2-oxo-3-methylvalerate and Degenerative Diseases, Central Nervous System
2-oxo-3-methylvalerate has been researched along with Degenerative Diseases, Central Nervous System in 2 studies
alpha-keto-beta-methylvaleric acid: RN given refers to parent cpd
3-methyl-2-oxovaleric acid : A 2-oxo monocarboxylic acid that is valeric acid carrying oxo- and methyl substituents at C-2 and C-3, respectively. An alpha-keto acid analogue and metabolite of isoleucine in man, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD).
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Huang, HM | 2 |
| Zhang, H | 1 |
| Xu, H | 2 |
| Gibson, GE | 2 |
| Ou, HC | 1 |
| Chen, HL | 1 |
| Fowler, C | 1 |
Other Studies
2 other studies available for 2-oxo-3-methylvalerate and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation.
Topics: Calcium; Cations, Divalent; Cytochrome c Group; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; | 2003 |
Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death.
Topics: Animals; Caspase 3; Caspases; Cell Death; Cell Membrane Permeability; Chromatin; Cyclosporine; Cytoc | 2003 |