2-oxindole has been researched along with Neoplasms in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 17 (80.95) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y; Xu, C; Zhao, G | 1 |
| Ghodsi, R; Yousefian, M | 1 |
| Bertrand, H; Chew, EH; Dang, TM; Hayes, JD; Nagle, AA; Reddy, SA; Tajima, H; Wells, G; Wong, SC | 1 |
| Awrey, DE; Ban, F; Chirgadze, NY; Edwards, L; Feher, M; Forrest, B; Green, E; Hodgson, R; Kiarash, R; Lang, Y; Laufer, R; Leung, G; Li, SW; Liu, Y; Mak, TW; Mao, G; Mason, JM; Pan, G; Patel, NK; Pauls, HW; Plotnikova, O; Qiu, W; Sampson, PB; Wei, X | 1 |
| Awrey, DE; Ban, F; Beletskaya, I; Cumming, G; Edwards, L; Feher, M; Forrest, B; Hodgson, R; Huang, P; Kiarash, R; Laufer, R; Li, SW; Liu, Y; Luo, X; Madeira, B; Mak, TW; Mao, G; Mason, JM; Nadeem, V; Pan, G; Patel, NK; Pauls, HW; Plotnikova, O; Sampson, PB; Wei, X | 1 |
| Crooks, PA; Madadi, NR; Penthala, NR; Yerramreddy, TR | 1 |
| Bondavalli, F; Botta, M; Schenone, S | 1 |
| Baraldi, PG; Baraldi, S; Basso, G; Bortolozzi, R; Lopez-Cara, LC; Mattiuzzo, E; Oliva, P; Prencipe, F; Romagnoli, R; Salvador, MK; Viola, G | 1 |
| Abdel-Aziz, HA; Afifi, SA; Attia, MI; Eldehna, WM; Keeton, AB; Piazza, GA | 1 |
| Bernard, D; Li, X; Liu, L; Lu, J; McEachern, D; Shargary, S; Sun, D; Sun, W; Wang, S; Yu, S; Zhao, T; Zhao, Y; Zou, P | 1 |
| Baska, F; Boon, TC; Greff, Z; Horváth, Z; Kéri, G; Németh, G; Orfi, L; Szántai-Kis, C; Szokol, B; Zsákai, L | 1 |
| Al-As'ad, RM; Alaskar, AS; Aljada, A; El-Abadelah, MM; Sabri, SS; Saleh, AM; Zahra, JA | 1 |
| Deng, X; Fang, T; Guo, K; Jiang, J; Song, S; Su, W; Wang, J; Wang, Y; Wu, AA; Wu, X; Xu, Q | 1 |
| Golding, BT; Hardcastle, IR; Zhang, B | 1 |
| Dong, H; Li, J; Ouyang, L; Song, S; Xu, C; Zhang, H | 1 |
| Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M | 1 |
| Carvalho, ÂR; de Oliveira, LF; Dietrich, F; Kaiser, S; Machado, MM; Manica, F; Oliveira Battastini, AM; Ortega, GG; Pittol, V | 1 |
| Filip, B; Gulewicz, K; Kuraś, M; Pilarski, R; Wietrzyk, J | 1 |
| Almerico, AM; Ippolito, M; Lauria, A; Pantano, L; Tutone, M | 1 |
| Giulianotti, MA; Ouyang, J; Yu, Y; Zhang, L; Zou, H | 1 |
| Bouska, J; Gandhi, VB; Giranda, VL; Gong, J; Guan, R; Jarvis, K; Johnson, EF; Jong, RD; Klinghofer, V; Li, Q; Liu, X; Luo, Y; Magnone, SR; Oleksijew, A; Oltersdorf, T; Park, C; Rosenberg, SH; Shi, Y; Shoemaker, A; Zhu, GD | 1 |
5 review(s) available for 2-oxindole and Neoplasms
| Article | Year |
|---|---|
Structure-activity relationship studies of indolin-2-one derivatives as vascular endothelial growth factor receptor inhibitors and anticancer agents.
Topics: Angiogenesis Inhibitors; Animals; Humans; Indoles; Molecular Structure; Neoplasms; Neovascularization, Pathologic; Protein Kinase Inhibitors; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Structure-Activity Relationship; Sunitinib | 2020 |
Antiangiogenic agents: an update on small molecule VEGFR inhibitors.
Topics: Angiogenesis Inhibitors; Animals; Chemistry, Pharmaceutical; Drug Design; Humans; Indoles; Inhibitory Concentration 50; Models, Chemical; Neoplasms; Neovascularization, Pathologic; ortho-Aminobenzoates; Phthalimides; Receptors, Vascular Endothelial Growth Factor; RNA, Catalytic; Signal Transduction; Triazines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Small-molecule MDM2-p53 inhibitors: recent advances.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Crystallography, X-Ray; Humans; Imidazoles; Indoles; Models, Molecular; Neoplasms; Oxindoles; para-Aminobenzoates; Piperazines; Protein Interaction Maps; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Small Molecule Libraries; Structure-Activity Relationship; Tumor Suppressor Protein p53 | 2015 |
2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014).
Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Drug Design; Humans; Indoles; Molecular Targeted Therapy; Neoplasms; Oxindoles; Patents as Topic | 2016 |
Molecular modeling approaches in the discovery of new drugs for anti-cancer therapy: the investigation of p53-MDM2 interaction and its inhibition by small molecules.
Topics: Antineoplastic Agents; Benzodiazepinones; Drug Design; Humans; Imidazolines; Indoles; Molecular Dynamics Simulation; Neoplasms; Oxindoles; Protein Structure, Tertiary; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2010 |
16 other study(ies) available for 2-oxindole and Neoplasms
| Article | Year |
|---|---|
The Development of 3-substituted Indolin-2-one Derivatives as Kinase Inhibitors for Cancer Therapy.
Topics: Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Neoplasms; Protein Kinase Inhibitors; Structure-Activity Relationship | 2022 |
3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.
Topics: Acrolein; Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Cytokines; Cytoskeletal Proteins; HEK293 Cells; Humans; Indoles; Kelch-Like ECH-Associated Protein 1; Mice; Monocytes; Neoplasms; NF-E2-Related Factor 2; NF-kappa B | 2014 |
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Discovery; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Indoles; MCF-7 Cells; Mice; Models, Chemical; Molecular Structure; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Spiro Compounds; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2015 |
The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor ag
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Cell Survival; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Female; HCT116 Cells; Humans; Indazoles; Indoles; Male; MCF-7 Cells; Mice, Nude; Mice, SCID; Models, Chemical; Molecular Structure; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2015 |
Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Imidazolidines; Indoles; Neoplasms | 2010 |
Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Glutathione; Humans; Indoles; Membrane Potential, Mitochondrial; Neoplasms; Oxindoles; Reactive Oxygen Species; Structure-Activity Relationship | 2017 |
New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres.
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Drug Carriers; Drug Resistance, Neoplasm; Humans; Hydrazones; Indoles; Lactic Acid; Microspheres; Neoplasms; Oxindoles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2017 |
A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.
Topics: Animals; Area Under Curve; Blotting, Western; Cell Line, Tumor; Cell Proliferation; HCT116 Cells; Humans; Indoles; Inhibitory Concentration 50; Kinetics; Mice; Microsomes; Molecular Structure; Neoplasms; Oxindoles; Protein Binding; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Spiro Compounds; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2013 |
[Developing FGFR inhibitors as potential anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Computer Simulation; Gene Expression Regulation, Neoplastic; Humans; Indoles; Mutation; Neoplasms; Oxindoles; Receptors, Fibroblast Growth Factor; Thiophenes; Up-Regulation | 2013 |
Synthesis and biological evaluation of new pyridone-annelated isoindigos as anti-proliferative agents.
Topics: Apoptosis; Caco-2 Cells; Cell Proliferation; HEK293 Cells; Humans; Indoles; K562 Cells; Neoplasms; Oxindoles; Pyridones; Structure-Activity Relationship | 2014 |
Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9.
Topics: Antineoplastic Agents; Cell Proliferation; Circular Dichroism; Fusion Proteins, bcr-abl; Humans; Indole Alkaloids; Indoles; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Molecular Structure; Neoplasms; Nuclear Magnetic Resonance, Biomolecular; Oxindoles; Protein Kinase Inhibitors; Rhizosphere; Spectrometry, Mass, Electrospray Ionization; Spiro Compounds; Streptomyces; Tumor Cells, Cultured | 2014 |
The discovery of oxazolones-grafted spirooxindoles via three-component diversity oriented synthesis and their preliminary biological evaluation.
Topics: Antineoplastic Agents; Azo Compounds; Benzylidene Compounds; Cell Line, Tumor; Cycloaddition Reaction; Drug Discovery; Humans; Indoles; Models, Molecular; Neoplasms; Oxazolone; Oxindoles; Pyrrolidines; Spiro Compounds; Stereoisomerism; Thiosemicarbazones | 2015 |
Genotoxicity and cytotoxicity of oxindole alkaloids from Uncaria tomentosa (cat's claw): Chemotype relevance.
Topics: Antineoplastic Agents, Phytogenic; Cat's Claw; Cell Survival; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Humans; Indole Alkaloids; Indoles; Inhibitory Concentration 50; Leukocytes; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Molecular Structure; Neoplasms; Oxindoles; Phytotherapy; Plant Bark; Plant Extracts; Plant Leaves; Plants, Medicinal; Risk Assessment; Structure-Activity Relationship | 2016 |
Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Cat's Claw; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Neoplasms; Oxindoles; Phytotherapy; Plant Bark; Plant Extracts | 2010 |
Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Indoles; Models, Molecular; Neoplasms; Oxindoles; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Indoles; Mice; Models, Molecular; Molecular Structure; Neoplasms; Oxindoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2006 |