2-propanol has been researched along with Corneal Wavefront Aberration in 9 studies
2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.
Corneal Wavefront Aberration: Asymmetries in the topography and refractive index of the corneal surface that affect visual acuity.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Faramarzi, A | 1 |
| Hassanpour, K | 1 |
| Yazdani, S | 1 |
| Moshirfar, M | 1 |
| Narang, P | 2 |
| Agarwal, A | 3 |
| Ashok Kumar, D | 1 |
| Holladay, J | 1 |
| Jaganathasamy, N | 1 |
| Kumar, DA | 1 |
| Sivagnanam, S | 1 |
| Wu, J | 1 |
| Zhong, X | 1 |
| Yang, B | 1 |
| Wang, Z | 1 |
| Yu, K | 1 |
| Torii, H | 1 |
| Negishi, K | 1 |
| Watanabe, K | 1 |
| Saiki, M | 1 |
| Kato, N | 1 |
| Tsubota, K | 1 |
| Parsipour, F | 1 |
| Razmju, H | 1 |
| Khatavi, F | 1 |
| Panahi, M | 1 |
| Nouralishahi, A | 1 |
| Peyman, A | 1 |
| van Philips, LA | 1 |
| Rudolph, M | 1 |
| Laaser, K | 1 |
| Bachmann, BO | 1 |
| Cursiefen, C | 1 |
| Epstein, D | 1 |
| Kruse, FE | 1 |
| Visser, N | 1 |
| Bauer, NJ | 1 |
| Nuijts, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Descemet Endothelial Thickness Comparison Trial[NCT02373137] | Phase 4 | 38 participants (Actual) | Interventional | 2015-01-22 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The BSCVA was recorded at 4 meters by a masked refractionist certified for the study using a protocol adapted from the Age-Related Eye Disease Study using Early Treatment Diabetic Retinopathy Study charts: chart R(2110), chart 1(2111), and chart 2(2112) (Precision Vision, Woodstock, IL). (NCT02373137)
Timeframe: 24 Months
| Intervention | LogMar (Mean) |
|---|---|
| UT-DSAEK | 0.15 |
| DMEK | 0.09 |
The BSCVA was recorded at 4 meters by a masked refractionist certified for the study using a protocol adapted from the Age-Related Eye Disease Study using Early Treatment Diabetic Retinopathy Study charts: chart R(2110), chart 1(2111), and chart 2(2112) (Precision Vision, Woodstock, IL). (NCT02373137)
Timeframe: 6 months
| Intervention | logMAR (Mean) |
|---|---|
| UT-DSAEK | 0.22 |
| DMEK | 0.05 |
(NCT02373137)
Timeframe: 24 months
| Intervention | cells/mm^2 (Mean) |
|---|---|
| UT-DSAEK | 1626 |
| DMEK | 1400 |
composite measure (NCT02373137)
Timeframe: 3, 6, 12, 24 months
| Intervention | new adverse events reported (Number) | |||
|---|---|---|---|---|
| Adverse Events at 3 months | Adverse Events at 6 months | Adverse Events at 12 months | Adverse Events at 24 months | |
| DMEK | 6 | 5 | 4 | 0 |
| UT-DSAEK | 4 | 4 | 1 | 0 |
The BSCVA was recorded at 4 meters by a masked refractionist certified for the study using a protocol adapted from the Age-Related Eye Disease Study using Early Treatment Diabetic Retinopathy Study charts: chart R(2110), chart 1(2111), and chart 2(2112) (Precision Vision, Woodstock, IL). (NCT02373137)
Timeframe: 3 and 12 months
| Intervention | logMAR (Mean) | |
|---|---|---|
| 3 Months | 12 Months | |
| DMEK | 0.11 | 0.04 |
| UT-DSAEK | 0.24 | 0.16 |
As measured by Pentacam (NCT02373137)
Timeframe: 24 months
| Intervention | root mean square in micrometers (Mean) | |||
|---|---|---|---|---|
| 24 Months Anterior Cornea 4.0-mm | 24 Months Posterior Cornea 4.0-mm | 24 Months Anterior Cornea 6.0-mm | 24 Months Posterior Cornea 6.0-mm | |
| DMEK | 0.211 | 0.086 | 0.679 | 0.260 |
| DSAEK | 0.215 | 0.155 | 0.707 | 0.450 |
Corneal anterior and posterior surface higher-order aberrations (HOA) were measured with Scheimpflug imaging (Pentacam) before surgery and at 3, 6, and 12 months post-operatively. Zernike orders 3-8 were calculated at 4.0- and 6.0-mm-diameter optical zones. The results reported here represent total HOA (Sum of Zernike orders 3-8). Note a single observation was not available for one eye in the DMEK group at 6 months, this was analyzed with last observation carried forward. (NCT02373137)
Timeframe: 3, 6, 12 months
| Intervention | root mean square in micrometers (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 Months Anterior Cornea 4.0-mm | 3 Months Posterior Cornea 4.0-mm | 3 Months Anterior Cornea 6.0-mm | 3 Months Posterior Cornea 6.0-mm | 6 Months Anterior Cornea 4.0-mm | 6 Months Posterior Cornea 4.0-mm | 6 Months Anterior Cornea 6.0-mm | 6 Months Posterior Cornea 6.0-mm | 12 Months Anterior Cornea 4.0-mm | 12 Months Posterior Cornea 4.0-mm | 12 Months Anterior Cornea 6.0-mm | 12 Months Posterior Cornea 6.0-mm | |
| DMEK | 0.288 | 0.116 | 0.829 | 0.346 | 0.243 | 0.095 | 0.724 | 0.288 | 0.241 | 0.098 | 0.723 | 0.284 |
| UT-DSAEK | 0.274 | 0.217 | 0.897 | 0.621 | 0.230 | 0.179 | 0.739 | 0.505 | 0.228 | 0.159 | 0.725 | 0.459 |
(NCT02373137)
Timeframe: 3, 6, 12 months
| Intervention | cells/mm^2 (Mean) | ||
|---|---|---|---|
| 3 Months | 6 Months | 12 Months | |
| DMEK | 2037 | 1963 | 1855 |
| UT-DSAEK | 2114 | 2113 | 2070 |
(NCT02373137)
Timeframe: Baseline 12 months
| Intervention | eyes (Count of Units) | |
|---|---|---|
| Graft Rejection | Graft Failure | |
| DMEK | 0 | 1 |
| UT-DSAEK | 0 | 1 |
As measured by Optical coherence tomography (OCT) and Pachymetry (NCT02373137)
Timeframe: 3, 6, 12, 24 months
| Intervention | root mean square in micrometers (Mean) | |||
|---|---|---|---|---|
| 3 months | 6 months | 12 months | 24 months | |
| DMEK | 516.5 | 519.67 | 521.36 | 526.88 |
| UT-DSAEK | 589.36 | 592.24 | 585.96 | 593.67 |
As measured by Pentacam densitometry (NCT02373137)
Timeframe: 24 months
| Intervention | eyes (Number) | ||
|---|---|---|---|
| Mild Interface Haze at 24 months | Moderate Interface Haze at 24 months | Severe Interface Haze at 24 months | |
| DMEK | 0 | 0 | 0 |
| UT-DSAEK | 0 | 1 | 0 |
As measured by Pentacam densitometry (NCT02373137)
Timeframe: 3, 6, 12 months
| Intervention | eyes (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Mild Interface Haze at 3 months | Moderate Interface Haze at 3 months | Severe Interface Haze at 3 months | Mild Interface Haze at 6 months | oderate Interface Haze at 6 months | Severe Interface Haze at 6 months | Mild Interface Haze at 12 months | oderate Interface Haze at 12 months | Severe Interface Haze at 12 months | |
| DMEK | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| UT-DSAEK | 2 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 |
"The National Eye Institute has developed the validated Visual Functioning Questionnaire (NEI-VFQ) to assess the effect of ocular conditions and vision on patient quality of life. The answers to the questionnaire are transformed into sub-scales, including: general health, general vision, ocular pain, near activities, distance activities, social functioning, mental health, role difficulties, dependency, driving, color vision, peripheral vision. Participants are assigned a numerical value for each sub-scale based on their answers between 0-100, where higher numbers indicate better visual function. These sub-scales are then combined according to National Eye Institute guidelines into an overall composite score for each participant. This overall composite score is also on a scale of 0-100, where higher numbers indicate better visual function.~Composite score based on National Eye Institute guidelines." (NCT02373137)
Timeframe: Baseline, 12 months
| Intervention | Composite scores on a scale (Mean) | |
|---|---|---|
| Baseline | 12 Months | |
| DMEK | 72.3 | 87.3 |
| UT-DSAEK | 72.5 | 85.9 |
1 trial available for 2-propanol and Corneal Wavefront Aberration
| Article | Year |
|---|---|
Combined wavefront-guided laser in situ keratomileusis and aspheric ablation profile with iris registration to correct myopia.
Topics: Adolescent; Adult; Astigmatism; Contrast Sensitivity; Corneal Topography; Corneal Wavefront Aberrati | 2013 |
8 other studies available for 2-propanol and Corneal Wavefront Aberration
| Article | Year |
|---|---|
Lower- and higher-order aberrations after photorefractive keratectomy with and without compensation of pupil centroid shift: fellow eye comparison.
Topics: Adult; Astigmatism; Cornea; Corneal Wavefront Aberration; Female; Humans; Iris; Lasers, Excimer; Mal | 2020 |
Pinhole pupilloplasty: Small-aperture optics for higher-order corneal aberrations.
Topics: Aged; Cornea; Corneal Topography; Corneal Wavefront Aberration; Humans; Iris; Light; Male; Middle Ag | 2019 |
Application of Purkinje images for pinhole pupilloplasty and relevance to chord length mu.
Topics: Aged; Astigmatism; Corneal Wavefront Aberration; Female; Humans; Iris; Male; Middle Aged; Pseudophak | 2019 |
Changes in higher-order aberrations after iris-fixated phakic intraocular lens implantation.
Topics: Adult; Corneal Topography; Corneal Wavefront Aberration; Female; Humans; Iris; Lens Implantation, In | 2013 |
Wavefront aberration and contrast sensitivity after implantation of foldable and rigid iris claw phakic intraocular lenses: Artiflex versus artisan.
Topics: Contrast Sensitivity; Corneal Wavefront Aberration; Follow-Up Studies; Humans; Hyperopia; Iris; Myop | 2016 |
Higher-order aberrations after iris-fixated foldable phakic intraocular lens implantation and wavefront-guided photorefractive keratectomy for the correction of myopia.
Topics: Adult; Corneal Topography; Corneal Wavefront Aberration; Female; Humans; Iris; Lens Implantation, In | 2011 |
Corneal higher-order aberrations after Descemet's membrane endothelial keratoplasty.
Topics: Adult; Aged; Aged, 80 and over; Cornea; Corneal Wavefront Aberration; Descemet Stripping Endothelial | 2012 |
Residual astigmatism following toric intraocular lens implantation related to pupil size.
Topics: Aberrometry; Astigmatism; Corneal Topography; Corneal Wavefront Aberration; Female; Humans; Iris; Le | 2012 |