2-methylene-3-hexylbutanedioic-acid has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for 2-methylene-3-hexylbutanedioic-acid and Neoplasms
| Article | Year |
|---|---|
Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction.
Bioassay-guided fractionation of two cyanobacterial extracts from Papua New Guinea has yielded hoiamide D in both its carboxylic acid and conjugate base forms. Hoiamide D is a polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS)-derived natural product that features two consecutive thiazolines and a thiazole, as well as a modified isoleucine residue. Hoiamide D displayed inhibitory activity against p53/MDM2 interaction (EC(50)=4.5 μM), an attractive target for anticancer drug development. Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Cyanobacteria; Depsipeptides; Drug Design; Humans; Inhibitory Concentration 50; Isoleucine; Magnetic Resonance Spectroscopy; Models, Chemical; Neoplasms; Proto-Oncogene Proteins c-mdm2; Ribosomes; Thiazoles; Thiazolidines; Tumor Suppressor Protein p53 | 2012 |