Compounds > 2-piperidone
Page last updated: 2024-08-21

2-piperidone and Neoplasms

2-piperidone has been researched along with Neoplasms in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19904 (11.76)18.7374
1990's4 (11.76)18.2507
2000's5 (14.71)29.6817
2010's17 (50.00)24.3611
2020's4 (11.76)2.80

Authors

AuthorsStudies
Das, U; Dimmock, JR; Okudaira, N; Roayapalley, PK; Sakagami, H; Sharma, RK1
Bazzaro, M; Linder, S1
Cha, KS; Choi, YS; Kim, DJ; Kim, DK; Kim, EH; Kim, IJ; Kim, SS; Ku, BJ; Lee, CW; Song, KH1
Barbosa-Filho, JM; Bezerra, DP; Contessoto, NSA; Cornélio, ML; da Silveira, NJF; Girol, AP; Henrique, T; Oliani, SM; Silveira, ER; Stefanini, ACB; Tajara, EH; Zanon, CF1
Bai, E; Chen, Q; Du, X; Fu, W; Jiang, C; Jin, R; Li, W; Liang, G; Qiu, P; Wang, J; Wang, L; Wei, T; Wu, J; Xu, H; Yao, S1
Bauer, MR; Cunha, AC; Dhiman, A; Fersht, AR; Gogna, R; Gomm, JJ; Hansen, LA; Hideg, K; Holmes, M; Holmes, TR; Jones, LJ; Kiparoidze, S; Kuppusamy, ML; Kuppusamy, P; Madan, E; Nagane, M; Park, YA; Parker, TM; Pelham, CJ; Selvendiran, K; Shaik, K; Shee, K; Smith, SD; Tomás, AR1
Gunia-Krzyżak, A; Koczurkiewicz, P; Pękala, E; Piska, K; Wójcik-Pszczoła, K1
Duan, L; Hu, L; Li, W; Liao, G; Liu, Z; Ma, L; Wu, P; Yang, D; Zeng, L1
Altdörfer, V; Dörfel, D; Fuchs, AR; Grünebach, F; Kropp, KN; Maurer, S; Müller, MR; Rittig, SM; Salih, HR; Schmidt, M; Schnitte, S1
D'Arcy, P; Gurajada, D; Linder, S; Lundqvist, A; Sarhan, D; Wennerberg, E1
Kisselev, AF1
Anchoori, RK; Chen, X; Hung, CF; Jiang, R; Karanam, B; Matsui, W; Orlowski, RZ; Peng, S; Roden, RB; Rudek, MA; Tanno, T; Walters, KJ; Wang, JW; Zhao, M1
Cleveland, J; Farnet, CM; Jiang, H; Ju, J; Kwong, T; Lim, SK; Lohman, JR; Ma, M; Seo, JW; Shen, B; Yang, C; Zazopoulos, E1
Czarnik, AW; DeWitt, SH; Jacques, V; Judge, TM; Van der Ploeg, LH1
Armstrong, EA; Canon, J; Francis, DM; Harari, PM; Huang, S; Iyer, G; Li, C; Ma, F; Werner, LR1
Amjad, MW; Bukhari, SN; Hussain, MA; Jantan, I; Leng, J; Naeem-Ul-Hassan, M; Qin, HL; Sher, M; Zhang, CP1
Balzarini, J; Das, U; De Clercq, E; Dimmock, JR; Hossain, M; Kawase, M; Sakagami, H; Umemura, N1
Giralt, E; Lo Re, D1
Giannakakou, P; Hamel, E; Liotta, D; Malik, S; Snyder, JP; Thomas, SL; Zhong, D; Zhou, W1
Ishikawa, Y; Matsui, C; Nishiyama, S; Obata, R; Tachibana, M; Umezawa, K1
Fang, H; Li, M; Li, Q; Wang, X; Xu, W; Yuan, Y; Zhang, L; Zhang, X; Zhu, H1
Bao, L; Dai, HQ; Ding, R; Gao, H; Li, SF; Liu, HW; Wang, QX; Wen, HA; Zhang, LX; Zhao, F1
Bezerra, DP; Costa-Lotufo, LV; de Moraes, MO; Pessoa, C; Saker-Neto, N; Silveira, ER1
LINDROOS, B; NYYSSOENEN, O; SETAELAE, K1
LEYNS, J1
Das, U; Dimmock, JR; Kawase, M; Pati, HN; Quail, JW; Sakagami, H1
Umezawa, K1
Allen, TM; Arora, VK; Chen, M; Dimmock, JR; Kao, GY1
Burzynski, SR1
Eriguchi, N; Hara, H; Kumabe, T; Nishida, H; Sugita, Y; Tsuda, H; Yoshida, H1
Hamada, M; Homma, Y; Imoto, M; Nakae, K; Sawa, T; Takeuchi, T; Yoshimoto, Y1
Green, S1
Fireman, BH; Friedman, GD; Selby, JV1
Burzynski, B; Burzynski, SR; Liau, MC; Szopa, M1

Reviews

7 review(s) available for 2-piperidone and Neoplasms

ArticleYear
Piperlongumine (piplartine) as a lead compound for anticancer agents - Synthesis and properties of analogues: A mini-review.
    European journal of medicinal chemistry, 2018, Aug-05, Volume: 156

    Topics: Animals; Antineoplastic Agents, Phytogenic; Chemistry Techniques, Synthetic; Dioxolanes; Drug Discovery; Humans; Neoplasms; Piper; Piperidones; Structure-Activity Relationship

2018
The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy.
    European journal of medicinal chemistry, 2018, Nov-05, Volume: 159

    Topics: Dose-Response Relationship, Drug; Humans; Ligands; Molecular Structure; Neoplasms; Piperidones; Protein Binding; Proto-Oncogene Proteins c-mdm2; Structure-Activity Relationship; Tumor Suppressor Protein p53

2018
The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer.
    Molecules (Basel, Switzerland), 2017, Feb-09, Volume: 22, Issue:2

    Topics: Animals; Antineoplastic Agents; Biological Products; Cell Line, Tumor; Cell Movement; Drug Evaluation, Preclinical; Humans; Macrolides; Neoplasm Metastasis; Neoplasms; Piperidones

2017
Overview of the therapeutic potential of piplartine (piperlongumine).
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2013, Feb-14, Volume: 48, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Drugs, Investigational; Fruit; Humans; Medicine, Ayurvedic; Neoplasms; Patents as Topic; Piper; Piperidones

2013
[Screening of bioactive metabolites that suppress inflammation].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, Volume: 52, Issue:13 Suppl

    Topics: Animals; Anti-Inflammatory Agents; Benzamides; Biological Products; Cell Differentiation; Cyclohexanones; Depsipeptides; Drug Design; Drug Evaluation, Preclinical; Inflammation; Inflammation Mediators; Lipopolysaccharides; Neoplasms; NF-kappa B; Osteoclasts; Piperidones; Signal Transduction

2007
Potential of antineoplastons in diseases of old age.
    Drugs & aging, 1995, Volume: 7, Issue:3

    Topics: Aged; Aging; Animals; Antineoplastic Agents; Benzeneacetamides; Drug Combinations; Glutamine; Growth Inhibitors; Humans; Neoplasms; Peptides; Phenylacetates; Piperidones

1995
'Antineoplastons'. An unproved cancer therapy.
    JAMA, 1992, Jun-03, Volume: 267, Issue:21

    Topics: Benzeneacetamides; Humans; Neoplasms; Peptides; Piperidines; Piperidones

1992

Trials

2 trial(s) available for 2-piperidone and Neoplasms

ArticleYear
A prospective cohort study on effects of gemigliptin on cardiovascular outcomes in patients with type 2 diabetes (OPTIMUS study).
    Scientific reports, 2020, 11-04, Volume: 10, Issue:1

    Topics: Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Incidence; Kaplan-Meier Estimate; Male; Neoplasms; Piperidones; Prognosis; Prospective Studies; Pyrimidines; Republic of Korea; Treatment Outcome

2020
Toxicological study on antineoplastons A-10 and AS2-1 in cancer patients.
    The Kurume medical journal, 1995, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Child; Drug Combinations; Female; Glutamine; Humans; Male; Middle Aged; Neoplasms; Phenylacetates; Piperidones

1995

Other Studies

25 other study(ies) available for 2-piperidone and Neoplasms

ArticleYear
1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)- 4-Piperidone Hydrochloride and Related Compounds: Potent Cytotoxins Demonstrate Greater Toxicity to Neoplasms than Non- Malignant Cells.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2022, Volume: 18, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cytotoxins; Drug Screening Assays, Antitumor; Neoplasms; Piperidones; Structure-Activity Relationship

2022
Dienone Compounds: Targets and Pharmacological Responses.
    Journal of medicinal chemistry, 2020, 12-24, Volume: 63, Issue:24

    Topics: Alkenes; Animals; Antineoplastic Agents; Antiprotozoal Agents; Apoptosis; Azepines; Benzylidene Compounds; Cell Line; Humans; Neoplasms; Oxidative Stress; Piperidones; Plasmodium falciparum; Proteasome Endopeptidase Complex; Receptors, Steroid; Ubiquitin

2020
Biological and physical approaches on the role of piplartine (piperlongumine) in cancer.
    Scientific reports, 2020, 12-17, Volume: 10, Issue:1

    Topics: Alkaloids; Annexin A1; Anti-Inflammatory Agents; Antineoplastic Agents; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CCL2; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Neoplasm Invasiveness; Neoplasms; Piper; Piperidones; Tumor Microenvironment

2020
Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors.
    European journal of medicinal chemistry, 2018, Jan-20, Volume: 144

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; Humans; I-kappa B Kinase; Mice, Nude; Molecular Docking Simulation; Neoplasms; NF-kappa B; Phosphorylation; Piperidones; Signal Transduction

2018
The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.
    The Journal of biological chemistry, 2018, 03-23, Volume: 293, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Curcumin; Female; Humans; Mice; Mice, Nude; Mutant Proteins; Mutation; Neoplasms; Piperidones; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2018
The Deubiquitinase Inhibitor b-AP15 and Its Effect on Phenotype and Function of Monocyte-Derived Dendritic Cells.
    Neoplasia (New York, N.Y.), 2019, Volume: 21, Issue:7

    Topics: Apoptosis; Bortezomib; Cell Line, Tumor; Dendritic Cells; Deubiquitinating Enzymes; Enzyme Inhibitors; Humans; Monocytes; Neoplasms; Piperidones; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ubiquitin

2019
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells.
    Cancer immunology, immunotherapy : CII, 2013, Volume: 62, Issue:8

    Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Combined Modality Therapy; Cytokines; Cytotoxicity, Immunologic; HCT116 Cells; HeLa Cells; Humans; Immunotherapy, Adoptive; K562 Cells; Killer Cells, Natural; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, SCID; Neoplasms; Piperidones; Protease Inhibitors; Proteasome Endopeptidase Complex; T-Lymphocytes; TNF-Related Apoptosis-Inducing Ligand; Ubiquitination; Xenograft Model Antitumor Assays

2013
A novel bullet hits the proteasome.
    Cancer cell, 2013, Dec-09, Volume: 24, Issue:6

    Topics: Animals; Female; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Neoplasms; Piperidones; Proteasome Inhibitors

2013
A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer.
    Cancer cell, 2013, Dec-09, Volume: 24, Issue:6

    Topics: Animals; Boronic Acids; Bortezomib; Cell Line, Tumor; Endoplasmic Reticulum Stress; Female; Genes, p53; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms; Piperidones; Proteasome Inhibitors; Pyrazines; Ubiquitination

2013
Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.
    Biochemistry, 2014, Dec-16, Volume: 53, Issue:49

    Topics: Antibiotics, Antineoplastic; Bacterial Proteins; Base Sequence; Bioreactors; Cell Line, Tumor; Cell Survival; Drug Design; Gene Silencing; Humans; Macrolides; Models, Biological; Molecular Sequence Data; Molecular Structure; Multigene Family; Mutant Proteins; Neoplasms; Piperidones; Polyketide Synthases; Polyketides; Protein Engineering; Recombinant Proteins; Stereoisomerism; Streptomyces; Structure-Activity Relationship

2014
Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Mar-24, Volume: 112, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Female; Humans; Inflammation; Leukocytes, Mononuclear; Mice; Mice, SCID; Models, Chemical; Neoplasm Transplantation; Neoplasms; Piperidones; Quinazolinones; Stereoisomerism; Thalidomide; Tumor Necrosis Factor-alpha

2015
Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:9

    Topics: Acetates; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Disease Models, Animal; Humans; Mice; Neoplasms; Piperidones; Protein Binding; Proto-Oncogene Proteins c-mdm2; Radiation Tolerance; Radiation, Ionizing; Signal Transduction; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2015
Synthesis of α,β-Unsaturated Carbonyl-Based Compounds, Oxime and Oxime Ether Analogs as Potential Anticancer Agents for Overcoming Cancer Multidrug Resistance by Modulation of Efflux Pumps in Tumor Cells.
    Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

    Topics: Antineoplastic Agents; Cell Proliferation; Cyclohexanones; Drug Resistance, Multiple; ErbB Receptors; Ethers; Humans; Models, Molecular; Mutation; Neoplasms; Oximes; Piperidones; Proto-Oncogene Proteins B-raf; Structure-Activity Relationship; Tetralones; Tubulin; Tubulin Modulators; Tumor Cells, Cultured

2016
Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones.
    Bioorganic & medicinal chemistry, 2016, 05-15, Volume: 24, Issue:10

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Mice; Neoplasms; Piperidones; Structure-Activity Relationship

2016
EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.
    Cell cycle (Georgetown, Tex.), 2008, Volume: 7, Issue:15

    Topics: Antineoplastic Agents; Benzylidene Compounds; Cell Hypoxia; Curcumin; Cytoskeleton; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Epothilones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubules; Mitosis; Neoplasms; Paclitaxel; Piperidones; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Von Hippel-Lindau Tumor Suppressor Protein

2008
Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-kappaB.
    Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6

    Topics: Animals; Antioxidants; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Humans; Inhibitory Concentration 50; Jurkat Cells; Lipopolysaccharides; Mice; Models, Chemical; Neoplasms; NF-kappa B; Nitric Oxide; Piperidones

2009
Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione.
    Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16

    Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Proliferation; HL-60 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Phenylalanine; Piperidones; Protease Inhibitors; Structure-Activity Relationship; Swine

2010
Chemical constituents from endophytic fungus Fusarium oxysporum.
    Fitoterapia, 2011, Volume: 82, Issue:5

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Biological Products; Cell Line, Tumor; Fusarium; Humans; Methicillin-Resistant Staphylococcus aureus; Neoplasms; Phytotherapy; Piperidones; Pyridones

2011
[EFFECT OF IONIZING RAYS OF MITOSIS IN MALIGNANT AND BENIGN EPIDERMAL HYPERPLASIA IN MICE. V. EFFECT OF A SINGLE CONTACT IRRADIATION FOLLOWING A 10-DAY PERIOD OF PRETREATMENT WITH CARCINOGENS OR TUMOR-INDUCING AGENTS].
    Strahlentherapie, 1963, Volume: 122

    Topics: Benz(a)Anthracenes; Benzeneacetamides; Carcinogens; Cell Division; Hyperplasia; Hypertrophy; Mice; Mitosis; Neoplasms; Piperidones; Radiation Effects; Research; Skin; Skin Neoplasms; Strontium Isotopes; Surface-Active Agents; Toxicology; Yttrium Isotopes

1963
[RADIUM TREATED BOTRYOID SARCOMA OF THE VAGINA IN A 10-MONTH OLD GIRL].
    Nederlandsch tijdschrift voor verloskunde en gynaecologie, 1965, Volume: 64

    Topics: Benzeneacetamides; Female; Humans; Infant; Mesenchymoma; Neoplasms; Piperidones; Radium; Rhabdomyosarcoma, Embryonal; Vaginal Neoplasms

1965
Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:1

    Topics: Benzylidene Compounds; Cell Line, Tumor; Cell Survival; Cytotoxins; Humans; Hydrophobic and Hydrophilic Interactions; Models, Biological; Neoplasms; Piperidones; Sensitivity and Specificity

2008
Cytotoxic evaluation of some N-acyl and N-acyloxy analogues of 3,5-bis(arylidene)-4-piperidones.
    Drug design and discovery, 1994, Volume: 12, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Membrane; Drug Screening Assays, Antitumor; Drug Stability; Humans; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Neoplasms; Piperidones; Prodrugs; Structure-Activity Relationship

1994
Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities.
    The Journal of antibiotics, 2000, Volume: 53, Issue:10

    Topics: Animals; Antibiotics, Antineoplastic; Cell Movement; Cell Survival; Chemotaxis; DNA; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Fermentation; Humans; Lactones; Macrolides; Melanoma, Experimental; Mice; Neoplasms; Piperidones; Protein Biosynthesis; RNA; Streptomyces; Tumor Cells, Cultured; Wound Healing

2000
Screening prescription drugs for possible carcinogenicity: eleven to fifteen years of follow-up.
    Cancer research, 1989, Oct-15, Volume: 49, Issue:20

    Topics: Anti-Bacterial Agents; Atropa belladonna; Carcinogens; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Esophageal Neoplasms; Folic Acid; Follow-Up Studies; Gastrointestinal Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neomycin; Neoplasms; Phenylbutazone; Piperidones; Plants, Medicinal; Plants, Toxic; Polymyxin B; Propantheline; Secobarbital; Sulfathiazoles; Vitamins

1989
Chemo-surveillance: a novel concept of the natural defence mechanism against cancer.
    Drugs under experimental and clinical research, 1987, Volume: 13 Suppl 1

    Topics: Antineoplastic Agents; Benzeneacetamides; Humans; Neoplasms; Peptides; Piperidines; Piperidones

1987