Compounds > 2-piperidone
Page last updated: 2024-08-21

2-piperidone and Hepatocellular Carcinoma

2-piperidone has been researched along with Hepatocellular Carcinoma in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (20.00)18.2507
2000's1 (6.67)29.6817
2010's7 (46.67)24.3611
2020's4 (26.67)2.80

Authors

AuthorsStudies
Chen, J; Hoffmann, M; Li, Y; Liu, L; MacGorman, K; Palmisano, M; Zhou, S1
Cheng, X; Tian, P; Yan, X; Zheng, W1
Gao, ZF; Hou, GG; Meng, QG; Sun, Y; Wang, CH; Xin, WY; Yan, WB; Yao, BR1
Cong, W; Gao, ZF; Hou, GG; Sun, Y; Sun, YF; Wang, CH; Yan, WB; Zhang, JJ; Zhang, YL1
Chen, X; Ding, Y; Ge, J; Wang, B; Yu, B1
Chen, M; Fan, X; Ji, J; Lu, C; Song, J; Tu, J; Weng, Q; Wu, F; Xu, M; Zhang, D; Zhao, Z; Zheng, L1
Chen, X; Li, W; Shang, SQ; Shen, HQ; Zhao, XL1
Jin, X; Jin, Y; Li, X; Tin, L; Wu, Y; Zhang, F; Zhang, Y; Zhao, R1
Hou, L; Jiang, H; Liang, Y; Liu, L; Lu, Z; Meng, X; Pan, S; Song, X; Wang, J; Yin, D; Zheng, T1
Han, T; Liang, Y; Liu, H; Liu, L; Pan, S; Song, R; Tian, L; Wang, L1
Fang, X; Jiang, H; Liang, Y; Liu, H; Liu, J; Liu, L; Meng, X; Song, R; Tian, L; Wang, J; Wang, L; Yin, D; Zheng, T1
Ashida, H; Fukuda, I; Kodoi, R; Nishiumi, S; Yamamoto, N; Yoshida, K1
Hara, H; Iemura, A; Sata, M; Tsuda, H; Uchida, M; Yamana, K1
Eriguchi, N; Hara, H; Ishii, K; Nishida, H; Sasaki, K; Sugihara, S; Tanaka, N; Tsuda, H; Yoshimura, S1
Tsuda, H1

Trials

1 trial(s) available for 2-piperidone and Hepatocellular Carcinoma

ArticleYear
Single-Dose Pharmacokinetics, Safety, and Tolerability of Avadomide (CC-122) in Subjects With Mild, Moderate, or Severe Renal Impairment.
    Clinical pharmacology in drug development, 2020, Volume: 9, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Female; Genetic Pleiotropy; Glioblastoma; Hematologic Neoplasms; Humans; Liver Neoplasms; Male; Middle Aged; Piperidones; Quinazolinones; Renal Insufficiency; Safety; Severity of Illness Index; Ubiquitin-Protein Ligases

2020

Other Studies

14 other study(ies) available for 2-piperidone and Hepatocellular Carcinoma

ArticleYear
Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression.
    Cancer medicine, 2020, Volume: 9, Issue:12

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Piperidones; RNA, Circular; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
Discovery of novel NF-кB inhibitor based on scaffold hopping: 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine.
    European journal of medicinal chemistry, 2020, Jul-15, Volume: 198

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Dose-Response Relationship, Drug; Drug Design; Humans; Inflammation; Lipopolysaccharides; Liver Neoplasms; MAP Kinase Signaling System; Mice; Molecular Docking Simulation; NF-kappa B; Phosphorylation; Piperidones; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2020
Trifluoromethyl-substituted 3,5-bis(arylidene)-4-piperidones as potential anti-hepatoma and anti-inflammation agents by inhibiting NF-кB activation.
    Journal of enzyme inhibition and medicinal chemistry, 2021, Volume: 36, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lipopolysaccharides; Liver Neoplasms; Molecular Docking Simulation; Molecular Structure; NF-kappa B; Phosphorylation; Piperidones; Structure-Activity Relationship

2021
Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells.
    European journal of pharmacology, 2018, Apr-15, Volume: 825

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Survival; Deubiquitinating Enzymes; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Hep G2 Cells; Humans; Liver Neoplasms; Piperidones; Receptor, Notch1; Unfolded Protein Response; Wnt Signaling Pathway

2018
Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/β-catenin pathway inactivation through ICAT.
    Cancer letters, 2019, Sep-28, Volume: 460

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Mice, Nude; Neoplasm Invasiveness; Piperidones; RNA, Long Noncoding; Tumor Burden; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2019
Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil.
    Current cancer drug targets, 2015, Volume: 15, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase 9; Female; Fluorouracil; Humans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrroles; Xenograft Model Antitumor Assays

2015
EF24 Suppresses Invasion and Migration of Hepatocellular Carcinoma Cells
    BioMed research international, 2016, Volume: 2016

    Topics: Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Movement; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; Phosphorylation; Piperidones; Proto-Oncogene Proteins pp60(c-src)

2016
Diphenyl difluoroketone: a potent chemotherapy candidate for human hepatocellular carcinoma.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Animals; Apoptosis; Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin B1; Cyclooxygenase 2; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Nude; NF-kappa B; Piperidones; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Xenograft Model Antitumor Assays

2011
In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Liver Neoplasms, Experimental; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Piperidones; Tumor Burden; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays

2012
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.
    Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Resistance, Neoplasm; Drug Therapy, Combination; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Niacinamide; Phenylurea Compounds; Piperidones; Sorafenib; Treatment Outcome; Von Hippel-Lindau Tumor Suppressor Protein; Xenograft Model Antitumor Assays

2013
Antagonistic and agonistic effects of indigoids on the transformation of an aryl hydrocarbon receptor.
    Archives of biochemistry and biophysics, 2008, Feb-15, Volume: 470, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Indigo Carmine; Indoles; Liver; Mice; Piperidones; Receptors, Aryl Hydrocarbon

2008
Inhibitory effect of antineoplaston A10 and AS2-1 on human hepatocellular carcinoma.
    The Kurume medical journal, 1996, Volume: 43, Issue:2

    Topics: Antineoplastic Agents; Benzeneacetamides; Carcinoma, Hepatocellular; Drug Combinations; Glutamine; Humans; Liver Neoplasms; Phenylacetates; Piperidones; Tumor Cells, Cultured

1996
The inhibitory effect of the combination of antineoplaston A-10 injection with a small dose of cis-diamminedichloroplatinum on cell and tumor growth of human hepatocellular carcinoma.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:5

    Topics: alpha-Fetoproteins; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Carcinoma, Hepatocellular; Cell Division; Cisplatin; Dose-Response Relationship, Drug; Humans; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Piperidones; Tumor Cells, Cultured

1992
Inhibitory effect of antineoplaston A-10 on breast cancer transplanted to athymic mice and human hepatocellular carcinoma cell lines. The members of Antineoplaston Study Group.
    The Kurume medical journal, 1990, Volume: 37, Issue:2

    Topics: Administration, Oral; Animals; Benzeneacetamides; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Piperidines; Piperidones; Transplantation, Heterologous; Tumor Cells, Cultured

1990