Ritch, R; Shields, MB; Walter, MA, 2004)
"Rieger syndrome is a dysembryogenetic disease in which labyrinthic damage can be associated with other genetic anomalies."	1.32	Rieger syndrome: case report. ( Megighian, D; Poli, P; Savastano, M, 2003)
"Medication of glaucoma is only initially effective."	1.32	[Secondary glaucoma due to progressive iris atrophy--a century after the first description. Case report]. ( Goś, R; Jurowski, P; Kapica, A; Zdzieszyńska, M, 2004)
"Presbyopia is an early manifestation of physiological ageing resulting in the impossibility to read without additional spectacle correction."	1.32	[Geriatric eye diseases]. ( De Laey, JJ; Tassignon, MJ, 2004)
"In the initial treatment of glaucoma, prostaglandin analogs have indisputable advantages: better efficacy than timolol--particularly for inducing low or even very low IOP--but also their possible use in normotensive glaucoma, posology of a single instillation per day, and no systemic effects."	1.32	[Initial medical treatment: beta-blockers or prostaglandins. Prostaglandins: a modern glaucoma treatment]. ( Baudouin, C, 2004)
"Cataract was the earliest complication to appear."	1.32	Ocular complications after iodine brachytherapy for large uveal melanomas. ( Heikkonen, J; Kivelä, T; Puusaari, I, 2004)
"The pathogenesis of pseudoexfoliation syndrome (PEX) remains unknown."	1.31	Detection of herpes simplex virus in pseudoexfoliation syndrome and exfoliation glaucoma. ( Detorakis, ET; Kozobolis, VP; Pallikaris, IG; Spandidos, DA, 2002)
"The glaucoma was controlled in 9 of 17 eyes at the early stage, which underwent laser iridotomy (4 of 9 eyes also underwent laser iridoplasty)."	1.31	The management of secondary glaucoma in nanophthalmic patients. ( Huang, S; Qiu, C; Ye, T; Yu, M, 2002)
"Glaucoma is a leading cause of irreversible blindness in Canada."	1.31	Molecular characterisation of congenital glaucoma in a consanguineous Canadian community: a step towards preventing glaucoma related blindness. ( Héon, E; Klose, R; Levin, AV; Martin, SN; Priston, M; Sutherland, J, 2000)
" These results provide evidence of gene duplication causing developmental disease in humans, with increased gene dosage of either FOXC1 or other, as yet unknown genes within the duplicated segment being the probable mechanism responsible for the phenotype."	1.31	Chromosomal duplication involving the forkhead transcription factor gene FOXC1 causes iris hypoplasia and glaucoma. ( Bhattacharya, SS; Clark, BJ; Ebenezer, ND; Fox, M; Hitchings, RA; Jordan, T; Khaw, PT; Lehmann, OJ; Leroy, BP; Ocaka, L; Payne, A; Povey, S, 2000)
"Intraocular pressure was lowered, and visual field loss was stabilized with topical medications."	1.31	Unilateral glaucoma in Sotos syndrome (cerebral gigantism). ( Flynn, JT; Gedde, SJ; Yen, MT, 2000)
"Glaucoma is a common disease but its molecular etiology is poorly understood."	1.31	Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice. ( Anderson, MG; Chang, B; Davisson, M; Hawes, NL; Heckenlively, JR; John, SW; Savinova, OV; Smith, RS; Wilpan, R; Zabaleta, A, 2001)
"Axenfeld-Rieger syndrome is a genetically heterogeneous, autosomal dominant disorder that is characterized by anterior segment defects, glaucoma, and extraocular anomalies."	1.31	Genetic analysis of PITX2 and FOXC1 in Rieger Syndrome patients from Brazil. ( Alward, WL; Betinjane, AJ; Borges, AS; Carani, JC; Nishimura, DY; Sheffield, VC; Stone, EM; Susanna, R, 2002)
" The data presented provide additional evidence for the pathogenicity of altered gene dosage of FOXC1 and suggest that a common mechanism is responsible for rearrangements of 6p25."	1.31	Ocular developmental abnormalities and glaucoma associated with interstitial 6p25 duplications and deletions. ( Bhattacharya, SS; Ebenezer, ND; Ekong, R; Fraser, S; Hitchings, RA; Jordan, T; Khaw, PT; Lehmann, OJ; McGill, JI; Mungall, AJ; Ocaka, L; Povey, S; Sowden, JC; Walter, MA, 2002)
"Glaucoma is a group of ocular disorders leading to reduced visual capabilities and sometimes blindness."	1.30	Fine mapping of the gene for autosomal dominant juvenile-onset glaucoma with iridogoniodysgenesis in 6p25-tel. ( Graff, C; Jerndal, T; Wadelius, C, 1997)
"Glaucomas are a major cause of blindness."	1.30	Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. ( Anderson, MG; Chang, B; Davisson, MT; Hawes, NL; Heckenlively, JR; John, SW; Roderick, TH; Savinova, O; Smith, RS; Zabaleta, A, 1999)
"This glaucoma is usually resistant to medical therapy and can lead to blindness."	1.29	Linkage of autosomal dominant iris hypoplasia to the region of the Rieger syndrome locus (4q25). ( Alward, WL; Héon, E; Kalenak, JW; Sheffield, VC; Sheth, BP; Stone, EM; Streb, LM; Sunden, SL; Taylor, CM, 1995)
"Secondary glaucoma has been the greatest postoperative problem: It could be controlled medically in five eyes, surgically in two eyes, but remained uncontrolled in one eye."	1.29	[Iris black diaphragm intraocular lenses in traumatic Aniridia]. ( Althaus, C; Reinhard, T; Sundmacher, R, 1994)
"Intraoperative explosive choroidal hemorrhage (ECH) is a rare, but severe complication of intraocular surgery."	1.29	[Intraoperative explosive choroidal hemorrhage (report of four cases)]. ( Bao, G; Cheng, B; Zheng, Y, 1993)
"In yohimbine-pretreated rabbits, the reduction of cAMP level in the photocoagulated iris-ciliary body was absent."	1.29	In vivo cAMP level in rabbit iris-ciliary body after topical epinephrine treatment. ( Gallar, J; Liu, JH, 1996)
"Primary juvenile glaucoma is a rare form of glaucoma that typically affects individuals between 3 and 20 years of ages and is inherited as an autosomal dominant trait."	1.29	Clinical features of five pedigrees genetically linked to the juvenile glaucoma locus on chromosome 1q21-q31. ( Del Bono, EA; Hutchinson, BT; Schuman, JS; Walton, DS; Wiggs, JL, 1995)
"Also this syndrome was considered to be related to Chandler's syndrome Clinically."	1.28	Iris nevus syndrome (report of 9 cases). ( Liu, Y; Pang, Y; Ye, T, 1991)
"Posterior scleritis is an often misdiagnosed disease of the eye."	1.28	[Secondary angle-block glaucoma in posterior scleritis]. ( Mangouritsas, G; Ulbig, M, 1991)
"Glaucoma was present before surgery in four eyes, which persisted in all cases and developed in four new cases."	1.28	Complications of sulcus-supported intraocular lenses with iris sutures, implanted during penetrating keratoplasty after intracapsular cataract extraction. ( Böker, T; Brauweiler, P; Busin, M; Spitznas, M, 1990)
"Four of the patients with Fuchs' heterochromic cyclitis and four of the patients with uveitis showed evidence of an inflammatory cell infiltrate, which was a mixture of interleukin-2 receptor-negative T helper and suppressor cells, B lymphocytes, and plasma cells."	1.28	Immunohistochemical analysis of iris biopsy specimens from patients with Fuchs' heterochromic cyclitis. ( Baarsma, GS; de Jong, VM; de Vries, PT; Kijlstra, A; Mooy, CM; Murray, PI; Visser-de Jong, E, 1990)
"The fall of intraocular pressure is mainly connected with improvement of the aqueous outflow."	1.28	[The late results of the surgical treatment of glaucoma in patients with atherosclerosis and diabetes mellitus]. ( Kozina, LV; Krivitskiĭ, AK, 1990)
"Presented are the results of surgical treatment glaucoma in congenital aniridia (10 eyes), in the syndrome of closed anterior chamber (7 eyes), in Sturge-Weber's syndrome (7 eyes) in marfan's disease (2 eyes), in Lowe's disease (2 eyes) and Recklinghausen's disease (1 eye)."	1.28	[Treatment of glaucoma in children in congenital pathologic syndromes]. ( Koraszewska-Matuszewska, B; Samochowiec-Donocik, E, 1989)
"Glaucoma is the most serious long-term complication of the surgical method and occurs most frequently in aphakic eyes."	1.28	Vitrectomy and fluid/silicone-oil exchange for giant retinal tears: 5 years follow-up. ( Billington, BM; Leaver, PK, 1989)
"The exfoliation syndrome is thought to be a very rare disease in China."	1.28	Pseudoexfoliation syndrome in Chinese. ( Mao, WS; Ye, TC; Zhang, J, 1989)
"Their glaucoma was characterized by early onset of high intraocular pressures, lability of the pressure both with and without medical treatment, poor response to such treatment and resistance of the optic nerve head to damage even into early middle age."	1.27	Autosomal dominant iridogoniodysgenesis: glaucoma management. ( Boyd, TA; Ombres, RS; Pearce, WG; Salter, AB; Wyatt, HT, 1983)
" Short- or long-term use of timolol neither caused, increased nor decreased leak of the dye from the iris vessels, either at the pupillary border, or in other areas of the iris."	1.27	Vascular effects of timolol and pilocarpine in the iris. A simultaneous bilateral fluorescein angiographic study. ( Airaksinen, PJ; Alanko, HI, 1983)
"Intraocular pressure was experimentally elevated by injecting fluid through a cannula into the anterior chamber, using a special Guyon syringe."	1.27	[Intraocular pulse fluctuations in pressure in neovascularization glaucoma in comparison to other forms of glaucoma (results of direct manometric measurements)]. ( Jaeger, W, 1986)
"Long-term postoperative complications were observed between 6 months and 5 years of follow-up."	1.27	Complications associated with the use of silicone oil in 150 eyes after retina-vitreous surgery. ( Federman, JL; Schubert, HD, 1988)
"Three laser techniques for the treatment of glaucoma are described."	1.27	Laser therapy for glaucoma. ( Kitazawa, Y; Mishima, S; Shirato, S, 1985)
"The intraocular pressure was controlled (less than or equal to 21 mm Hg) in 107 eyes by surgery alone and in two eyes with medication by three to four weeks postoperatively."	1.27	Filtering iridocycloretraction in chronic closed-angle glaucoma. ( Kolesnikova, LN; Nesterov, AP, 1985)
"Although myopia is associated with anatomical factors that offer considerable protection from primary angle closure glaucoma, its presence does not eliminate the possibility of this disease."	1.27	Primary angle closure glaucoma in a myopic kinship. ( Hagan, JC; Lederer, CM, 1985)
"Intraocular pressure was increased 6 mmHg or more 1 to 2 hours after ALI in 19 of 50 eyes with anatomical narrow iridocorneal angles and in 23 of 50 eyes with chronic angle-closure glaucoma."	1.27	Acute intraocular pressure response to argon laser iridotomy. ( Cohen, BH; Kass, MA; Kolker, AE; Krupin, T; Stone, RA, 1985)
" 5 It is suggested that the slowly reversible after-effects of acute and chronic administration of cholinomimetic miotics can be explained by desensitization of iris sphincter cholinoceptors."	1.26	Subsensitivity to cholinoceptor stimulation of the human iris sphincter in situ following acute and chronic administration of cholinomimetic miotic drugs. ( Smith, SA; Smith, SE, 1980)
"Surgery on the genitalia revealed male pseudohermaphroditism and bilateral gonadoblastoma."	1.26	Aniridia, male pseudohermaphroditism, gonadoblastoma, mental retardation, and del 11p13. ( de Grouchy, J; Diebold, N; Dufier, JL; Nihoul-Fékété, C; Phuc, LH; Rappaport, R; Schmelck, PH; Turleau, C, 1981)
"Also, iritis was seen in all cases, but it disappeared within one week."	1.26	Argon laser iridotomy in angle-closure glaucoma: a comparison of two methods. ( Kitazawa, Y; Shirato, S; Yamamoto, T, 1982)
"Pupillary block glaucoma is a potential complication of implantation."	1.26	Laser photomydriasis in pseudophakic pupillary block. ( Baras, I; Barasch, KR; Galin, MA; Obstbaum, SA, 1981)
"Although metastases from malignant melanomas of the ciliary body and choroid are common, similar tumors from the iris are rare."	1.26	Tumors of the anterior uvea. I. Metastasizing malignant melanoma of the iris. ( Morgan, G; Rahi, AH; Sunba, MS, 1980)
"The iris naevus syndrome is now thought to represent one end of the clinical spectrum of an iridocorneal endothelial syndrome which also includes those clinical entities classified previously as Chandler's syndrome and essential iris atrophy."	1.26	The iris naevus (Cogan-Reese) syndrome: light and electron microscopic observations. ( Eagle, RC; Fine, BS; Font, RL; Yanoff, M, 1980)
"Histologically, the nonpigmented nevus cells in the angle were distinguishable from a proliferation of corneal endothelium."	1.26	Diffuse iris nevus manifested by unilateral open angle glaucoma. ( Fine, BS; Hidayat, A; Nik, NA; Zimmerman, LE, 1981)
"Congenital nonprogressive facial hemiatrophy is reported in association with anisometropia and ipsilateral cornea, iris, angle abnormalities, and juvenile glaucoma."	1.26	Congenital nonprogressive facial hemiatrophy with ipsilateral eye abnormalities and juvenile glaucoma. ( Cohen, JS, 1979)
"Medical treatment of the glaucoma was successful."	1.26	Rieger's anomaly with congenital glaucoma a case presentation of postnatal anterior segment maturation. ( Leib, ML; Little, JM; Saheb, NN, 1979)
"The operative and postoperative complications are described in a series of 537 eyes with lens implants, with suggestions for prophylaxis and treatment."	1.26	Surgical and postoperative problems with Binkhorst 2- and 4-loop lenses. ( Ghosh, T; Pearce, JL, 1977)
"Secondary glaucoma was found to be associated with intraocular reticulum cell sarcoma in approximately two-thirds of the reported cases, and neovascular glaucoma in about one-quarter of these cases."	1.26	Intraocular reticulum cell sarcoma: its dramatic response to systemic chemotherapy and its angiogenic potential. ( Dallow, RI; Sullivan, SF, 1977)
"On 31 eyes (23 patients, average age 74 years) with cataract and primary open-angle or chronic angle-closure glaucoma modified trabeculectomy with lobelike iridencleisis was performed combined with cataract-extraction."	1.26	[Trabeculectomy-iridencleisis combined with cataract extraction]. ( Payer, H, 1978)
"The glaucoma was controlled with miotic therapy following an iridectomy."	1.26	Russell-Silver dwarfism. ( Howard, RO; Kass, MA; Silverman, JP, 1976)
"Although vision drop, lens opacities and PS were less marked in the prophylactic group, it appears that PI is a surgical procedure not without its hazards."	1.26	Peripheral iridectomy in closed angle glaucoma-- late complications. ( Berson, D; Floman, N; Landau, L, 1977)
"Mixed glaucoma is a rare, fortuitous combination of open-angle and angle-closure glaucoma rather than a distinct entity, and it might be advisable to avoid the term, which tends to be used for primary glaucomas of uncertain classification."	1.26	Mixed glaucoma. ( Hyams, SW; Keroub, C; Pokotilo, E, 1977)
"Cataracts were present in 18% of affected patients; glaucoma in 13%; and strabismus in 34%."	1.26	Familial aniridia with preserved ocular function. ( Elsas, FJ; Kenyon, KR; Maumenee, IH; Yoder, F, 1977)
"Pupillary-block glaucoma is the first postoperative complication seen following the implantation of an intraocular lens, and in our series occurred at an incidence of 3-8%."	1.26	Pseudophakic pupillary-block glaucoma. ( Kaback, M; Werner, D, 1977)
"Postoperative complications were minimal: a shallow chamber that spontaneously reformed; vitreous loss, which did not affect the outcome; and breakdown of the conjunctival flap, which resulted in loss of the bleb."	1.26	Trabeculectomy as treatment for glaucoma: a preliminary report. ( Loewenthal, LM, 1977)
"Whenever a patient with suspected iris nevus syndrome or essential iris atrophy is subjected to glaucoma surgery, a biopsy specimen of the iris should be obtained for histological study."	1.25	Iris nevus (Cogan-Reese) syndrome. A cause of unilateral glaucoma. ( Scheie, HG; Yanoff, M, 1975)
"The most useful miotic in the treatment of glaucoma is still pilocarpine."	1.23	Diagnosis and treatment of glaucoma; a review of recent developments. ( McBAIN, EH, 1954)

Research

Studies (1,948)

Authors

Clinical Trials (14)

Trial Overview

Trial Outcomes

Average Ganglion Cell Layer (GCL) Thickness

Timeframe	Studies, this research(%)	All Research%
pre-1990	1502 (77.10)	18.7374
1990's	143 (7.34)	18.2507
2000's	123 (6.31)	29.6817
2010's	104 (5.34)	24.3611
2020's	76 (3.90)	2.80

Authors	Studies
Hatcher, JB	1
De Castro-Abeger, A	1
Brown, EN	1
Robinson, JL	1
Shieh, C	1
Xu, M	1
Li, K	1
He, W	1
Bastelica, P	1
Giraud, JM	1
Streho, M	1
Fénolland, JR	1
Liang, T	1
Zhang, C	2
Feng, ZX	1
Hu, M	1
Cui, Y	1
Li, J	2
Leng, F	1
Wu, Q	1
Li, L	2
Menapace, R	2
D'cruz, RP	1
Rao, A	2
Yan, YJ	1
Wu, LL	1
Laroche, D	1
Rickford, K	1
Sakkari, S	1
Stodolska-Nowak, A	1
Adamski, W	1
Brązert, A	1
Sygut, J	1
Marszałek, A	1
Rospond-Kubiak, I	1
Cheng, YY	1
Cheng, SM	1
Xu, HJ	1
Yin, J	1
Chen, H	2
Porporato, N	1
Chong, R	1
Xu, BY	1
Tun, TA	1
Quah, JH	1
Tan, M	1
Baskaran, M	2
Cheng, CY	1
Aung, T	3
Bari, A	1
Asif, MI	1
Anjum, S	1
Sinha, R	1
Shukla, AG	1
Vaidya, S	1
Yaghy, A	1
Di Nicola, M	1
Kaliki, S	1
Fulco, E	1
Myers, JS	1
Shields, JA	2
Shields, CL	2
Mitchell, WG	1
Azuara-Blanco, A	3
Foster, PJ	2
Halawa, O	1
Burr, J	1
Ramsay, CR	1
Cooper, D	1
Cochran, C	1
Norrie, J	1
Friedman, D	1
Chang, D	1
Wanichwecharungruang, B	1
Pattanapongpaiboon, W	1
Kongsomboon, K	1
Parivisutt, N	1
Annopawong, K	1
Seresirikachorn, K	1
Slagle, G	1
Griffin, J	1
Sponsel, WE	1
Lian, Z	1
Liu, S	1
Jin, G	1
Zheng, D	1
Thananjeyan, AL	1
Karaconji, T	1
Flaherty, M	1
Zagora, S	1
Jamieson, RV	1
Grigg, JRB	1
Yamashita, T	1
Shiihara, H	1
Terasaki, H	1
Fujiwara, K	1
Tanaka, M	1
Sakamoto, T	1
Lam, SS	1
Amarasekera, DC	1
Razeghinejad, R	1
Venkataraman, P	1
Haripriya, A	1
Mohan, N	1
Rajendran, A	1
Shabto, JM	1
Price, KW	1
Allen, JC	2
Craven, C	1
Jones, JK	1
Wells, J	1
Gaur, S	1
Sindhu, N	1
Singh, DV	1
Bhattacharya, M	1
Sharma, A	2
Shinde, D	2
Narang, P	2
Narang, R	2
Kurysheva, NI	1
Sharova, GA	1
Gollrad, J	1
Böker, A	1
Vitzthum, S	1
Besserer, A	1
Heufelder, J	1
Gauger, U	1
Böhmer, D	1
Budach, V	1
Zeitz, O	1
Joussen, AM	1
Urkude, J	1
Singh, R	2
Titiyal, JS	2
Sharma, N	2
Agarwal, A	1
Kong, XY	1
Zhang, H	1
Qiao, CY	1
Sheng, Q	1
Zhai, R	1
Sun, Y	2
Fan, X	1
Ying, Y	1
Kong, X	1
Cherkas, E	1
Negretti, GS	1
Zeiger, JS	1
Yan, Y	1
Shi, H	1
Zhao, Y	4
Cao, Y	1
Xie, Z	1
Abdolkarimi, D	3
Cunha, DL	3
Lahne, M	3
Moosajee, M	3
Lončarić, K	1
Tadić, R	1
Radmilović, M	1
Vatavuk, Z	1
Arora, M	1
Satpute, K	1
Shaikh, N	1
Ing, E	1
Lozano, DC	1
Cepurna, WO	1
Chan, F	1
Yang, YF	1
Morrison, JC	1
Keller, KE	1
Li, Y	2
Liu, J	2
Tian, Q	1
Ma, X	1
Bi, H	1
Weber, C	1
Fink, D	1
Löffler, K	1
Holz, FG	1
Liegl, R	1
Finger, RP	1
Pytak, RA	1
Pirie, CG	1
Harman, CD	1
Anderson, AL	1
Yao, SX	1
Komáromy, AM	1
Soydan, A	1
Kaymaz, A	1
Usui, S	1
Okazaki, T	1
Fujino, T	1
Kawashima, R	1
Hashida, N	1
Matsushita, K	1
Morii, E	1
Nishida, K	1
Gulmez Sevim, D	1
Sener, H	1
Evereklioglu, C	2
Yuan, Y	1
Wang, W	2
Xiong, R	1
Zhang, J	2
Li, C	2
Yang, S	1
Friedman, DS	1
He, M	2
Eibenberger, K	1
Heimann, H	2
Gatchalian, L	1
Kacperek, A	1
Hussain, R	1
Bhasin, P	1
Panday, M	1
Dhanapal, P	1
Rallo-López, AJ	1
Orts-Llácer, J	1
Cauto-Picazo, C	1
Peñarrocha-Oltra, S	1
Martínez-Costa, R	1
Jedlickova, J	1
Vajter, M	1
Barta, T	1
Black, GCM	1
Perveen, R	1
Mares, J	1
Fichtl, M	1
Kousal, B	1
Dudakova, L	1
Liskova, P	1
Mansoori, T	2
Alshehri, M	1
Bin Helayel, H	1
Vargas, JM	1
Almutlak, M	1
Fairaq, R	1
Singh, K	2
Singh, S	1
Singh, KK	1
Vashist, U	1
Kaur, H	1
Jain, N	1
Mittal, V	1
Kapoor, R	1
Parameswarappa, DC	1
Dhurandhar, D	1
Peguda, HK	2
Rani, PK	1
Bauchau, JC	1
Janssens, X	1
Dal Maso, L	1
Levecq, L	1
Gupta, S	5
Warjri, G	1
Gupta, V	4
Liu, X	2
Zhang, Y	2
Bian, A	1
Zhou, Q	1
Wang, D	2
Li, Z	2
Zhang, F	1
Chang, P	1
Fu, Y	1
Canabrava, S	1
Canedo Domingos Lima, AC	1
Arancibia, AEL	1
Bicalho Dornelas, LF	1
Ribeiro, G	1
Shahzadi, M	1
Firasat, S	1
Kaul, H	1
Afshan, K	1
Afzal, R	1
Naz, S	1
Bharathi, M	1
Balakrishnan, D	1
Senthil, S	3
Shreya, TS	1
Senthilkumar, VA	1
Mishra, C	1
Krishnadas, R	1
Zibura, AE	1
Robertson, JB	1
Westermeyer, HD	1
Yu, X	1
Chen, W	2
Xu, W	1
Verma, N	1
Jawaid, Q	1
Liu, Q	1
Wang, X	1
Zhang, S	1
Pieklarz, B	1
Grochowski, ET	1
Dmuchowska, DA	1
Saeed, E	1
Sidorczuk, P	1
Mariak, Z	2
Huang, Y	1
Ye, Z	1
Lee, C	1
Li, G	1
Stamer, WD	1
Ethier, CR	1
Márquez, MA	1
Juárez, CP	1
Sánchez, MC	1
Luna, JD	1
Madhangi, M	1
Dutta, D	1
Show, S	1
Bhat, VK	1
Rather, MI	1
Tiwari, A	1
Singh, N	1
Duvvari, MR	1
Murthy, GJ	1
Kumar, A	1
Nongthomba, U	1
Bedos, L	1
Grahn, BH	1
Philibert, H	1
Campbell, J	1
Sandmeyer, L	1
Abdeen, W	1
Esmael, AF	1
Gawdat, G	1
El-Fayoumi, D	1
Vupparaboina, KK	1
Padhy, D	1
Raj, N	1
Pradhan, A	1
Goud, A	1
Jana, S	1
Richariya, A	1
Nüßle, S	1
Lübke, J	1
Chen, Z	1
Liang, X	1
Wang, P	1
Wang, J	2
Rho, S	1
Lim, SH	2
Puthalath, AS	1
Gupta, N	1
Samanta, R	1
Verma, PK	1
Turner, AJ	1
Vander Wall, R	1
Klistorner, A	1
Graham, SL	1
Seiler, R	1
Gunzinger, JM	1
Rüschoff, JH	1
Barthelmes, D	1
Bode, PK	1
Gerth-Kahlert, C	1
Bontzos, G	1
Giarmoukakis, A	1
Tsilimbaris, M	1
Dervenis, N	1
Mikropoulou, AM	1
Dervenis, P	1
Lewis, A	1
Bryant, TK	1
Feinberg, EE	1
Peeler, CE	1
Ali, A	1
Rosenfeld, C	1
Rosenberg, E	1
Sharma, S	1
Wandel, TL	1
Gehle, P	1
Goergen, B	1
Pilger, D	1
Ruokonen, P	1
Robinson, PN	1
Salchow, DJ	1
Pose-Bazarra, S	1
Kumari, R	1
Saha, BC	1
Tabatabaei, SA	1
Salabati, M	1
Soleimani, M	1
Fernández-Vigo, JI	1
De-Pablo-Gómez-de-Liaño, L	1
Almorín-Fernández-Vigo, I	1
Fernández-Vigo, C	1
Macarro-Merino, A	1
García-Feijóo, J	1
Fernández-Vigo, JÁ	1
Jovanović, V	1
Nikolić, L	1
Thineshkumar, S	1
Nyborg, D	1
Ruhlmann, P	1
Grauslund, J	1
Chahal, R	1
Mohite, AA	1
Bansal, A	1
Agraharam, SG	1
Bore, M	1
Choudhari, N	1
Chaurasia, S	1
Chansangpetch, S	1
Nguyen, A	1
Mora, M	2
Badr, M	1
Porco, TC	1
Lin, SC	5
Wqgrowska, M	1
Wilczyfiski, M	1
Omulecki, W	1
Sihota, R	3
Agarwal, E	1
James, M	1
Verma, M	1
Kumar, L	1
Dada, T	2
Kapoor, KS	1
Jain, K	1
Purang, AK	1
Pegu, J	1
Dubey, S	1
Alías, L	1
Crespi, J	1
González-Quereda, L	1
Téllez, J	1
Martínez, E	1
Bernal, S	1
Gallano, MP	1
Bengarai, W	1
Chokrani, H	1
Berraho, A	2
Aounzou, S	1
Chraibi, F	1
El Bahloul, M	1
El Abdellaoui, M	1
Benatiya Andaloussi, I	1
Tahri, H	1
Lee, AY	1
Lee, CS	1
Pieters, M	1
Maa, AY	1
Cockerham, G	1
Lynch, MG	1
Thomas, R	2
Thomas, A	2
Walland, M	1
Mengersen, K	2
Rahhal-Ortuño, M	1
Díaz-Llopis, M	1
Alonso-Muñoz, L	1
Rahhal, MS	1
Bluwol, E	1
Wang, Q	1
Perez, CI	1
Masis, M	1
Feinstein, M	1
Hsia, YC	1
Morlino, S	1
Alesi, V	1
Calì, F	1
Lepri, FR	1
Secinaro, A	1
Grammatico, P	1
Novelli, A	1
Drago, F	1
Castori, M	1
Baban, A	1
Shakrawal, J	1
Selvan, H	2
Angmo, D	1
Frisina, R	1
Parrozzani, R	1
Tozzi, L	1
Pilotto, E	1
Midena, E	1
Sivakumar, P	1
Vedachalam, R	1
Shivananda, N	1
Gupta, G	1
Gupta, PC	1
Thakur, A	1
Murugan, B	1
Ram, J	1
Swaminathan, S	1
Lu, H	1
Williams, RW	1
Lu, L	1
Jablonski, MM	1
Azevedo-Pinto, S	1
Pereira-Silva, P	1
Rocha-Sousa, A	1
Lee, NY	1
Lee, YE	1
Mok, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Biometric Characteristics Of The Eye With Microcornea/Microphthalmia And Congenital Cataract Before And After Cataract Extraction[NCT04759560]		133 participants (Anticipated)	Observational	2020-07-25	Recruiting
Treatment Outcomes of MicroPulse Trans-scleral Cyclophotocoagulation (mTSCPC) in Uncontrolled Glaucoma at the University of Montreal Hospital Center (CHUM)[NCT03187418]		52 participants (Actual)	Interventional	2017-06-19	Completed
The Effects of Latanoprost, Bimatoprost and Travoprost on Periocular Skin Pigmentation[NCT00705757]	Phase 4	89 participants (Actual)	Interventional	2008-03-31	Completed
Incidence of Visual Symptom Following Laser (Nd:YAG ) Peripheral Iridotomy (LPI) in Relation to Position of LPI[NCT01758237]		214 participants (Actual)	Interventional	2008-01-31	Completed
Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis[NCT01486693]		60 participants (Anticipated)	Observational	2011-10-31	Recruiting
[NCT00000131]	Phase 3	0 participants	Interventional	1988-08-31	Completed
Ultra-wide Fluorescein angiograpHy to Evaluate the Progression of Retinal ischeMia After aflibErcept Injections in patientS With Central Retinal Vein Occlusion in Real Life (HERMES Study)[NCT02880644]		65 participants (Actual)	Observational [Patient Registry]	2017-01-26	Completed
A Phase IV Open Label Trial of the Safety, Tolerability and Efficacy of 0.5mg Ranibizumab Intravitreal Injections Combined With Wide Field Angiography Guided Panretinal Photocoagulation vs. 0.5mg Ranibizumab Intravitreal Injection Monotherapy in Subjects [NCT01710839]	Phase 4	30 participants (Actual)	Interventional	2012-10-31	Completed
Correlation Between the Visual Acuity and the OCT Pattern of Macular Edema Secondary to Retinal Vein Occlusion[NCT03489915]		30 participants (Anticipated)	Observational	2018-05-01	Not yet recruiting
Cutaneous Prostaglandin Application: Nail Growth, Nail Brittleness, and Eye Pressure[NCT02448043]		45 participants (Actual)	Interventional	2015-06-04	Completed
Pigment Dispersion Syndrome With and Without Glaucoma[NCT00001152]		175 participants	Observational	1976-06-30	Completed
Phenotype-Genotype Correlation in Aniridia[NCT00265590]		100 participants	Observational	2005-12-07	Completed
Comparison of Combined Phacotrabeculectomy and Trabeculectomy Only in the Treatment of Primary Angle-closure Glaucoma[NCT01298635]		31 participants (Actual)	Interventional	2005-01-31	Completed
Short-term Intraocular Pressure Control After YAG Iridotomy - Comparison Between Brimonidine 0.1% vs. 0.2%[NCT01417858]		50 participants (Anticipated)	Interventional	2010-11-30	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

In micrometer, determined by optical coherence tomography (OCT) (NCT03187418)
Timeframe: 18 months

Average Retinal Nerve Fiber Layer (RNFL) Thickness

Intervention	micrometers (Mean)
Micropulse Trans-scleral CPC	53

In micrometer, determined by optical coherence tomography (OCT) (NCT03187418)
Timeframe: 18 months

Cup-to-disc Ratio (CDR)

Intervention	micrometers (Mean)
Micropulse Trans-scleral CPC	62

Progression of CDR compared to baseline, assessed by an ophthalmologist on dilated fundus examination (NCT03187418)
Timeframe: 18 months

Cup-to-disc Ratio (CDR) Assessed by Optical Coherence Tomography (OCT)

Intervention	ratio (Mean)
Micropulse Trans-scleral CPC	0.82

Progression of vertical CDR compared to baseline, assessed by optical coherence tomography (OCT) parameters (NCT03187418)
Timeframe: 18 months

Intraocular Pressure (IOP)

Intervention	ratio (Mean)
Micropulse Trans-scleral CPC	0.82

In millimeters of mercury (mmHg), measured with the Goldmann applanation tonometer (NCT03187418)
Timeframe: 18 months

Mean Deviation (MD)

Intervention	millimeters of mercury (mm Hg) (Mean)
Micropulse Trans-scleral CPC	15.2

Determined by Humphrey automated perimetry Sita 24-2 visual field testing (NCT03187418)
Timeframe: 18 months

Number of Participants With Repeat Treatments

Intervention	decibel (dB) (Mean)
Micropulse Trans-scleral CPC	-15.16

Number of participants needing a repeat laser treatment during the study (NCT03187418)
Timeframe: 18 months

Pattern Standard Deviation (PSD)

Intervention	Participants (Count of Participants)
Micropulse Trans-scleral CPC	10

Determined by Humphrey automated perimetry Sita 24-2 visual field testing (NCT03187418)
Timeframe: 18 months

Visual Field Index (VFI)

Intervention	decibel (dB) (Mean)
Micropulse Trans-scleral CPC	7.87

Determined by Humphrey automated perimetry Sita 24-2 visual field testing (NCT03187418)
Timeframe: 18 months

Corrected Distance Visual Acuity (CDVA)

Intervention	percents (Mean)
Micropulse Trans-scleral CPC	57

Number of lines reduction or improvement from baseline on Snellen acuity chart at 6 meters (NCT03187418)
Timeframe: 1 week, 1 month, 3 months, 6 months, 12 months, 18 months

Intraocular Pressure (IOP)

Intervention	LogMAR (Mean)
	1 week	1 month	3 months	6 months	12 months	18 months
Micropulse Trans-scleral CPC	0.81	0.84	0.79	0.77	0.79	0.82

In millimeters of mercury (mmHg), measured with the Goldmann applanation tonometer (NCT03187418)
Timeframe: 1 week, 1 month, 3 months, 6 months, 12 months

Number of Intraocular Pressure Lowering Medications

Intervention	millimeters of mercury (mm Hg) (Mean)
	1 week	1 month	3 months	6 months	12 months
Micropulse Trans-scleral CPC	18.2	19.2	18.6	17.9	16.7

Number of drops and oral medications used by the patient compared to baseline (NCT03187418)
Timeframe: 1 week, 1 month, 3 months, 6 months, 12 months, 18 months

Pain Level During Laser Treatment

Intervention	glaucoma medication classes (Mean)
	1 week	1 month	3 months	6 months	12 months	18 months
Micropulse Trans-scleral CPC	3.5	3.4	3.4	3.4	3.2	3.2

Using a verbal analog scale for pain level (none = no subjective feeling of pain, mild = pain easily tolerable, moderate = pain tolerable with difficulty, severe = pain intolerable) (NCT03187418)
Timeframe: 1 day

The Extent of Latanoprost, Bimatoprost and Travoprost Induced Periocular Skin Hyperpigmentation Over a One Year Time Course in Newly Diagnosed Primary Open Angle and Ocular Hypertension Patients.

Intervention	Participants (Count of Participants)
	None	Mild	Moderate	Severe
Micropulse Trans-scleral CPC	34	12	6	0

"Periocular skin color was measured with the Minolta Chroma Meter CR-400 and the L*a*b* system, also known as Commission Internationale de l'Eclairage. This is a well-accepted unit of measurement in which L* corresponds to brightness and a* and b* correspond to chromaticity.~Measurements were taken at baseline and 1 year. Data from each time point and each location (upper and lower eyelids or cheeks/face) were averaged, and subtracted from the baseline value for that location. Six predetermined areas on and around the upper and lower eyelid and 2 areas of the face/cheek were measured.Upper and lower eyelid values were averaged and reported as single value for each location ie;-upper eyelids, lower eyelid and cheek/face. A decrease in luminance indicates increased pigmentation at the site of measurement." (NCT00705757)
Timeframe: one year

Central Foveal Outcome

Intervention	Lab* (Mean)
	Upper Lid	Lower Lid	Cheek/Face
Lumigan	-0.90	-0.37	0.30
Travatan	-0.90	0.17	0.51
Xalatan	-1.42	0.48	0.55

Mean change in Central Foveal Volume on High Resolution OCT. (NCT01710839)
Timeframe: 12 months

Neovascularization of the Iris, Optic Nerve and Elsewhere

Intervention	cubic millimeters (Mean)
Targeted Pan Retinal Laser Combined With 0.5mg Ranibizumab	-0.15
Ranibizumab 0.5mg	-0.15

Percent of patients that develop neovascularization of the iris, optic nerve and/or elsewhere. (NCT01710839)
Timeframe: 12 months

Total Number of Intravitreal Injections Over a 12 Month Period

Intervention	percentage of patients (Number)
Targeted Pan Retinal Laser Combined With 0.5mg Ranibizumab	8.33
Ranibizumab 0.5mg	0

Assess the number of intravitreal injections over 12 months. (NCT01710839)
Timeframe: 12 months

Visual Acuity

Intervention	injections (Mean)
Targeted Pan Retinal Laser Combined With 0.5mg Ranibizumab	8.7
Ranibizumab 0.5mg	9.5

Evaluate the mean change from baseline in ETDRS best-corrected visual acuity at 12 months. The ETDRS protocol is a widely accepted international standard for macular laser photocoagulation treatment. A higher score represents better functioning. (NCT01710839)
Timeframe: 12 month period

Adverse Events

Intervention	ETDRS BCVA Letters (Mean)
Targeted Pan Retinal Laser Combined With 0.5mg Ranibizumab	14.9
Ranibizumab 0.5mg	10.7

Incidence and severity of adverse events (ocular and non-ocular). (NCT01710839)
Timeframe: 12 months

Visual Field

Intervention	Participants (Count of Participants)
	Notable Ocular Events	Serious Non-Ocular Events
Ranibizumab 0.5mg	2	0
Targeted Pan Retinal Laser Combined With 0.5mg Ranibizumab	17	2

Goldman Visual Field changes at 6 and 12 months from baseline. Goldmann perimetry is a method used to map a patient's field of vision (central and peripheral). Changes will be assessed by manual digital quantification of GVF plots. (NCT01710839)
Timeframe: 6 and 12 Months

Nail Brittleness at 30 Days of Treatment

Intervention	square degrees (Mean)
	Month 6	Month 12
Ranibizumab 0.5mg	102	-1875
Targeted Pan Retinal Laser Combined With 0.5mg Ranibizumab	-1269	-1628

"Scale Title: Nail Brittleness (1-4)~Subjective assessment by subjects on scale of 1 (no brittleness) to 4 (maximum brittleness)." (NCT02448043)
Timeframe: Baseline, 30 days

Number of Days Until the First Nail Chipped

Intervention	Score on a scale (Mean)
Right Hand Bimatoprost 0.01% Drops, Left Hand Placebo	2.25
Left Hand Bimatoprost 0.01% Drops, Right Hand Placebo	2.43

Average number of days post-treatment until the first nail chipped (NCT02448043)
Timeframe: Baseline to 30 days

Change From Baseline in Nail Length of Digits

Intervention	Days (Mean)
Bimatoprost 0.01% Drops	8.38
Placebo	6.26

Measured by digital calipers (Ironton 6 in. Stainless Steel Digital Fractional Caliper, Northern Tool and Equipment, Burnsville, MN, USA) (NCT02448043)
Timeframe: Baseline, 30 Days

Change From Baseline in Nail Length of Hands

Intervention	mm (Mean)
	Thumb	Forefinger	Middle Finger	Ring Finger	Pinky Finger
Bimatoprost 0.01% Drops	1.58	1.26	0.90	1.33	1.63
Placebo	1.48	1.02	1.40	1.76	1.62

Measured by digital calipers (Ironton 6 in. Stainless Steel Digital Fractional Caliper, Northern Tool and Equipment, Burnsville, MN, USA) (NCT02448043)
Timeframe: Baseline, 30 days

Intraocular Pressure at 30 Days of Treatment

Intervention	mm (Mean)
	Total Nail Growth (power = 1.0)	Individual Nail Growth
Bimatoprost 0.01% Drops	13.49	1.34
Placebo	15.10	1.51

IOP using a Goldmann applanation tonometer (GAT) between 7:30 AM and 10:00 AM (NCT02448043)
Timeframe: Between 7:30 AM and 10:00 AM at 30 days post treatment

Intervention	mm Hg (Mean)
	Both eyes	Right eye	Left eye
Left Hand Bimatoprost 0.01% Drops, Right Hand Placebo	13.91	14.0	13.82
Right Hand Bimatoprost 0.01% Drops, Left Hand Placebo	16.42	16.38	16.46

Article	Year
[Progress in the research of plateau iris]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2022, Jan-11, Volume: 58, Issue:1 Topics: Glaucoma; Glaucoma, Angle-Closure; Humans; Intraocular Pressure; Iris; Iris Diseases	2022
A systematic approach to the management of microspherophakia. Indian journal of ophthalmology, 2022, Volume: 70, Issue:7 Topics: Corneal Diseases; Ectopia Lentis; Glaucoma; Humans; Iris; Randomized Controlled Trials as Topic; Ret	2022
[Primary anterior chamber angle closure: progression from suspect to glaucoma. Part 2. Predictors of primary angle closure]. Vestnik oftalmologii, 2022, Volume: 138, Issue:4 Topics: Anterior Chamber; Anterior Eye Segment; Glaucoma; Glaucoma, Angle-Closure; Gonioscopy; Humans; Intra	2022
Proton Therapy for 166 Patients with Iris Melanoma: Side Effects and Oncologic Outcomes. Ophthalmology. Retina, 2023, Volume: 7, Issue:3 Topics: Female; Glaucoma; Humans; Iris; Iris Neoplasms; Melanoma; Middle Aged; Proton Therapy; Retrospective	2023
Indian journal of ophthalmology, 2022, Volume: 70, Issue:12 Topics: Animals; Aniridia; Cataract; Glaucoma; Humans; Iris; Mice; PAX6 Transcription Factor; Zebrafish	2022
Indian journal of ophthalmology, 2022, Volume: 70, Issue:12 Topics: Animals; Aniridia; Cataract; Glaucoma; Humans; Iris; Mice; PAX6 Transcription Factor; Zebrafish	2022
Indian journal of ophthalmology, 2022, Volume: 70, Issue:12 Topics: Animals; Aniridia; Cataract; Glaucoma; Humans; Iris; Mice; PAX6 Transcription Factor; Zebrafish	2022
Indian journal of ophthalmology, 2022, Volume: 70, Issue:12 Topics: Animals; Aniridia; Cataract; Glaucoma; Humans; Iris; Mice; PAX6 Transcription Factor; Zebrafish	2022
Diagnosis and treatment of microspherophakia. Journal of cataract and refractive surgery, 2020, Volume: 46, Issue:12 Topics: Corneal Diseases; Ectopia Lentis; Glaucoma; Humans; Iris; Lens Implantation, Intraocular; Lens Sublu	2020
Role of lens extraction and laser peripheral iridotomy in treatment of glaucoma. Current opinion in ophthalmology, 2018, Volume: 29, Issue:1 Topics: Cataract; Cataract Extraction; Glaucoma; Humans; Iris; Laser Therapy; Lens, Crystalline	2018
Management of complications of cosmetic iris implants in a phakic eye: a case report and literature review. International ophthalmology, 2019, Volume: 39, Issue:5 Topics: Adult; Corneal Edema; Cosmetic Techniques; Device Removal; Eye Color; Glaucoma; Humans; Intraocular	2019
Cyclodialysis: an updated approach to surgical strategies. Acta ophthalmologica, 2019, Volume: 97, Issue:8 Topics: Ciliary Body; Glaucoma; Humans; Intraocular Pressure; Iris; Ocular Hypotension; Ophthalmologic Surgi	2019
Ghrelin in ocular pathophysiology: from the anterior to the posterior segment. Peptides, 2013, Volume: 47 Topics: Animals; Ciliary Body; Databases, Bibliographic; Gene Expression; Ghrelin; Glaucoma; Humans; Hyperte	2013
Weill-Marchesani syndrome with advanced glaucoma and corneal endothelial dysfunction: a case report and literature review. BMC ophthalmology, 2015, Jan-09, Volume: 15 Topics: Adult; Corneal Diseases; Ectopia Lentis; Female; Glaucoma; Humans; Iris; Lens Implantation, Intraocu	2015
Postoperative results of cosmetic iris implants. Journal of cataract and refractive surgery, 2016, Volume: 42, Issue:10 Topics: Cosmetic Techniques; Device Removal; Glaucoma; Humans; Iris; Lens Implantation, Intraocular; Postope	2016
Iridoschisis: a case report and literature review. BMC ophthalmology, 2017, Mar-14, Volume: 17, Issue:1 Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Cataract; Female; Glaucoma; Humans; Intraocular Pr	2017
Prostanoids for the management of glaucoma. Expert opinion on drug safety, 2008, Volume: 7, Issue:6 Topics: Animals; Antihypertensive Agents; Eye Color; Glaucoma; Humans; Intraocular Pressure; Iris; Ocular Hy	2008
CYP1B1, a developmental gene with a potential role in glaucoma therapy. Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:8 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cornea; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme Sys	2009
Recovery of orbital fat pad prolapsus and deepening of the lid sulcus from topical bimatoprost therapy: 2 case reports and review of the literature. Cutaneous and ocular toxicology, 2010, Volume: 29, Issue:3 Topics: Adipose Tissue; Administration, Topical; Aged; Amides; Antihypertensive Agents; Bimatoprost; Clopros	2010
What's new in laser treatment for glaucoma? Current opinion in ophthalmology, 2012, Volume: 23, Issue:2 Topics: Ciliary Body; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Iridectomy; Iris; Laser	2012
Histology and fine structure of the iris and outflow system following latanoprost therapy. Survey of ophthalmology, 2002, Volume: 47 Suppl 1 Topics: Antihypertensive Agents; Eye Color; Glaucoma; Humans; Intraocular Pressure; Iris; Iris Diseases; Lat	2002
Prostaglandin postscript: a personal reflection. Survey of ophthalmology, 2002, Volume: 47 Suppl 1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Drug Therapy, Combination; Eye Color; Glaucoma	2002
Ocular trauma-related glaucoma. Ophthalmology clinics of North America, 2002, Volume: 15, Issue:2 Topics: Ciliary Body; Eye Injuries; Glaucoma; Humans; Hyphema; Intraocular Pressure; Iris; Trabecular Meshwo	2002
[Current place of laser in the management of glaucomas]. Journal francais d'ophtalmologie, 2002, Volume: 25, Issue:8 Topics: Adult; Argon; Chronic Disease; Erbium; Follow-Up Studies; Glaucoma; Glaucoma, Angle-Closure; Glaucom	2002
[Phakic intraocular lenses. Current status and limitations]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2004, Volume: 101, Issue:3 Topics: Adolescent; Adult; Age Factors; Astigmatism; Cataract; Contact Lenses; Follow-Up Studies; Glaucoma;	2004
Anterior segment development relevant to glaucoma. The International journal of developmental biology, 2004, Volume: 48, Issue:8-9 Topics: Animals; Cornea; Disease Models, Animal; Ectoderm; Eye; Eye Proteins; Forkhead Transcription Factors	2004
[Congenital glaucoma and trabeculodysgenesis. Clinical and genetic aspects]. Journal francais d'ophtalmologie, 2006, Volume: 29, Issue:2 Topics: Abnormalities, Multiple; Cornea; Glaucoma; Humans; Iris; Trabecular Meshwork	2006
[Anterior segment optical coherence tomography in glaucoma]. Klinische Monatsblatter fur Augenheilkunde, 2008, Volume: 225, Issue:3 Topics: Anterior Eye Segment; Cornea; Glaucoma; Gonioscopy; Humans; Image Processing, Computer-Assisted; Iri	2008
[Clinical picture and treatment of hemorrhagic glaucoma]. Oftalmologicheskii zhurnal, 1982, Volume: 37, Issue:4 Topics: Diabetic Retinopathy; Diagnosis, Differential; Eye Diseases; Glaucoma; Hemorrhage; Humans; Iris; Met	1982
Ocular neovascularization with retinal vascular occlusion-III. Incidence of ocular neovascularization with retinal vein occlusion. Ophthalmology, 1983, Volume: 90, Issue:5 Topics: Adult; Age Factors; Aged; Anterior Chamber; Eye; Female; Glaucoma; Humans; Iris; Ischemia; Male; Mid	1983
Aqueous humor outflow. Current topics in eye research, 1984, Volume: 4 Topics: Animals; Anterior Chamber; Aqueous Humor; Ciliary Body; Cytochalasin B; Cytochalasin D; Cytochalasin	1984
[Traumatic aniridia]. Oftalmologicheskii zhurnal, 1984, Issue:2 Topics: Biomechanical Phenomena; Cataract Extraction; Contact Lenses; Contusions; Eye Injuries; Glaucoma; Go	1984
Current concepts in laser iridotomy. International ophthalmology clinics, 1984,Fall, Volume: 24, Issue:3 Topics: Animals; Cataract; Corneal Diseases; Corneal Opacity; Edema; Glaucoma; Haplorhini; Humans; Iris; Las	1984
Cryosurgery in small animal ophthalmology. The Veterinary clinics of North America. Small animal practice, 1980, Volume: 10, Issue:2 Topics: Animals; Carbon Dioxide; Cat Diseases; Cataract; Cataract Extraction; Cats; Corneal Diseases; Cryosu	1980
[Angle-closure glaucoma. Semeiology]. Journal francais d'ophtalmologie, 1980, Volume: 3, Issue:2 Topics: Acute Disease; Aged; Anterior Chamber; Anthropometry; Eye; Female; Fluorescein Angiography; Glaucoma	1980
Intraocular lens disasters: peripheral anterior synechia. Ophthalmology, 1980, Volume: 87, Issue:7 Topics: Adult; Aged; Anterior Chamber; Cornea; Corneal Diseases; Endothelium; Eye; Eye Diseases; Female; Gla	1980
Current concepts in small animal glaucoma: recognition and treatment. The Veterinary clinics of North America. Small animal practice, 1980, Volume: 10, Issue:2 Topics: Animals; Cat Diseases; Cats; Diuretics; Dog Diseases; Dogs; Glaucoma; Gonioscopy; Iris; Lens, Crysta	1980
Iridocapsular intraocular lenses and extracapsular cataract surgery. International ophthalmology clinics, 1982,Summer, Volume: 22, Issue:2 Topics: Adult; Aged; Cataract Extraction; Corneal Diseases; Equipment Failure; Female; Glaucoma; Humans; Iri	1982
Small-pupil phacoemulsification and trabeculectomy. International ophthalmology clinics, 1994,Spring, Volume: 34, Issue:2 Topics: Cataract Extraction; Glaucoma; Humans; Iris; Lenses, Intraocular; Pupil Disorders; Trabeculectomy	1994
Laser iridotomy. Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:3 Topics: Acute Disease; Animals; Anterior Eye Segment; Chronic Disease; Contraindications; Glaucoma; Humans;	1996
Ultrasound biomicroscopy of the anterior segment. Journal of the American Optometric Association, 1996, Volume: 67, Issue:8 Topics: Anterior Eye Segment; Ciliary Body; Glaucoma; Humans; Image Processing, Computer-Assisted; Iris; Mic	1996
[Intraocular smooth muscle physiology relating to pathogenesis and therapy of glaucoma]. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 1996, Volume: 32, Issue:5 Topics: Acetylcholine; Animals; Aqueous Humor; Dobutamine; Epinephrine; Female; Glaucoma; Humans; Iris; Male	1996
Malignant glaucoma and its management. The British journal of ophthalmology, 1997, Volume: 81, Issue:2 Topics: Algorithms; Glaucoma; Humans; Iris; Laser Therapy; Postoperative Complications	1997
Exfoliation syndrome in a 17-year-old girl. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:8 Topics: Adolescent; Biopsy; Conjunctiva; Elastin; Exfoliation Syndrome; Female; Glaucoma; Humans; Iris; Micr	1997
New aspects in the laser treatment of glaucoma. Current opinion in ophthalmology, 1991, Volume: 2, Issue:2 Topics: Glaucoma; Humans; Iris; Laser Therapy; Light Coagulation; Sclerostomy; Trabeculectomy	1991
Laser treatment of glaucoma. Current opinion in ophthalmology, 1992, Volume: 3, Issue:2 Topics: Glaucoma; Humans; Iris; Laser Therapy; Light Coagulation; Sclerostomy; Trabeculectomy	1992
Atrial septal defect with interatrial aneurysm and Axenfeld-Rieger syndrome. Acta ophthalmologica Scandinavica, 2000, Volume: 78, Issue:1 Topics: Abnormalities, Multiple; Adult; Anterior Eye Segment; Echocardiography; Eye Abnormalities; Face; Fem	2000
Axenfeld-Rieger syndrome in the age of molecular genetics. American journal of ophthalmology, 2000, Volume: 130, Issue:1 Topics: Anterior Eye Segment; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 4; Chromosomes, Human, P	2000
The pharmacology of bimatoprost (Lumigan). Survey of ophthalmology, 2001, Volume: 45 Suppl 4 Topics: Amides; Animals; Antihypertensive Agents; Bimatoprost; Cloprostenol; Glaucoma; Intraocular Pressure;	2001
Use of argon laser energy to produce iridotomies. Transactions of the American Ophthalmological Society, 1979, Volume: 77 Topics: Animals; Eye Color; Follow-Up Studies; Glaucoma; Haplorhini; Humans; Intraoperative Complications; I	1979
The ocular effects of cannabinoids. Current topics in eye research, 1979, Volume: 1 Topics: Animals; Aqueous Humor; Cannabinoids; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Cil	1979
Current concepts in ophthalmology: the glaucomas. The New England journal of medicine, 1978, Jul-27, Volume: 299, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Glaucoma; Humans; Intraocular Pressure; Iris; Mid	1978
Complications of implant surgery in children. Journal - American Intra-Ocular Implant Society, 1979, Volume: 5, Issue:1 Topics: Adolescent; Adult; Amblyopia; Anterior Chamber; Blepharospasm; Child; Corneal Diseases; Eye Diseases	1979
[Rubeosis iridis and neovascular glaucoma]. Journal francais d'ophtalmologie, 1979, Volume: 2, Issue:11 Topics: Animals; Diabetic Retinopathy; Fluorescein Angiography; Glaucoma; Humans; Iris; Ischemia; Light Coag	1979
[Aphakic glaucoma (a brief review of the literature)]. Oftalmologicheskii zhurnal, 1976, Volume: 31, Issue:4 Topics: Anterior Chamber; Cataract Extraction; Choroid; Cryosurgery; Follow-Up Studies; Glaucoma; Gonioscopy	1976
Congenital ophthalmic anomalies in cattle. Modern veterinary practice, 1976, Volume: 57, Issue:2 Topics: Albinism; Animals; Anophthalmos; Cataract; Cattle; Cattle Diseases; Coloboma; Exophthalmos; Eye Abno	1976
[Clinical ocular biometry (oculometry)]. Bulletin de la Societe belge d'ophtalmologie, 1976, Volume: 172, Issue:1 Topics: Accommodation, Ocular; Anterior Chamber; Biometry; Cornea; Corneal Diseases; Eye; Eye Abnormalities;	1976
[Uveopathies, early diagnosis and treatment (survey of Soviet and foreign literature)]. Oftalmologicheskii zhurnal, 1975, Volume: 30, Issue:2 Topics: Cataract; Cataract Extraction; Eye Diseases; Glaucoma; Gonioscopy; Humans; Hypothalamic Diseases; Ir	1975
Guidelines for indications of intraocular lens implantation and selection of the proper lens. Ophthalmic surgery, 1975,Winter, Volume: 6, Issue:4 Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, General; Anterior Chamber; Cataract; Cataract Extr	1975
Ultrasound biomicroscopy in glaucoma. Acta ophthalmologica. Supplement, 1992, Issue:204 Topics: Anterior Chamber; Ciliary Body; Equipment Design; Glaucoma; Gonioscopy; Humans; Iris; Lens, Crystall	1992
[Surgical therapy of glaucoma]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1990, Volume: 87 Suppl Topics: Cataract Extraction; Glaucoma; Glaucoma, Open-Angle; Humans; Iris; Suture Techniques; Trabeculectomy	1990
Acute pseudophakic pupillary block glaucoma. Annals of emergency medicine, 1990, Volume: 19, Issue:3 Topics: Acute Disease; Glaucoma; Humans; Intraocular Pressure; Iris; Lenses, Intraocular; Male; Middle Aged	1990
Medical management of acute postoperative intraocular pressure rises associated with anterior segment ophthalmic laser surgery. International ophthalmology clinics, 1990,Spring, Volume: 30, Issue:2 Topics: Anterior Eye Segment; Clonidine; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therapy; Trabec	1990
[Treatment of an acute glaucoma attack]. Deutsche medizinische Wochenschrift (1946), 1990, Aug-03, Volume: 115, Issue:31-32 Topics: Acute Disease; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therapy	1990
Laser therapy in glaucoma: an overview and update. International ophthalmology clinics, 1990,Summer, Volume: 30, Issue:3 Topics: Argon; Ciliary Body; Glaucoma; Humans; Iris; Laser Therapy; Light Coagulation; Mydriasis; Physical P	1990
[Contribution of the argon laser in iridotomy using the Yag laser]. Journal francais d'ophtalmologie, 1989, Volume: 12, Issue:8-9 Topics: Adult; Aged; Argon; Eye Hemorrhage; Female; Glaucoma; Humans; Iris; Laser Therapy; Male; Middle Aged	1989
Corneal decompensation after argon laser iridectomy. Archives of ophthalmology (Chicago, Ill. : 1960), 1988, Volume: 106, Issue:11 Topics: Aged; Aged, 80 and over; Cataract; Cataract Extraction; Corneal Diseases; Edema; Female; Glaucoma; H	1988
Selected eye defects of special importance in pediatrics. Pediatric clinics of North America, 1987, Volume: 34, Issue:6 Topics: Bibliographies as Topic; Cataract; Child; Child, Preschool; Coloboma; Ectopia Lentis; Eye Abnormalit	1987
[Heterochromia complicata Fuchs]. Klinische Monatsblatter fur Augenheilkunde, 1988, Volume: 192, Issue:2 Topics: Adult; Cataract; Eye Color; Eye Diseases; Female; Glaucoma; Humans; Iris; Male; Middle Aged; Syndrom	1988
[Iridocorneotrabecular dysgenesis in a patient sample of the Münster University Eye Clinic]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1988, Volume: 85, Issue:1 Topics: Cornea; Glaucoma; Humans; Infant; Iris; Syndrome; Trabecular Meshwork	1988
YAG lasers in cataract surgery. International ophthalmology clinics, 1987,Fall, Volume: 27, Issue:3 Topics: Cataract Extraction; Glaucoma; Humans; Iris; Laser Therapy; Lens Capsule, Crystalline; Macular Edema	1987
Complications of intraocular lenses. International ophthalmology clinics, 1987,Fall, Volume: 27, Issue:3 Topics: Corneal Diseases; Endophthalmitis; Equipment Failure; Glaucoma; Humans; Iris; Lenses, Intraocular; R	1987
[Peripheral iridectomy in the treatment of closed-angle glaucoma]. Oftalmologicheskii zhurnal, 1987, Issue:7 Topics: Glaucoma; Humans; Intraocular Pressure; Iris; Methods	1987
A common pathway for developmental glaucomas. Transactions of the American Ophthalmological Society, 1987, Volume: 85 Topics: Adolescent; Adult; Anterior Chamber; Anterior Eye Segment; Ciliary Body; Female; Glaucoma; Gonioscop	1987
Congenital glaucoma--diagnosis and management. Transactions of the ophthalmological societies of the United Kingdom, 1986, Volume: 105 ( Pt 5) Topics: Glaucoma; Humans; Iris; Prognosis; Tonometry, Ocular; Trabecular Meshwork	1986
Doyne lecture. Heterochromic iridocyclitis. Transactions of the ophthalmological societies of the United Kingdom, 1985, Volume: 104 ( Pt 3) Topics: Adrenal Cortex Hormones; B-Lymphocytes; Cataract; Cataract Extraction; Chorioretinitis; Eye Color; G	1985
Microsurgery with the neodymium:YAG laser: an overview. International ophthalmology clinics, 1985,Fall, Volume: 25, Issue:3 Topics: Anterior Chamber; Anterior Eye Segment; Aphakia, Postcataract; Contact Lenses; Glaucoma; Humans; Iri	1985
Neonatal ophthalmology. The Veterinary clinics of North America. Equine practice, 1985, Volume: 1, Issue:1 Topics: Animals; Animals, Newborn; Anophthalmos; Blepharitis; Cataract; Chorioretinitis; Coloboma; Conjuncti	1985
Autonomic drugs in ophthalmology: some problems and promises. Section III: Sympathomimetic drugs. Annals of ophthalmology, 1974, Volume: 6, Issue:9 Topics: Adrenergic beta-Agonists; Albuterol; Animals; Aqueous Humor; Cats; Cornea; Depression, Chemical; Epi	1974
Closed-angle glaucoma. Experimental results. The British journal of ophthalmology, 1974, Volume: 58, Issue:1 Topics: Cyclopentanes; Glaucoma; Gonioscopy; Humans; Intraocular Pressure; Iris; Moxisylyte; Phenylephrine;	1974
Recent contributions to the study of diabetic angiopathy and neuropathy. Advances in metabolic disorders, 1972, Volume: 6 Topics: Autonomic Nervous System; Capillary Fragility; Capillary Permeability; Coronary Disease; Diabetes Co	1972
The lens. Archives of ophthalmology (Chicago, Ill. : 1960), 1972, Volume: 87, Issue:4 Topics: Anesthesia, General; Anesthesia, Local; Attitude to Health; Cataract; Cataract Extraction; Edema; Gl	1972
Recent advances in veterinary and comparative ophthalmology. Advances in veterinary science and comparative medicine, 1972, Volume: 16 Topics: Animals; Cataract; Cats; Cattle; Ciliary Body; Conjunctivitis; Cornea; Dogs; Eye Diseases; Eye Neopl	1972
Mechanisms of glaucoma in eyes with uveal malignant melanomas. International ophthalmology clinics, 1972,Spring, Volume: 12, Issue:1 Topics: Ciliary Body; Eye Neoplasms; Glaucoma; Humans; Intraocular Pressure; Iris; Melanoma; Retinal Detachm	1972
Pediatric ophthalmology in small animal practice. The Veterinary clinics of North America, 1973, Volume: 3, Issue:3 Topics: Animals; Cat Diseases; Cataract; Cats; Coloboma; Cornea; Dermoid Cyst; Dog Diseases; Dogs; Entropion	1973
Recent advances in the surgical treatment of glaucoma. The British journal of ophthalmology, 1974, Volume: 58, Issue:4 Topics: Acetazolamide; Ciliary Body; Glaucoma; Gonioscopy; Humans; Hydrophthalmos; Intraocular Pressure; Iri	1974
Provocative tests in angle-closure glaucoma: a brief review with commentary. Ophthalmic surgery, 1974,Summer, Volume: 5, Issue:2 Topics: Acute Disease; Aqueous Humor; Darkness; Glaucoma; Gonioscopy; Humans; Intraocular Pressure; Iris; My	1974
The phakomatoses. International ophthalmology clinics, 1972,Spring, Volume: 12, Issue:1 Topics: Angiomatosis; Anterior Chamber; Arteriovenous Fistula; Ataxia Telangiectasia; Brain Neoplasms; Choro	1972
[Syndrome of the ciliary plexus of the orbit or syndrome of the reflexogenic orbital zone]. Revue d'oto-neuro-ophtalmologie, 1966, Volume: 38, Issue:7 Topics: Ciliary Body; Eye Diseases; Glaucoma; Humans; Hyperopia; Iris; Orbit; Reflex	1966
[Clinical course, prognosis and therapy of malignant uveal melanoma]. Klinische Monatsblatter fur Augenheilkunde, 1968, Volume: 153, Issue:1 Topics: Adult; Aged; Eye Neoplasms; Female; Glaucoma; Humans; Iris; Male; Melanoma; Middle Aged; Neoplasm Me	1968
Pharmacology and toxicology of ophthalmic drugs. Archives of ophthalmology (Chicago, Ill. : 1960), 1968, Volume: 80, Issue:4 Topics: Adolescent; Adult; Aged; Amblyopia; Anaphylaxis; Animals; Anti-Inflammatory Agents; Arthritis; Catar	1968
Surgical anatomy of glaucoma. Survey of ophthalmology, 1968, Volume: 13, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Anterior Chamber; Ciliary Body; Conjunctiva; Glaucoma; Humans; Iris;	1968
Glaucoma. Archives of ophthalmology (Chicago, Ill. : 1960), 1969, Volume: 81, Issue:3 Topics: Animals; Aqueous Humor; Cataract; Cataract Extraction; Cattle; Cholinesterase Inhibitors; Ciliary Bo	1969
Edema of the graft following penetrating keratoplasty. International ophthalmology clinics, 1968,Fall, Volume: 8, Issue:3 Topics: Chronic Disease; Corneal Dystrophies, Hereditary; Corneal Injuries; Corneal Transplantation; Desceme	1968
[Cataractogenic role of glaucoma surgery]. L'Annee therapeutique et clinique en ophtalmologie, 1968, Volume: 19 Topics: Cataract; Glaucoma; Humans; Intraocular Pressure; Iris; Miotics; Postoperative Complications; Sclera	1968
Photocoagulation coreplasty. Transactions of the Pacific Coast Oto-Ophthalmological Society annual meeting, 1969, Volume: 50 Topics: Adolescent; Adult; Aged; Cataract Extraction; Child; Child, Preschool; Cornea; Edema; Eye Diseases;	1969
[Review on operations and operative instruments, 1969]. Ganka. Ophthalmology, 1971, Volume: 13, Issue:2 Topics: Anesthesia; Cataract Extraction; Choroid; Conjunctiva; Cornea; Eye Injuries; Eyelids; Face; Glaucoma	1971
The treatment of open- and narrow-angle glaucoma. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1971, Apr-10, Volume: 45, Issue:15 Topics: Carbonic Anhydrase Inhibitors; Cholinesterase Inhibitors; Eye; Glaucoma; Humans; Intraocular Pressur	1971
[Morphology of the iridocorneal region and its relation to glaucoma problems]. Bucherei des Augenarztes, 1971, Volume: 56 Topics: Aged; Aging; Ciliary Body; Cornea; Glaucoma; Humans; Iris; Microscopy, Electron; Middle Aged	1971
[Sympatomatology of congenital glaucoma]. Revista brasileira de oftalmologia, 1970, Volume: 29, Issue:1 Topics: Adolescent; Adult; Anterior Chamber; Blood Pressure; Child; Child, Preschool; Ciliary Body; Cornea;	1970
[Importance of the use of a surgical microscope in surgery of glaucoma]. Ganka. Ophthalmology, 1971, Volume: 13, Issue:12 Topics: Anterior Chamber; Aqueous Humor; Conjunctiva; Cornea; Glaucoma; Humans; Iris; Methods; Microscopy; M	1971

Article	Year
Predictors of long-term intraocular pressure control after lens extraction in primary angle closure glaucoma: results from the EAGLE trial. The British journal of ophthalmology, 2023, Volume: 107, Issue:8 Topics: Cataract Extraction; Glaucoma; Glaucoma, Angle-Closure; Humans; Intraocular Pressure; Iridectomy; Ir	2023
Fourteen-Year Outcome of Angle-Closure Prevention with Laser Iridotomy in the Zhongshan Angle-Closure Prevention Study: Extended Follow-up of a Randomized Controlled Trial. Ophthalmology, 2023, Volume: 130, Issue:8 Topics: Acute Disease; Eye Abnormalities; Follow-Up Studies; Glaucoma; Glaucoma, Angle-Closure; Gonioscopy;	2023
Scleral-fixated intraocular lens implantation in microspherophakia. Indian journal of ophthalmology, 2014, Volume: 62, Issue:5 Topics: Adolescent; Adult; Corneal Diseases; Ectopia Lentis; Female; Follow-Up Studies; Glaucoma; Humans; Ir	2014
YAG laser peripheral iridotomy for the prevention of pigment dispersion glaucoma a prospective, randomized, controlled trial. Ophthalmology, 2011, Volume: 118, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Disease Progression; Exfoliation Syndrome;	2011
Increase and decrease of measurements of iris density of glaucoma patients treated with latanoprost over 36 months. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2008, Volume: 24, Issue:1 Topics: Aged; Female; Follow-Up Studies; Glaucoma; Humans; Image Processing, Computer-Assisted; Iris; Latano	2008
Goniophotocoagulation in the management of rubeosis iridis. Lasers in surgery and medicine, 1981, Volume: 1, Issue:3 Topics: Adult; Aged; Argon; Clinical Trials as Topic; Follow-Up Studies; Glaucoma; Glaucoma, Open-Angle; Hum	1981
Use of the neodymium:YAG laser to create iridotomies in monkeys and humans. Transactions of the American Ophthalmological Society, 1984, Volume: 82 Topics: Animals; Corneal Opacity; Female; Glaucoma; Humans; Iris; Laser Therapy; Lasers; Macaca fascicularis	1984
A prospective, controlled study to compare the Scheie procedure with Watson's trabeculectomy. Ophthalmic surgery, 1980, Volume: 11, Issue:10 Topics: Cataract; Clinical Trials as Topic; Follow-Up Studies; Glaucoma; Humans; Hyphema; Iris; Male; Method	1980
A comparison between peripheral iridectomy with thermal sclerostomy and trabeculectomy: a controlled study. The British journal of ophthalmology, 1981, Volume: 65, Issue:11 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Female; Glaucoma; Hot Temperature; Humans; Intrao	1981
Comparison of argon laser iridotomy and sequential argon laser and Nd:YAG laser iridotomy in dark irides. Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:4 Topics: Aged; Aluminum Silicates; Eye Color; Female; Follow-Up Studies; Glaucoma; Humans; Iris; Laser Therap	1996
Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. Ophthalmology, 1995, Volume: 102, Issue:9 Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Clonidine; Double-Blind Method; Glaucoma; Hum	1995
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
Natural history and clinical management of central retinal vein occlusion. The Central Vein Occlusion Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:4 Topics: Aged; Cohort Studies; Female; Glaucoma; Guidelines as Topic; Humans; Iris; Light Coagulation; Male;	1997
The incidence and time-course of latanoprost-induced iridial pigmentation as a function of eye color. Survey of ophthalmology, 1997, Volume: 41 Suppl 2 Topics: Adrenergic beta-Antagonists; Double-Blind Method; Europe; Eye Color; Glaucoma; Humans; Incidence; In	1997
Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. Survey of ophthalmology, 2001, Volume: 45 Suppl 4 Topics: Adrenergic beta-Antagonists; Amides; Antihypertensive Agents; Bimatoprost; Cloprostenol; Conjunctiva	2001
Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients. Journal of glaucoma, 2001, Volume: 10, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Eye Color; Female; Glaucoma; Humans; Incide	2001
Mechanisms in open-angle glaucoma. The British journal of ophthalmology, 1978, Volume: 62, Issue:5 Topics: Dose-Response Relationship, Drug; Glaucoma; Humans; Intraocular Pressure; Iris; Phenylephrine; Piloc	1978
Trabeculectomy: a re-evaluation after three years and a comparison with Scheie's procedure. Ophthalmic surgery, 1975,Spring, Volume: 6, Issue:1 Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Blister; Ciliary Body; D	1975
Neodymium: YAG and argon laser iridotomy. Long-term follow-up in a prospective, randomized clinical trial. Ophthalmology, 1988, Volume: 95, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Argon; Clinical Trials as Topic; Follow-Up Studies; Glaucoma; Humans	1988
[Surgical peripheral iridectomy and argon laser iridotomy in primary closed-angle glaucoma. Comparative statistical study]. Journal francais d'ophtalmologie, 1988, Volume: 11, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Female; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therapy;	1988
Low-energy linear-incision neodymium: YAG laser iridotomy versus linear-incision argon laser iridotomy. A prospective clinical investigation. Ophthalmology, 1987, Volume: 94, Issue:12 Topics: Argon; Burns; Clinical Trials as Topic; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therapy;	1987
Peripheral anterior synechiae formation after trabeculoplasty. Archives of ophthalmology (Chicago, Ill. : 1960), 1988, Volume: 106, Issue:2 Topics: Aged; Aged, 80 and over; Cornea; Female; Glaucoma; Humans; Iris; Laser Therapy; Male; Middle Aged; T	1988
Argon laser trabeculoplasty in narrow angle glaucoma. Eye (London, England), 1987, Volume: 1 ( Pt 5) Topics: Aged; Eye; Glaucoma; Humans; Iris; Laser Therapy; Middle Aged; Prospective Studies; Trabeculectomy;	1987
Neodymium YAG and dye laser iridotomy--a comparative study. Transactions of the ophthalmological societies of the United Kingdom, 1986, Volume: 105 ( Pt 5) Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Cataract; Corneal Opacity; Glaucoma; Humans; Hyphe	1986
Corneal endothelial changes following short pulsed laser iridotomy and surgical iridectomy. Transactions of the ophthalmological societies of the United Kingdom, 1986, Volume: 105 ( Pt 5) Topics: Aged; Aged, 80 and over; Cell Count; Cornea; Corneal Injuries; Endothelium; Glaucoma; Humans; Iris;	1986
Q-switched neodymium-YAG laser iridotomy. A field trial with a portable laser system. Archives of ophthalmology (Chicago, Ill. : 1960), 1986, Volume: 104, Issue:4 Topics: Aged; Alaska; Clinical Trials as Topic; Female; Glaucoma; Humans; Inuit; Iris; Laser Therapy; Male;	1986
Q-switched neodymium-YAG laser iridotomy in patients in whom the argon laser fails. Archives of ophthalmology (Chicago, Ill. : 1960), 1986, Volume: 104, Issue:4 Topics: Argon; Clinical Trials as Topic; Corneal Opacity; Glaucoma; Hemorrhage; Humans; Intraocular Pressure	1986
Laser iridectomy. A controlled study comparing argon and neodymium: YAG. Ophthalmology, 1986, Volume: 93, Issue:1 Topics: Adult; Aged; Argon; Eye Diseases; Female; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therap	1986
Laser peripheral iridectomy comparing Q-switched neodymium YAG with argon. Transactions of the ophthalmological societies of the United Kingdom, 1985, Volume: 104 ( Pt 1) Topics: Argon; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therapy; Postoperative Complications; Pos	1985
A current study of the Moorfields glacuoma trial. Transactions of the ophthalmological societies of the United Kingdom, 1970, Volume: 90 Topics: Female; Glaucoma; Humans; Intraocular Pressure; Iris; Male; Middle Aged; Prospective Studies; Visual	1970

2-propanol and Glaucoma

Research Excerpts

Research

Studies (1,948)

Authors

Clinical Trials (14)

Trial Overview

Trial Outcomes

Average Ganglion Cell Layer (GCL) Thickness

Average Retinal Nerve Fiber Layer (RNFL) Thickness

Cup-to-disc Ratio (CDR)

Cup-to-disc Ratio (CDR) Assessed by Optical Coherence Tomography (OCT)

Intraocular Pressure (IOP)

Mean Deviation (MD)

Number of Participants With Repeat Treatments

Pattern Standard Deviation (PSD)

Visual Field Index (VFI)

Corrected Distance Visual Acuity (CDVA)

Intraocular Pressure (IOP)

Number of Intraocular Pressure Lowering Medications

Pain Level During Laser Treatment

The Extent of Latanoprost, Bimatoprost and Travoprost Induced Periocular Skin Hyperpigmentation Over a One Year Time Course in Newly Diagnosed Primary Open Angle and Ocular Hypertension Patients.

Central Foveal Outcome

Neovascularization of the Iris, Optic Nerve and Elsewhere

Total Number of Intravitreal Injections Over a 12 Month Period

Visual Acuity

Adverse Events

Visual Field

Nail Brittleness at 30 Days of Treatment

Number of Days Until the First Nail Chipped

Change From Baseline in Nail Length of Digits

Change From Baseline in Nail Length of Hands

Intraocular Pressure at 30 Days of Treatment

Reviews

Trials

Other Studies

Authors	Studies
Hatcher, JB	1
De Castro-Abeger, A	1
Brown, EN	1
Robinson, JL	1
Shieh, C	1
Xu, M	1
Li, K	1
He, W	1
Bastelica, P	1
Giraud, JM	1
Streho, M	1
Fénolland, JR	1
Liang, T	1
Zhang, C	2
Feng, ZX	1
Hu, M	1
Cui, Y	1
Li, J	2
Leng, F	1
Wu, Q	1
Li, L	2
Menapace, R	2
D'cruz, RP	1
Rao, A	2
Yan, YJ	1
Wu, LL	1
Laroche, D	1
Rickford, K	1
Sakkari, S	1
Stodolska-Nowak, A	1
Adamski, W	1
Brązert, A	1
Sygut, J	1
Marszałek, A	1
Rospond-Kubiak, I	1
Cheng, YY	1
Cheng, SM	1
Xu, HJ	1
Yin, J	1
Chen, H	2