Page last updated: 2024-08-24

2-oxindole and Neoplasms

2-oxindole has been researched along with Neoplasms in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (9.52)29.6817
2010's17 (80.95)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Liu, Y; Xu, C; Zhao, G1
Ghodsi, R; Yousefian, M1
Bertrand, H; Chew, EH; Dang, TM; Hayes, JD; Nagle, AA; Reddy, SA; Tajima, H; Wells, G; Wong, SC1
Awrey, DE; Ban, F; Chirgadze, NY; Edwards, L; Feher, M; Forrest, B; Green, E; Hodgson, R; Kiarash, R; Lang, Y; Laufer, R; Leung, G; Li, SW; Liu, Y; Mak, TW; Mao, G; Mason, JM; Pan, G; Patel, NK; Pauls, HW; Plotnikova, O; Qiu, W; Sampson, PB; Wei, X1
Awrey, DE; Ban, F; Beletskaya, I; Cumming, G; Edwards, L; Feher, M; Forrest, B; Hodgson, R; Huang, P; Kiarash, R; Laufer, R; Li, SW; Liu, Y; Luo, X; Madeira, B; Mak, TW; Mao, G; Mason, JM; Nadeem, V; Pan, G; Patel, NK; Pauls, HW; Plotnikova, O; Sampson, PB; Wei, X1
Crooks, PA; Madadi, NR; Penthala, NR; Yerramreddy, TR1
Bondavalli, F; Botta, M; Schenone, S1
Baraldi, PG; Baraldi, S; Basso, G; Bortolozzi, R; Lopez-Cara, LC; Mattiuzzo, E; Oliva, P; Prencipe, F; Romagnoli, R; Salvador, MK; Viola, G1
Abdel-Aziz, HA; Afifi, SA; Attia, MI; Eldehna, WM; Keeton, AB; Piazza, GA1
Bernard, D; Li, X; Liu, L; Lu, J; McEachern, D; Shargary, S; Sun, D; Sun, W; Wang, S; Yu, S; Zhao, T; Zhao, Y; Zou, P1
Baska, F; Boon, TC; Greff, Z; Horváth, Z; Kéri, G; Németh, G; Orfi, L; Szántai-Kis, C; Szokol, B; Zsákai, L1
Al-As'ad, RM; Alaskar, AS; Aljada, A; El-Abadelah, MM; Sabri, SS; Saleh, AM; Zahra, JA1
Deng, X; Fang, T; Guo, K; Jiang, J; Song, S; Su, W; Wang, J; Wang, Y; Wu, AA; Wu, X; Xu, Q1
Golding, BT; Hardcastle, IR; Zhang, B1
Dong, H; Li, J; Ouyang, L; Song, S; Xu, C; Zhang, H1
Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M1
Carvalho, ÂR; de Oliveira, LF; Dietrich, F; Kaiser, S; Machado, MM; Manica, F; Oliveira Battastini, AM; Ortega, GG; Pittol, V1
Filip, B; Gulewicz, K; Kuraś, M; Pilarski, R; Wietrzyk, J1
Almerico, AM; Ippolito, M; Lauria, A; Pantano, L; Tutone, M1
Giulianotti, MA; Ouyang, J; Yu, Y; Zhang, L; Zou, H1
Bouska, J; Gandhi, VB; Giranda, VL; Gong, J; Guan, R; Jarvis, K; Johnson, EF; Jong, RD; Klinghofer, V; Li, Q; Liu, X; Luo, Y; Magnone, SR; Oleksijew, A; Oltersdorf, T; Park, C; Rosenberg, SH; Shi, Y; Shoemaker, A; Zhu, GD1

Reviews

5 review(s) available for 2-oxindole and Neoplasms

ArticleYear
Structure-activity relationship studies of indolin-2-one derivatives as vascular endothelial growth factor receptor inhibitors and anticancer agents.
    Archiv der Pharmazie, 2020, Volume: 353, Issue:12

    Topics: Angiogenesis Inhibitors; Animals; Humans; Indoles; Molecular Structure; Neoplasms; Neovascularization, Pathologic; Protein Kinase Inhibitors; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Structure-Activity Relationship; Sunitinib

2020
Antiangiogenic agents: an update on small molecule VEGFR inhibitors.
    Current medicinal chemistry, 2007, Volume: 14, Issue:23

    Topics: Angiogenesis Inhibitors; Animals; Chemistry, Pharmaceutical; Drug Design; Humans; Indoles; Inhibitory Concentration 50; Models, Chemical; Neoplasms; Neovascularization, Pathologic; ortho-Aminobenzoates; Phthalimides; Receptors, Vascular Endothelial Growth Factor; RNA, Catalytic; Signal Transduction; Triazines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2007
Small-molecule MDM2-p53 inhibitors: recent advances.
    Future medicinal chemistry, 2015, Volume: 7, Issue:5

    Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Crystallography, X-Ray; Humans; Imidazoles; Indoles; Models, Molecular; Neoplasms; Oxindoles; para-Aminobenzoates; Piperazines; Protein Interaction Maps; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Small Molecule Libraries; Structure-Activity Relationship; Tumor Suppressor Protein p53

2015
2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014).
    Expert opinion on therapeutic patents, 2016, Volume: 26, Issue:2

    Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Drug Design; Humans; Indoles; Molecular Targeted Therapy; Neoplasms; Oxindoles; Patents as Topic

2016
Molecular modeling approaches in the discovery of new drugs for anti-cancer therapy: the investigation of p53-MDM2 interaction and its inhibition by small molecules.
    Current medicinal chemistry, 2010, Volume: 17, Issue:28

    Topics: Antineoplastic Agents; Benzodiazepinones; Drug Design; Humans; Imidazolines; Indoles; Molecular Dynamics Simulation; Neoplasms; Oxindoles; Protein Structure, Tertiary; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53

2010

Other Studies

16 other study(ies) available for 2-oxindole and Neoplasms

ArticleYear
The Development of 3-substituted Indolin-2-one Derivatives as Kinase Inhibitors for Cancer Therapy.
    Current medicinal chemistry, 2022, Volume: 29, Issue:11

    Topics: Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Neoplasms; Protein Kinase Inhibitors; Structure-Activity Relationship

2022
3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention.
    ChemMedChem, 2014, Volume: 9, Issue:8

    Topics: Acrolein; Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Cytokines; Cytoskeletal Proteins; HEK293 Cells; Humans; Indoles; Kelch-Like ECH-Associated Protein 1; Mice; Monocytes; Neoplasms; NF-E2-Related Factor 2; NF-kappa B

2014
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
    Journal of medicinal chemistry, 2015, Jan-08, Volume: 58, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Discovery; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Indoles; MCF-7 Cells; Mice; Models, Chemical; Molecular Structure; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Spiro Compounds; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2015
The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor ag
    Journal of medicinal chemistry, 2015, Jan-08, Volume: 58, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Cell Survival; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Female; HCT116 Cells; Humans; Indazoles; Indoles; Male; MCF-7 Cells; Mice, Nude; Mice, SCID; Models, Chemical; Molecular Structure; Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2015
Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
    Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Imidazolidines; Indoles; Neoplasms

2010
Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents.
    European journal of medicinal chemistry, 2017, Jul-07, Volume: 134

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Glutathione; Humans; Indoles; Membrane Potential, Mitochondrial; Neoplasms; Oxindoles; Reactive Oxygen Species; Structure-Activity Relationship

2017
New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; Drug Carriers; Drug Resistance, Neoplasm; Humans; Hydrazones; Indoles; Lactic Acid; Microspheres; Neoplasms; Oxindoles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer

2017
A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.
    Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13

    Topics: Animals; Area Under Curve; Blotting, Western; Cell Line, Tumor; Cell Proliferation; HCT116 Cells; Humans; Indoles; Inhibitory Concentration 50; Kinetics; Mice; Microsomes; Molecular Structure; Neoplasms; Oxindoles; Protein Binding; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Spiro Compounds; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2013
[Developing FGFR inhibitors as potential anti-cancer agents].
    Acta pharmaceutica Hungarica, 2013, Volume: 83, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Computer Simulation; Gene Expression Regulation, Neoplastic; Humans; Indoles; Mutation; Neoplasms; Oxindoles; Receptors, Fibroblast Growth Factor; Thiophenes; Up-Regulation

2013
Synthesis and biological evaluation of new pyridone-annelated isoindigos as anti-proliferative agents.
    Molecules (Basel, Switzerland), 2014, Aug-25, Volume: 19, Issue:9

    Topics: Apoptosis; Caco-2 Cells; Cell Proliferation; HEK293 Cells; Humans; Indoles; K562 Cells; Neoplasms; Oxindoles; Pyridones; Structure-Activity Relationship

2014
Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9.
    Bioorganic & medicinal chemistry letters, 2014, Nov-01, Volume: 24, Issue:21

    Topics: Antineoplastic Agents; Cell Proliferation; Circular Dichroism; Fusion Proteins, bcr-abl; Humans; Indole Alkaloids; Indoles; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Molecular Structure; Neoplasms; Nuclear Magnetic Resonance, Biomolecular; Oxindoles; Protein Kinase Inhibitors; Rhizosphere; Spectrometry, Mass, Electrospray Ionization; Spiro Compounds; Streptomyces; Tumor Cells, Cultured

2014
The discovery of oxazolones-grafted spirooxindoles via three-component diversity oriented synthesis and their preliminary biological evaluation.
    Bioorganic & medicinal chemistry letters, 2015, Sep-01, Volume: 25, Issue:17

    Topics: Antineoplastic Agents; Azo Compounds; Benzylidene Compounds; Cell Line, Tumor; Cycloaddition Reaction; Drug Discovery; Humans; Indoles; Models, Molecular; Neoplasms; Oxazolone; Oxindoles; Pyrrolidines; Spiro Compounds; Stereoisomerism; Thiosemicarbazones

2015
Genotoxicity and cytotoxicity of oxindole alkaloids from Uncaria tomentosa (cat's claw): Chemotype relevance.
    Journal of ethnopharmacology, 2016, Aug-02, Volume: 189

    Topics: Antineoplastic Agents, Phytogenic; Cat's Claw; Cell Survival; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Humans; Indole Alkaloids; Indoles; Inhibitory Concentration 50; Leukocytes; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Molecular Structure; Neoplasms; Oxindoles; Phytotherapy; Plant Bark; Plant Extracts; Plant Leaves; Plants, Medicinal; Risk Assessment; Structure-Activity Relationship

2016
Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Dec-01, Volume: 17, Issue:14

    Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Cat's Claw; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Neoplasms; Oxindoles; Phytotherapy; Plant Bark; Plant Extracts

2010
Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Indoles; Models, Molecular; Neoplasms; Oxindoles; Vascular Endothelial Growth Factor Receptor-2

2011
Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
    Bioorganic & medicinal chemistry letters, 2006, Jul-01, Volume: 16, Issue:13

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Indoles; Mice; Models, Molecular; Molecular Structure; Neoplasms; Oxindoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Stereoisomerism; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2006